Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium by Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou

“…<i>fimA</i> expression was quantified by qRT-PCR, and fimbriation visualized by transmission electron microscopy. Adhesive properties were evaluated through FimH sequence analysis, yeast agglutination, mannose-binding/inhibition assays, and HT-29 cell adherence. …”
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Fatal risk factors and the efficacy of glucocorticoid therapy in severe fever with thrombocytopenia syndrome: a multicenter retrospective cohort study by Fang Zhong, Shiyu Zhang, Chengxi Zheng, Dilihumaer Zhayier, Shuting Liu, Qinyu You, Hongming Huang, Bin Zhu, Jin Tian, Zhiliang Hu, Zhiliang Hu, Zhiliang Hu, Xin Zheng, Baoju Wang, Zhihang Peng, Zhihang Peng, Zhihang Peng

“…A nomogram was used to visualize the predictive model. ROC curves, calibration curves, and DCA curves were conducted to assess model accuracy and clinical applicability. …”
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Meta-analysis of the synergistic effect of traditional Chinese medicine compounds combined with conventional Western medicine in the treatment of osteoporosis by Huan Jin, Huan Jin, Cai Huang, Yan Zhang, Ying Dong, Qi Xiong, Di Wang, Di Wang, Ziyi He, Ziyi He, Lin Shen, Chen Ma, Zixian Wang, Lingfeng Zeng, Bo Shuai

“…This study systematically evaluated the synergistic effect of traditional Chinese medicine (TCM) compounds combined with conventional Western medicine (such as bisphosphonates and calcium) compared to Western medicine alone in the treatment of OP through a meta-analysis.MethodsBased on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Measurement Tool for Systematic Review Assessment guidelines, databases such as PubMed and Embase were systematically searched (as of March 2025), and 13 randomized controlled trials (RCTs), involving a total of 2,403 patients, were included.ResultsThe integrated Chinese and Western medicine group showed significantly higher lumbar and femoral neck Bone mineral density (BMD) growth rates than the control group, alongside reduced pain visual analogue scale (VAS) scores. …”
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Association of white matter hyperintensity burden and infarct volume in the anterior choroidal artery territory with early neurological progression: a dual-center retrospective stu... by Weiwei Gao, Weiwei Gao, Lixue Wang, Junyi Huang, Yitao Yu, Jingjing She, Jingjing She, Jingjing She, Mingyang Wang, Lijuan Cai, Lijuan Cai, Taishan Kang, Xingyu Chen, Xingyu Chen, Jianzhong Lin, Renjing Zhu, Renjing Zhu, Renjing Zhu

“…WMH burden and infarct volume were assessed using the Fazekas visual rating scale and an automated volumetric quantification method based on lesion prediction algorithm, respectively. …”
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Impact of Teleworking on Work‐Related and Home‐Related Stress at During the First Global Lockdown–The International COVISTRESS Study by Sébastien Couarraze, Guillaume Decormeille, Louis Delamarre, Fouad Marhar, Karen Gbaglo, Raimundo Avilès Dorlhiac, Mickael Berthon, Andy Su‐I Liu, Samuel Antunes, Bruno Pereira, Julien S Baker, Morteza Charkhabi, Ukadike C Ugbolue, Reza Bagheri, José J. Gil‐Cosano, Marek Zak, The COVISTRESS Network, Maëlys Clinchamps, Frédéric Dutheil

“…Work‐related and home‐related stress levels were evaluated using an uncalibrated visual analog scale, with a range from 0 (none) to 100 (maximum). …”
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How could 20-minute neighbourhoods impact health and health inequalities? A policy scoping review by Roxana Pollack, Jonathan R Olsen, Alison Heppenstall, Andreas Hoehn, Jennifer Boyd, Vicki Ponce Hardy, Jennifer Littlejohn, Amy Stevenson, Richard Mitchell, Petra Meier, Jonathan Stokes

“…We used Sankey diagrams to visually aggregate the thematic codes for each place relating to pathways to health outcomes and social determinants (mechanisms). …”
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Evaluation of the therapeutic effect of repeated photodynamic therapy-assisted SRP treatments on class II furcation by Yikuan Wu, Haoyu Li, Yixiang Wang, Beiying Zhang, Chunsheng Bi, Xiaojun Li

“…Subgingival microbiota was analyzed via 16S rRNA sequencing, while patient-reported outcomes (PROs) included Visual Analog Scale (VAS) and oral health impact (OHIP-14). …”
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Comparison of two portable metabolic systems for measuring energy expenditure at rest and during exercise in untrained women by Feng Gao, Feng Gao, Feng Gao, Yujing Chan-Yu, Yujing Chan-Yu, Zhi Li, Zhi Li, Yongfu Liu, Yongfu Liu, Fei Liu, Fei Liu, Di Liu, Wenjun Yu, Wenjun Yu, Weiwei Chen, Junhua Wang, Junhua Wang, Junhua Wang, Shenglong Le, Shenglong Le, Shenglong Le

“…Agreement between the two systems was evaluated by calculating Pearson correlation coefficients and visually examining Bland–Altman plots.ResultsThe number of participants who completed resting and exercise measurements was 18 and 19, respectively. …”
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Agarwood Chromone Alleviates Gastric Ulcers by Inhibiting the NF-κB and Caspase Pathways Based on Network Pharmacology and Molecular Docking by Canhong Wang, Yulan Wu, Bao Gong, Junyu Mou, Xiaoling Cheng, Ling Zhang, Jianhe Wei

“…Finally, binding of the core compounds to the key targets was verified via molecular docking and visualized. <b>Results:</b> The pharmacological results show that the CHRs reduced the gastric occurrence and ulcer inhibition rates by up to more than 70% in a dose-dependent manner. …”
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The oncolytic avian reovirus p17 protein suppresses invadopodia formation via disruption of TKs5 complexes and oncogenic signaling pathways by Chao-Yu Hsu, Jyun-Yi Li, Jyun-Yi Li, Wei-Ru Huang, Wei-Ru Huang, Tsai-Ling Liao, Tsai-Ling Liao, Hsiao-Wei Wen, Chi-Young Wang, Chi-Young Wang, Lon-Fye Lye, Brent L. Nielsen, Hung-Jen Liu, Hung-Jen Liu, Hung-Jen Liu, Hung-Jen Liu, Hung-Jen Liu

“…Furthermore, invadopodia detection, gelatin degradation assay, and Fluorescence imaging was performed to visualize invadopodia structures and assess extracellular matrix degradation. …”
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Anti-VEGF drugs compared with laser photocoagulation for the treatment of proliferative diabetic retinopathy: a systematic review and individual participant data meta-analysis by Mark Simmonds, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Matthew Walton, Rob Hodgson, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, João Pereira Figueira, Sobha Sivaprasad, John G Lawrenson, Tunde Peto, David Steel

“…Key outcomes were best corrected visual acuity, diabetic macular oedema and vitreous haemorrhage. …”
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Development and external validation of a nomogram prediction model based on quantitative coronary angiography for predicting ischemic lesions: a multi-centre study by Shuai Yang, Shuai Yang, Shuang Leng, Shuang Leng, Zhouchi Wang, Jiang Ming Fam, Jiang Ming Fam, Adrian Fatt Hoe Low, Adrian Fatt Hoe Low, Ru-San Tan, Ru-San Tan, Ping Chai, Ping Chai, Lynette Teo, Lynette Teo, Chee Yang Chin, Chee Yang Chin, John C. Allen, Mark Yan-Yee Chan, Mark Yan-Yee Chan, Khung Keong Yeo, Khung Keong Yeo, Aaron Sung Lung Wong, Aaron Sung Lung Wong, Soo Teik Lim, Soo Teik Lim, Qinghua Wu, Liang Zhong, Liang Zhong, Liang Zhong

“…An external validation (n = 107 patients) was performed to assess the nomogram model's discrimination and consistency.ResultsLesion length, minimal lumen diameter, stenosis flow reserve, percent diameter stenosis by visual estimation, and weight were included as predictors in the nomogram. …”
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Adolescents and adults with FOXP1 syndrome show high rates of anxiety and externalizing behaviors but not psychiatric decompensation or skill loss by Tess Levy, Tess Levy, Hailey Silver, Hailey Silver, Renee Soufer, Renee Soufer, Audrey Rouhandeh, Audrey Rouhandeh, Audrey Rouhandeh, Alexander Kolevzon, Alexander Kolevzon, Alexander Kolevzon, Alexander Kolevzon, Joseph D. Buxbaum, Joseph D. Buxbaum, Joseph D. Buxbaum, Joseph D. Buxbaum, Joseph D. Buxbaum, Joseph D. Buxbaum, Paige M. Siper, Paige M. Siper, Paige M. Siper

“…To date, much of the literature focuses on childhood symptoms and little is known about the FOXP1 syndrome phenotype in adolescence or adulthood.MethodsA series of caregiver interviews and standardized questionnaires assessed psychiatric and behavioral features of 20 adolescents and adults with FOXP1 syndrome. …”
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Three-Dimensional-Printed Isoniazid Chewable Gels for On-Demand Latent Tuberculosis Treatment in Children by Amanda de O. E. Moreira, Lêda Maria S. Azevedo Neta, Márcia Pietroluongo, Ana Paula dos S. Matos, Beatriz B. Correa, Beatriz H. Ortiz, André da S. Guimarães, Marcio Nele, Carollyne M. Santos, Ana Elizabeth C. Fai, Maria Helena Gonçalves, Flávio M. Shimizu, Monique S. Dos Santos, Rosemberg B. Moure, Diogo D. Nascimento, André Luis de A. Guimarães, Saint Clair dos S. G. Junior, Alessandra L. Vicosa, Lucio M. Cabral

“…This study aims to develop innovative 3D-printed chewable gels containing INH for LTBI treatment. <b>Methods</b>: The gels were formulated using gelatin and carrageenan gum, sugar-free sweeteners, and flavoring. …”
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Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies by Xingyao Chen, Xingyao Chen, Xingyao Chen, Nuo Chen, Nuo Chen, Nuo Chen, Peng Lai, Peng Lai, Yiqi Sun, Jie Yu, Ming Xin, Deliang Zhu, Fanrong Liang, Fanrong Liang, Fanrong Liang, Qian Song, Shirui Cheng, Shirui Cheng, Shirui Cheng, Zhengjie Li, Zhengjie Li, Zhengjie Li, Zhengjie Li

“…In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the encompassed studies.MethodsA systematic search of neuroimaging studies investigating the brain activity differences between CLBP and Healthy controls (HCs) was conducted in seven databases up to December 22, 2024. …”
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Prevalence of cardiovascular diseases and risk factor assessment in breast cancer survivors exposed to cardiotoxic therapy by Marina V. Vitsenya, Irina V. Barinova, Nana V. Pogosova, Tatevik A. Terteryan, David T. Kuchiev, Yulia V. Khrushcheva, Anna A. Gerasimova, Anastasiya Y. Filatova, Nursiyat M. Ibragimova, Olga O. Frolkova, Fail T. Ageev

“…The patients were examined for CVDs and their risk factors, with assessment of clinical status, serum lipids, glucose, creatinine, and C-reactive protein, levels of physical activity (International Physical Activity Questionnaire), stress (Visual Analog Scale), anxiety and depression (Hospital Anxiety and Depression Scale, HADS), and sleep quality (Pittsburgh Sleep Quality Questionnaire). …”
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CT-SEGMENTED BONE SUV IN MULTIPLE MYELOMA: A COMPARATIVE STUDY OF ¹⁸F-FDG AND ⁶⁸GA-PSMA PET/CT by Alexandre Mercuri Barbosa, Maria Emília Seren Takahashi, Stephan Pinheiro Macedo Souza, Edna Marina Souza, Sérgio Querino Brunetto, Cármino Antonio de Souza, Irene Gyongyver Heidemarie Lorand-Metze, Celso Darío Ramos

“…Materials and Methods: The study included ¹⁸F-FDG and ⁶⁸Ga-PSMA PET/CT images acquired within a 1- to 8-day interval from 15 patients (53% male, mean age 66.7 ± 10.7 years) with symptomatic, biopsy-proven MM. …”
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Prevalence and associated factors of syphilis among female sex workers in East Africa: a systematic review and meta-analysis by Solomon Gedfie, Woldeteklehymanot Kassahun, Abdu Jemal, Muluken Gashaw, Alembante Bazezew, Marye Nigatie, Getinet Kumie, Tadesse Misganaw, Zewdu Tefera, Bewuketu Belete Alemu, Bahriew Mezgebu, Brhanu Kassanew, Ephrem Tamrat, Wagaw Abebe, Agenagnew Ashagre, Assefa Sisay, Yalewayker Gashaw, Melese Abate Reta, Melese Abate Reta

“…Publication bias was evaluated visually using funnel plots and statistically through Egger’s weighted regression test.ResultsA total of 16,456 articles were retrieved, among which 24 studies involving 25,979 female sex workers were included in the final meta-analysis. …”
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Comparison of Endoscopic Unilateral Laminectomy for Bilateral Decompression (Endo‐ULBD) and Posterior Lumbar Interbody Fusion (PLIF) in Managing Multi‐Segmental Lumbar Spinal Steno... by Kunpeng Su, Qingyu Yao, Mingzhi Liu, Sheng Chang, Mengxuan Wang, Antao Lin, Guantong Sun, Yichen Jiang, Shengwei Meng, Hao Zhang, Wentao Liu, Hongtao Ge, Zengjie Wu, Zirui Wang, Derong Xu, Chuanli Zhou

“…Clinical outcomes were evaluated using the Visual Analog Scale (VAS), the Japanese Orthopedic Association (JOA) score, and the Oswestry Disability Index (ODI), which were assessed preoperatively and at follow‐up. …”
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Variation in Mesopic Retinal Sensitivity Relative to Distance from Geographic Atrophy in Age-Related Macular Degeneration by Souvick Mukherjee, PhD, Emily Vance, MPH, Leon von der Emde, MD, Thilaka Arunachalam, BS, Tharindu De Silva, PhD, Alisa T. Thavikulwat, MD, Christine Orndahl, PhD, Caroline Nyaiburi, MS, Maria Abraham, ScM, Keri Hammel, MS, SriniVas R. Sadda, MD, Emily Y. Chew, MD, Maximilian Pfau, MD, PhD, Wai T. Wong, MD, PhD, Brett G. Jeffrey, PhD, Tiarnán D.L. Keenan, BM BCh, PhD

“…Overall, the degree and extent of decreased visual function beyond GA borders have important implications for the design of clinical trials, decision-making in clinical practice, and insights into AMD pathophysiology. …”
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