Dynamic Coordination of Alternative Splicing and Subgenome Expression Bias Underlies Rusty Root Symptom Response in <i>Panax ginseng</i> by Jing Zhao, Juzuo Li, Xiujuan Lei, Peng Di, Hongwei Xun, Zhibin Zhang, Jian Zhang, Xiangru Meng, Yingping Wang

“…Ginseng rusty root symptoms (GRSs) compromise the yield and quality of <i>Panax ginseng</i>. While transcriptomic analyses have demonstrated extensive remodeling of stress signaling networks, the post-transcriptional defense circuitry remains obscure. …”
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VPS25 Promotes an Immunosuppressive Microenvironment in Head and Neck Squamous Cell Carcinoma by Li-Guo Chen, Yu-Han Fang, Kui-Ming Wang, Wei Zhang, Gang Chen

“…It promoted tumor cell proliferation and migration while reducing immune cell infiltration in the tumor microenvironment (TME). …”
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The energy-health-environment nexus: assessing the transboundary impacts of coal-fired power plants by Raja Dhar, Sayantan Sarkar, Chen Luo, Megha Anand, Shyamasree Dasgupta, Ujjwal Neogi, Apostolos Bossios, Rausan Zamir, Mohammad Shoeb, Joyanto Routh

“…The study establishes causality between power plant emissions, particulate matter characteristics, and population exposure levels while accounting for social, demographic, and economic factors, the study establishes. …”
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HDAC6 inhibition by ITF3756 modulates PD-L1 expression and monocyte phenotype: insights for a promising immune checkpoint blockade co-treatment therapy by Valeria Spadotto, Chiara Ripamonti, Andrea Ghiroldi, Elisabetta Galbiati, Pietro Pozzi, Roberta Noberini, Tiziana Bonaldi, Tiziana Bonaldi, Christian Steinkühler, Gianluca Fossati

“…PD-L1 and CD40 expression levels were assessed by flow cytometry. Transcriptomic and proteomic analyses were performed to characterize changes in gene and protein expression profiles. …”
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GPATCH11 variants cause mis-splicing and early-onset retinal dystrophy with neurological impairment by Andrea Zanetti, Gwendal Dujardin, Lucas Fares-Taie, Jeanne Amiel, Jérôme E. Roger, Isabelle Audo, Matthieu P. Robert, Pierre David, Vincent Jung, Nicolas Goudin, Ida Chiara Guerrera, Stéphanie Moriceau, Danielle Amana, Nurit Assia Batzir, Anat Bachar-Zipori, Lina Basel Salmon, Nathalie Boddaert, Sylvain Briault, Ange-Line Bruel, Christine Costet-Fighiera, Luisa Coutinho Santos, Cyril Gitiaux, Karolina Kaminska, Paul Kuentz, Naama Orenstein, Nicole Philip-Sarles, Morgane Plutino, Mathieu Quinodoz, Cristina Santos, Sabine Sigaudy, Mariana Soeiro e Sá, Efrat Sofrin, Ana Berta Sousa, Rui Sousa-Luis, Christel Thauvin-Robinet, Erwin L. van Dijk, Khaoula Zaafrane-Khachnaoui, Dinah Zur, Josseline Kaplan, Carlo Rivolta, Jean-Michel Rozet, Isabelle Perrault

“…Proteomic analysis of mouse retina confirms the roles GPATCH11 plays in RNA processing, splicing, and transcription regulation, while also suggesting additional functions in synaptic plasticity and nuclear stress response. …”
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Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism by Xin Zhang, Johannes Gschwind, Vanessa Erben, Katrin Bennewitz, Xiaogang Li, Carsten Sticht, Gernot Poschet, Ingrid Hausser, Thomas Fleming, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll

“…Acrolein (ACR) is an endogenous reactive unsaturated aldehyde that can be detoxified by the aldo-keto reductase (AKR) enzyme system. While it has been shown that accumulation of ACR is associated with several health problems, including inflammation, oxidative stress, and cardiovascular disease the study aimed to analyze whether an endogenous accumulation of ACR is causal for vascular dysfunction in an akr7a3 mutant zebrafish model. …”
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Transcriptional responses in different mouse models of septic liver injury differ from those in patients with septic liver injury by Qin Yan, Qin Yan, Qin Yan, Wei Fan, Wei Fan, Wei Fan, Xinsen He, Xinsen He, Xinsen He, Shi Zheng, Shi Zheng, Shi Zheng, Xiaolin Zhong, Xiaolin Zhong, Xiaolin Zhong

“…IntroductionSepsis, particularly sepsis-induced liver injury (SLI), exhibits acute onset and high mortality (up to 80%). While murine models are widely used for mechanistic studies due to limited human sample availability, their accuracy in replicating human SLI pathophysiology remains debated. …”
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Genome-resolved metatranscriptomics unveils distinct microbial functionalities across aggregate sizes in aerobic granular sludge by A.Y.A. Mohamed, Laurence Gill, Alejandro Monleon, Mario Pronk, Mark van Loosdrecht, Pascal E. Saikaly, Muhammad Ali

“…Flocculent sludge (FL; <0.2 mm) predominantly featured active nitrifiers and fermentative polyphosphate-accumulating organisms (PAOs) from Candidatus Phosphoribacter, while small granules (SG; 0.2–1.0 mm) and large granules (LG; >1.0 mm) hosted more metabolically active PAOs affiliated with Ca. …”
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Selenium mitigated cadmium-induced ovarian retardation in female Procambarus clarkii by regulating vitellogenin synthesis and transfer in the hepatopancreas by Huijun Yang, Yifan Yang, Aijie Mo, Yongchao Yuan

“…The results showed that Cd accumulation in the hepatopancreas caused a reduced hepatopancreas index (HPI), decreased protein content, histopathological damage, and oxidative stress, while Se supplementation reduced Cd levels, mitigated damage, and restored tissue integrity and antioxidant defenses. …”
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Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion by Jie Dong, Lupeng Wang, Breanna T. Sullivan, Lixin Sun, Victor M. Martinez Smith, Lisa Chang, Jinhui Ding, Weidong Le, Charles R. Gerfen, Huaibin Cai

“…Abstract Striatonigral neurons, traditionally known for promoting locomotion, comprise diverse subtypes with distinct transcriptomic profiles. However, their specific contributions to locomotor regulation remain incompletely understood. …”
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Epiplakin expression is lost in psoriatic skin lesions and is downregulated by IFN-γ in ex vivo skin cultures by Hannes Kühtreiber, Corinne Drexler, Corinne Drexler, Melanie Salek, Lisa Auer, Johannes Griss, Michael Mildner, Peter Fuchs, Peter Fuchs

“…Proteins of the plakin family are predominantly expressed in the epidermis and play a crucial role in cytoskeletal assembly by crosslinking intracellular structural components with cell–cell junctions and the plasma membrane. While most plakins are critical for maintaining epidermal integrity, the role of epiplakin (EPPK1) in inflammatory skin disorders has not been thoroughly investigated. …”
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First data on cholesterol metabolism in Ornithodoros argasid ticks: Molecular and functional characterization of the N-terminal domain of Niemann-Pick C1 proteins by Lucía de Dios-Blázquez, Ana Laura Cano-Argüelles, Ricardo Pérez-Sánchez, María González-Sánchez, Ana Oleaga

“…The aim of this study was to assess the structure, function, and protective efficacy of the NPC1 orthologues identified previously in the midgut transcriptomes of argasid ticks Ornithodoros erraticus and Ornithodoros moubata. …”
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Differential responses of Bradyrhizobium sp. SUTN9-2 to plant extracts and implications for endophytic interactions within different host plants by Teerana Greetatorn, Pakpoom Boonchuen, Pongdet Piromyou, Pongpan Songwattana, Jenjira Wongdee, Kamonluck Teamtisong, Nantakorn Boonkerd, Shusei Sato, Neung Teaumroong, Panlada Tittabutr

“…When exposed to extracts from chili and tomato, SUTN9-2 exhibits cell elongation, polyploidy, and reduced cell viability, with the effects being less pronounced for tomato extract. Transcriptomic and cytological analyses revealed that genes associated with CAMP resistance, nitrogen metabolism, nitrogen fixation, defense responses, and secretion systems were upregulated, while genes related to the cell cycle and certain CAMP-resistance mechanisms were downregulated, particularly in response to chili extract. …”
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Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells by Sophia Varriano, Amy Yu, Yu Qing Xu, Devorah M. Natelson, Anthony Ramadei, Frida E. Kleiman

“…The estrogen signalling pathway is highly dynamic and primarily mediated by estrogen receptors (ERs) that transcriptionally regulate the expression of target genes. While transcriptional functions of ERs have been widely studied, their roles in RNA biology have not been extensively explored. …”
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Identification and Application of a Novel Patulin Degrading Enzyme From Meyerozyma guilliermondii by Yu Zhang, Qianhua Zhao, Solairaj Dhanasekaran, Esa Abiso Godana, Yue Zhang, Xue Bai, Qiya Yang, Hongyin Zhang

“…Notably, MgSDR1 shows efficient PAT degradation ability in fresh pear juice while maintaining key quality parameters, such as color parameters, pH, polyphenol oxidase activity, the contents of vitamin C, total phenols, titratable acidity, and soluble solids. …”
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The Immune‐Related Gene CD48 Is a Prognostic Biomarker Associated With the Breast Cancer Tumor Microenvironment by Yi Zhao, Hengheng Zhang, Wenwen Wang, Guoshuang Shen, Miaozhou Wang, Zhen Liu, Jiuda Zhao, Jinming Li

“…ABSTRACT Background While tumor cells can affect the biological behavior of malignant tumors, the tumor microenvironment (TME) also plays an important role in the occurrence, development, and metastasis of tumors. …”
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Targeting myeloid cells in pancreatic ductal adenocarcinoma: from primary tumors to liver metastasis by Ruining Gong, Ying Chen, Chang Li, Huan Zhang, Zimin Liu, Qian Yu

“…This ineffectiveness is not well understood, as clinical trials often involve patients with advanced diseases, such as liver and peritoneal metastases, while most preclinical studies focus on primary tumors. …”
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A noncarcinoma mouse cell line is nonsusceptible to Newcastle disease virus established by spontaneous immortalization by Hanlue Li, Zijie Zhou, Chuanyu Chang, Weiwei Shi, Yuzhen Li, Qiaolin Wei, Fanxing Meng, Jianxia Tian, Qiqi Hao, Jinming Liu, Haijin Liu, Zengqi Yang, Sa Xiao

“…In contrast, NDV did not have a significant effect on SLM-21, indicating that SLM-21 was a nonsusceptible cell line to NDV, while MEF50 was a susceptible cell line. The NDV authentic sialic acid (SA) receptors SA 2,3-Gal and SA 2,6-Gal were expressed in SLM-21. …”
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Ferroptosis and Charcot–Marie–Tooth Disease 1A: Emerging Evidence for a Pathogenic Association by Jacob B. White, Kayla L. Sanchez, Antonio Currais, David Soriano-Castell, Pamela Maher, Salvador Soriano

“…CMT1A, the most common subtype, is caused by a duplication in PMP22, encoding an essential membrane protein for Schwann cell myelin integrity. While the mechanisms of peripheral neurodegeneration in CMT1A are poorly understood, excessive oxidative stress, particularly lipid peroxidation, is a known pathological feature, and antioxidant therapy has reversed the CMT1A phenotype in a mouse model. …”
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Depletion of regulatory T cells enhances the T cell response induced by the neoantigen vaccine with weak immunogenicity by Ruichen Huang, Qiao Zhou, Jiajun Liu, Yang Xia, Yang Jiao, Bi Zhao, Tangtao Feng, Haosu Zhou, Xiuyan Song, Hao Qin, Jun Wang, Lan Cheng, Yunye Ning, Qinying Sun, Yanfang Liu, Xiaoping Su, Yuchao Dong, Wei Zhang

“…Besides, compared to the Vac group, more neoantigen-targeted and TAA-targeted T cells were detected in the combinational group by TCR sequencing. The results of transcriptomic sequencing and flow cytometry showed that the number of Tregs in the combinational group was lower, while the proportions of memory effector T cells and effector T cells were higher than those in the vaccine group. …”
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