Cobalt Chloride-simulated Hypoxia Promoted Ossification of the Posterior Longitudinal Ligament Through the HIF1A–BMP4 Axis by Shihao Lu, Junbin Liu, Junzhe Sheng, Aochen Xu, Zichuan Wu, Chen Xu, Jiabin Yuan, Yang Liu

“…Immunohistochemistry was performed to visualize HIF1A in tissue samples. Osteogenic differentiation was evaluated through Alizarin Red S staining and alkaline phosphatase (ALP) assays, with optical density (OD) values measured using a microplate reader. …”
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Relationship between Hyponatremia and Peripheral Neuropathy in Patients with Diabetes by Yongze Zhang, Chuanchuan Li, Lingning Huang, Ximei Shen, Fengying Zhao, Cailin Wu, Sunjie Yan

“…A restricted cubic spline was used to flexibly model and visualize the relationship between the serum sodium level and DPN, followed by logistic regression with adjustment. …”
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Health-related quality of life and productivity burden for non-professional caregivers of adults with rare diseases: a real-world study by Ben Johnson, Gregor Gibson, Daniel Baskerville, Giorgio Castellano, Jonathan de Courcy, Halima Iqbal, James Piercy, Angela Williams, Rafael Pinedo-Villanueva, Angela Rylands

“…Patients’ mean (SD) EuroQol visual analogue scale (EQ VAS) score was 50.9 (23.3) and mean EQ-5D utility was 0.460 (0.350). …”
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Cost utility analysis of acute rehabilitation approaches in the management of traumatic anterior shoulder dislocation by Henry Nwankwo, James Mason, Martin Underwood, Helen Parsons, Aminul Haque, David Torgerson, Chetan Modi, Rebecca S. Kearney

“…Aims: We aimed to conduct a cost-utility analysis comparing one session of advice, supporting materials, and option to self-refer to physiotherapy with the same advice and materials, plus an additional programme of physiotherapy for people with a first-time, traumatic anterior shoulder dislocation. Methods: We conducted an economic evaluation within a randomized controlled trial from the UK NHS and personal social services (PSS) perspective. …”
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The effect of listening to music and drawing on coping with dysmenorrhea complaints in nursing students: randomized controlled trial by Burcu Küçükkaya, Şükran Başgöl

“…Abstract Aim To examine the effect of listening to music and drawing on coping with dysmenorrhea complaints of nursing students. Methods The study was a double-blind, three parallel-group randomized controlled trial conducted between August 2023 and May 2024 at Bartın University, Faculty of Health Sciences, Department of Nursing. …”
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Construction of dynamic ceRNA regulatory networks in osteogenesis during fracture healing based on transcriptomic analysis by Shuhang Guo, Shen Wang, Shaoxun Yuan, Xinyi Gu, Jin Deng, Chen Huang, Xinyi Zeng, Qingguo Lu, Xiaofeng Yin

“…This study aimed to investigate the key molecules involved in fracture healing and their potential competing endogenous RNA (ceRNA) regulatory mechanisms within the first 28 days post-fracture using bioinformatics methods. The experiment was conducted on 15 adult male SD rats, with tibia callus tissue samples collected at days 0, 3, 7, 14, and 28 (n = 3) post-fracture. …”
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Real-World Outcomes of Allogeneic Immunosafe Plasma Rich in Growth Factors Eye Drops for Refractory Ocular Surface Diseases: A Prospective Observational Study by Rosa Alvarado-Villacorta, Jesús Merayo-Lloves, Ronald M. Sánchez-Ávila, Belén Alfonso-Bartolozzi, Carlos Lisa, Luis Fernández-Vega-Cueto, José F. Alfonso, Eduardo Anitua

“…We aimed to evaluate the safety and clinical outcomes of allogeneic is-ePRGF therapy for refractory OSD in real-world practice. Methods A single-center cohort was conducted involving consecutive patients with severe OSD nonresponsive to conventional therapy. …”
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Midterm Outcomes Following Conversion of Failed Ankle Arthrodesis to Total Ankle Arthroplasty, Including Patients With a Deficient Fibula by George Lian MD, William Ip MD, Andrea Hankins, Michele Guillen, Carol Parise PhD

“…Secondary outcomes were evaluated postoperatively with a visual analog scale, the American Orthopaedic Foot & Ankle Society (AOFAS) ankle and hindfoot score, a satisfaction survey, and radiographic assessment of the arthroplasty and any concomitant hindfoot fusions. …”
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Indicators of rheumatoid arthritis disease activity. An association with a patient’s psychological status by V. V. Rybakova, Yu. A. Olyunin, E. V. Likhacheva, E. L. Nasonov

“…All the patients underwent clinical examination; the following parameters were recorded: patient global assessment; physician’s global assessment; pain visual analogue scale (VAS), by measuring in millimeters; number of painful joints (NPJ), and number of swollen joints (NSJ). …”
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Engagement and Follower Growth: Social Media Strategies of Swiss Athletes at the Paris Olympics by Larssyn Staley, Florian Droux

“…In total, 183 posts of 21 athletes were coded for post type, likes, comments, engagement rate, visual elements, caption themes and collaborations. …”
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Gender characteristics of the course of toxoplasmic encephalitis in HIV-infected patients by T.A. Veliieva, K.I. Bodnia, P.V. Nartov, І.M. Asoyan, V.D. Makarenko, I.V. Krokhmal

“…The purpose was to analyze the gender characteristics of TE in HIV-infected patients. Materials and methods. A retrospective analysis of the gender characteristics of the TE course was performed in 23 HIV-infected patients. …”
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Elevated Blink Rates Predict Mind Wandering: Dopaminergic Insights into Attention and Task Focus by Leigh M. Riby, Lewis Marr, Lynn Barron-Millar, Joanna Greer, Colin Joseph Hamilton, Deborah McGann, Jonathan Smallwood

“…During the task (3-stimulus visual oddball procedure), participants discriminated between an infrequently seen target stimulus, an infrequent novel stimulus (for evaluating task engagement and distraction), and a commonly occurring nontarget stimulus. …”
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The Importance of the Correlation between CCT and Corneal Curvature in Refractive Surgery by Mimoza Ismaili

“…Background: The aim of this study was to analyze the relationship between central corneal thickness (CCT) and corneal curvature (CC) in patients with refractive anomalies and emmetropes, in three different age groups. Methods and Results: The study included 330 respondents, with a total of 660 eyes, divided into two groups. …”
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Ocular graft host disease after allogeneic stem cell transplant: unique risk factors and outcomes by Maaly A.M Abdel Fattah, Ghada ElGohary, Shahrukh K Hashmi

“…The ophthalmological examination included visual acuity (VA) testing, refraction, tear break-up time, Schirmer’s test, slit-lamp biomicroscopy, and dilated ophthalmoscopy. …”
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Ecosystem service trade-offs and synergies based on the mechanical equilibrium model: A case study of the urban agglomeration on the northern slope of the Tianshan Mountains by Jiazhen Chen, Alimujiang Kasimu, Lina Tang, Fuqiang Han, Miyesier Jumai

“…The mechanical equilibrium model was used to visualize the interactions and trade-offs among ESs at the grid scale. …”
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Risk Prediction of Postoperative Renal Dysfunction Based on Preoperative Lipid Profiles in Renal Transplant Recipients: A Retrospective Cohort Study by Zhang H, Zhang H, Li R, Zhuo L, Liu L, Tan L, Li R, Zhang S

“…A nomogram was developed as a visual predictive tool to present the interplay between these variables graphically. …”
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Treatment Cessation in Patients with Diabetic Maculopathy under Intravitreal Anti-VEGF Therapy Following a Treat-and-Extend Protocol by Lucia Saucedo, PhD, Isabel B. Pfister, PhD, Christin Schild, PhD, Justus G. Garweg, MD, PhD

“…Methods: Baseline characteristics, best-corrected VA, OCT biomarkers over time, and injection details were collected from patients' medical records. …”
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Novel Cross Screw with Staple for First MTP Joint Arthrodesis Compared to Dorsal Plate Fixation: Retrospective Clinical and Radiographic Evaluation by Stephen R. Arndt MD, Shirin Zahra BS, Mark Moldavsky MS

“…Dorsal plating (DP) group for 1st MTP joint was used for as control group. Methods: Pre-op and post-op Visual Analog Score (VAS) were assessed. …”
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GENETIC ASPECTS OF PANNICULITIS IN A RUSSIAN POPULATION: A PILOT STUDY by M. Yu. Krylov, O. N. Egorova, B. S. Belov

“…In the WCP group, analysis of variance showed an association of IL-1RA  gene VNTR polymorphism with the intensity of pain, assessed by the visual analogue scale. The carriers of the A1A1 genotype had more severe pain than those of the A1A2 genotype (83.3±11.5 and 20.0±18.2 mm, respectively; p = 0.008).Conclusion. …”
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Management of Postoperative Pain Following Primary Total Knee Arthroplasty: A Level I Evidence-Based Bayesian Network Meta-Analysis by Filippo Migliorini, Marcel Betsch, Tommaso Bardazzi, Giorgia Colarossi, Hani Ayad Mohamed Elezabi, Arne Driessen, Frank Hildebrand, Mario Pasurka

“…This Bayesian network meta-analysis compared different treatment options for the management of postoperative pain following primary TKA. <b>Methods:</b> This study was conducted following the 2020 PRISMA statement. …”
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