Effect of simultaneous intravitreal ranibizumab and extended-release dexamethasone injection on patients with naïve versus refractory retinal vein occlusion macular edema: a prospe... by Yao-Yao Sun, Jie Meng, Shan-Shan Li, Qin Xiao, Tian-Zi Zhang, Heng Miao, Ming-Wei Zhao, Hui-Jun Qi

“…The mean changes in best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measured as main outcomes. …”
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Modified double-row suture bridge technique for anterior colliculus fractures combined with deltoid ligament injury: a retrospective study by Jianlong Ni, Zhihao Chen, Wang Wei, Ruiying Li, Dazhi Wang, Dongjian Wang, Zenan Tian, Zhikun Jia, Qichun Song, Meng Feng, Zhibin Shi

“…The purpose of the present study was to describe the application of a modified double-row suture bridge technique and evaluate its early clinical outcomes in the management of anterior colliculus fracture combined with deltoid ligament injury. Methods From 2020 to 2022, 12 patients with anterior colliculus fracture combined with deltoid ligament injury were treated using a modified double-row suture bridge technique. …”
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Rapid detection of SARS-CoV-2 RNA using a one-step fast multiplex RT-PCR coupled to lateral flow immunoassay by Insaf Bel Hadj Ali, Hejer Souguir, Mouna Melliti, Mohamed Vall Taleb Mohamed, Monia Ardhaoui, Kaouther Ayouni, Sondes Haddad-Boubaker, Yusr Saadi Ben Aoun, Henda Triki, Ikram Guizani

“…Methods We developed various simplex fast-PCRs for screening sets of primer pairs newly designed or selected from literature or from validated WHO diagnostics, targeting S, N, E, RdRp or ORF1ab genes. …”
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Pointwise Structure–Function Analysis of the Ellipsoid Zone in Retinitis Pigmentosa Using an Artificial Intelligence-Assisted OCT and Microperimetry Overlay by Jesse A. Most, BA, An D. Le, MS, PhD, Melanie D. Tran, BS, Evan H. Walker, MS, Aneesh Swamy, Dirk-Uwe G. Bartsch, PhD, William R. Freeman, MD, Truong Nguyen, PhD, Cheolhong An, PhD, Shyamanga Borooah, MBBS, PhD

“…Subjects: Patients with clinically confirmed RP. Methods: Same-day spectral-domain OCT (SD-OCT) and microperimetry near-infrared images were overlaid in patients with confirmed RP. …”
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Prevention of extubation failure in neurocritical care patients with residual disorder of consciousness: the Brain-Injured Patients Extubation Readiness (BIPER) study protocol for... by Emmanuel Futier, Bruno Pereira, Russell Chabanne, Elodie Caumon, Dominique Morand, Audrey De Jong, Jean-Michel Constantin, Matthieu Jabaudon, Thomas Godet, Benjamin Andanson, Pierre Borrel, Leo Astier, Nathalie Bourguignon, Lise Laclautre

“…The intervention condition consists of extubation triggered by a clinical score evaluating deglutition, gag reflex, cough and visual tracking (Coma Recovery Scale-Revised Visual Scale).Objective: To determine whether adoption of an extubation protocol based on a clinical score can lessen extubation failure compared with usual care in brain-injured patients with residual disorder of consciousness.Outcome: The primary outcome measure is extubation failure, defined within 5 days following extubation. …”
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A RT-ERA-CRISPR/Cas12a assay for rapid point-of-care duck hepatitis A virus detection by Di Sun, Yukun Zhu, Mingshu Wang, Jingming Wang, Wenze Cheng, Zheng Li, Yuan Deng, Xumin Ou, Renyong Jia, Shun Chen, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Yu He, Zhen Wu, Anchun Cheng

“…Isothermal amplification technologies are often combined with lateral flow assays or visual readout methods for detecting pathogen nucleic acids in non-laboratory settings. …”
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Global burden of breast cancer and application of patient-reported outcomes in clinical trials: a systematic analysis based on the global burden of disease study 2021 and WHO inter... by Jiaxin Hao, Jiaxin Hao, Yijia Gong, Yijia Gong, Xiaowen Zhang, Xiaowen Zhang, Xiaowen Zhang, Minghong Du, Minghong Du, Minghong Du, Huan Wang, Huan Wang, Huan Wang, Guolin Guo, Mengqing Zhou, Tian Tian, Hongguo Rong, Hongguo Rong, Hongguo Rong

“…This study aims to evaluate the global burden and the application of patient-reported outcomes (PROs) in clinical trials of breast cancer.MethodsData of breast cancer burden is extracted from the Global Burden of Disease Study (GBD) 2021 database. …”
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Acute Pharmacological Effects of Two Synthetic Cathinones in Humans: An Observational Study of <i>N</i>-Ethylhexedrone and <i>N</i>-Ethyl-nor-pentedrone by Melani Núñez-Montero, Clara Pérez-Mañá, Olga Hladun, Lourdes Poyatos, Dolly Andrea Caicedo, Georgina De la Rosa, Martha Catalina Argote, Soraya Martín, Mireia Ventura, Nunzia La Maida, Annagiulia Di Trana, Silvia Graziano, Simona Pichini, Magì Farré, Esther Papaseit

“…However, still, little is known with regard to their pharmacological effects in humans. <b>Methods</b>: For the first time, we conducted a naturalistic, prospective observational study in 16 participants (7 women and 9 men) with a previous history of psychostimulant recreational use. …”
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Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial CellsSUMMARY by Siyuan Ma, Nawras W. Habash, Mrunal K. Dehankar, Nidhi Jalan-Sakrikar, Shawna A. Cooper, Abid A. Anwar, Sofia Jerez, Papawee Sutthirat, Jinhang Gao, Tamir Diamond, Jing Jiao, Caixin Qiu, Jingchun Yang, Sumera I. Ilyas, Markcus Lee, Usman Yaqoob, Sheng Cao, Rebecca G. Wells, Vijay H. Shah, Moira B. Hilscher

“…We studied spatial changes in immune cells in the sinusoid that contribute to congestive fibrosis and portal hypertension (PHTN). Methods: To visualize the distribution of immune cells in congestive hepatopathy (CH), we performed imaging mass cytometry (IMC) on liver tissue from patients with CH, Fontan-associated liver disease (FALD), and controls. …”
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Model of superior semicircular canal dehiscence: asymmetrical vestibular dysfunction induces reversible balance impairment by Sean S. Hong, P. Ashley Wackym, P. Ashley Wackym, Damian J. Murphy, Eran Peci, Matthew Y. Kiel, Aaron Tucker, Nicolas L. Carayannopoulos, Shrivaishnavi C. Chandrasekar, Nikhil Suresh, Umut A. Utku, Justin D. Yao, Justin D. Yao, Todd M. Mowery, Todd M. Mowery

“…In this study, we completed our assessment of this model to include reversible asymmetrical vestibular impairments that interfere with balance.MethodsAdult Mongolian gerbils (N = 6) were trained to complete a balance beam task. …”
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Catheter-associated urinary tract infections in urethral stricture patients indwelling suprapubic catheter: Insights from a retrospective investigation into specific antibiogram an... by Jiahao Lin, Changhao Hou, Yubo Gu, Wei Yuan, Xianjie Xiu, Zhenwei Yu, Ruihang Zhang, Guangyu Mao, Qiang Fu, Lujie Song

“…Clinical data, bacterial pathogens, and resistance patterns were collected. Heatmaps visualized resistance profiles. Descriptive statistics summarized demographics and perioperative variables; while binary logistic regression models were applied to identify independent risk factors for SPCAB and MDRB. …”
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The Connection between Galaxy Mergers, Star Formation, and Active Galactic Nuclei Activity in the HSC-SSP by Kiyoaki Christopher Omori, Connor Bottrell, Sabine Bellstedt, Aaron S. G. Robotham, Hassen M. Yesuf, Andy D. Goulding, Marcin Sawicki, Tohru Nagao, Tsutomu T. Takeuchi

“…We quantitatively examine the merger–SFR–AGN connection using Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) galaxies using novel methods for both galaxy classification and property measurements. …”
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Atelectasis predicts poor prognosis in pediatric macrolides-unresponsive Mycoplasma pneumoniae pneumonia with A2063/2064G mutations treated with azithromycin by Jie Cheng, Ya Liu, Guangli Zhang, Yuanyuan Li, Xiaoyin Tian, Liping Tan, Zhengxiu Luo

“…ObjectiveWe aimed to investigate prognostic indicators for pediatric macrolides-unresponsive Mycoplasma pneumoniae pneumonia (MUMPP) cases with A2063/2064G mutations with azithromycin therapy.MethodsThis was a retrospective observational cohort study conducted at the Children’s Hospital of Chongqing Medical University. …”
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Topical Application of VitB6 Ameliorates PM2.5-Induced Dry Eye via NFκB Pathway in a Murine Model by Jinyu Hu, Yanmei Zeng, Liying Tang, Lei Ye, Cheng Chen, Qian Ling, Xiaoyu Wang, Liangqi He, Xu Chen, Yixin Wang, Qianmin Ge, Yi Shao

“…<b>Background/Objectives:</b> Dry eye (DE) is mainly characterized by dryness, foreign body sensation, eye pain and visual impairment. Their possible causes are mainly inflammation, tissue damage and neurosensory abnormalities, and vitamin B6 (VitB6) attenuates the inflammatory response by modulating the NF-κB pathway to quench reactive oxygen species (ROS). …”
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Randomized controlled trial of nalfurafine for refractory pruritus in hemodialysis patients by Ping Zhang, Shilong Xiang, Bicheng Liu, Xiaohui Wang, Xiaoping Yang, Chaoyang Ye, Zunsong Wang, Yanlin Li, Li Zhou, Caili Wang, Hongbo Li, Jian Huang, Ai Peng, Xiaoping Wang, Deguang Wang, Jie Xiao, Wenli Chen, Hong Cheng, Nan Mao, Jianqin Wang, Lin Yang, Jianghua Chen

“…The primary end point was the mean decrease in the mean visual analogue scale (VAS) from baseline.Results A total of 141 patients were included. …”
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Safety Profile of Antipsychotics as Predictors of the Quality of Life in Patients with Schizophrenia—An Inpatient Welfare Institution-Based Cross-Sectional Study by Aleksandra D. Petrovic, Ana M. Barjaktarevic, Olivera Z. Kostic, Sara S. Mijailovic, Slobodan M. Jankovic, Marija V. Andjelkovic, Marijana S. Stanojevic Pirkovic, Katarina D. Parezanovic Ilic, Vladimir S. Janjic, Jana Mojsilovic, Jana Arsenijevic, Danijela B. Jovanovic, Sanja Knezevic, Nevena Folic, Milovan Stevic, Dejana Ruzic Zecevic, Nemanja Z. Petrovic, Marina J. Kostic

“…UKU scores were negatively correlated with the EuroQoL 5-Dimension 5-Level (EQ-5D-5L) index, Visual Analog Scale (VAS) score, the Quality-of-Life Enjoyment and Satisfaction Questionnaire—Short Form (Q-LES-Q-SF) score, and the scores of physical and psychological domains of the World Health Organization Quality-of-Life Scale (WHOQOL-BREF). …”
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Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospect... by Willem A Bemelman, Pieter J Tanis, Lianne Koens, Vivian P Bastiaenen, Bartholomeus JGA Corten, Elise AJ de Savornin Lohman, Joske de Jonge, Anne C Kraima, Hilko A Swank, Jaap LP van Vliet, Gijs JD van Acker, Anna AW van Geloven, Klaas H in 't Hof, Philip R de Reuver, Charles C van Rossem, Gerrit D Slooter, Valeska Terpstra, Marcel GW Dijkgraaf

“…After visual inspection and digital palpation of the removed specimen, the operating surgeon will report whether macroscopic abnormalities suspicious for a malignant neoplasm are present, and if he or she believes additional microscopic examination by the pathologist is indicated. …”
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Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDS by Zehra Özsoy, Şerife Asya Germe, Gizem Ayan, Güllü Sandal Uzun, Mustafa Ekici, Erdinç Ünaldı, Levent Kılıç, Ali Akdoğan, Şule Apras Bilgen, Sedat Kiraz, Ali İhsan Ertenli

“…Demographic characteristics, disease duration, bDMARD use follow-up period, comorbidities, RA extra-articular findings, visual analog scale (VAS) global, VAS pain, VAS fatigue, Health Assessment Questionnaire-Disability index were recorded for RA patients included in the study. …”
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N-Butyl-2-Cyanoacrylate Adhesive Versus Absorbable Tacks in Laparoscopic Groin Hernia Repair: A Multicenter Randomized Clinical Trial by Clayton C. Petro, MD, Benjamin K. Poulose, MD, Michael J. Rosen, MD, Alfredo M. Carbonell, II, DO, Adel G. El-Ghazzawy, MD, Jeremy A. Warren, MD, Emanuele Lo Menzo, MD, Ajita S. Prabhu, MD, David M. Krpata, MD, Samuel Szomstein, MD, Vimal Narula, MD, Crystal F. Totten, MD, Kelly R. Haisley, MD, Andrew C. Bernard, MD, Henrik O. Berdel, MD, Jessica K. Reynolds, MD, Zachary D. Warriner, MD, John S. Roth, MD

“…The primary outcome was improvement in pain (visual analog scale [VAS]) at 6 months. The noninferiority margin was 0.9 (α = 0.025; β = 80%). …”
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Investigating the effects of mobile bottom fishing on benthic carbon processing and storage: a systematic review protocol by Stacey L. Felgate, John Aldridge, Stefan G. Bolam, Sarah Breimann, Emil de Borger, Jolien Claes, Jochen Depestele, Graham Epstein, Clement Garcia, Natalie Hicks, Michel Kaiser, Jack H. Laverick, Gennadi Lessin, Finbarr G. O’Neill, Sarah Paradis, Ruth Parker, Ryan Pereira, Alex J. Poulton, Claire Powell, Craig Smeaton, Paul Snelgrove, Justin Tiano, Johan van der Molen, Sebastiaan van de Velde, Marija Sciberras

“…Results will be reported in narrative and quantitative syntheses using a variety of visual tools including forest plots. Meta-analysis will be conducted where sufficient data exists.…”
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