Automated Quantification of Retinopathy of Prematurity Stage via Ultrawidefield OCT by Spencer S. Burt, BA, Aaron S. Coyner, PhD, Elizabeth V. Roti, BS, Yakub Bayhaqi, PhD, John Jackson, MD, Mani K. Woodward, MS, Shuibin Ni, PhD, Susan R. Ostmo, MS, Guangru Liang, BS, Yali Jia, PhD, David Huang, MD, Michael F. Chiang, MD, Benjamin K. Young, MD, Yifan Jian, PhD, John Peter Campbell, MD

“…Purpose: Retinopathy of prematurity (ROP) stage is defined by the visual appearance of the vascular-avascular border, which reflects a spectrum of pathologic neurovascular tissue (NVT). …”
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Clinical effect of external application of Rutongyu medicine film in the treatment of hyperplasia of mammary gland (乳痛愈药膜治疗乳腺增生病临床疗效观察) by HAN Jianping (韩建萍), LI Ying (李影), HOU Pengxiao (候朋晓), ZHANG Ning (张宁), REN Yaxing (任亚星), LIU Haihan (刘海涵), DAI Wei (代巍), ZHANG Chunyan (张春艳), YUE Yuzi (岳玉姿), LI Yiliang (李以良), TANG Ling (唐玲)

“…Objective To observe the clinical effect of external application of Rutongyu medicine film in the treatment of hyperplasia of mammary gland. Methods Totally 96 patients with hyperplasia of mammary gland were randomly divided into the treatment group (n=48) and control group (n=48). …”
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Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial by Zhi-Xiu Lin, Tin Muk Ho, Yan-Fang Xian, Kam Leung Chan, Qing-Qing Xu, Cho Wing Lo, Justin Che Yuen Wu, Kam Lun Hon, Sin Bond Leung, Chon Pin Chia, Chi Him Sum, Tak Yee Chow, Pui Kuan Cheong, Jessica Yuet Ling Ching, Hongwei Zhang, Ka Chun Leung, Wai Ling Lin

“…Purpose To evaluate the efficacy and safety of YPV on AR patients with the lung and spleen Qi deficiency type using a randomized, double-blind, placebo-controlled clinical trial (RCT). Study design and methods Between April 2022 and June 2023, a total of 58 participants were recruited and randomly allocated to receive either YPV (n = 29) or placebo (n = 29) for 8 consecutive weeks. …”
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Elevated thiamine level is associated with activating interaction between HIF-1α and SLC19A3 in experimental myopic guinea pigs by Zhongyu Ma, Jiawen Hao, Zhaohui Yang, Miao Zhang, Ruixue Zhang, Jizhao Xin, Bo Bao, Xuewei Yin, Xuewei Yin, Hongsheng Bi, Hongsheng Bi, Hongsheng Bi, Dadong Guo, Dadong Guo, Dadong Guo, Dadong Guo

“…This study aimed to investigate the process of thiamine changes in choroidal tissue of guinea pigs with negative lens-induced myopia (LIM).MethodsThe right eyes of guinea pigs in the LIM group wore −6.0D lenses to model experimental myopia. …”
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Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using s... by Zhaorui Cheng, Xiangyu Yang, Yi Ren, Huimin Wang, Qi Zhang, Sailing Lin, Wenhao Wu, Xiaolu Yang, Jiahan Zheng, Xinzhu Liu, Xin Tao, Xiaoyong Chen, Yuxin Qian, Xiushen Li

“…This study aims to investigate these mechanisms using single-cell RNA sequencing data. Methods: Single-cell RNA sequencing data from HCC patients were obtained from the GEO database. …”
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Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy by Min Jung Koh, Min Ji Koh, Jessica Y. Hsueh, Lindsey Gallagher, Malika Danner, Alan Zwart, Marilyn Ayoob, Deepak Kumar, Michael Carrasquilla, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…The five-item EQ-5D-3L, a well-established tool for quantifying patient-reported health status, was administered to each patient at baseline (prior to relugolix treatment) and again 1 h before the start of SBRT. Higher EQ Visual Analog Scale (VAS) overall scores reflected better quality of life (range 0 to 100). …”
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Impact of maternal antenatal nutrition and infection treatment interventions on Longitudinal Infant Development and Growth in rural Ethiopia: protocol of the LIDG child follow-up s... by Alemayehu Worku, Yemane Berhane, Luke C Mullany, Charles A Nelson, Lian V Folger, Anne CC Lee, Maria Andersson, Parul Christian, Krysten North, Yoseph Yemane Berhane, Nebiyou Fasil, Sitota Tsegaye, Kalkidan Yibeltal, Fred Van Dyk, Sara Cherkerzian, Firehiwot Workneh, Workagegnhu Tarekegn Kidane, Theresa I Chin, Sarah K G Jensen, Mulatu Melese, Unmesha Roy Paladhi, Betelhem Haimanot Abate, Atsede Teklehaimanot, Tizita Lemma Melka, Stephen Pihl, Winko W An, Sonya V Troller-Renfree, Moriah E Thomason, Terrie Inder, P Ellen Grant

“…This study will examine the effects of prenatal nutrition and infection management interventions on long-term growth and neurodevelopmental outcomes of offspring.Methods The Enhancing Nutrition and Antenatal Infection Treatment (‘ENAT’) study (ISRCTN15116516) was a pragmatic, open-label, 2×2 factorial, randomised clinical effectiveness study implemented in 12 rural health centres in Amhara, Ethiopia. …”
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Association between atherogenic index of plasma and physical dysfunction: a cross-sectional study of middle-aged and older adults in China by Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Yun Chang, Yun Chang, Yun Chang, Yun Chang, Hechen Shen, Hechen Shen, Hechen Shen, Hechen Shen, Hechen Shen, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao

“…The restricted cubic splines were used to examine possible non-linear associations and visualize the dose–response relationship between AIP and physical dysfunction. …”
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Predicting diabetic retinopathy stages using a simple nerve conduction measuring device, DPNCheck®: a retrospective observational study by Mayu Sakai, Mayu Sakai, Mayu Sakai, Takehiro Kato, Takehiro Kato, Takuma Ishihara, Ken Takao, Ken Takao, Tokuyuki Hirose, Tokuyuki Hirose, Sodai Kubota, Sodai Kubota, Saki Kubota-Okamoto, Saki Kubota-Okamoto, Toshinori Imaizumi, Toshinori Imaizumi, Yoshihiro Takahashi, Yoshihiro Takahashi, Masami Mizuno, Masami Mizuno, Takuo Hirota, Takuo Hirota, Yukio Horikawa, Yukio Horikawa, Hirokazu Sakaguchi, Hirokazu Sakaguchi, Shin Tsunekawa, Daisuke Yabe, Daisuke Yabe, Daisuke Yabe

“…Aims/introductionDiabetic retinopathy (DR) often remains asymptomatic until it reaches advanced stages, when delayed treatment can lead to irreversible visual impairment. To promote timely ophthalmology visits, this study investigated the utility of a simple nerve conduction device, DPNCheck®, as a predictor of DR severity. …”
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Greater neural pattern similarity to the native language is associated with better novel word learning by Yuan Feng, Yuan Feng, Yuan Feng, Yuan Feng, Aqian Li, Aqian Li, Aqian Li, Aqian Li, Jing Qu, Jing Qu, Jing Qu, Jing Qu, Huiling Li, Huiling Li, Huiling Li, Huiling Li, Xiaoyu Liu, Xiaoyu Liu, Xiaoyu Liu, Xiaoyu Liu, Jingxian Zhang, Jingxian Zhang, Jingxian Zhang, Jingxian Zhang, Jiayi Yang, Jiayi Yang, Jiayi Yang, Jiayi Yang, Leilei Mei, Leilei Mei, Leilei Mei, Leilei Mei

“…Nevertheless, it is still unclear how the utilization of the L1 neural strategies affects visual word learning in a new language.MethodsTo address this question, the present study scanned native Chinese speakers while performing implicit reading tasks before 9-day form-meaning learning in Experiment 1 and before 12-day comprehensive word learning in Experiment 2. …”
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Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and economic analysis by Mark Simmonds, Matthew Walton, Rob Hodgson, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, John Lawrenson, Tunde Peto, David Steel

“…Anti-vascular endothelial growth factor therapy may be more effective in people with poorer initial visual acuity. Anti-vascular endothelial growth factor had no impact on vision in people with non-proliferative retinopathy. …”
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A CECT-Based Radiomics Nomogram Predicts the Overall Survival of Patients with Hepatocellular Carcinoma After Surgical Resection by Peng Zhang, Yue Shi, Maoting Zhou, Qi Mao, Yunyun Tao, Lin Yang, Xiaoming Zhang

“…The optimal performance model was further visualized as a nomogram, and its predictive accuracy was evaluated via calibration curves and decision curve analysis (DCA). …”
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Risk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study by Linru Fu, Xinyan Liu, Zhao Tian, Zhe Du, Xinyi Wang, Xiuqi Wang, Xiaodong Li, Tao Xu, Zhijing Sun

“…A nomogram was developed to visualize the predictive factors. Results A total of 359 patients were included, with 268 (74.7%) succeeding with MTX and 91 (25.3%) required surgery. …”
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A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry ey... by Di Zhang, Taige Chen, Qi Liang, Xuebing Feng, Jiaxuan Jiang, Zeying Chen, Yun Tang, Yiran Chu, Bin Wang, Kai Hu

“…Abstract Background Patients with refractory dry eye disease (DED) often face the threat of diminished visual quality and have limited responses to existing treatments. …”
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Comparison of therapeutic effects of 0.05% Cyclosporine A versus 0.1% Fluorometholone in Chinese patients with mild dry eye unresponsive to artificial tears: a randomized control s... by Huijuan Gao, Lu Zhao, Aoxue Du, Xia Zhang, Mengdi Chai, Lin Liu, Emmanuel Eric Pazo, Ruihua Wei

“…Abstract Background To assess and compare the therapeutic outcomes of 0.05% Cyclosporine A (CsA) ophthalmic solution versus 0.1% Fluorometholone (FML) eyedrops in Chinese patients with mild dry eye disease (DED) unresponsive to conventional artificial tears (AT). Methods A total of 43 patients with mild DED, who have failed to respond to conventional AT therapy for over 3 months, were randomly assigned to receive either 0.05% CsA or 0.1% FML twice daily for 6-months. …”
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Late gadolinium enhancement cardiovascular magnetic resonance with generative artificial intelligence by Omer Burak Demirel, Fahime Ghanbari, Christopher W. Hoeger, Connie W. Tsao, Adele Carty, Long H. Ngo, Patrick Pierce, Scott Johnson, Kathryn Arcand, Jordan Street, Jennifer Rodriguez, Tess E. Wallace, Kelvin Chow, Warren J. Manning, Reza Nezafat

“…The generative AI-based model improved visual image sharpness, resulting in lower blur metric compared to low-resolution counterparts (AI-enhanced from 1.5 × 3 mm2 resolution: 0.3 ± 0.03 vs 0.35 ± 0.03, P < 0.01). …”
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Predicting Imminent Conversion to Exudative Age-Related Macular Degeneration Using Multimodal Data and Ensemble Machine Learning by T.Y.Alvin Liu, MD, Yuxuan Liu, MS, Madeleine S. Gastonguay, BS, Dan Midgett, PhD, Nathanael Kuo, PhD, Yujie Zhao, Kareef Ullah, Gwyneth Alexander, Todd Hartman, Neslihan D. Koseoglu, MD, Craig Jones, PhD

“…Participants: Patients seen at the Wilmer Eye Institute between 2013 and 2021 with eAMD in ≥1 eye. Methods: Spectral domain OCT volumes prior to conversion and the corresponding clinical data (age, best-corrected visual acuity, sex, and fellow-eye status) were collected and used for model training or testing. …”
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Comparison of the effects of acupoint application combined with moxibustion in different sequences on alleviating symptoms in patients with knee osteoarthritis based on inheritance... by LI Suqian (李苏茜), TANG Ling (唐玲), E Haiyan (鄂海燕), CHEN Hong (陈宏), DENG Jianhua (邓建华), ZHOU Jie (周洁), LI Ye (李野)

“…The course of treatment was 2 weeks. The visual analogue scale (VAS) was used for knee pain measurement, and a self-made scale were used to evaluate patient satisfaction. …”
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Posterior iliac crest vs. proximal tibia: distinct sources of anti-inflammatory and regenerative cells with comparable 6-month clinical outcomes in treatment of osteoarthritis by E. Mormone, L. Savastano, G. Rossi, F. Maruccia, G. Di Maggio, N. P. Sinisi, M. Sandri, M. Copetti, E. De Santis, V. Guerra, G. Biancofiore, C. Cisternino, E. Caradonna, P. Graziano, F. L. Gorgoglione

“…Thirty patients with knee OA grade I-IV, according to Kellgren-Lawrence (KL), were distributed into each group. Visual Analog Scale (VAS) and Western Ontario & McMaster Universities Arthritis Index (WOMAC) score were used for clinical outcome evaluation. …”
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The role of adipose-derived stem cells in knee osteoarthritis treatment: insights from a triple-blind clinical study by Simin Sajadi, Mohammad Amin Khadembashiri, Gholamreza Raissi, Mohamad Mehdi Khadembashiri, Korosh Mansouri, Homayoun Hadizadeh-Kharazi, Mohammad Taghi Joghataei, Seyed Pezhman Madani, Bijan Forogh, Sina Parsipour

“…This study aims to evaluate the safety and efficacy of allogeneic ADMSC in treating knee OA. Methods This triple-blind, interventional clinical trial included 20 patients with idiopathic knee OA, meeting the American College of Rheumatology (ACR) criteria. …”
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