Bipolar disorders and creativity: the roles of ambition, effort-based decision-making, and exploration by Samson Tse, Sheri L. Johnson, Chong Ho Yu, Winnie Yuen, Iris Lo, Luke Clark, Luke Clark, Erin E. Michalak, Erin E. Michalak, Manon Ironside, Kiana Modavi

“…The current work is the first to examine ambition, exploration versus exploitation ratio, and insensitivity to effort/rewards among individuals with and without BD in an Asian cultural context.MethodsWriters and visual artists from Hong Kong who were diagnosed with BD completed a questionnaire to assess lifetime creative accomplishments, a self-rated measure of ambition, and two laboratory-based tasks: the observe-or-bet task to detect exploration versus exploitation tendencies, and an effort discounting task to measure sensitivity to effort required and reward level.ResultsThe sample included 44 participants diagnosed with BD and 69 control participants, with 87 (77%) being female and an average age of 35.1 years (range: 18 to 65). …”
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Exploring the interaction effects of subclinical hypothyroidism and major depressive disorder on brain networks by Shuai Zhao, Jindan Wu, Xiaomei Liu, Yishan Du, Xiaoqin Wang, Yi Xia, Hao Sun, Haowen Zou, Xumiao Wang, Zhilu Chen, Rui Yan, Hao Tang, Qing Lu, Zhijian Yao

“…This study aimed was to investigate the neurological mechanisms underlying this co-occurrence using a data-driven approach to analyze brain activity patterns. Methods Twenty-nine patients diagnosed with MDD without any comorbid conditions (nSHypo-MDD) were included in the study, along with 29 MDD patients who also had SHypo (SHypo-MDD), 26 patients with SHypo only, and 29 healthy individuals as controls (HCs). …”
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Long-Term Outcomes of Modified Expansive Open-Door Laminoplasty Combined with Short-Level Anterior Cervical Fusion in Multilevel Cervical Spondylotic Myelopathy by Szu-Wei Chen, Kuang-Ting Yeh, Cheng-Huan Peng, Chia-Ming Chang, Hao-Wen Chen, Tzai-Chiu Yu, Ing-Ho Chen, Jen-Hung Wang, Wan-Ting Yang, Wen-Tien Wu

“…Key outcome measures included the Pavlov ratio, C2–C7 angle, Japanese Orthopedic Association (JOA) score, and Visual Analog Scale (VAS) for neck pain. Patients were monitored for adjacent segment degeneration (ASD) and other postoperative changes over the long-term follow-up. …”
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The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation by Felix Knab, Giambattista Guaitoli, Mohamed Ali Jarboui, Felix von Zweydorf, Fatma Busra Isik, Franziska Klose, Anto Praveen Rajkumar, Thomas Gasser, Thomas Gasser, Christian Johannes Gloeckner

“…With LRRK2 inhibitors entering clinical trials, there is an unmet need for biomarkers that reflect LRRK2-specific pathology and target engagement.MethodsIn this study, we used induced pluripotent stem cells derived from a patient with Parkinson’s disease carrying the LRRK2 G2019S mutation and an isogenic gene-corrected control to generate human dopaminergic neurons. …”
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The effects of the physical procedures in patients with diabetic neuropathy by Grbović Vesna, Stefanović Srđan, Đukić Svetlana, Nurković Jasmin, Zdravković-Petrović Nataša, Parezanović-Ilić Katarina, Divjak Ana, Jurišić-Škevin Aleksandra

“…To asses their pain before and after every of 3 cycles, we used visual analog scale (VAS). We also evaluated quality of life before the 1st and after the 3rd cycle with the European Quality of Life Questionnaire (EQ-5D-3L). …”
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Statistical learning to identify and characterise neurodevelopmental outcomes at 2 years in babies born preterm: model development and validation using population-level data from E... by Sadia Haider, Athanasios Tsanas, G. David Batty, Rebecca M. Reynolds, Heather C. Whalley, Simon R. Cox, Riccardo E. Marioni, Cheryl Battersby, James P. Boardman

“…This study applies statistical learning to a national database to identify transdomain clusters and their maternal and neonatal predictors. Methods: Latent class analysis (LCA) was used to derive transdomain clusters from parent-reported visual, auditory, neuromotor, and communication impairments in preterm-born children at two years corrected age using the UK National Neonatal Research Database data (N = 27,261). …”
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Blood-brain barrier disruption mediates the association between cerebral small vessel disease and clinical outcome after stroke: a secondary analysis of the Lesion Evolution in Str... by Derrick N. Okine, Derrick N. Okine, Kyle C. Kern, Kyle C. Kern, Kyle C. Kern, Marie Luby, Lawrence L. Latour, Rebecca F. Gottesman

“…WMH were visually graded on baseline FLAIR for presence and severity (minor or moderate-severe). …”
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Layered structural engineering of Bi2O3/PP and WO3/PP composites for γ-ray shielding in high energy range: anisotropic attenuation mechanisms via Monte Carlo simulation and experim... by Xiangjie Duan, Jie Zhao, Shuaida Song, Na Zhou, Jizhuang Fan, Bo Tian, Yunchen Du

“…Herein, FLUKA Monte Carlo simulations capable of visualizing γ-photon transport behaviors are investigated in Bi2O3/PP and WO3/PP multi-layer composites with various layered configurations. …”
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Associations of long-term joint exposure to multiple ambient air pollutants with the incidence of age-related eye diseases by Yingan Li, Yuzhou Zhang, Ka Wai Kam, Poemen Chan, Dong Liu, Ebenezer Zaabaar, Xiu Juan Zhang, Mary Ho, Mandy PH Ng, Patrick Ip, Alvin Young, Chi Pui Pang, Clement C. Tham, Mei Po Kwan, Li Jia Chen, Jason C. Yam

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Evaluation of the risk factors for rhegmatogenous retinal detachment associated with choroidal detachment from the viewpoint of treatment patterns: a retrospective study by Kai Gao, Zi-Ye Chen, Zhuang-Ling Lin, Ya-Ping Liu, Bao-Yi Liu, Yuan Ma, Zi-Tong Chen, Rebiya●Tuxun, Lan Jiang, Zhuo-Jun Xu, Chin-Ling Tsai, Kun-Bei Lai, Tao Li

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An interpretable machine learning model based on computed tomography radiomics for predicting programmed death ligand 1 expression status in gastric cancer by Lihuan Dai, Jinxue Yin, Xin Xin, Chun Yao, Yongfang Tang, Xiaohong Xia, Yuanlin Chen, Shuying Lai, Guoliang Lu, Jie Huang, Purong Zhang, Jiansheng Li, Xiangguang Chen, Xi Zhong

“…The SHAP waterfall plots were used to visualize the decision-making process for a single individual. …”
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Massive rotator cuff tears: geometric classification, complete repair, and prognosis by Liwei Ying, MA, Qingguo Zhang, MA, Li Ying, PhD, Linlin Sha, MA, Dawei Han, MA, Yu Hui, BA, Quan Gan, BA, Huixia Fan, BA, Junbo Liang, PhD, Xiaobo Zhou, PhD

“…Background: This study aims to summarize tear patterns of massive rotator cuff tears (MRCTs) and outline our surgical techniques for complete repair. Methods: From January 2018 to May 2023, 394 shoulders in 389 individuals with consecutive MRCT received arthroscopic MRCT repair. …”
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Real-time intestinal perfusion assessment for anastomotic site selection using laser speckle contrast imaging: Verification in a porcine model by Danique J.I. Heuvelings, Mahdi Al-Taher, Joost Calon, Manish Chand, Laurents P.S. Stassen, Tim Lubbers, Kevin P. Wevers, Luigi Boni, Nicole D. Bouvy, Wido Heeman

“…Therefore, we explored the efficacy and feasibility of a new laser speckle contrast imaging system to assess real-time intestinal perfusion. Methods: Three gradually perfused porcine small bowel loops were created, and five senior surgeons were asked to assess the perfusion differences based on laser speckle contrast images using PerfusiX-Imaging®. …”
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Rapid Therapeutic Drug Monitoring of Voriconazole Based on High-Performance Liquid Chromatography: A Single-Center Pilot Study in Outpatients by Satoru Morikawa, Yusuke Yagi, Moemi Okazaki, Narika Yanagisawa, Tomoaki Ishida, Kohei Jobu, Takumi Maruyama, Takahiro Kato, Miyuki Matsushita, Yu Arakawa, Yuka Yamagishi, Yukihiro Hamada

“…Safety was monitored for renal, hepatic, and visual toxicities. <b>Results</b>: HPLC-UV significantly reduced reporting times (0.433 h vs. 74.3 h, <i>p</i> < 0.001), and Deming’s regression analyses showed a strong correlation with LC-MS/MS results (Pearson’s r = 0.988). …”
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Efficacy and Safety of a Dexamethasone Implant in Patients with Diabetic Macular Edema at Tertiary Centers in Korea by Byung Gil Moon, Joo Yong Lee, Hyeong Gon Yu, Ji Hun Song, Young-Hoon Park, Hyun Woong Kim, Yong-Sok Ji, Woohyok Chang, Joo Eun Lee, Jaeryung Oh, Inyoung Chung

“…A total of 186 eyes from 165 patients were included. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), complications, and number of retreatments were collected. …”
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Association between psychosocial factors at work and health outcomes after retirement: a protocol for a systematic review and meta-analysis by Hisashi Eguchi, Akizumi Tsutsumi, Akiomi Inoue, Yuka Kobayashi, Norito Kawakami, Kotaro Imamura, Asuka Sakuraya, Natsu Sasaki, Yumi Asai, Hideaki Arima, Emiko Ando, Reiko Inoue, Mai Iwanaga, Yasumasa Otsuka, Kanami Tsuno, Ayako Hino, Kazuhiro Watanabe, Akihito Shimazu

“…For the assessment of meta-bias, publication bias will be assessed by using Egger’s test, as well as visually on a funnel plot. Heterogeneity will be assessed using the χ² test with Cochran’s Q statistic and I2.Ethics and dissemination Results and findings will be submitted and published in a scientific peer-reviewed journal and will be disseminated broadly to researchers and policy-makers interested in the translatability of scientific evidence into good practices.PROSPERO registration number CRD42018099043.…”
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Identification of Causal Genes and Potential Drug Targets for Restless Legs Syndrome: A Comprehensive Mendelian Randomization Study by Ruiyi Qian, Xue Zhao, Dongbin Lyu, Qingqing Xu, Kai Yuan, Xin Luo, Wanying Wang, Yang Wang, Yutong Liu, Yu Cheng, Yingting Tan, Fan Mou, Chengmei Yuan, Shunying Yu

“…Molecular docking was used to visualize the binding structure and fine affinity for <i>MAN1A2</i> and the drugs predicted by DSigDB. …”
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External application of Traditional Chinese medicine in the treatment of acute gouty arthritis (中药外敷治疗急性痛风性关节炎临床效果及护理) by LI Juan (李娟), ZHENG Xiaoya (郑小雅), ZHANG Haiying (张海英), DU Danying (杜丹颖), HAN Shuhua (韩淑花), LI Yan (李雁)

“…Objective To observe the clinical effect of external application of Traditional Chinese Medicine(TCM) in the treatment of acute gouty arthritis. Methods Totally 61 patients with acute gouty arthritis who met the inclusion criteria were included as research subjects. …”
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CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…The Community Health and Intergenerational study aims to holistically examine ageing in place by investigating the resilience and vulnerability factors of the ageing process in the biological, psychological and social domains within the environment.Methods and analysis Using a cohort multiple randomised controlled trial design, comprehensive health profiles of community-dwelling older adults will be collected. …”
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Distinctive clinical features of early and late-onset Ménière’s disease by Jianwei Lin, Heng Xiao, Heng Xiao, Heng Xiao, Chenxin Lin, Gengliang Huang, Xiaojing Guo, Huimin Cai, Huimin Cai, Huimin Cai, Shengnan Ye, Shengnan Ye, Shengnan Ye

“…PurposeTo compare the clinical characteristics of patients with early and late-onset Ménière’s disease (MD) and to investigate the impact of psychological factors between the two groups.MethodsThe patients were divided into two groups based on their age of onset: early-onset (&lt;45 years old) and late-onset (&gt;55 years old). …”
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