STABLE trial of spectacle provision and driving safety among myopic motorcycle users in Vietnam: study protocol for a stepped-wedge, cluster randomised trial by Vinh Chi Le, Kien Gia To, Van Dat Le, Le Nguyen, Graeme MacKenzie, Lovemore Nyasha Sigwadhi, Prabhath Piyasena, Mai Tran, Ving Fai Chan, Rohit C. Khanna, Mike Clarke, Lynne Lohfeld, Heather Dickey, Augusto Azuara-Blanco, Asha Latha Mettla, Sridevi Rayasam, Han Thi Ngoc Doan, Dung Van Do, Phuoc Hong Le, Charlie Klauer, Richard Hanowski, Zeb Bowden, Lynn Murphy, Joanne Thompson, Susan McMullan, Cliona McDowell, Raja Narayanan, Julie-Anne Little, Huong Thu Ha, Sangchul Yoon, Rahul Goel, Lan Luong, Xuan Nguyen, Nathan Congdon

“…Secondary outcomes include visual function, cost-effectiveness and self-reported crash events. …”
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Advanced Doppler Ultrasound Insights: A Multicenter Prospective Study on Healthy Skin by Priscila Giavedoni, Jorge Romaní, Francisco de Cabo, Francisco Javier García-Martínez, Mónica Quintana-Codina, Esther Roè-Crespo, Irene Fuertes de Vega, Xavier Soria-Gili, Rafael Aguayo-Ortiz, Patricia Garbayo-Salmons, Gonzalo Castillo, David Vidal-Sarró, Jordi Mollet, Laura Serra, Carlos Gonzalez, Emilio López-Trujillo, Miquel Just, Marc Combalia, Sebastian Podlipnik, Josep Malvehy, Ximena Wortsman

“…<b>Objective:</b> This study aimed to evaluate the visible vessels of healthy skin using Doppler ultrasound. <b>Methods:</b> Prospective multicenter study using Doppler ultrasound to analyze healthy skin. …”
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Real-Life Clinical Use and Outcomes of Fusion Imaging-Guided Percutaneous Microwave Ablation of Hepatocellular Carcinoma: Experience from Two Italian Centers by Pierpaolo Biondetti, Francesco Cicchetti, Gaetano Valerio Davide Amato, Velio Ascenti, Niccolò Finardi, Jacopo Tintori, Francesco Ugo Iovino, Carolina Lanza, Salvatore Alessio Angileri, Pierluca Torcia, Anna Maria Ierardi, Giacomo Vignati, Lorenzo Giovanni Monfardini, Gianpaolo Carrafiello

“…<b>Conclusions:</b> USFI-guided MWA is a safe and effective option for treating HCC nodules not adequately visualized with conventional US, expanding eligibility to complex cases.…”
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Acute pharmacological effects of α-PVP in humans: a naturalistic observational study by Georgina De la Rosa, Georgina De la Rosa, Esther Papaseit, Esther Papaseit, Olga Hladun, Olga Hladun, Lourdes Poyatos, Dolly Andrea Caicedo, Dolly Andrea Caicedo, Martha Catalina Argote, Martha Catalina Argote, Soraya Martín, Mireia Ventura, Nunzia La Maida, Annagiulia Di Trana, Silvia Graziano, Simona Pichini, Magí Farré, Magí Farré, Clara Pérez-Mañá, Clara Pérez-Mañá

“…Since the pharmacology of α-PVP remains scarcely studied, we aimed to evaluate the acute pharmacological effects and its abuse potential in humans after intranasal administration.MethodsWe carried out a non-controlled observational study in a naturalistic environment in nine participants (3 women and six men) with a previous history of psychostimulant use. …”
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Automated pixel-based quantification of porcine circovirus 2 genome in formalin-fixed, paraffin-embedded tissues using in situ hybridisation by Mònica Sagrera, Mònica Sagrera, Mònica Sagrera, Àlex Cobos, Àlex Cobos, Àlex Cobos, Àlex Cobos, Laura Garza-Moreno, Mónica Pérez, Mónica Pérez, Mónica Pérez, Gema García-Buendía, Gema García-Buendía, Gema García-Buendía, Eva Huerta, Eva Huerta, Eva Huerta, Anna Maria Llorens, Anna Maria Llorens, Anna Maria Llorens, David Espigares, Marina Sibila, Marina Sibila, Marina Sibila, Joaquim Segalés, Joaquim Segalés, Joaquim Segalés

“…In situ hybridisation (ISH) enables the localisation of viral genomes in tissue sections but is traditionally assessed visually, which may introduce subjectivity.MethodsThis study developed an automated pixel classifier to quantify the PCV2 genome using RNAscope® ISH technology. …”
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Comparison of intravitreal anti-VEGF agents and oral carbonic anhydrase inhibitors in the treatment of cystoid macular edema secondary to retinitis pigmentosa by Jia Liang, Xueping Wu, Lu Chen, Lujia Feng, Xiangqing Hei, Yingying Diao, Yuke Ji, Huiyan Zheng, Zhenhua Zou, Dong Fang, Shaochong Zhang

“…Medical records were reviewed to assess best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure (IOP) at baseline and at 1, 3, 6, and 12 months post-treatment using Generalized Estimation Equations (GEE). …”
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Age-Related Variations in Anterior, Posterior, and Total Corneal Astigmatism by Pothikamjorn T, Surawatsatien N, Ueathaweephol S, Somkijrungroj T

“…Preoperative counseling should address potential long-term shifts toward ATR orientation, which may influence visual outcomes in patients receiving toric IOLs aligned along other axes. …”
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Efficacy and safety of phacotrabeculectomy versus phacogoniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre non-inferiority randomised controlled... by Xiulan Zhang, Xi Zhang, Yi Zhang, Li Tang, Guangxian Tang, Hengli Zhang, Aiguo Lv, Huiping Yuan, Yunhe Song, Lin Xie, Lan Lu, Kun Hu, Xiaohong Liang, Xiaowei Yan, Yingzhe Zhang, Wulian Song, Meichun Xiao, Xiaohuan Zhao, Xiaomin Zhu, Xinbo Gao, Minwen Zhou, Sujie Fan

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Bidirectional dynamic frame prediction network for total-body [68Ga]Ga-PSMA-11 and [68Ga]Ga-FAPI-04 PET images by Qianyi Yang, Wenbo Li, Zhenxing Huang, Zixiang Chen, Wenjie Zhao, Yunlong Gao, Xinlan Yang, Yongfeng Yang, Hairong Zheng, Dong Liang, Jianjun Liu, Ruohua Chen, Zhanli Hu

“…The ROI analysis conducted on our generated dynamic PET sequences also revealed that our method can accurately predict temporal voxel intensity changes, maintaining overall visual consistency with the ground truth. …”
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Advancing Nanomedicine Through Electron Microscopy: Insights Into Nanoparticle Cellular Interactions and Biomedical Applications by Akhtar S, Zuhair F

“…Electron microscopes enables scientists to visualize nanoparticles and cells with enhanced clarity and magnification. …”
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Artistic Features of Jiangnan Gardens During the Mid-16th Century as Reflected in the Picture of a Famous Garden in Jinchang by Shiyuan PANG, Xiao HUANG

“…It also helps to form a clearer understanding of the typical artistic features of Jiangnan gardens in the mid-16th century.MethodsThe research method of mutual verification of literature and image is employed to reconstruct the garden depicted in the Picture of a Famous Garden in Jinchang. …”
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Prediction model of ocular metastasis from primary liver cancer: Machine learning‐based development and interpretation study by Jin‐Qi Sun, Shi‐Nan Wu, Zheng‐Lin Mou, Jia‐Yi Wen, Hong Wei, Jie Zou, Qing‐Jian Li, Zhao‐Lin Liu, San Hua Xu, Min Kang, Qian Ling, Hui Huang, Xu Chen, Yi‐Xin Wang, Xu‐Lin Liao, Gang Tan, Yi Shao

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The clinical features and perfusion density in paracentral acute middle maculopathy by optical coherence tomography angiography study by Zhengfeng Liu, Xuemei Pan, Dan Wang, Yingying Zou, Peipei Liu, Ying Wang, Hongsheng Bi, Xiaofeng Xie

“…Results: The mean age of patients was 48.08 (range 14–72) years. The best corrected visual acuity (BCVA) was from finger count (FC) to 1.0. …”
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Pt@ZnCo₂O₄ Microspheres as Peroxidase Mimics: Enhanced Catalytic Activity and Application for L-Cysteine Detection by Shuqi Liao, Weisen Deng, Feng Yang, Jutao Zhou, Ling Wu, Donghong Yu, Zhong Cao

“…Based on the optimal loading ratio of 12.5% of Pt@ZnCo₂O₄, a colorimetric sensor for visual detection of L-cysteine (L-Cys) was constructed, exhibiting a wide linear range of 0.1~50 µM and a low detection limit of 0.0163 µM. …”
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The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses by Dustyn Barnette, Amy L. Inselman, Pravin Kaldhone, Grace S. Lee, Kelly Davis, Sumit Sarkar, Pritpal Malhi, J. Edward Fisher, Joseph P. Hanig, Richard D. Beger, E. Ellen Jones

“…Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a dynamic approach capable of generating 2D ion images to visualize the distribution of an analyte of interest across a tissue section.MethodsGiven the importance of lipid metabolism and neurotransmitters in the developing central nervous system, this study incorporates MALDI MSI to assess lipid distributions across mouse gestational day (GD) 18 fetuses, with and without observable NTDs following maternal exposure on GD 8 to morphine (400 mg/kg BW) or the NTD positive control valproic acid (VPA) (500 mg/kg BW).ResultsAnalysis of whole-body mouse fetuses revealed differential lipid distributions localized mainly in the brain and spinal cord, which included several phosphatidylcholine (PC) species such as PCs 34:1, 34:0, and 36:2 localized to the cortex or hippocampus and lyso PC 16:0 across all brain regions. …”
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Efficacy and safety of ozone injection into the intervertebral foramen for treating patients with chronic, intractable postherpetic neuralgia: a one-year follow-up study by Jiang-Lin Wang, Jiang-Lin Wang, Hai-Li Li, Xiang-Bo Liu, Jia-Gui Zhao, Dong Huang, Cheng Wu, Jia-Shuang Wang, Jia-Shuang Wang, Jun Chen, Jun Chen

“…Here, we reported the efficacy and safety of a standardized therapeutic approach with CT-guided intervertebral foramen injection of ozone (IVFO) in patients with chronic intractable thoracic and lumbar (PHN) (n = 56) who had been tolerant or insensitive to first-line drugs, such as gabapentin (GBP) or pregabalin.MethodsVisual analogue scale (VAS), quantitative sensory testing (von Frey filaments only), and infrared thermography were used to identify and quantify the pain intensity, area of mechanical hyperalgesia, and skin temperature in the included patients with PHN before and after IVFO treatment. …”
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The effect of topical TRanexamic Acid versus placebo on acute postoperative pain following Distal Radius fracture fixation: protocol for a randomised controlled trial at a quaterna... by Ryan Paul, Atefeh Noori, Christian Veillette, Darius Luke Lameire, Aazad Abbas, Jonathan Persitz, Heather Baltzer, Emily Collett, Andrea Chan

“…The primary outcome is acute postsurgical pain as measured by the visual analogue scale (VAS). Pain outcomes will be between postoperative days 0 to 7, and at 2 and 6 weeks postsurgery. …”
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Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice by Yulia Dwi Setia, Yulia Dwi Setia, Mio Kokubo-Tanaka, Ryusei Tanaka, Akemi Yoshida, Eiji Nagayasu, Parnian Ahmadi, Parnian Ahmadi, Parnian Ahmadi, Ayako Yoshida, Ayako Yoshida, Haruhiko Maruyama

“…In the present study, we investigated the pathogenesis and the mechanisms underlying goblet cell down-regulation in the early phase of infection.MethodsMale C57BL/6 mice were orally infected with 300 oocysts. …”
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Real-time augmented feedback for gait training: are gait responses affected by the choice of target parameter? by Mathilde Legrand, Mathilde Legrand, Mathilde Legrand, Florette Grenet, Olivia Hochstrasser, Olivia Hochstrasser, Andreas Luft, Andreas Luft, Roger Gassert, Roger Gassert, Roger Gassert, Olivier Lambercy, Olivier Lambercy, Chris Easthope Awai

“…BackgroundAugmented visual feedback (AVF) is a promising approach for gait rehabilitation after stroke. …”
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Novel minimally invasive carpal tunnel release using a specialized surgical kit: a prospective multi-center case series by Hsuan-Fu Chen, Shun-Min Chang, Chih-Ming Kao, Yu-Lin Chen, Li-Ting Kao, Ya-Chuan Hsu, Yin-Chih Fu, Yan-Hsiung Wang, Wen-Chih Liu, Tien-Ching Lee

“…Outcomes were assessed through Visual Analog Scale (VAS), Boston Carpal Tunnel Questionnaire (BCTQ), grip and pinch strength measurements, and nerve conduction velocity (NCV) testing at regular intervals over 24 weeks post-surgery. …”
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