Novel Hyperplastic Expansion of White Adipose Tissue Underlies the Metabolically Healthy Obese Phenotype of Male LFABP Null Mice by Anastasia Diolintzi, Yinxiu Zhou, Angelina Fomina, Yifei Sun, Seema Husain, Labros S. Sidossis, Susan K. Fried, Judith Storch

“…Transcriptomic analysis of SAT revealed that <i>Lfabp</i> deletion alters the expression of multiple pathways that modulate adipose expansion and function including cholesterol biosynthesis, adipogenesis, and extracellular matrix remodeling. …”
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RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice by Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su

“…RSPO2, primarily expressed in oocytes, interacts with GDF9:BMP15 to preserve transcriptomic integrity in preantral granulosa cells. …”
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Hypoxia-induced RHCG as a key regulator in psoriasis and its modulation by secukinumab by Shun Guo, Qian Zhang, Yuan-jie Liu, Yun-yao Hu, Cong Liu, Hui Shen, Jia Liu

“…We employed bioinformatics approaches, including spatial transcriptomics analysis, single-cell transcriptomics analysis, and bulk data analysis, to elucidate the biological functions of RHCG. …”
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Genome-wide identification and functional analysis of R2R3-MYB genes in Acer pseudosieboldianum: insights into low temperature stress response and anthocyanin biosynthesis by Shikai Zhang, Dong Zeng, Heng Zhang, Luwei Ding, Dongyuan Guo, Peilin Sun, Zhiming Han, Guanzheng Qu, Tuya Siqin, Xiangling You

“…Cis-regulatory element analysis identified 34 genes enriched in low-temperature response motifs, while transcriptomic and qPCR validation highlighted 22 cold-responsive and 14 leaf color-associated ApseMYB genes, including ApseMYB31 (28-fold induction at 4 °C) and ApseMYB16 (52-fold upregulation during leaf reddening). …”
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Investigation of the impact of ultraviolet B irradiation on apoptosis and proliferation in A375 melanoma cells by Wang Jingyang, Yuan Zhixiang, Chen Taoyu, Guo Jiaqi, Qu Ying, Hou Tao, Zhu Lvyun, Shao Tong

“…UVB- activated p53 induced G2/M arrest through p21-mediated inhibition of CDK1/cyclin B, while simultaneous suppression of PI3K-AKT signaling and pyrimidine metabolism disrupted survival pathways and DNA repair, creating a self-reinforcing cytotoxic cascade. …”
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A meta-analysis approach for annotation and identification of lncRNAs controlling perirenal fat deposition in suckling lambs by María Alonso-García, Beatriz Gutiérrez-Gil, Rocío Pelayo, Pablo A. S. Fonseca, Héctor Marina, Juan José Arranz, Aroa Suárez-Vega

“…Based on the analysis of perirenal fat transcriptomes, this research explored the relevance of these regulatory elements to fat deposition in suckling lambs. …”
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Neoantigen-based immunotherapy: advancing precision medicine in cancer and glioblastoma treatment through discovery and innovation by Moawiah M Naffaa, Ola A Al-Ewaidat, Sopiko Gogia, Valiko Begiashvili

“…The integration of AI-driven tools and multi-omic data has refined neoantigen discovery, while combination therapies are being developed to address issues like immune suppression and scalability. …”
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Endothelial sensitivity to pro-fibrotic signals links systemic exposure to pulmonary fibrosis by Lena Möbus, Laura Ylä-Outinen, Luca Mannino, Giorgia Migliaccio, Karoliina Kosunen, Nicoletta D’Alessandro, Angela Serra, Dario Greco

“…Abstract Pulmonary fibrosis (PF) is a life-threatening condition characterised by excessive extracellular matrix deposition and tissue scarring. While much of PF research has focused on alveolar epithelial cells and fibroblasts, endothelial cells have emerged as active contributors to the disease initiation, especially in the context of systemic exposure to pro-fibrotic substances. …”
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Combined transcriptional and metabolomic analysis of flavonoids in the regulation of female flower bud differentiation in Juglans sigillata Dode by Jinyan Chen, Wenwen Li, Wen’ e Zhang, Chunxiang Li, Ruipu Wang, Xuejun Pan, Jian Peng

“…Abstract Juglans sigillata Dode is rich in flavonoids, but the low ratio of female to male flower buds limits the development of the J. sigillata industry. While the abundance of flavonoids in J. sigillata is known, whether flavonoids influence female flower bud differentiation has not been reported. …”
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A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma by Xingyang Zhao, Feichao Xuan, Zirong Li, Xiangyi Yin, Xiaojun Zeng, Jiali Chen, Chihua Fang

“…This study confirmed KIF20A as a promising immunogenic antigen through transcriptomic mRNA sequencing analysis in the context of HCC. …”
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Computational analysis of the functional impact of MHC-II-expressing triple-negative breast cancer by Yang Cui, Weihang Zhang, Xin Zeng, Yitao Yang, Sung-Joon Park, Kenta Nakai, Kenta Nakai

“…Major histocompatibility complex class II (MHC-II) is essential for immune surveillance within the TME. While MHC-II genes are typically expressed by professional antigen-presenting cells, they are also expressed in tumor cells, potentially facilitating antitumor immune responses. …”
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Transcriptional engineering for value enhancement of oilseed crops: a forward perspective by Charli Kaushal, Mahak Sachdev, Mansi Parekh, Harini Gowrishankar, Mukesh Jain, Subramanian Sankaranarayanan, Bhuvan Pathak

“…Plant-derived oils provide 20%–35% of dietary calories and are a primary source of essential omega-6 (linoleic) and omega-3 (α-linolenic) fatty acids. While traditional breeding has significantly increased yields in key oilseed crops like soybean, sunflower, canola, peanut, and cottonseed, overall gains have plateaued over the past few decades. …”
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Classification of and detection techniques for RNAi-induced effects in GM plants by Cecilia Diaz, Steve U. Ayobahan, Samson Simon, Luise Zühl, Andreas Schiermeyer, Elke Eilebrecht, Sebastian Eilebrecht

“…Endogenous approaches, such as host-induced gene silencing (HIGS), involve genetically modified (GM) plants, while exogenous methods include spray-induced gene silencing (SIGS). …”
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Defense mechanism of tea plant (Camellia sinensis L.) to tolfenpyrad reveals emerging role of melatonin in pesticide residue control by Xinru Wang, Chengmin Zha, Zihan Wang, Wenwen Fan, Chenyang Ji, Xinzhong Zhang, Zongmao Chen, Fengjian Luo, Li Zhou

“…This study investigated distribution of tolfenpyrad as well as physiological, metabolomic, transcriptomic and hormonal responses of tea plants to tolfenpyrad application. …”
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Identification of the disulfidptosis-related key gene CD2AP as a potential biomarker and new therapeutic target for LUAD patients by comprehensive multi-omics analysis by Zhiwu Lin, Jing Lv, Chuanqiang Dai, Yuanwei Zhai, Jiudong Jiang, Yang Gao, Rulin Li, Jiangang Fan, Yang Yu, Liang Wu, Yanchun Yang

“…Methods We analyzed CD2AP expression and clinical significance in LUAD using data from TCGA, GEO, and other public databases. We employed transcriptomics, methylation analysis, immune infiltration assays, and spatial transcriptomics. …”
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Switch-like gene expression modulates disease risk by Alber Aqil, Yanyan Li, Zhiliang Wang, Saiful Islam, Madison Russell, Theodora Kunovac Kallak, Marie Saitou, Omer Gokcumen, Naoki Masuda

“…Abstract While switch-like gene expression (“on” in some individuals and “off” in others) has been linked to biological variation and disease susceptibility, a systematic analysis across tissues is lacking. …”
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Hepatic YAP1-TFE3 Rearranged Epithelioid Hemangioendothelioma by Mira M. Lotfalla, Andrew L. Folpe, Karen J. Fritchie, Patricia T. Greipp, Gretchen G. Galliano, Kevin C. Halling, Taofic Mounajjed, Jorge Torres-Mora, Rondell P. Graham

“…As this tumor exhibits epithelioid morphology, it frequently causes diagnostic confusion with other epithelioid vascular neoplasms as well as carcinoma. While 90% of classic EHE are driven by a WWTR1-CAMTA1 fusion gene, a histologically distinctive subset of EHE has been recently shown to harbor a different fusion gene, YAP1-TFE3. …”
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The Proinflammatory Cytokines IL-18, IL-21, and IFN-γ Differentially Regulate Liver Inflammation and Anti-Mitochondrial Antibody Level in a Murine Model of Primary Biliary Cholangi... by Ya-Fei Xu, Yuan Yao, Min Ma, Shu-Han Yang, Peng Jiang, Jinjun Wang, Koichi Tsuneyama, Chan Wang, Xiangdong Liu, Liang Li, Zhe-Xiong Lian

“…We found that livers from p40-/-IL-2Rα-/- mice exhibit similar transcriptomic characters of PBC patients. In p40-/-IL-2Rα-/- mice, deletion of IL-18 has no remarkable effect on disease progression, while deletion of IL-21 indicates that it is necessary for AMA production but independent of liver inflammation and cholangitis. …”
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Establishing a robust genetic sequencing and gene expression data library in cardiovascularly healthy cats by Joanna L. Kaplan, Victor N. Rivas, Jalena R. Wouters, Michael W. Vandewege, Samantha P. Harris, Joshua A. Stern

“…Abstract Cardiovascular disease is a leading cause of increased morbidity and mortality in cats, with hypertrophic cardiomyopathy (HCM) significantly overrepresented. While feline HCM is hereditary, the genetic etiology of disease remains poorly understood. …”
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Candida albicans impacts carbohydrate metabolism of Enterococcus faecalis in interkingdom biofilms by Nicole de Mello Fiallos, Iriana J. Zanin dos Santos, Debra N. Brunson, Jessica K. Kajfasz, Lin Zeng, Rossana de Aguiar Cordeiro, José A. Lemos, Jacqueline Abranches

“…Mannose-PTS activity and glycerol quantification assays were conducted to investigate changes in carbohydrate metabolism.Results Transcriptomic analysis revealed 149 E. faecalis genes differentially expressed in dual-species biofilms. …”
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