Comparative analysis of dorsal and tail skin reveals region-dependent heterogeneity in axolotl skin regeneration by Lieke Yang, Qian Chen, Jinman Li, Yan Hu, Yaoxin Liu, Binbin Lu, Shuaibin Pei, Tingyi Huang, Yanmei Liu, Ji-Feng Fei

“…Here, we demonstrate that adult axolotl tail skin achieves scarless regeneration, while dorsal skin repair results in fibrotic scarring. …”
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Sodium houttuyfonate prevents NiO-NPs induced lung injury in rats through the TNF-α/JAK-STAT signaling pathway by Zongtong Yang, Tiefeng Sun, Mengru Zhang, Xiaojing Li, Yi Wang, Wei Li, Qiwei Wang, Xinru Wang, Shizeng Liu, Wenhui Wang, Ping Wang

“…Concurrently, network pharmacology and transcriptomic analyses were conducted to identify key molecular targets and signaling pathways. …”
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Comparative analysis of library preparation approaches for FFPE gene expression profiling and related recommendations by Sara Pignatta, Marcella Tazzari, Valentina Indio, Maria Maddalena Tumedei, Francesco Limarzi, Francesca Tauceri, Michela Tebaldi, Dalila Fanelli, Jenny Bulgarelli

“…Notably, Kit A achieved comparable gene expression quantification to Kit B while requiring 20-fold less RNA input, a crucial advantage for limited samples, albeit with increased sequencing depth. …”
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PROS1‐MERTK Axis Drives Tumor Microenvironment Crosstalk and Progression in Papillary Thyroid Microcarcinoma by Wenqian Zhang, Ye Zhang, Zhu Liu, Zhiyuan Wang, Huaqin Wang, Xiaoyu Ji, Hongyue Su, Fan Yang, Lirong Yan, Ying Xu, Hao Zhang, Wei Sun

“…Abstract The incidence of papillary thyroid carcinoma (PTC) has been rising annually, with papillary thyroid microcarcinoma (PTMC) accounting for more than half of the cases. While most PTMCs exhibit indolent growth and a favorable prognosis, some undergo clinical progression with poor outcomes. …”
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Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. by Charles C White, Hyun-Sik Yang, Lei Yu, Lori B Chibnik, Robert J Dawe, Jingyun Yang, Hans-Ulrich Klein, Daniel Felsky, Alfredo Ramos-Miguel, Konstantinos Arfanakis, William G Honer, Reisa A Sperling, Julie A Schneider, David A Bennett, Philip L De Jager

“…In secondary analyses, we explored the mechanism of these associations and found that ENC1 may be related to the previously documented effect of depression on cognitive decline, while UNC5C may alter the composition of presynaptic terminals. …”
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Regulation of tumor growth by leukocyte-specific protein 1 in T cells by Riri Kwon, Bong-Ki Hong, Kang-Gu Lee, Eunbyeol Choi, Laurent Sabbagh, Chul-Soo Cho, Naeun Lee, Wan-Uk Kim

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Unveiling PANoptosis in Acute Kidney Injury: An Integrative Multi-Dimensional Approach to Identify Key Biomarkers by Wang N, Zhang L, Xu Z, Xu Q, Lu Y, Niu P, Yan L, Wang L, Cao H, Shao F

“…PANoptosis, a highly regulated and complex form of programmed inflammatory cell death, integrates the molecular mechanisms of apoptosis, pyroptosis, and necroptosis. While this process has been implicated in various inflammatory conditions, its specific role in AKI remains unclear.Methods: The role of PANoptosis in AKI was investigated using single-cell RNA sequencing (scRNA-seq) and bulk transcriptomic data. …”
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CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation by Edward Abadir, Robin E. Gasiorowski, Kaitao Lai, Fiona Kupresanin, Adelina Romano, Pablo A. Silveira, Tsun‐Ho Lo, Phillip D. Fromm, Marina L. Kennerson, Harry J. Iland, P. Joy Ho, P. Mark Hogarth, Kenneth Bradstock, Derek N.J. Hart, Georgina J. Clark

“…To confirm the value of CD300f as a leukemic target, we showed that CD300f antibodies bind to AML from 85% of patient samples. While one CD300f monoclonal antibody (mAb) reportedly did not bind healthy hematopoietic stem cells, transcriptomic analysis found that CD300f transcripts are expressed by healthy HSPC. …”
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Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer’s disease by Alessia Caramello, Nurun Fancy, Clotilde Tournerie, Maxine Eklund, Vicky Chau, Emily Adair, Marianna Papageorgopoulou, Nanet Willumsen, Johanna S. Jackson, John Hardy, Paul M. Matthews

“…Here we showed that L5,6 RORB+FOXP2+ and L3,5,6 GAD1+FOXP2+ neurons, which accumulate amyloid-β intracellularly from early Braak stages, are selectively vulnerable to degeneration in AD, while L3 RORB+GPC5+ neurons, which accumulate pTau but not amyloid-β, are not lost even at late Braak stages. …”
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LDHB silencing enhances the effects of radiotherapy by impairing nucleotide metabolism and promoting persistent DNA damage by Haibin Deng, Fatlind Malsiu, Huixiang Ge, Tereza Losmanova, Michaela Medová, Nicola Zamboni, Wenxiang Wang, Ren-Wang Peng, Jinming Tang, Patrick Dorn, Thomas Michael Marti

“…These findings suggest that LDHB supports metabolic homeostasis and DNA damage repair in NSCLC, while its silencing enhances the effects of radiotherapy by impairing nucleotide metabolism and promoting persistent DNA damage.…”
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Atrial Cardiomyopathy in Atrial Fibrillation: A Multimodal Diagnostic Framework by Paschalis Karakasis, Panayotis K. Vlachakis, Panagiotis Theofilis, Nikolaos Ktenopoulos, Dimitrios Patoulias, Barbara Fyntanidou, Antonios P. Antoniadis, Nikolaos Fragakis

“…Electroanatomic mapping is discussed as a key invasive tool for substrate localization, while electrocardiographic indices such as P-wave morphology and dispersion serve as accessible surrogates of electrical remodeling. …”
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Morpho-Physiological and Molecular Responses to Seedling-Stage Drought Stress in Different Cowpea Cultivars by Inocent Paulin Ritte, Marceline Egnin, Gregory Christopher Bernard, Desmond Mortley, Osagie Idehen, Michelle Pamelas Okoma, Conrad Bonsi

“…California Blackeye (72.2%) and TVu11987 (69.4%) had the highest recovery rates, indicating greater drought tolerance, while TVu2428 had the lowest (2.8%). Gene expression analyses revealed significant drought-induced variation across cultivars and time points. …”
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Personalized Microbiome Modulation to Improve Clinical Outcomes in Pediatric Inflammatory Bowel Disease: A Multi-Omics and Interventional Approach by Adrian Goldiș, Radu Dragomir, Marina Adriana Mercioni, Christian Goldiș, Diana Sirca, Ileana Enătescu, Laura Olariu, Oana Belei

“…Symptoms such as bloating and abdominal pain decreased, while energy levels increased (<i>p</i> < 0.001). …”
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Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes by Zhenli Guo, Shizhong Liu, Xianghong Hou, Xin Zhou, Yan Wang, Yi Rong, Xinzhi Li, Rui Yang, Ketao Ma

“…Furthermore, isorhamnetin pretreatment reduced intracellular glucose and lactate levels while increasing ATP content in a concentration-dependent manner. …”
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Multi-omics profiling of Nanhaia speciosa and Nanhaia fordii: insights into lectin dynamics, nodulation, and triterpenoid saponin biosynthesis by Zhiying Li, Jiabin Wang, Junfang Zhang, Yunliu Fu, Yonglin Jing, Bilan Huang, Huazhou Wu, Chunyang Meng, Li Xu

“…Results To analyze the differences and underlying basis between N. speciosa and N. fordii, we conducted a comprehensive comparison of their genomic, transcriptomic, and metabolomic data. Using PacBio HiFi and Hi-C data, we achieved high-quality haploid genomes for both N. speciosa and N. fordii. …”
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ATRX, OLIG2, MGMT, and IDH2 in Glioblastoma: Essential Molecular Mechanisms and Therapeutic Significance by Andrea Pop-Crisan, Radu Pirlog, Lavinia-Lorena Pruteanu, Constantin Busuioc, Ovidiu-Laurean Pop, Deo Prakash Pandey, Cornelia Braicu, Ioana Berindan-Neagoe

“…<i>Results</i>: The expression analysis revealed that ATRX is downregulated at the gene level but overexpressed at the protein level, while OLIG2 is consistently overexpressed at both levels. …”
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Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress by Iart Luca Shytaj, Francesco Andrea Procopio, Mohammad Tarek, Irene Carlon‐Andres, Hsin‐Yao Tang, Aaron R Goldman, MohamedHusen Munshi, Virender Kumar Pal, Mattia Forcato, Sheetal Sreeram, Konstantin Leskov, Fengchun Ye, Bojana Lucic, Nicolly Cruz, Lishomwa C Ndhlovu, Silvio Bicciato, Sergi Padilla‐Parra, Ricardo Sobhie Diaz, Amit Singh, Marina Lusic, Jonathan Karn, David Alvarez‐Carbonell, Andrea Savarino

“…Glycolytic metabolism has been identified as a determinant of susceptibility to HIV‐1 infection, but its role in the development and maintenance of HIV‐1 latency has not been elucidated. By combining transcriptomic, proteomic, and metabolomic analyses, we here show that transition to latent HIV‐1 infection downregulates glycolysis, while viral reactivation by conventional stimuli reverts this effect. …”
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Blockade of CLEVER-1 restrains immune evasion and enhances anti-PD-1 immunotherapy in gastric cancer by Tianwei Xu, Jing Qin, Xiaolei Zhang, Zihao Zhang, Xinxin Guo, Yifan Cao, Yichao Gu, Kuan Yu, Leihao Wang, Zhenbin Shen

“…Transcriptomic and phenotypic analyses revealed that CLEVER-1+TAMs display a dynamic immunophenotype and critically suppress T-cell function, fostering an immunosuppressive microenvironment. …”
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Medical Hemorrhoid Gel Ameliorates Croton Oil-Induced Hemorrhoids by Suppressing the NLRP3 Inflammasome Activation via NF-&amp;kappa;B Signaling Pathway by Ai Z, Yuan D, Li Y, Cai J, Zhou D, Liu W

“…Specifically, MHG suppressed the levels of the pro-inflammatory mediator TNF-α, while it enhanced the levels of the anti-inflammatory mediator IL-10. …”
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Multi-omics analysis reveals the role of the autophagy-related gene AGT in chemotherapy resistance in colorectal cancer and the therapeutic potential of its inhibitors by Wenjiao Cai, Tao Xiang, Xiaoli Liu, Chong Fu

“…Drug sensitivity analysis was conducted based on the CTRP database, while immune infiltration was assessed using the CIBERSORT and ESTIMATE methods. …”
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