Enhancing basal cell carcinoma classification in preoperative biopsies via transfer learning with weakly supervised graph transformers by Johan Björkman, Sigrid Lagerroth, Jan Siarov, Filmon Yacob, Noora Neittaanmäki

“…These findings reinforce the utility of pre-trained models in computational pathology, where access to large, labeled datasets is often limited, and task-specific challenges require nuanced understanding of the visual data.…”
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Association Between Chronic Pain, Coping Strategies, and Sleep Quality in Rural Chinese Older Adults: A Cross-Sectional Study by Tao X, Cheng C, Bai J

“…A self-reported questionnaire was used to collect data on socio-demographic items, chronic pain (visual analogue scale, VAS), coping strategies (Coping Strategies Questionnaire-Revised, CSQ-R), and sleep quality (Athens Insomnia Scale, AIS). …”
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Differential dynamic functional network connectivity in different motor subtypes of Parkinson's disease by Yu Pan, Hang Qu, Yi Zhao, Zhaoxia Qin, Jiangbing Liu, Wei Wang

“…Compared with the ARD group, the TD group exhibited significantly increased connectivity between the Executive Control Network (ECN) and Visual Network (VIS) in the sparse high-frequency state. …”
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Feasibility of an at-home telerehabilitation programme for upper limb impairment post-stroke by Louise van Wyk, Maatje Kloppers, Lee-Ann J. Jacobs-Nzuzi Khuabi

“…Setting: Bishop Lavis, South Africa, a low-income area. Methods: A single-site parallel randomised feasibility study was conducted. …”
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Transcriptomic and metabolomic analyses reveal phenolic metabolism regulated by melatonin in pear peel by Shuai Yan, Liangliang Zhao, Deying Zhao, Gongxun Xu, Yufei Wang, Zhiqin Zhou, Cungang Cheng

“…However, the mechanisms by which pre-harvest application of melatonin regulates the metabolism of phenolic compounds in pear pericarp remain poorly understood. Methods In this study, the effect of pre-harvest spraying of melatonin on the synthesis of phenolics in pear peel and the regulatory mechanism were investigated using a multi-disciplinary approach, integrating physiological and biochemical, transcriptomic, and metabolic analyses, and the “Yuluxiang” pear as the test material. …”
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Breast cancer burden (1990–2040) in individuals aged 55 and above: a GBD 2021 analysis of global trends, sex-specific risk factors, and intervention impact by Shimao Jian, Wanmei Lin, Yuewen Tang, Guangyu Yao

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Research progress of oxidative stress in the pathogenesis and treatment of diabetic complications by ZHOU Dalei*，YUAN Jing，HAN Chaoyong，YOU Lanying，XU Jin，LIU Dandan，HUANG Luxin，HUANG Junjie，YUAN Yu，SUN Jie，ZHENG Kang

“…Objective To study the effects of ultrasound -guided proximal continuous adductor canal block (ACB) and mid - segment continuous ACB on postoperative pain and muscle strength of quadriceps femoris in elderly patients undergoing total knee arthroplasty (TKA) . Methods Eighty elderly patients scheduled for elective TKA under general anesthesia at Zhongda Hospital Southeast University from October 2022 to December 2023 were selected and randomly divided into two groups according to the random number table method：the ultrasound - guided proximal ACB group (group P，n = 40) and the ultrasound-guided mid-segment ACB group (group M，n = 40) . …”
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A Study on the Effects of Gluteal Muscle Activation on the Electromyography of Lower Limb Muscles in Young Male Patients With Patellofemoral Pain Syndrome by Wu Yue, Ren Shuang, Huang Hongshi, Ao Yingfang, Gou Bo

“…Additionally, the explosive power (EP) of the lower limbs and the visual analog scale (VAS) pain value of the knee joint were evaluated. …”
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Evaluation of the impact of a course of therapy with an injectable form of chondroitin sulfate on the duration of remission and quality of life in patients with osteoarthritis by P. S. Kovalenko, I. S. Dydykina, O. G. Alekseeva, E. L. Shakhramanova, A. S. Potapova, S. I. Glukhova, E. G. Zotkin

“…Parenteral forms of chondroitin sulfate (CS) used for the background therapy of OA are characterized by proven efficacy and safety and, compared to oral forms, have greater bioavailability, faster onset of symptom-modifying effect and maintenance of more stable remission, which can significantly improve patients' quality of life.Objective: to evaluate the clinical efficacy and safety of two-month therapy with injectable CS and the duration of positive dynamics after the end of treatment in patients with knee OA (KOA).Material and methods. The open prospective observational study involved 35 patients (mainly women) aged 50–75 years with stage II–III KOA. …”
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Effectiveness of Intravitreal Dexamethasone Implant Treatment for Diabetic Macular Edema in Vitrectomized Eyes by Hüseyin Baran Özdemir, Murat Hasanreisoğlu, Murat Yüksel, Mestan Ertop, Gökhan Gürelik, Şengül Özdek

“…Objectives:To report the effectiveness and long-term outcomes of intravitreal dexamethasone implantation for diabetic macular edema (DME) in vitrectomized eyesMaterials and Methods:Medical records of patients were retrospectively reviewed. …”
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The Impact of Obesity on Pain Perception During and After Subcutaneous Injections: A Cross-Sectional Analysis by Candelaria de la Merced Díaz-González, Josefa María Ramal-López, Milagros de la Rosa-Hormiga

“…A caliper was used to measure ASFs, height and weight were used to calculate BMI, and the Visual Analog Scale (VAS) was used to measure pain. (3) Results: The sample amounted to 202 participants, which was not considered representative of the study population. …”
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A Nomogram Based on S100A7 and Clinicopathological Characteristics to Predict the Efficacy of Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Study by Zhang T, Yu X, Yang X, Li Y, Li X, Ma L

“…A prediction model was constructed and visualized using a nomogram for clinical prediction of NAC efficacy.Results: A total of 76 patients with BC who underwent NAC were included in this study; of these patients, 49 were sensitive to NAC, whereas 27 were insensitive to NAC. …”
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Your brain on art, nature, and meditation: a pilot neuroimaging study by Beatrix Krause-Sorio, Sergio Becerra, Prabha Siddarth, Stacey Simmons, Taylor Kuhn, Helen Lavretsky

“…The instructions were to meditate on the connection to a Universal Soul linked to a sense of expansion and universal connectedness (“one with everything”), which was prompted by a video of the galactic nebula that also controlled for the visual stimuli of the two other conditions.MethodsNine healthy adults (mean age = 29; range = 19–42; 5 women) underwent a block design fMRI scan using a Siemens 3T Prisma scanner. …”
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Omega-3 Polyunsaturated Fatty Acids Effect on Neuropathy of the Peripheral Nervous System in Dietary Obese Rats: Is the Source of These Fatty Acids Important for Outcome? by Davidson E, Obrosov O, Coppey L, Yorek M

“…However, other sources exist that could be a better environmental, safety, and/or economic choice.Methods: Male Sprague Dawley rats 12 weeks of age were fed a 45% kcal diet to induce obesity and model pre-diabetes. …”
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Improving the functionality of intraoperative nerve monitoring during thyroid surgery: is lidocaine an alternative? by K.V. Bosenko

“…The role of intraoperative nerve monito­ring (IONM) in thyroid surgery remains a controversial issue for surgeons regardless of their training and experience. This monitoring method is not intended to visualize the recurrent laryngeal nerve, but rather to assess its function intraoperatively and to help make a prognosis in patients who develop recurrent laryngeal nerve paralysis. …”
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OTX2 expression contributes progression of gastric cancer in young adults by Jingming Zhai, Ting Lyu, Yimin Guo, Yanhui An, Yali Xiang, Linying Xie, Chao Zeng

“…CytoHubba is used to construct protein interaction networks (PPI) and perform visual analysis to screen out core genes. We obtained 10 hub molecules, including FBXO44, FBXO6, HERC5, FBXL13, FBXO41, NT5E, BMP4, TRIM36, ACAN, ALPL by PPI network with MCODE. …”
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Pre‐Percutaneous Coronary Intervention C‐Reactive Protein Levels and In‐Stent Restenosis: A Systematic Review and Meta‐Analysis by Himanshu Rai, Renitha Reddi, J. J. Coughlan, Rory Durand, Daniel O'Callaghan, Roisin Colleran, Robert A. Byrne

“…No evidence of publication bias was detected either visually by Begg's funnel plots or by Egger's test (p = 0.08). …”
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Role of Sesamoid Position and Recurrence of Hallux Valgus Deformity by Thomas L. Lewis BSc (Hons) MBChB (Hons) FRCS (TrMFSTEdOrth), Robbie Ray MBChB, ChM(TFRCSed(TrO) FEBOTOrth), Evelyn Murphy MBBCh BAO MCh FRCS (TrOrth), Min Jia Chua MB BS FRCSEd, Clare Watt BNurs, Peter Robinson BSc(Hons), MBChB, FRCS(TrOrth), Peter Lam MBBS (Hons), FRACS, FAOA

“…Secondary outcomes included clinical patient reported outcome measures including the Manchester-Oxford Foot Questionnaire (MOXFQ) and Visual Analogue Scale for Pain. All p-values < 0.05 were considered significant. …”
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Safety profile of ramelteon from the perspective of physicians and pharmacists: a 20-year real-world pharmacovigilance analysis based on the FAERS database by Jianhong Wu, Yujie Zhou, Linghe Qiu, Liang Liu, Fei Wang, Lili Zhen, Na Li

“…This study analyzes adverse events associated with ramelteon based on data from the FDA Adverse Event Reporting System (FAERS) database. Methods Case reports submitted by physicians and pharmacists were extracted from the FAERS database from the first quarter of 2005 to the third quarter of 2024. …”
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Unilateral Biportal Endoscopic Debridement and Drainage for Lumbar Infectious Spondylodiscitis: A Retrospective Study and Preliminary Results by Chu R, Cui W, Chen W, Zhuang Y, Yin G, Peng W, Zhang S

“…Clinical outcomes were assessed by the visual analog scale (VAS) scores of the back, Oswestry Disability Index (ODI), the modified MacNab criteria (MNC), and regular serological tests at pre- and post-operation.Results: Fourteen patients (87.5%) experienced a significant improvement in their clinical symptoms. …”
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