Rheumatoid arthritis and psoriatic arthritis: is the disease impact different? A large matching study at diagnosis and after 1 year of treatment by Annette H M van der Helm-van Mil, Pascal H P de Jong, Sytske Anne Bergstra, Elise van Mulligen, Ilja Tchetverikov, Jolanda J Luime, Marijn Vis, Marc R Kok, Maikel van Oosterhout, Jos H van der Kaap, Selinde V J Snoeck Henkemans, Anne-Fleur van den Biggelaar

“…The difference in disease impact between RA and PsA was measured with the following PROs: pain (Visual Analogue Scale (VAS), 0–100), fatigue (VAS), activity limitation (Health Assessment Questionnaire-Disability Index) and health impact (general health (VAS) and 36-item Short-Form Health Survey (SF-36)). …”
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Efficacy and safety of photobiomodulation combined with oral cryotherapy on oral mucosa pain in patients with burning mouth syndrome: a multi-institutional, randomized, controlled... by Chenghui Lu, Xuan Zhou, Chenglong Yang, Xinxiang Jiang, Xin Li, Zefan Huang, Qing Du, Guoyao Tang

“…The coprimary outcome measures were changes in visual analogue scale (VAS) scores and the overall response rate between baseline and 7 weeks of treatment. …”
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Machine learning prediction of HER2-low expression in breast cancers based on hematoxylin–eosin-stained slides by Jun Du, Jun Shi, Dongdong Sun, Yifei Wang, Guanfeng Liu, Jingru Chen, Wei Wang, Wenchao Zhou, Yushan Zheng, Haibo Wu

“…Results A publicly available TCGA-BRCA dataset and an in-house USTC-BC dataset were applied to evaluate our AI model and the state-of-the-art method SlideGraph + in terms of accuracy (ACC), the area under the receiver operating characteristic curve (AUC), and F1 score. …”
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The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy... by Ahmet Serhat Genç, Ali Kerim Yılmaz, Berna Anıl, Esra Korkmaz Salkılıç, Enes Akdemir, Berna Güzel, Ahmet Mor, Hacı Ahmet Yarar, Nizamettin Güzel, Lokman Kehribar

“…This study aimed to evaluate the effects of Naturagen® 4 Joint product containing type I, II, and III collagen on pain, quality of life, and physical functions in patients with meniscopathy. Methods This randomized, double-blind, placebo-controlled clinical study included 32 patients (collagen = 17 and placebo = 15) with meniscopathy. …”
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NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance by Qingyan Tian, Haiyue Guo, Mengyao Zhang, Kunmao Jiang, Fan Hu, Yan Xu, Li Wan, Xiaokai Zhou, Yinbing Pan, Wentao Liu, Chun-Yi Jiang

“…Confocal laser scanning microscopy was utilized to visualize NETs in the dorsal root ganglion (DRG) and in cells. …”
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Meta-analyses of the effects of high-intensity interval training in elite athletes — part II: relationships between the mean effects on various performance measures by Hans-Peter Wiesinger, Hans-Peter Wiesinger, Hans-Peter Wiesinger, Will G. Hopkins, Nils Haller, Nils Haller, Julia Blumkaitis, Tilmann Strepp, Thomas Leonhard Stöggl, Thomas Leonhard Stöggl

“…Here, we extend the analyses to relationships between mean changes of these measures and consider implications for understanding and improving HIIT that were not apparent in the previous analyses.MethodsThe data were mean changes from HIIT with highly trained endurance and elite other (mainly team sport) athletes in studies where two or more measures or predictors of performance were available. …”
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Effects of plant active substances in rheumatoid arthritis—a systematic review and network meta-analysis by Qiuwei Peng, Jian Wang, Kesong Li, Congming Xia, Chuanhui Yao, Qiuyan Guo, Xun Gong, Xiaopo Tang, Quan Jiang

“…The main focus was on assessing primary outcomes, including the Visual Analogue Scale (VAS), inflammatory markers, Swollen Joint Count (SJC), Tender Joint Count (TJC), and Disease Activity Score on 28 joints (DAS28). …”
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The burden of refraction disorders in 204 countries and territories from 1990 to 2021: A systematic analysis from the global burden of disease 2021 by Yunhan Shen, Linyan Wang, Yuxin Cui, Bangxun Mao, Grace Loy Ming Hooi, Oluwatobi Idowu, Juan Ye, Tiansheng Zhu

“…Background: Refraction disorders are common eye conditions that cause blurred vision and, if left uncorrected, remain a leading cause of moderate to severe visual impairment worldwide. Despite this, a comprehensive assessment of the associated burden is lacking. …”
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Effect of superficial cervical plexus nerve block with Ropivacaine or a combination of different adjuvants on perioperative analgesia and quality of postoperative recovery in patie... by Xiaoyu Kang, Caifen Li, Liuyu Lu, Xiaotong Qin, Yonghao Wang, Yang Lu, Li Ma, Shaoliang Zhu, Zheng Gong

“…The primary observation index were postoperative resting and active Visual Analogue Score. The secondary observation index were hemodynamics, intraoperative sedative and analgesic medication use, postoperative analgesic requirements, postoperative recovery indicators, Richards-Campbell Sleep Questionnaire scores, Quality of Postoperative Recovery-15 scores, and adverse reactions. …”
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Differential effects of sound interventions tuned to 432 Hz or 443 Hz on cardiovascular parameters in cancer patients: a randomized cross-over trial by Anna Hohneck, Ánxelo Maia Rodríguez, Simone Weingärtner, Kirsten Merx, Felicitas Sarodnick, Fritjof von Gagern, Athanasios Mavratzas, Iris Burkholder, Gerhard Schumacher, Wolf-Karsten Hofmann, Ralf-Dieter Hofheinz

“…Before (pre) and after (post) intervention, cardiovascular parameters were measured using the VascAssist2.0. In addition, visual analogue scales (VAS) for emotional well-being, anxiety, stress, pain and sadness were also assessed pre and post intervention. …”
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Diagnostic value of nuclear medicine modaities for the detection of sentinel lymph nodes in patients with breast cancer by E. A. Nikolaeva, A. S. Krylov, A. D. Ryzhkov, Kh. Kh. Batyrov, A. A. Parokonnaya, M. E. Bilik, T. V. Zakharova, A. V. Svetlyakova, A. I. Pronin

“…Nuclear medicine imaging of sln with lymphotropic radiopharmaceuticals in patients with breast cancer is an effective and reliable method of navigation during surgery to perform a biopsy. …”
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Metformin treatment for patients with hand osteoarthritis: protocol for the multicentre, randomised, placebo-controlled METRO trial by David J Hunter, Robin Christensen, Marius Henriksen, Henning Bliddal, Karen Ellegaard, Mikael Boesen, Tue Kragstrup, Filip K Knop, Anna Dossing, Kasper Staberg Madsen, Asbjørn S Poulsen, Rasmus Oscar

“…The primary endpoint is the between-group difference in least squares means for the change in the Visual Analogue Scale (VAS) finger joint pain scores between the metformin and placebo groups at 16 weeks. …”
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Neurophysiological findings in Attention Deficit Hyperactivity Disorder, a Pandora’s box with therapeutic implications by Montserrat Gerez-Malo, Armando Tello, Maria Jimena Martin-Salas, Lauro Castanedo, Arturo Mendizábal, Oscar Meneses Luna, Leslie Quintanar, Carlos Acosta

“…This study aimed to identify dysfunctional mechanisms behind ADHD symptoms and test if targeting these dysfunctions can improve clinical outcomes. Methods: 230 children with ADHD diagnosis studied with hypothesis-related variables from electroencephalogram (EEG) visual inspection and quantitative z-scored power, coherence and ratios, and from event-related brain potentials (ERPs) z-sored P50, N100, N200, P300 latencies amplitudes and ratios. …”
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Efficacy of repetitive transcranial magnetic stimulation for smoking cessation: a systematic review and meta-analysis by Youssef A. Ismail, Omar K. Habib, Yahya El-Banan, Raneem Ramadan, Mohamed O. Henidak, Mohamed E. El-Badry, Ahmed R. Rabea, Amira A. Fouad, Salsapeel I. El-Tahlawy, Rahma M. El-Shawa, Mohamed Atef, Rahma A. Abd El-Kader, Abdullah El-Lawendy, Mariam El-Morsy, Mariam S. El-Rayes, Hanem El-Hasanen, Moaz Abouelmagd

“…However, no significant effects were observed for self-reported cigarette consumption (MD = -2.74, 95% CI [-7.26 to 1.79], P = 0.24) or the Visual Analog Scale for craving (SMD = -0.29, 95% CI [-0.67 to 0.10], P = 0.14). …”
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Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes by Charlie R. Faulks, Dean T. Biddau, Michael D. Selby, Ralph J. Mobbs, Gregory M. Malham

“…Patient reported outcome measures included visual analog scale (VAS) back pain, Oswestry disability index (ODI) and 12-Item Short Form Survey (SF-12) measured at preoperative, 6-week, 6-month, 12-month, and 24-month time points. …”
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Anterior cervical discectomy and fusion in treating acute myelopathy caused by Brucella cervical spondylitis: a case series by Long Chen, Tao Zhang, Xing-yu Chen, Yi-zhe Wang, Xing-guo Tan, Da-shuai Huang, Yan-peng Lu, Song-kai Li

“…Clinical data such as age, gender, surgery duration, follow-up period, medication duration, time to bone fusion, ASIA classification, Visual Analog Scale (VAS) score, Japanese Orthopaedic Association (JOA) score, and Neck Disability Index (NDI) score were collected both preoperatively and postoperatively. …”
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Enhanced transdermal delivery of lidocaine cream via ultrasound and microneedle rollers by Jiaxiao Sun, Yang Yang, Yang Yang, Juanjuan Zheng, Hao Liang, Feng Yan, Wensheng Zhang, Wensheng Zhang, Wenqin Xie

“…ObjectiveThe aim of this study is to determine the most effective physical parameters for optimizing the transdermal delivery of lidocaine cream.MethodsPreliminary experiments were conducted to optimize ultrasound settings while ensuring safety, guided by visual and histopathological evaluations following observations of skin burns in rats. …”
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Multimodal Analgesia Approach in Acute Low Back Pain Management: A Phase III Study of a Novel Analgesic Combination of Etoricoxib/Tramadol by Miguel A. Zuqui-Ramírez, Victor M. Belalcazar-López, Adelfia Urenda-Quezada, Alejandro González-Rebatu y González, José G. Sander-Padilla, Laura A. Lugo-Sánchez, Ileana C. Rodríguez-Vázquez, Kevin F. Rios-Brito, María M. Arguedas-Núñez, Emmanuel Canales-Vázquez, Jorge González-Canudas

“…The proportion of patients with a 30% reduction in Visual Analogue Scale (VAS) score was statistically significant when comparing the treatment groups on the third day of follow-up [p = 0.008, CI 95% 0.241 (0.061–0.421)]. …”
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Machine learning model for predicting corneal stiffness and identifying keratoconus based on ocular structures by Longhui Li, Yifan Xiang, Xi Chen, Duoru Lin, Lanqin Zhao, Jun Xiao, Zhenzhe Lin, Jianyu Pang, Xiaotong Han, Lixue Liu, Yuxuan Wu, Zhenzhen Liu, Jingjing Chen, Jing Zhuang, Keming Yu, Haotian Lin

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A high‐resolution model of the grapevine leaf morphospace predicts synthetic leaves by Daniel H. Chitwood, Efrain Torres‐Lomas, Ebi S. Hadi, Wolfgang L. G. Peterson, Mirjam F. Fischer, Sydney E. Rogers, Chuan He, Michael G. F. Acierno, Shintaro Azumaya, Seth Wayne Benjamin, Devendra Prasad Chalise, Ellice E. Chess, Alex J. Engelsma, Qiuyi Fu, Jirapa Jaikham, Bridget M. Knight, Nikita S. Kodjak, Adazsofia Lengyel, Brenda L. Muñoz, Justin T. Patterson, Sundara I. Rincon, Francis L. Schumann, Yujie Shi, Charlie C. Smith, Mallory K. St. Clair, Carly S. Sweeney, Patrick Whitaker, James Wu, Luis Diaz‐Garcia

“…Societal Impact Statement Grapevine leaves are emblematic of the strong visual associations people make with plants. Leaf shape is immediately recognizable at a glance, and therefore, this is used to distinguish grape varieties. …”
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