CHANGES IN CALPROTECTIN LEVEL, ITS RELATIONSHIP TO THE CLINICAL AND LABORATORY PARAMETERS OF DISEASE ACTIVITY AND SIGNIFICANCE FOR PREDICTING THE THERAPEUTIC RESPONSE IN RHEUMATOID... by A. O. Pchelintseva, A. P. Zhornyak, N. G. Ionichenok, E. Yu. Panasyuk, A. E. Ilyina, I. A. Andrianova, E. E. Gubar, E. S. Tsvetkova, M. V. Cherkasova, E. N. Aleksandrova, L. N. Denisov, E. L. Nasonov

“…To assess RA activity, tender and swollen joint count, pain, patient’s and physician’s assessment of global disease activity on 100-mm visual analogue scale and DAS28 were used. Functional status was evaluated by HAQ and RAPID3. …”
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EULAR standardised training model for ultrasound-guided, minimally invasive synovial tissue biopsy procedures in large and small joints by Annamaria Iagnocco, Andrew Filer, Gabriel Herrero-Beaumont, Peter Balint, Ingrid Moller, Esperanza Naredo, Lene Terslev, Alessandra Bruns, Aurélie Najm, Ana Rodriguez, Raquel Largo, Stefano Alivernini, Jesús Garrido, Maria Antonietta D’Agostino, Jacqueline Uson, Juhani Koski, Maribel Miguel, Carlos Guillén-Astete, David A. Bong, George A.W. Bruyn, Carlos Acebes

“…Objectives To develop an EULAR training model for education in synovial tissue biopsy (STB) under ultrasound guidance (UG) following a stepwise approach: (1) development of educational material on UGSTB in large and small joints; (2) assessment of the validity, reliability and feasibility of the UGSTB educational procedure on cadaveric specimens; (3) validation of this procedure in live patients.Methods Using a nominal group (NG) and a DELPHI consensus methodology, educational audio-visual (AV) material and minimal requirements for education in UGSTB were developed by an expert panel. …”
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Cognition and behavior in adults with neurofibromatosis type 1 by Anja Bos-Roubos, Anja Bos-Roubos, Anja Bos-Roubos, Hanneke van Leeuwen, Hanneke van Leeuwen, Hanneke van Leeuwen, Ellen Wingbermühle, Ellen Wingbermühle, Ellen Wingbermühle, Ellen Wingbermühle, Louisa van den Bosch, Lindsey Ossewaarde, Walter Taal, Walter Taal, Laura de Graaff, Laura de Graaff, Laura de Graaff, Jos Egger, Jos Egger, Jos Egger, Jos Egger, Jos Egger

“…Cognition and behavior was tested against population means constructed by bootstrapping.ResultsPerformance on the cognitive measures oral reading speed, visuospatial copying, visuospatial immediate recall, visual learning/imprinting, and visual memory immediate recall in the NF1 group were lower than normative means. …”
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Comparison of the TNM9th and 8th editions for localized and locally advanced anal squamous cell carcinoma treated nonsurgically and proposal of a new stage grouping system by Aihong Zheng, Yiwen Wang, Shuang Li, Yingjie Wang, Hong'en Xu, Jieni Ding, Bingchen Chen, Tao Song, Lei Lai

“…Survival comparisons between the T and N stages and the different staging systems were performed using the Kaplan–Meier method and log‐rank test, followed by correlation analysis and variable importance analysis (VIA). …”
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Long-Term Safety and Efficacy of Lenabasum, a Cannabinoid Receptor Type 2 Agonist, in Patients with Dermatomyositis with Refractory Skin Disease: Follow-Up Data from a 3-Year Open-... by Caroline J. Stone, Geeta Ahuja, Lais Lopes Almeida Gomes, Joy Poroye, Daniella Forman Faden, Lillian Xie, Rui Feng, Barbara White, Victoria P. Werth

“…Key aims include evaluating the drug’s long-term effectiveness and assessing disease manifestation recurrence. Methods: The phase 2 lenabasum trial enrolled patients with treatment-resistant, skin-predominant DM. …”
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Monitoring Anthropogenically Disturbed Parcels with Soil Erosion Dynamics Change Based on an Improved SegFormer by Zhenqiang Li, Jialin Li, Jie Li, Zhangxuan Li, Kuncheng Jiang, Yuyang Ma, Chuli Hu

“…Currently, traditional methods for change detection, such as field surveys and visual interpretation, suffer from time inefficiencies, complexity, and high resource consumption. …”
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Key motor and non-motor features in early dementia with Lewy bodies by Anna Planas-Ballvé, Anna Planas-Ballvé, José Rios, Lourdes Ispierto, Mireia Gea, Laia Grau, Marta Jiménez, Cynthia Cáceres, Sílvia Martínez, Katrin Beyer, Ramiro Álvarez, Pau Pastor, Dolores Vilas, Dolores Vilas

“…ObjectiveThe objective of our study was to characterize early-stage dementia with Lewy bodies (DLB) focusing on motor and non-motor symptoms.MethodsThis cross-sectional study prospectively included newly diagnosed DLB patients within 3 years of cognitive symptom onset. …”
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Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease by Ziqing Feng, MD, Kang Yu, MD, Yupei Chen, MS, Gengyuan Wang, MS, Yuqing Deng, MD, Wei Wang, MD, Ruiwen Xu, MD, Yimin Zhang, MD, Peng Xiao, PhD, Jin Yuan, MD, PhD

“…Participants: The study included 29 healthy subjects (51 eyes) and 62 DED patients (95 eyes). Methods: All subjects underwent comprehensive ophthalmic examinations, dry eye tests, and in vivo confocal microscopy to visualize the whorl-like corneal nerve at the inferior whorl (IW) region and the straight nerve at the central cornea. …”
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Exploring family physicians’ mental health referrals via centralized referral systems in Quebec, Canada: a qualitative descriptive study by Jessica Spagnolo, Marie Beauséjour, Marie-Josée Fleury, Jean-François Clément, Claire Gamache, Lyne Couture, Carine Sauvé, Shane Knight, Christine Gilbert, Richard Fleet, Helen-Maria Vasiliadis

“…Methods: A qualitative descriptive study with 20 participants working in the healthcare sector was conducted. …”
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The efficacy and safety of glycosaminoglycan-peptide complex in patients with knee osteoarthritis and comorbidity: a multicenter prospective study by L. I. Alekseeva, E. A. Taskina, N. G. Kashevarova, E. P. Sharapova, E. A. Strebkova, S. G. Anikin, N. V. Chichasova, T. A. Raskina, E. V. Zonova, E. N. Otteva, E. I. Shmidt, S. P. Yakupova, I. B. Vinogradova, O. N. Ivanova, V. A. Lila, B. V. Zavadovsky, P. A. Shesternya, A. M. Lila

“…Objective: to evaluate the efficacy and safety of glycosaminoglycan-peptide complex (GPC, Rumalon) used in patients with knee osteoarthritis (OA) and comorbidities (hypertension and/or type 2 diabetes mellitus (T2DM).Patients and methods: A 10-month multicenter (13 centers from 10 subjects of the Russian Federation) prospective study included 179 patients with Stages II–III primary tibiofemoral knee OA and comorbidity, a walking pain intensity of ≥40 mm on a visual analogue scale (VAS), and a need for nonsteroidal anti-inflammatory drugs (for at least 30 days in the previous 3 months). …”
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Machine Learning Model Based on Prognostic Nutritional Index for Predicting Long‐Term Outcomes in Patients With HCC Undergoing Ablation by Nan Zhang, Ke Lin, Bin Qiao, Liwei Yan, Dongdong Jin, Daopeng Yang, Yue Yang, Xiaohua Xie, Xiaoyan Xie, Bowen Zhuang

“…The PDP and SHAP algorithms were employed for visual interpretation. Furthermore, time‐AUC and decision curve analysis demonstrated that the Aorsf model provided superior clinical benefits compared to other models. …”
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Does the number of drain tubes influence the formation of postoperative spinal epidural hematoma following biportal endoscopic unilateral laminotomy for bilateral decompression (BE... by Zhuolin Zhong, Jingjing Ying, Shaohua Zhang, Kaili Cai, Xiaowei Jing, Zhengyu Xu, Lejian Jiang, Tianxin Wu, Guojun Wei, Qingfeng Hu

“…Demographic data were collected, including preoperative visual analog scale (VAS) scores for leg pain and preoperative blood pressure (BP). …”
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Opioid versus opioid-free analgesia after surgical discharge: protocol for a systematic review and meta-analysis by Charbel El-Kefraoui, Ghadeer Olleik, Marc-Aurele Chay, Araz Kouyoumdjian, Philip Nguyen-Powanda, Fateme Rajabiyazdi, Uyen Do, Alexa Derksen, Tara Landry, Alexandre Amar-Zifkin, Agnihotram V. Ramanakumar, Marc-Olivier Martel, Gabriele Baldini, Liane Feldman, Julio F Fiore Jr

“…When trials report outcomes for a common domain (eg, pain intensity) using different scales, we will convert effect sizes to a common standard metric (eg, Visual Analogue Scale). Minimally important clinical differences reported in previous literature will be considered when interpreting results. …”
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Effectiveness of bright light therapy and combination with myopic defocus for controlling myopic eye growth in schoolchildren: study protocol for a randomised controlled trial (pha... by Dennis Yan-yin Tse, Rachel Ka Man Chun, Chi Ho To, Ian G Morgan, Jinxiao Lian, Carly SY Lam, Wai-Ching Lam, Christopher Kai Shun Leung, Lai Ming Ho, Ying Hon, Billy Kin Kwok Cheung, Desmond Man Kit Lam, Andy Chi Wai Kong, Thomas C Lam

“…Introduction Myopia and its complications can lead to irreversible visual impairment and even blindness, making this a worldwide public health concern for the 21st century. …”
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Hyperuricemia predicts adverse clinical outcomes after arthroscopic microfracture of osteochondral lesions of the talus by Yuanqiang Li, Zhenyu Wang, Guo Zheng, Lin Ma, Xin Xin Li, Yan Liang, Xinyu Xie, Xiaolin Zhang, Chengsong Yuan, Wan Chen

“…Clinical characteristics recorded and analyzed included Visual Analog Scale (VAS score), American Orthopaedic Foot & Ankle Society score (AOFAS), and 36-Item Short Form Health Survey score (SF-36). …”
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Low density of intratumoral M1-macrophage infiltration may correlate with worse prognosis in low-grade early-stage uterine endometrioid carcinoma by Michiko Nagamine, Hiroshi Ogi, Maki Hirai, Ikoi Omatsu, Sanzo Moriwaki, Saya Shibata, Satoru Yasukawa, Kaori Yoriki, Motohiro Kojima, Taisuke Mori, Kyoko Itoh, Eiichi Konishi

“…In addition, clusters of foam cells in the stroma were visually examined. Results: Compared with the cured group, the primary tumor of recurrent group demonstrated significantly lower densities of CD68-positive macrophages and M1 macrophage. …”
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Contemporary carotid artery stenting practices and peri-procedural outcomes in different European countries: ROADSAVER study multicentric insights by Stefan Müller-Hülsbeck, Zsolt Vajda, Piotr Odrowąż-Pieniążek, Zoltán Ruzsa, Roel Beelen, Aleksandar Gjoreski, Koen Deloose, Sérgio Castro, Benjamin Faurie, Alejandro Tomasello Weitz, Arne Schwindt, Paweł Latacz, Antonio Orgaz Pérez-Grueso, Vladimir Cvetić, Ralf Langhoff, Sasko Kedev, all ROADSAVER study investigators

“…Trial registration Clinicaltrials.gov identifier: NCT03504228. Visual Abstract…”
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Characterisation of combined abiotic and biotic stresses effects on lettuce plants via a multi-analysis approach by Roberta Bulgari, Roberta Bulgari, Jouhaina Riahi, Riccardo Cecire, Riccardo Cecire, Luisella Celi, Mery Malandrino, Gica Stefanescu Miralles, Gica Stefanescu Miralles, Lorenzo Comba, Luca Alfarano, Luca Alfarano, Massimo Pugliese, Massimo Pugliese

“…These findings pave the way to the development of proactive, reliable, and effective methods for stress detection in lettuce cultivation, also including non-destructive optical approaches.…”
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Real-time detection of Chinese cabbage seedlings in the field based on YOLO11-CGB by Hang Shi, Hang Shi, Changxi Liu, Changxi Liu, Miao Wu, Miao Wu, Hui Zhang, Hui Zhang, Hang Song, Hang Song, Hao Sun, Hao Sun, Yufei Li, Yufei Li, Jun Hu, Jun Hu

“…However, the similarity between the characteristics of Chinese cabbage seedlings and some weeds is a great challenge for accurate detection.MethodsThis study introduces an enhanced detection method for Chinese cabbage seedlings, employing a modified version of YOLO11n, termed YOLO11-CGB. …”
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[68Ga]Ga-FAPI-46 PET/CT for Staging Suspected/Confirmed Lung Cancer: Results on the Surgical Cohort Within a Monocentric Prospective Trial by Lucia Zanoni, Emilia Fortunati, Giulia Cuzzani, Claudio Malizia, Filippo Lodi, Veronica Serena Cabitza, Irene Brusa, Stefano Emiliani, Marta Assenza, Filippo Antonacci, Francesca Giunchi, Alessio Degiovanni, Marco Ferrari, Filippo Natali, Thomas Galasso, Gian Piero Bandelli, Simona Civollani, Piero Candoli, Antonietta D’Errico, Piergiorgio Solli, Stefano Fanti, Cristina Nanni

“…To evaluate T&N-staging diagnostic performance of [68Ga]Ga-FAPI-46 PET/CT (FAPI) in a suspected/confirmed lung cancer surgical cohort. Methods: Patients were enrolled in a prospective monocentric trial (EudraCT: 2021-006570-23) to perform FAPI, in addition to conventional-staging-flow-chart (including [18F]F-FDG PET/CT-FDG). …”
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