Exogenous 24-Epibrassinolide Improves Resistance to Leaf Spot Disease Through Antioxidant Regulation and Phenylpropanoid Metabolism in Oats by Zheng Wang, Kuiju Niu, Guiqin Zhao, Yuehua Zhang, Jikuan Chai, Zeliang Ju

“…The application of 1 mg·L⁻¹ EBR significantly decreased disease index and increased chlorophyll content under pathogen inoculation while also enhancing antioxidant enzyme (SOD, CAT, and APX) activity and reducing pathogen-induced O₂^•− production rate and MDA content. …”
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Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis by Zhixiang He, Zichen Song, Leilei Meng, Wenhui Cheng, Fan Huang, Mao Zheng, Wenhui Xu, Rong Xiao, Haoshu Fang, Yaling Zhu

“…Herein, we explored the RNA sequencing technology to profile the transcriptomic changes in liver tissue between LBP-deficient rats and WT rats at multiple time points after LPS administration. …”
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Integrative machine learning and bioinformatics analysis to identify cellular senescence-related genes and potential therapeutic targets in ulcerative colitis and colorectal cancer by Tianle Xue, Yunpeng Chen, Xiaomeng Li, Zhixiang Zhou, Qiyang Chen

“…The IML approach identified five pivotal genes (ABCB1, CXCL1, TACC3, TGFβI, and VDR) that individually exhibited AUC values > 0.7, while their combined diagnostic model achieved an AUC of 0.989. …”
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LST1 expression correlates with immune infiltration and predicts poor prognosis in acute myeloid leukemia by Haitao Xu, Dangui Chen, Jia Lu, Lihong Wang, Fei Chen, Long Zhong

“…Discovering new biomarkers is crucial for improving risk assessment and customizing treatment approaches. While leukocyte-specific transcript 1 (LST1) is implicated in inflammation and immune regulation, its function in AML remains ambiguous. …”
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A Maternal Gene Regulator CPEB2 Is Involved in Mating-Induced Egg Maturation in the <i>Cnaphalocrocis medinalis</i> by Yi Duan, Yueran Xiao, Guo Cai, Kepeng Wang, Chenfan Zhao, Pengcheng Liu

“…Tissue culture-based hormonal assays demonstrated the juvenile hormone-dependent regulation of <i>CmCPEB2</i>, as JH treatment induced its transcription, while knockdown of the JH-responsive transcription factor <i>CmKr</i>-h1 in the moths suppressed <i>CmCPEB2</i> expression post-mating. …”
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Genome-Wide Identification and Expression Analysis of <i>UBP</i> Genes in Peppers (<i>Capsicum annuum</i> L.) by Xuerui Chang, Tiantian Wang, Jiaxin Huang, Jia Xu, Yangyang Ruan, Yanping Liang, Jing Wang

“…<i>CaUBPs</i> were implicated in the stress response and organ growth, with <i>CaUBP17/34/35</i> showing significant changes in expression under heat stress. While most genes were not expressed in leaves, the expression of several genes (<i>CaUBP3/17/27/32/35/38</i>) in flowers was significantly altered. …”
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microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements. by Alexander Schwickert, Esther Weghake, Kathrin Brüggemann, Annika Engbers, Benjamin F Brinkmann, Björn Kemper, Jochen Seggewiß, Christian Stock, Klaus Ebnet, Ludwig Kiesel, Christoph Riethmüller, Martin Götte

“…Luciferase activation assays confirmed direct miR-142-3p-dependent regulation of the 3'-untranslated region of ITGAV and WASL. siRNA-mediated depletion of ITGAV and WASL resulted in a significant reduction of cellular invasiveness, highlighting the contribution of these factors to the miRNA-dependent invasion phenotype. While knockdown of WASL significantly reduced the number of membrane protrusions compared to controls, knockdown of ITGAV resulted in a decreased cell volume, indicating differential contributions of these factors to the miR-142-3p-induced phenotype. …”
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Tumor Necrosis Factor Alpha and Insulin-Like Growth Factor 1 Induced Modifications of the Gene Expression Kinetics of Differentiating Skeletal Muscle Cells. by Swanhild U Meyer, Stefan Krebs, Christian Thirion, Helmut Blum, Sabine Krause, Michael W Pfaffl

“…Pathologically increased TNF-α levels have a negative effect on muscle cell differentiation efficiency, while IGF1 can have a positive effect; therefore, we intended to elucidate the impact of TNF-α and IGF1 on gene expression during the early stages of skeletal muscle cell differentiation.…”
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FAK inhibition disrupts tumor growth, apoptosis, and transcriptional regulation in GI-NETs by Lara Toffoli, Angeliki Ditsiou, Luca Triboli, Victorine Hamm, Eva Moschioni, Francesca D’Este, Teresa Gagliano

“…Assays assessing viability and apoptosis were performed in both 2D and 3D culture conditions, while invasion and colony formation were assessed in 2D culture. …”
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Constitutive expression of full-length or partial of SOC1 genes for yield enhancement in tomato by Gharbia H. Danial, Gharbia H. Danial, Jirapa Jaikham, Guo-qing Song

“…The increased expression of CLF and EZA1 appears to explain the unchanged flowering time of the GmSOC1 transgenic plants, while the repressed expression of DWARF genes likely contributes to enhanced branching. …”
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Comprehensive pan-cancer analysis of NLRs family as prognostic and immunity markers based on multi-omics data by Xianhui Wen, Miaomiao Cui, Junhua Zhang, Hai Huang

“…NLRs expression was connected with immune cell infiltration (ICI) and cancer-related pathways, positively correlating with cytotoxic T cells, NK cells, CD8 T cells, and exhausted T cells, while negatively correlating with neutrophils and naïve T cells. …”
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Druggable genome-wide Mendelian randomization integrating GWAS and eQTL/pQTL data identifies targets for lung squamous cell carcinoma by Shizhao Cheng, Hao Zhang, Zhenliang Shi, Daqiang Sun

“…Patients with low expression of CPA4, DNMT1 and YBX1 had better prognosis, while patients with high expression of MST1 had better prognosis. …”
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Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis. by Lucilla Pizzo, Micaela Lasser, Tanzeen Yusuff, Matthew Jensen, Phoebe Ingraham, Emily Huber, Mayanglambam Dhruba Singh, Connor Monahan, Janani Iyer, Inshya Desai, Siddharth Karthikeyan, Dagny J Gould, Sneha Yennawar, Alexis T Weiner, Vijay Kumar Pounraja, Arjun Krishnan, Melissa M Rolls, Laura Anne Lowery, Santhosh Girirajan

“…We hypothesized that the 16p12.1 deletion sensitizes the genome for disease, while "second-hits" in the genetic background modulate the phenotypic trajectory. …”
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A comprehensive assessment using multiple factors based on HAS-Flow analysis predicts ATL development and progression by Hideaki Nakamura, Tatsuro Watanabe, Akemi Sato, Atsushi Kawaguchi, Kaoru Uchimaru, Yorifumi Satou, Eisaburo Sueoka

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Pyroptosis-related lncRNAs are potential biomarkers for predicting prognoses and immune landscapes in patients with gastric adenocarcinoma by Haidu Hong, Yuancheng Huang, Zehong Yang, Xiaotao Jiang, Hong Liu

“…Conclusions Using PRlncRNA as a prognostic indicator for STAD, we identified predictive biomarkers and immunotherapy targets while refreshing our understanding.…”
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Analysis of immune status and prognostic model incorporating lactate metabolism and immune-related genes in clear cell renal cell carcinoma by Jun Wu, Yuqian Wu, Yefeng Sun, Jianhang You, Wenjie Zhang, Tao Zhao

“…Immune microenvironment analysis demonstrated that the high‐risk group exhibited higher immune cell infiltration, while the low‐risk group was enriched for metabolism‐related pathways. …”
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Comprehensive analysis of inhibin-β A as a potential biomarker for gastrointestinal tract cancers through bioinformatics approaches by Rohit Kumar Verma, Prashant Kumar Srivastava, Ashutosh Singh

“…By utilizing GEPIA2, which uses transcriptomic data from TCGA, we examined the expression of INHBA across different GI tract cancers. …”
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SUMOylation-regulated genes in colon cancer: expression patterns and clinical implications by Wen Peng, Zirong Yang, Ru Yan, Lan Mu, Lan Li, Shan Jin, Shisheng Tan

“…Cluster 1 exhibited advanced tumor stages (N-stage, p < 0.05) and may present an immunosuppressive microenvironment marked by reduced HLA/immune checkpoint gene expression, while Cluster 2 showed enhanced anti-tumor immunity (activated dendritic cells, γδ T cells). …”
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Influence of secretome from porcine cardiosphere-derived cells on porcine macrophage polarization and their possible implications for cardiac remodeling post-myocardial infarction... by M. Pulido, M. A. de Pedro, M. A. de Pedro, A. M. Marchena, A. M. Marchena, V. Alvarez, J. G. Casado, J. G. Casado, J. G. Casado, F. M. Sanchez-Margallo, F. M. Sanchez-Margallo, F. M. Sanchez-Margallo, E. López, E. López, E. López

“…These findings suggest that S-CDCs modulate macrophage polarization to promote tissue repair and angiogenesis while minimizing excessive inflammation. This highlights their potential as a therapeutic strategy to enhance cardiac regeneration following MI.…”
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Cancer-associated foam cells hamper protective T cell immunity and favor tumor progression in human colon carcinogenesis by Barbara Vergani, Massimo Milione, Marco Vitellaro, Giulio Ferrero, Veronica Huber, Luca Lalli, Agata Cova, Paola Frati, Flavio Arienti, Licia Rivoltini, Simonetta Guarrera, Laura Cattaneo, Luca Sorrentino, Elena Daveri, Elena Casiraghi, Marta Zorza, Manuela Gariboldi, Patrizia Pasanisi, Daniele Morelli, Paola A Corsetto, Angela M Rizzo, Martina Stroscia, Vincenzo Lagano, Giovanna Sabella, Biagio E Leone

“…Background Colorectal cancer (CRC) remains a significant healthcare burden worldwide, characterized by a complex interplay between obesity and chronic inflammation. While the relationship between CRC, obesity and altered lipid metabolism is not fully understood, there are evidences suggesting a link between them. …”
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