Development of a machine learning-based predictive risk model combining fatty acid metabolism and ferroptosis for immunotherapy response and prognosis in prostate cancer by Zhenwei Wang, Zhihong Dai, Yuren Gao, Zhongxiang Zhao, Zhen Li, Liang Wang, Xiang Gao, Qiuqiu Qiu, Xiaofu Qiu, Zhiyu Liu

“…Functional enrichment analysis revealed distinct pathway activities, with high-risk patients showing enrichment in immune-related and proliferative pathways, while low-risk patients were enriched in metabolic pathways. …”
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Cross-Species Multi-Omics Analysis Reveals Myeloid-Driven Endothelial Oxidative Stress in Ischemic Stroke by Ziqi Cheng, Hua Zhu, Shi Feng, Yonggang Zhang, Xiaoxing Xiong

“…Methods: In this study, we integrated bulk RNA-sequencing (RNA-seq), single-cell RNA-seq (scRNA-seq), spatial transcriptomics, and flow cytometry data from human and mouse models of ischemic stroke. …”
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Dietary 5-hydroxytryptophan supplementation improves growth performance and intestinal health of weaned piglets by Yinzhao Xia, Xie Peng, Jiani Mao, Ju Luo, Huifeng Li, Dengjun Ma, Zhenguo Yang

“…Abstract This study investigated the effects of dietary 5-hydroxytryptophan (5-HTP) supplementation on growth performance, apparent total tract digestibility (ATTD), blood profile, intestinal morphology, transcriptomics, and microbial composition in weaned piglets. …”
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Neospora caninum hijacks host PFKFB3-driven glycolysis to facilitate intracellular propagation of parasites by De-Liang Tao, Jin-Ming Chen, Jiang-Ping Wu, Shan-Shan Zhao, Bu-Fan Qi, Xin Yang, Ying-Ying Fan, Jun-Ke Song, Guang-Hui Zhao

“…In this study, the analysis of metabolomics and transcriptomics revealed that N. caninum infection increases the expression of glycolysis-related enzymes and lactate production in caprine endometrial epithelial cells (EECs). …”
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Multi-omics reveals the mechanism of quality discrepancy between Gayal (Bos frontalis) and yellow cattle beef by Lin Han, Runqi Fu, Chunjia Jin, Huan Gao, Binlong Fu, Qian Li, Ye Yu, Min Qi, Jiawei Zhang, Shengyong Mao, Jing Leng

“…Genes related to intestinal amino acid absorption were upregulated in Gayal, while those connected to short-chain fatty acid absorption were downregulated. …”
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An interpretable survival model for diffuse large B-cell lymphoma patients using a biologically informed visible neural network by Jie Tan, Jiancong Xie, Jiarong Huang, Weizhen Deng, Hua Chai, Yuedong Yang

“…However, existing DLBCL prognostic models are mainly based on transcriptomic profiles, while genetic variation detection is more commonly used in clinical practice. …”
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Maternal exposure to polystyrene nanoplastics induces sex-specific cardiotoxicity in offspring mice by Xiuli Chen, Shenzhen Huang, Li Wang, Kan Liu, Haiying Wu

“…Fluid shear stress and atherosclerosis were significantly enriched in PS-NP-treated male offspring, while viral myocarditis was predominantly enriched in PS-NP-treated females. …”
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Single-cell and machine learning integration reveals ferroptosis-driven immune landscapes for melanoma stratification by Lei Wang, Lei Wang, Xueying Jin, Yuchen Wu, Runing Qiu, Jianfang Wang

“…Ferroptosis-immune subtypes were identified through consensus clustering and immune profiling, while prognostic models were constructed via LASSO/stepwise Cox regression and machine learning optimization.ResultsThree ferroptosis-immune subtypes exhibiting distinct survival outcomes and immune phenotypes were identified. …”
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NONO regulates m5C modification and alternative splicing of PTEN mRNAs to drive gastric cancer progression by Gaichao Zhao, Ruochen liu, Lingjun Ge, Dan Qi, Qishu Wu, Zini Lin, Houji Song, Liping Zhong, Hongjuan Cui

“…Abstract Background The effect of m5C modification on oncogene mRNAs has been well studied, while little is known about its influence on mRNAs of tumor suppressor genes (TSGs). …”
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Functional Verification of Differentially Expressed Genes Following DENV2 Infection in <i>Aedes aegypti</i> by Xiaoli Chen, Xinyu Zhou, Xiaoxue Xie, Bo Li, Teng Zhao, Haotian Yu, Dan Xing, Jiahong Wu, Chunxiao Li

“…In adult mosquitoes, knocking down defensin-A, defensin-A-like, and SMCT1 respectively reduced the DENV2 RNA copies, while knocking down UGT2B1 and ND4 respectively increased the DENV2 RNA copies. …”
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Brain miR-137 governs growth and development via GH/IGF-1 signaling by Keng-Mao Liao, Wei-Lun Hsu, Wan-Yi Huang, Wei-Jia Luo, Jung-Hsuan Chang, Sung-Liang Yu, Pan-Chyr Yang, Kang-Yi Su

“…Conditional deletion of Mir137 in the nervous system, but not in the liver, showed similar results, confirming the brain-specific role of miR-137. Transcriptomic analyses revealed that differentially expressed genes in the brain were enriched in development and neurogenesis while those in the liver showed diverse and less enrichments. …”
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Foliar Fe2O3 nanoparticles enhance cadmium tolerance in Amaranthus hypochondriacus by modulating cell wall immobilization and antioxidant defenses by Yanfeng Hu, Jia You, Yue Xiang, Runze Tian, Jianli Wang, Zhongbao Shen, Yansheng Li

“…Fe-NPs also reduced Cd-triggered oxidative damage by decreasing reactive oxygen species (ROS) and malondialdehyde (MDA) levels while enhancing antioxidant activities in leaves. …”
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Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression by Paul G. Pavicic, Patricia A. Rayman, Shadi Swaidani, Amit Rupani, Vladimir Makarov, Charles S. Tannenbaum, Robert P. Edwards, Anda M. Vlad, C. Marcela Diaz-Montero, Haider Mahdi

“…To effectively enhance the activity of immune checkpoint inhibition (ICI), there is a need to identify agents that target these immunosuppressive networks while promoting the recruitment of effector T cells into the TME. …”
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Synthesis of U-theraphotoxin-Pv1a_1, an Aedes aegypti larvicidal disulfide bridged peptide from the Colombian tarantula Pamphobeteus verdolaga (Araneae: Theraphosidae) by Sebastián Estrada-Gómez, Cristian Salinas-Restrepo, Leidy Johana Vargas-Muñoz, Fanny Guzmán, Cesar Segura, Davinia Pla, Libia Sanz, Juan J Calvete

“…U-theraphotoxin-Pv1a_1 sequence was gathered from venom proteomics and venom gland transcriptomics of Pamphobeteus verdolaga, and synthesized by solid phase using the Fmoc strategy followed by dimethyl sulfoxide promoted native disulfide bond formation. …”
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Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats by Pinar Sargin, Mark F. Roethle, Shuang Jia, Tarun Pant, Ashley E. Ciecko, Samantha N. Atkinson, Nita H. Salzman, Ru-Jeng Teng, Yi-Guang Chen, Susanne M. Cabrera, Martin J. Hessner

“…HCD+Lp299v pups exhibited increased plasma propionate and butyrate levels, which correlated with enriched fecal Bifidobacteriaceae and Clostridiales taxa. Islet transcriptomic and histologic analyses at 40-days of age revealed that rats fed HCD expressed an autophagy profile, while those provided HCD+Lp299v expressed ER-associated protein degradation (ERAD) and antioxidative defense pathways, including Nrf2. …”
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Molecular effects of clinically relevant chemotherapeutic agents on choline phospholipid metabolism in triple negative breast cancer cells by Caitlin M. Tressler, Kanchan Sonkar, Menglin Cheng, Vinay Ayyappan, Ruoqing Cai, Kristine Glunde

“…Specific chemotherapeutic drugs, including 5-fluorouracil and melphalan, resulted in the most significant effects on choline phospholipid metabolism, while other drugs did not significantly alter choline phospholipid metabolism. …”
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Staphylococcus aureus-specific TIGIT+ Treg are present in the blood of healthy subjects – a hurdle for vaccination? by Jonah Clegg, Jonah Clegg, Malgorzata E. Mnich, Malgorzata E. Mnich, Alberto Carignano, Giovanni Cova, Simona Tavarini, Chiara Sammicheli, Bruna Clemente, Megan Smith, Megan Smith, Emilio Siena, Monia Bardelli, Michela Brazzoli, Fabio Bagnoli, Rachel M. McLoughlin, Elisabetta Soldaini

“…As compared to polyclonally-activated CD4+ T cells, S. aureus-specific Tcon were enriched for the expression of the Th17-type cytokine genes IL17A, IL22 and IL26, while higher percentages of S. aureus-specific Treg expressed the T Cell Immunoreceptor with Ig and ITIM domains (TIGIT), a pleiotropic immune checkpoint. …”
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Multi-enzymatic biomimetic cerium‐based MOFs mediated precision chemodynamic synergistic antibacteria and tissue repair for MRSA-infected wounds by Shiqi Chen, Yifan Li, Qiang Ma, Jiayi Liang, Zhiyue Feng, Sihan Wang, Shuai Zhang, Ke Han, Boyan Sun, Hongping Wang, Haiyang Jiang

“…This system utilizes the inherent oxidase and peroxidase activities of a nanozyme to generate reactive oxygen species (ROS) for bacterial eradication, while its phosphate-ester hydrolase activity disrupts bacterial genetic material and energy metabolism. …”
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Response of Staphylococcus aureus to combination of virulent bacteriophage vB_SauM-515A1 and linezolid by Narina K. Abdraimova, Egor A. Shitikov, Dmitry A. Bespiatykh, Roman B. Gorodnichev, Ksenia M. Klimina, Vladimir A. Veselovsky, Daria I. Boldyreva, Alexandra S. Bogdanova, Alexandra S. Bogdanova, Dmitry V. Klinov, Dmitry V. Klinov, Maria A. Kornienko

“…Sequential administration resulted in antagonism, while simultaneous application demonstrated a synergistic effect, as confirmed through scanning electron microscopy. …”
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Genome-wide CRISPR/Cas9 screening identifies PTGR2 as a potential therapeutic target for sunitinib resistance in clear cell renal cell carcinoma by Wei Chang, Biao Zhang, Shujun Yang, Xingxing Zhang, Lili Zhang, Su Zhang, Jianzhong Lu, Wei Wang, Panfeng Shang, Zhongjin Yue

“…PTGR2 knockdown reduced KDM6A protein expression, while KDM6A overexpression partially reversed the sensitization effect of PTGR2 silencing, suggesting KDM6A is a major downstream effector. …”
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