Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response by Laura M. de Smalen, Volkan Adak, Aurel B. Leuchtmann, Konstantin Schneider-Heieck, Stefan A. Steurer, Christoph Handschin

“…Many of these adaptations are controlled by the modulation of transcriptional programs in myonuclei. While previous studies have explored alterations in DNA methylation and histone modifications in response to exercise, the specific changes in chromatin restructuring and accessibility, a prerequisite for transcription, are still poorly understood. …”
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SPINK1 facilitates tumor progression via the EGFR/JAK/STAT3 axis in oral squamous cell carcinoma: insights from single-cell RNA sequencing by Mingyan Bao, Zhangui Tang

“…ObjectiveThis study aimed to elucidate the functional role and molecular mechanisms of Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) in oral squamous cell carcinoma (OSCC) through integrative analysis of single-cell RNA sequencing (scRNA-seq) data.Materials and methodsCellular subpopulations within OSCC were stratified using transcriptomic datasets from the GEO database. Cell-cell communication networks were reconstructed to map ligand-receptor interactions, while Gene Set Variation Analysis (GSVA) and Gene Set Enrichment Analysis (GSEA) were employed to systematically investigate SPINK1-associated signaling pathways. …”
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SHMT inhibitor synergizes with 5-Fu to suppress gastric cancer via cell cycle arrest and chemoresistance alleviation by Huan Deng, Yajie Wang, Lin Xiao, Mei Feng, Weidong Dou, Yisheng Pan

“…Our investigations demonstrate that SHMT1 and SHMT2 functionally drive malignant progression and confer 5-fluorouracil (5-Fu) resistance in GC, while their selective inhibitor SHIN1 emerges as a novel therapeutic candidate for GC treatment. …”
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Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds. by Daniel P Depledge, Krystal J Evans, Alasdair C Ivens, Naveed Aziz, Asher Maroof, Paul M Kaye, Deborah F Smith

“…Comparing amastigote gene expression profiles between species confirms the proposal that Leishmania transcriptomes undergo little regulation but also identifies conserved genes that are regulated differently between species in the host. …”
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The future of immunohistochemistry: advancing precision medicine through artificial intelligence-driven spatial proteomics and multiplexed diagnostic technologies by Ruby Dhar, Arun Kumar, Subhradip Karmakar

“…This technique is broadening its application across numerous subspecialties, including neuropathology, hematopathology, and diagnosing infectious diseases, while emerging technologies such as deep visual proteomics and the combination with transcriptomics are set to transform tissue-based diagnostics by merging protein expression data with genetic information for a truly comprehensive characterization of diseases.…”
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Low-intensity laser exposure enhances rice (Oryza sativa L.) growth through physio-biochemical regulation, transcriptional modulation, and microbiome alteration by Yetong Qi, Yumeng Lei, Temoor Ahmed, Feng Cheng, Kangqi Lei, Han Yang, Hayssam M. Ali, Zhitao Li, Xingjiang Qi

“…Abstract Environmental stressors significantly impact plant growth and agricultural productivity, necessitating innovative approaches to enhance crop resilience and yield. While high-intensity laser applications in agriculture have traditionally been limited to destructive purposes due to their harmful effects on plant growth, the emergence of low-intensity laser technology presents new opportunities for crop improvement. …”
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A multi-type programmed cell death gene signature predicts survival and reveals therapeutic targets in osteosarcoma by Chunyang Wu

“…Single-cell analysis revealed COL13A1 expression in malignant cells while GM2A and FUCA1 were enriched in macrophages. …”
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Machine learning explores the prognostic and immuno-oncological impact of mitochondrial unfolded protein response in CESC by Keh-Sen Liu, Yen-Hsiang Chang, Hsing-Ju Wu, Hung-Yu Lin

“…Abstract Background Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) pose significant global health challenges. While the mitochondrial unfolded protein response (UPRmt) is known to influence cancer biology, its specific role in CESC remains unclear. …”
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Effects of Retinol and Retinyl Palmitate on UV-Induced Skin Ageing and Therapeutic Enhancement by Yuan Wang, Xin Nie, Jiangming Zhong, Jing Wang, Lanyue Zhang, Peng Shu

“…Metabolomics and transcriptomics analyses indicated that RT and RP exerted complementary effects through metabolic pathways, significantly elevating the overall therapeutic efficacy. …”
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RIOK1: A Novel Oncogenic Driver in Hepatocellular Carcinoma by Chunyan Ruan, Tianyu Shang, Sijia Zhang, Wenhong Ru, Yuefeng Yang, Yi Shen

“…Functional assays demonstrated that RIOK1 knockdown suppressed HCC cell proliferation, survival, and tumor growth in vivo, while RIOK1 overexpression enhanced these oncogenic phenotypes. …”
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Spatiotemporal profile of an optimal host response to virus infection in the primate central nervous system. by Olga A Maximova, Sarah L Anzick, Daniel E Sturdevant, Richard S Bennett, Lawrence J Faucette, Marisa St Claire, Stephen S Whitehead, Kishore Kanakabandi, Zong-Mei Sheng, Yongli Xiao, John C Kash, Jeffery K Taubenberger, Craig Martens, Jeffrey I Cohen

“…Viral infections of the central nervous system (CNS) are a major cause of morbidity largely due to lack of prevention and inadequate treatments. While mortality from viral CNS infections is significant, nearly two thirds of the patients survive. …”
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Targeting Sepsis: Disease Tolerance, Immune Resilience, and Compartmentalized Immunity by Alexis Garduno, Ignacio Martín-Loeches

“…Further research is required to establish biomarkers and treatment timing that optimize therapeutic efficacy while minimizing systemic risks.…”
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Multi-omics exploration of CAV1+ tumor epithelial subcelltype in oral squamous cell carcinoma and its impact on the immune microenvironment by Yan’an Shi, Yiting Shao, Bin Xia, Wenying Yang, Yan Wang, Lifu Yu, Yonghui Zhang

“…Utilizing spatial transcriptomics, we investigated the spatial distribution of these subcelltypes. …”
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Vascular-type heterogeneity is associated with differential gene expression profiles of endothelial cells under shear stress by Allaura A. Cox, Christopher James Ng

“…While several genes were differentially expressed by all 3 vascular EC types (44.2%), most differentially expressed genes were limited to 1 or 2 of the vascular types. …”
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A comparison of the expression patterns and diagnostic capability of the ncRNAs NEAT1 and miR-34a in non-obstructive azoospermia and severe oligospermia by Aya Salman, Abdullah F. Radwan, Olfat G. Shaker, Adel A., Ghadir A. Sayed

“…Results indicated that NEAT1 was significantly downregulated in severe oligospermia patients, while its levels in non-obstructive azoospermia patients did not differ significantly from healthy controls. …”
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Animal Wellness: The Power of Multiomics and Integrative Strategies by Ratan Kumar Choudhary, Sunil Kumar B. V., Chandra Sekhar Mukhopadhyay, Neeraj Kashyap, Vishal Sharma, Nisha Singh, Sina Salajegheh Tazerji, Roozbeh Kalantari, Pouneh Hajipour, Yashpal Singh Malik

“…Multiomic approaches, including phenomics, genomics, epigenomics, metabolomics, proteomics, transcriptomics, microbiomics, and metaproteomics, are widely employed to assess and enhance animal health. …”
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Meta_B cells: a computationally identified candidate immunosuppressive driver of gastric cancer metastasis revealed by single-cell analysis and machine learning by Tianchi Lei, Yiwen Jiang, Kexin Yang, Chuqi Meng, Yue An

“…Abstract Background Gastric cancer (GC) metastasis remains a major clinical challenge due to insufficient understanding of tumor microenvironment (TME) dynamics. While B cells are implicated in GC progression, their subset-specific roles in metastatic niches are poorly defined. …”
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Tumor-associated myeloid cells support murine T-ALL in the central nervous system via integrin signaling by Ryan S. Humphrey, Seohee Nam, Dennis C. Wylie, Lauren I. R. Ehrlich

“…Both T-ALL blasts and leukemia-associated myeloid cells in the CNS expressed elevated levels of adhesion molecules, and inhibition of integrin-mediated adhesion or downstream signaling prevented myeloid cells from supporting survival of T-ALL cells in vitro. Single-cell transcriptomic analyses revealed that leukemia-associated myeloid cells in the CNS undergo transcriptional changes, increasing the expression of genes associated with oxidative phosphorylation while reducing inflammatory signatures. …”
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MaizeCODE reveals bi-directionally expressed enhancers that harbor molecular signatures of maize domestication by Jonathan Cahn, Michael Regulski, Jason Lynn, Evan Ernst, Cristiane de Santis Alves, Srividya Ramakrishnan, Kapeel Chougule, Sharon Wei, Zhenyuan Lu, Xiaosa Xu, Umamaheswari Ramu, Jorg Drenkow, Cassidy Danyko, Melissa Kramer, Arun Seetharam, Matthew B. Hufford, W. Richard McCombie, Doreen Ware, David Jackson, Michael C. Schatz, Thomas R. Gingeras, Robert A. Martienssen

“…Transcriptomic analysis reveals that pollen grains share features with endosperm, and express dozens of “proto-miRNAs” potential vestiges of gene drive and hybrid incompatibility. …”
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Comparative Study of PPARγ Targets in Human Extravillous and Villous Cytotrophoblasts by Fulin Liu, Christine Rouault, Mickael Guesnon, Wencan Zhu, Karine Clément, Séverine A. Degrelle, Thierry Fournier

“…The online tool STRING was used to predict PPARγ and DEG protein interactions, while iRegulon was used to predict the binding sites for PPARγ and DEG promoters. …”
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