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  1. 5561
  2. 5562

    In-Silico discovery of novel cephalosporin antibiotic conformers via ligand-based pharmacophore modelling and de novo molecular design by Rayhan Chowdhury, Samia Akter Saima, Md. Al Amin, Md. Kawsar Habib, Ramisa Binti Mohiuddin, Ali Mohamod Wasaf Hasan, Roksana Khanam, Shahin Mahmud

    Published 2025-09-01
    “…This research aims to predict new compounds using ligand-based pharmacophore models while optimizing existing drugs. We employed a de novo approach to synthesize models of cephalosporin structural motifs, integrating the β-lactam core with potential antibiotic candidates. …”
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  3. 5563

    Coupling HEC-RAS and AI for River Morphodynamics Assessment Under Changing Flow Regimes: Enhancing Disaster Preparedness for the Ottawa River by Mohammad Uzair Anwar Qureshi, Afshin Amiri, Isa Ebtehaj, Silvio José Guimere, Juraj Cunderlik, Hossein Bonakdari

    Published 2025-02-01
    “…The Next-Gen GMDH addresses the complexity and limitations of standard GMDH by incorporating non-adjacent connections and optimizing intermediate layers, significantly reducing computational overhead while enhancing performance. …”
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  4. 5564

    Screening of Reference Genes for Quantitative Real-time PCR in Curcuma alismatifolia Bracts by Jianjun TAN, Lishan HUANG, Yiwei ZHOU, Yechun XU, Yuanjun YE

    Published 2025-02-01
    “…The RefFinder program was utilized to comprehensively assess the optimal reference genes for C. alismatifolia bract.…”
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  5. 5565

    EEG microstate analysis in children with prolonged disorders of consciousness by Yi Zhang, Zhichong Hui, Yuwei Su, Weihang Qi, Guangyu Zhang, Liang Zhou, Jiamei Zhang, Kaili Shi, Yonghui Yang, Lei Yang, Gongxun Chen, Sansong Li, Mingmei Wang, Dengna Zhu

    Published 2025-07-01
    “…Support vector machine (SVM) models were trained using combined temporal and spatial microstate features, optimized via grid search and random search algorithms. …”
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  6. 5566

    Safety assessment of temozolomidee: real-world adverse event analysis from the FAERS database by Yu Liu, Lan Ma, Lan Ma, Xiaojia Fu, Xiaojia Fu, Yi Zhang, Yi Zhang, Jinyu Zheng, Zhongjun Chen

    Published 2025-08-01
    “…Future studies should validate these signals through prospective trials and mechanistic research to optimize TMZ’s risk-benefit profile in glioma therapy.…”
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  7. 5567

    CNN–Transformer Hybrid Architecture for Underwater Sonar Image Segmentation by Juan Lei, Huigang Wang, Zelin Lei, Jiayuan Li, Shaowei Rong

    Published 2025-02-01
    “…FLSSNet is built upon a CNN and Transformer backbone network, integrating four core submodules to address various technical challenges: (1) The asymmetric dual encoder–decoder (ADED) is capable of simultaneously extracting features from different modalities and systematically modeling both local contextual information and global spatial structure. (2) The Transformer feature converter (TFC) module optimizes the multimodal feature fusion process through feature transformation and channel compression. (3) The long-range correlation attention (LRCA) module enhances CNN’s ability to model long-range dependencies through the collaborative use of convolutional kernels, selective sequential scanning, and attention mechanisms, while effectively suppressing noise interference. (4) The recursive contour refinement (RCR) model refines edge contour information through a layer-by-layer recursive mechanism, achieving greater precision in boundary details. …”
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  8. 5568

    Evolution, reconfiguration and low-carbon performance of green space pattern under diverse urban development scenarios: A machine learning-based simulation approach by Yujie Ren, Mengdie Zhou, Antian Zhu, Shucheng Shi, Hao Zhu, Yuzhu Chen, Shanshan Li, Tianhui Fan

    Published 2024-12-01
    “…In this study, we applied machine learning algorithms to model the non-linear relationships and threshold effects between green space evolution and carbon emissions/sequestration at different stages of ecological restoration in the Yangtze River Basin, China. …”
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  9. 5569

    The Use of Machine Learning for Analyzing Real-World Data in Disease Prediction and Management: Systematic Review by Norah Hamad Alhumaidi, Doni Dermawan, Hanin Farhana Kamaruzaman, Nasser Alotaiq

    Published 2025-06-01
    “…The search focused on extracting data regarding the ML algorithms applied; disease categories studied; types of study designs (eg, clinical trials and cohort studies); and the sources of RWE, including EHRs, patient registries, and wearable devices. …”
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  10. 5570

    Benchmarking Federated Few-Shot Learning for Video-Based Action Recognition by Nguyen Anh Tu, Nartay Aikyn, Nursultan Makhanov, Assanali Abu, Kok-Seng Wong, Min-Ho Lee

    Published 2024-01-01
    “…Additionally, we explore three meta-learning paradigms and three FL algorithms to investigate their effectiveness and suggest the optimal choices for performance improvement. …”
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  11. 5571

    Advancing sustainability: The impact of emerging technologies in agriculture by Ashoka Gamage, Ruchira Gangahagedara, Shyamantha Subasinghe, Jeewan Gamage, Chamini Guruge, Sera Senaratne, Thevin Randika, Chamila Rathnayake, Zammil Hameed, Terrence Madhujith, Othmane Merah

    Published 2024-12-01
    “…The integration of data analytics and machine learning algorithms is transforming supply chain management and enhancing the capabilities of predictive analytics in the context of crop diseases. …”
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  12. 5572

    A Comparison of Recent Global Time-Series Land Cover Products by Peilin Li, Yan Wang, Chisheng Wang, Lin Tian, Meijiao Lin, Siyao Xu, Chuanhua Zhu

    Published 2025-04-01
    “…The results indicate that while datasets exhibit spatial consistency, significant discrepancies exist in land cover classification, with each dataset demonstrating varying levels of accuracy depending on the environmental context and land cover type. …”
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  13. 5573

    Identifying low-risk breast cancer patients for axillary biopsy exemption: a multimodal preoperative predictive model by Jiaqi Zhang, Jianing Zhang, Zhihao Liu, Yudong Zhou, Xiaoni Zhao, Yalong Wang, Danni Li, Jinsui Du, Chenglong Duan, Yi Pan, Qi Tian, Feiqian Wang, Ke Wang, Lizhe Zhu, Bin Wang

    Published 2025-07-01
    “…Abstract Background As the most prevalent female malignancy worldwide, breast cancer frequently involves axillary lymph node metastasis (ALNM), which critically affects therapeutic algorithms. Current guidelines mandate preoperative ultrasound-guided axillary biopsy for suspicious lymph nodes, potentially exposing some low-risk patients with negative results to invasive risks. …”
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  14. 5574

    Predictive model for sarcopenia in chronic kidney disease: a nomogram and machine learning approach using CHARLS data by Renjie Lu, Shiyun Wang, Pinghua Chen, Fangfang Li, Fangfang Li, Pan Li, Qian Chen, Xuefei Li, Fangyu Li, Suxia Guo, Jinlin Zhang, Jinlin Zhang, Dan Liu, Zhijun Hu

    Published 2025-03-01
    “…Four machine learning algorithms were utilized, with the optimal model undergoing hyperparameter optimization to evaluate the significance of predictive factors.ResultsA total of 1,092 CKD patients were included, with 231 (21.2%) diagnosed with sarcopenia. …”
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  15. 5575

    ‘Machine Learning’ multiclassification for stage diagnosis of Alzheimer’s disease utilizing augmented blood gene expression and feature fusion by Manash Sarma, Subarna Chatterjee

    Published 2025-06-01
    “…DL classifier is used for developing models of both categories while GB (Gradient Boost), SVM (Support Vector Machine) classifier based models are built to identify AD stages from NCBI participants. …”
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  16. 5576

    Advances and challenges in immunotherapy in head and neck cancer by Hazem Aboaid, Taimur Khalid, Abbas Hussain, Yin Mon Myat, Rishi Kumar Nanda, Ramaditya Srinivasmurthy, Kevin Nguyen, Daniel Thomas Jones, Jo–Lawrence Bigcas, Kyaw Zin Thein

    Published 2025-06-01
    “…Future research should focus on refining biomarker-driven treatment algorithms, developing rational immunotherapy combinations, and leveraging tumor microenvironment modifications to enhance therapeutic efficacy.…”
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  17. 5577

    Evaluating Maize Residue Cover Using Machine Learning and Remote Sensing in the Meadow Soil Region of Northeast China by Zhengwei Liang, Jia Du, Weilin Yu, Kaizeng Zhuo, Kewen Shao, Weijian Zhang, Cangming Zhang, Jie Qin, Yu Han, Bingrun Sui, Kaishan Song

    Published 2024-10-01
    “…The Google Earth Engine (GEE) and remote sensing images from 2019 to 2023 were used to obtain spectral characteristics before the maize seedling stage in Northeast China, followed by constructing the CRC estimation models using machine learning algorithms. To avoid the impact of multicollinearity among data, three machine learning algorithms—ridge regression (RR), partial least squares regression (PLSR), and least absolute shrinkage and selection operator (LASSO)—were employed. …”
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  18. 5578

    Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes by Liping Wang, Ran Zhou, Guanghui Li, Xiaodan Zhang, Yan Li, Yinchen Shen, Junwei Fang

    Published 2025-01-01
    “…Mechanistic pathways governing gene-metabolite-lipid interactions were inferred via random walk with restart algorithms and validated by gene set enrichment analysis (GSEA). …”
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  19. 5579

    Electrophysiological changes in the acute phase after deep brain stimulation surgery by Lucia K. Feldmann, Diogo Coutinho Soriano, Jeroen Habets, Valentina D'Onofrio, Jonathan Kaplan, Varvara Mathiopoulou, Katharina Faust, Gerd-Helge Schneider, Doreen Gruber, Georg Ebersbach, Hayriye Cagnan, Andrea A. Kühn

    Published 2025-09-01
    “…While beta band activity is confirmed as a reliable biomarker for bradykinesia using chronic recordings, little is known about the ideal time point for initial electrophysiology-based programming. …”
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  20. 5580

    Population-based colorectal cancer risk prediction using a SHAP-enhanced LightGBM model by Guinian Du, Hui Lv, Yishan Liang, Jingyue Zhang, Qiaoling Huang, Guiming Xie, Xian Wu, Hao Zeng, Lijuan Wu, Jianbo Ye, Wentan Xie, Xia Li, Yifan Sun

    Published 2025-07-01
    “…BackgroundColorectal cancer (CRC) is a highly frequent cancer worldwide, and early detection and risk stratification playing a critical role in reducing both incidence and mortality. we aimed to develop and validate a machine learning (ML) model using clinical data to improve CRC identification and prognostic evaluation.MethodsWe analyzed multicenter datasets comprising 676 CRC patients and 410 controls from Guigang City People’s Hospital (2020-2024) for model training/internal validation, with 463 patients from Laibin City People’s Hospital for external validation. Seven ML algorithms were systematically compared, with Light Gradient Boosting Machine (LightGBM) ultimately selected as the optimal framework. …”
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