Mapping the key players in Kawasaki disease; role of inflammatory genes and protein-protein interactions by Wael Hafez, Feras Al-Obeidat, Asrar Rashid, Afsheen Raza, Nouran Hamza, Nesma Ahmed, Marwa M. Abdeljawad, Raziya Kadwa, Abdelhameed Elmesery, Muneir Gador, Dina Khair, Gihan Zina, fatema Abdulaal, Mina Wassef Girgiss, Maha Abdelhadi, Ahmed Abdelrahman, Mahmad Anwar Ibrahim, Mohamed El Sherbiny

“…Heatmaps were generated to visualize gene expression patterns. Results: Eighteen hub genes were identified in the KD versus control comparison, whereas 20 hub genes were identified in the acute versus convalescent analysis. …”
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Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort... by Adrián Borja-Flores, Salvador I. Macías-Hernández, Gabriela Hernández-Molina, Andric Perez-Ortiz, Eloy Reyes-Martínez, José Belzazar-Castillo de la Torre, Laura Ávila-Jiménez, María Cristina Vázquez-Bello, Marco Antonio León-Mazón, Janette Furuzawa-Carballeda, Gonzalo Torres-Villalobos, Fernanda Romero-Hernández, Cidronio Albavera-Hernández, Jesús Pérez-Correa, Hilda A. Castro-Rocha

“…The aim was to evaluate the effect of intra-articular injections (IAIs) of polymerized-collagen among patients with symptomatic knee osteoarthritis (OA) in delaying or preventing joint replacement surgery. Patients and Methods. This was a cohort study of 309 patients with knee OA. …”
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Postoperative pain and influencing factors after prophylactic extraction of impacted mandibular third molars: a multicenter prospective cohort study by Zhiwei Cao, Chengzhi Zhao, Renyi Wang, Qianxing Du, Kun Zhang, Jihong Zhao, Yang Xue, Bing Han, Jiuyan Jiang, Liwei Hu, Xuejuan Liao, Jian Pan

“…Postoperative pain was assessed using the Visual Analog Scale (VAS) at 1, 3, 7, and 30 days, while postoperative infection was documented at the same intervals. …”
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Non-tuberculous mycobacteria and other acid fast bacilli pathogens identification by qPCR and MALDI-ToF MS in tuberculosis-like lesions of slaughtered cattle from Ecuador by Solon Alberto Orlando, Solon Alberto Orlando, Leila Estefania Vera Loor, Joselyn Calderón, Melissa Joseth Carvajal-Capa, Fabrizio Arcos Alcívar, Pablo Torres-Lasso, W. Favián Maza Valle, Oliverio N. Vargas González, Naomi Mora-Jaramillo, Ariana León-Sosa, Ariana Rivera, Angel Sebastián Rodríguez-Pazmiño, Bernardo Castro-Rodriguez, Greta Franco Sotomayor, Greta Franco Sotomayor, Sandra Uruchima-Campoverde, Manuel Gonzalez, Jose Manuel Benitez-Medina, Natalia Jimenez-Pizarro, Javier Hermoso de Mendoza, Henry Parra-Vera, Miguel Angel Garcia-Bereguiain

“…While the importance of NTM in opportunistic infections in humans has been gaining attention, surveillance and control programs for cattle health and production remain predominantly focused on bovine tuberculosis (BTB) that it is caused exclusively by MTBC.MethodsIn this study, we conducted a comprehensive inspection of 5,803 cattle carcasses destined for human consumption across 22 abattoirs in five provinces of Ecuador’s coastal region, searching for lesions visually compatible with BTB (BTB-like lesions).ResultsA high prevalence of 13.4% (CI 95%: 12.8–14.6) for BTB-like lesions and 3.1% (CI 95%: 2.6–3.5) for acid-fast bacilli (AFB) presence in lesions was observed. …”
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Comparison of intraoperative and postoperative outcomes between open, wiltse, and percutaneous approach to traumatic thoracolumbar spine fractures without neurological injury: A sy... by Abdulrahman O. Al-Naseem, MB ChB (Hons), MSc, Yusuf Mehkri, MD, Sachiv Chakravarti, MD, Eli Johnson, MD, Margot Kelly-Hedrick, MD, Cathleen Kuo, MD, Melissa Erickson, MD, MBA, Khoi D. Than, MD, Brett Rocos, MD, BSc (Hons), MB, ChB, Deb Bhowmick, MD, Christopher I. Shaffrey, MD, Norah Foster, MD, Ali Baaj, MD, Nader Dahdaleh, MD, C. Rory Goodwin, MD, PhD, Theresa L. Williamson, MD, Yi Lu, MD, PhD, Muhammad M. Abd-El-Barr, MD, PhD

“…This systematic review and meta-analysis aims to compare perioperative outcomes between these approaches. Methods: PubMed, Web of Science, Scopus, Embase, and the Cochrane Library were searched for all relevant observational comparative studies. …”
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Deep anterior chamber depth may be a risk factor for axial length growth in children by Huijie Cao, Huijie Cao, Yongguo Xiang, Yongguo Xiang, Hong Cheng, Hong Cheng, Kexin Sun, Kexin Sun, Shijie Zheng, Shijie Zheng, Miaomiao Du, Miaomiao Du, Ning Gao, Ning Gao, Tong Zhang, Xin Yang, Jiuyi Xia, Wenjuan Wan, Wenjuan Wan, Ke Hu, Ke Hu

“…All participants underwent a standard ophthalmologic examination including uncorrected visual acuity (UCVA), noncycloplegic refraction, AL, and corneal topography in March 2023. …”
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Development and validation of an early diagnosis model for severe mycoplasma pneumonia in children based on interpretable machine learning by Si Xie, Mo Wu, Yu Shang, Wenbin Tuo, Jun Wang, Qinzhen Cai, Chunhui Yuan, Cong Yao, Yun Xiang

“…Therefore, there is an urgent need to establish an early warning model for SMPP to improve the prognosis of pediatric pneumonia. Methods The study comprised 597 SMPP patients aged between 1 month and 18 years. …”
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Identification of anoikis-related genes classification patterns and immune infiltration characterization in chronic rhinosinusitis with nasal polyps based on machine learning by Ziqi Chen, Lingmei Qu, Qing Hao, Shuang Teng, Shuo Liu, Qin Wu, Hongtian Yi, Xianji Shen, Liang Li, Zhaonan Xu, Yanan Sun

“…Although anoikis is implicated in immune regulation and CRSwNP pathogenesis, its specific mechanistic role remains poorly defined.MethodsThe GSE136825 and GSE179625 datasets were obtained from the GEO database and 338 anoikis-related genes (ARGs) were extracted from the literature and databases. …”
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The association and impact of radiographic, pathological emphysema and spirometric airway obstruction on patients with resectable lung adenocarcinoma by Yixiao Zhang, Lu Lang, Xiaojuan Guo, Kewu Huang, Jiawen Yi, Yuan Yuan, Min Zhu, Shu Zhang, Bin Hu, Xue Li, Yuhui Zhang

“…CT-defined emphysema at baseline was assessed visually and quantitatively, pathological emphysema was reviewed on postoperative specimen. …”
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Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa: study protocol... by David Macleod, Einoti Matayan, William Makupa, Jeremy John Hoffman, Simon Arunga, Francis Orishaba, Abel Ebong, Reena Yadav, Astrid Leck, Muna Elisante, Tara Mtuy, Sandip Das Sanyam, Victor H Hu, Matthew J Burton

“…The primary outcome is best spectacle corrected visual acuity (BSCVA) at three months. Primary analysis (intention-to-treat) will be by linear regression, with treatment arm and baseline BSCVA pre-specified covariates. …”
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SMART accelerates rate of cognitive gains in service members with mTBI and PTSD by Erin Venza, Jeffrey S. Spence, Jennifer Zientz, Cole Devlin, Jason Bailie, Jason Bailie, Jason Bailie, Andrew Darr, Andrew Darr, Andrew Darr, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Bond Chapman

“…High-level cognitive abilities were assessed with the Test of Strategic Learning and the Visual Selective Learning Task, and PTSD symptoms were measured using the PTSD Checklist (PCL-M). …”
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Test-retest reliability of diffusion kurtosis imaging metrics in the healthy adult brain by Liu-Yang Wu, Yao Xu, Lan-Lan Chen, Wen-Rui Yang, Yan Li, Song-An Shang, Xian-Fu Luo, Wei Xia, Jing Xia, Hong-Ying Zhang

“…Although the DKI reliability of GM regions varied, the default mode and visual areas consistently demonstrated the highest ICC reliability for a series of kurtosis-related metrics. …”
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Investigation of early-stage cardiovascular-kidney-metabolic syndrome on retinal structure and function evaluated by optical coherence tomography angiography by Yunyi Liang, Congbi Liang, Jianping Yang, Wanhua Li, Runyi Liang, Kun Li, Jingfeng Zhang, Peiqiong Lao, Junhua Zhu, Lin An, Zhaohao Liang, Chubin Ou

“…BackgroundThe retina serves as a non-invasive window to visualize systemic health, with optical coherence tomography angiography (OCTA) enabling simultaneous assessment of retinal structural thickness and vascular density. …”
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Non-inferiority comparison of medical glue and hook-wire for preoperative localization of multiple pulmonary nodules by Zexin Xie, Zexin Xie, Ran Ma, Ran Ma, Tao Gao, Tao Gao, Jingsong Liu, Jingsong Liu, Kewei Zhang, Kewei Zhang, Jun Li, Jun Li, Xiaotong Zhou, Xiaotong Zhou, Hao Zhang, Hao Zhang

“…However, precisely localizing deep-seated or poorly visualized nodules remains a prominent challenge. This study aims to compare the effectiveness and safety of medical glue vs. hook-wire in the CT-guided localization of multiple pulmonary nodules.MethodsA prospective cohort of patients scheduled for CT-guided localization of multiple pulmonary nodules between February 2024 and August 2024 was enrolled. …”
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Primary deltoid ligament repair versus trans-syndesmotic fixation for acute bimalleolar equivalent ankle fractures: A meta-analysis of comparative studies by Osama Z. Alzobi, Hammam Kayali, Loay Salman, Mohamed Kenawey, Ashraf Hantouly, Motasem Salameh, Bashir Zikria, Pieter D'Hooghe, Vinod Panchbhavi, Mohamed Mekhaimar, Salah AlBurdeni, Jasim Alsaei

“…They likewise reported comparable visual analog scale for pain (MD = −0.03; 95 % CI, −0.39-0.34; I2 = 0 %; P = 0.8), and lower complication rates (RR, 0.26; 95 % CI, 0.10–0.69; I2 = 0 %; P = 0.01). …”
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3D spectral CT-based fusion model predicts prognosis and postoperative adjuvant chemotherapy benefit in locally advanced rectal cancer by Shuxuan Fan, Jiaxin Liu, Xiaomeng Yang, Lisha Qi, Xiaomei Lu, Haiwei Liu, Xiaonan Cui

“…The SHapley Additive exPlanation (SHAP) algorithm was used to attribute interpretability to the optimal prediction model. The 3D-ROI method achieved satisfactory interobserver accuracy. …”
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Psychological correlates of COVID-19 vaccine attitudes among medical professionals: An exploratory data analysis by Aldo SITIBONDO, Aanuoluwapo AFOLABI, Jamel HAJJI, Abdulmohsen Mohammed Abdullah ALKHULAYFI, Izaddin Ahmad AZIZ, Zane Asher GREEN, Francesca BRUNO, Martina BARBERA, Murat YLDIRIM

“…Group comparisons of emotional responses were visualized using bar plots. Results: Most participants were fully vaccinated. …”
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Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing by Elena-Emilia Tudoroiu, Mădălina Georgiana Albu Kaya, Cristina Elena Dinu-Pîrvu, Lăcrămioara Popa, Valentina Anuța, Mădălina Ignat, Emilia Visileanu, Durmuș Alpaslan Kaya, Răzvan Mihai Prisada, Mihaela Violeta Ghica

“…<b>Objectives</b>: This study presents the development of new smart pH-sensitive collagen-hydroxyethylcellulose films, incorporating naproxen and phenol red, designed to provide controlled drug release while enabling real-time pH monitoring for burn care. <b>Methods</b>: Biopolymeric films were prepared by the solvent-casting method using ethanol and glycerol as plasticizers. …”
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Exome sequencing revealed a novel homozygous variant in TRMT61 A in a multiplex family with atypical Cornelia de Lange Syndrome from Rwanda by Esther Uwibambe, Abdoulaye Yalcouyé, Elvis Twumasi Aboagye, Lettilia Xhakaza, Kalinka Popel, Norbert Dukuze, Thashi Bharadwaj, Carmen de Kock, Isabelle Schrauwen, Suzanne M. Leal, Leon Mutesa, Ambroise Wonkam

“…We performed a molecular characterization of CdLS in a multiplex Rwandan family. Methods After a clinical evaluation of two affected siblings, DNA isolated from peripheral whole blood of the affected patients and their parents underwent Exome Sequencing (ES). …”
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De novo variant in GUCY2D gene causing atypical cone-rod dystrophy in a consanguineous family and literature review by Xin-He Fang, Fa-Yong Ke, Wen-Qing Zou, De-Jun Zhu, Mei-Jiao Ma, Yuan-Yuan Lian, Xue-Li Wu, Rui-Hua Wei, Xun-Lun Sheng

“…AIM: To analyze the pathogenicity and clinical features of patients in a consanguineous cone-rod dystrophy (CRD) family due to heterozygous variants in the GUCY2D gene. METHODS: Whole exome sequencing was used to screen for pathogenic genes and candidate pathogenic variants were obtained by bioinformatics analysis. …”
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