Low-dose RaDiation therapy for patients with KNee osteoArthritis (LoRD-KNeA): a protocol for a sham-controlled randomised trial by Jiyu Sun, Won Park, Dong Hyun Kim, Ji Hyun Lee, Joon Ho Wang, Hak Jae Kim, Kichul Shin, Min Jung Kim, Ji Young Kim, Byoung Hyuck Kim, Du Hyun Ro, Dae-Hee Lee, Eun-Hee Hong, Seong-Jun Cho, Hyuk-Soo Han

“…Key inclusion criteria are primary knee OA with Kellgren-Lawrence grade 2–3 and visual analogue scale 50–90 when walking at the baseline. …”
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Distinguishing features of microvascular abnormalities in high myopia retinoschisis via multimodal imaging by Yunhan Tao, Xuhui Chen, Tao Li, Xian Zhang, Xufang Sun

“…In the other patients, MVAs were visualized on en-face OCT and SS-OCTA, and fluorescence leakage was observed on FFA, which mimicked retinal vasculitis. …”
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Effect of seasonal exposure in aeroallergen-sensitised patients with irritable bowel syndrome-diarrhoea by Carlo Maria Rossi, Carlo Maria Rossi, Marco Vincenzo Lenti, Marco Vincenzo Lenti, Stefania Merli, Martina Fiorita, Martina Fiorita, Antonio Lo Bello, Antonio Lo Bello, Mario Andrea Latorre, Mario Andrea Latorre, Paola Ilaria Bianchi, Nicola Aronico, Annalisa De Silvestri, Antonio Di Sabatino, Antonio Di Sabatino

“…BackgroundPollen allergy may influence irritable bowel syndrome (IBS) symptoms; however, available data are scant.AimsThis study aims to assess symptom variability in atopic IBS patients.MethodsWe retrospectively analysed consecutive adult IBS patients evaluated between 2021 and 2024. …”
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Identification of hypoxia-related diagnostic biomarkers and immune signatures in diminished ovarian reserve by Minxue Song, Lili Ni, Zebing Ma, Xin Zhong, Yibing Liu, Jilin Kuang, Ping Li

“…This study investigated the genetic links between hypoxia and DOR.MethodsThe GSE87201 dataset for DOR was sourced from Gene Expression Omnibus database, normalized for common differentially expressed genes (Co-DEGs), and identified Hypoxia-related differentially expressed genes (HRDEGs) via GeneCards; Receiver Operating Characteristic (ROC) curves evaluated HRDEGs’ diagnostic value, and protein-protein interaction networks were visualized with STRING and Cytoscape. …”
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Feasibility of home initiation of an airway clearance device (SIMEOX) by telecare in people with non-cystic fibrosis bronchiectasis: a pilot study by Jean-Christian Borel, Nathalie Arnol, Sylvie Leroy, Marlène Murris-Espin, Rebecca Hamidfar, Marie Mahot, Raphael Abouly, Hughes Gauchez, Sophie Jacques, Eloise Joffray, Laurent Morin

“…We hypothesised that telecare would be an effective means to train people with NCFB in the handling of device and to monitor and promote device adherence.Objectives (1) To evaluate frequency of use of the SIMEOX for 10 weeks after telecare training. (2) To assess user satisfaction and clinical efficacy of the SIMEOX+telecare.Methods Multicentre, prospective, pilot study in adults with NCFB. …”
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Ocular manifestations in pediatric tumor suppressor gene mutations: a case series and literature review of RB1, NF1, NF2, VHL, and TSC by Aoxiang Wang, Chanyuan Wang, Wen Li, Jing Qiao, Yulin Luo, Yu Tian

“…We have summarized the ocular presentations of these common tumor suppressor gene mutations in pediatric patients. Methods We reviewed 11 representative case reports, documenting in detail the ocular manifestations and progression of each case. …”
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Risk prediction of stroke-associated pneumonia in acute ischemic stroke with atrial fibrillation using machine learning models by Tai Su, Peng Zhang, Peng Zhang, Bingyin Zhang, Zihao Liu, Zexing Xie, Xiaomei Li, Jixiang Ma, Tao Xin

“…The optimal prediction model was visualized using a nomogram. In this study, SAP was identified in 10.16% of cases. …”
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18F-FDG PET/CT-based deep learning models and a clinical-metabolic nomogram for predicting high-grade patterns in lung adenocarcinoma by Yue Guo, Xibin Jia, Chuanxu Yang, Chao Fan, Hui Zhu, Xu Chen, Fugeng Liu

“…CM model was built from clinical and PET/CT metabolic parameters via backwards stepwise logistic regression and visualized via a nomogram. The prediction performance of the models was evaluated mainly by the area under the curve (AUC). …”
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Symptom variability in outpatients with COPD and validation of the Colombian COPD Symptom Variability Instrument (EPOC-CoVaSy) by Eidelman Antonio González-Mejía, Olga Constanza Uñate-Suárez, Carlos José Bula- Gutiérrez, Yojana Patricia Patiño-Jiménez

“…According to the analysis of the diaries, the mean scores (visual analog scale) for all symptoms and the performance of activities of daily living ranged between 0.5 and 2.5, being higher in the morning (mean scores between 1.5 and 2.5) than in the afternoon and night (mean scores between 0.5 and 1.5); however, symptom variability was minimal. …”
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Exploring the influences of myopia in primary and secondary school students in Xinjiang using propensity score matching by Xiaopeng Hu, Xianyan Yuan, Hua Li, Haoxuan Gong, Zhicong Fu, Yuting Xie, Lin Zhu, Haina Chen, Yingli Yang, Dongsheng Rui

“…ObjectiveDue to the high prevalence of myopia among primary and secondary school students in Shihezi City in recent years, this study was conducted to understand the prevalence and the factors influencing it and to provide a scientific basis for future interventions to improve, protect, and promote the visual health of these students.MethodsThe study population consisted of primary and secondary school students in Shihezi City. …”
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Association between Apolipoprotein B and diabetic nephropathy: insights from the National Health and Nutrition Examination Survey 2007–2016 and Mendelian randomization analysis by Hui Wang, Sensen Wu, Dikang Pan, Yachan Ning, Yanhong Fu, Chunjing Feng, Jianming Guo, Zichuan Liu, Yongquan Gu

“…Then, we used restricted cubic splines (RCS) to flexibly model and visualize the relation of predicted ApoB levels with DN risk. …”
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Treatment of Hallux Rigidus: Comparison of Hemiarthroplasty with Cartiva Implant, Allograft Interpositional Arthroplasty, and Arthrodesis by Ryan Sanii MD, MPH, Kevin Phan MD, Drew Krumm MD, Daniel J. Patton MD, Tyler Madden MD, John G. Anderson MD, John D. Maskill MD, Donald R. Bohay MD, FACS, Michelle A. Padley PhD, Cameron G. Patthanacharoenphon MD

“…Methods: A retrospective cohort study of 99 patients was performed. …”
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Safety and efficacy of mycophenolate mofetil in treating neuromyelitis optica spectrum disorders: a protocol for systematic review and meta-analysis by Yang Chen, Ming Jin, Mengyu Han, Luqi Nong, Ziqiang Liu, You Chen, Huan Meng, Yali Qin, Zhijun Wang

“…The secondary outcomes will consist of the frequency and severity of adverse events, best-corrected visual acuity, relapse-free rate and time to the next attack. …”
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Comparison of percutaneous endoscopic lumbar discectomy (PELD) and unilateral biportal endoscopic (UBE) discectomy in the treatment of far lateral lumbar disc herniation (FLLDH): a... by Liang Li, Jilong An, Lei Guo, Xiuqi Shan, Yapeng Sun, Jiaqi Li, Fei Zhang, Wei Zhang

“…Abstract Purpose This study aimed to compare the clinical efficacy of percutaneous endoscopic lumbar discectomy (PELD) and unilateral biportal endoscopic (UBE) discectomy in treating patients with far lateral lumbar disc herniation (FLLDH). Methods From January 2020 to January 2022, 65 patients with FLLDH underwent either PELD or UBE discectomy. …”
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Gut Microbial Signatures in Long COVID: Potential Biomarkers and Therapeutic Targets by Soyoung Oh, Sujin An, Kihyun Park, Soohyung Lee, Yoo Min Han, Seong-Joon Koh, Joowon Lee, Hyerin Gim, Donghyun Kim, Haesook Seo

“…Here, we aimed to investigate connections between the gut microbiota and long COVID severity. Methods Fecal samples were collected from 31 patients with long COVID, 14 with COVID-19 but not long COVID, and 23 healthy controls. …”
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Deep learning-based cough classification using application-recorded sounds: a transfer learning approach with VGGish by Sanghoon Han, Yu-rim Lee, Ji-ho Lee, JinHee Jeon, Choongki Min, Kyungnam Kim, Donghoon Kim, Myung Pyo Kim, Young Mi Park, Uiri An, Kyoung Min Moon

“…To enhance interpretability, we applied Grad-CAM to visualize the features that influenced the model’s decision-making. …”
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UK Medical Cannabis Registry: An Analysis of Outcomes of Medical Cannabis Therapy for Hypermobility‐Associated Chronic Pain by Mary Dickinson, Simon Erridge, John Warner‐Levy, Evonne Clarke, Katy McLachlan, Ross Coomber, Wendy Holden, James J. Rucker, Michael W. Platt, Mikael H. Sodergren

“…Objective The study aims to evaluate the clinical outcomes in patients with hypermobility spectrum disorder (HSD) and hypermobile Ehlers–Danlos syndrome (hEDS) with chronic pain following treatment with cannabis‐based medicinal products (CBMPs). Methods This was a case series conducted with the UK Medical Cannabis Registry. …”
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Evaluation of lateral flow devices for rabies diagnosis in decomposed animal brain samples by Ryota Todoroki, Joely T. Ongtangco, Kazunori Kimitsuki, Nobuo Saito, Milagros R. Mananggit, Cornelio R. Velasco, Jaira D. Mauhay, Alyssa M. Garcia, Catalino S. Demetria, Yamada Kentaro, Akira Nishizono

“…This study evaluates the diagnostic accuracy of the ADTEC lateral flow device (LFD) for rabies post-mortem diagnosis using decomposed brain samples. Methods We used 34 animal heads submitted with a cold chain to an animal diagnostic laboratory located in central Philippines including 26 DFAT-positive and eight DFAT-negative samples. …”
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Association between circulating plasma CTRP3 levels and acute ischemic stroke: a systematic review and meta-analysis by Qingsheng Niu, Qingsheng Niu, Qingsheng Niu, Ziyi Zhu, Yaowen Jiang, Yaowen Jiang, Zhi Wan, Zhi Wan

“…Publication bias was evaluated using Egger’s regression test, Begg’s correlation analysis, and funnel plot visualizations.ResultsThe results indicated that patients with acute ischemic stroke exhibited significantly lower circulating levels of CTRP3 compared with control group (Z = 6.04, P < 0.00001). …”
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A placebo-controlled study of the doses and efficacy of Lentinula edodes mycelia for oxaliplatin-induced peripheral neuropathy in colorectal cancer by Shogen Boku, Hironaga Satake, Seiichiro Mitani, Kiyoshi Maeda, Toshihiro Kudo, Toshifumi Yamaguchi, Tatsuya Takagi, Hisato Kawakami, Hisato Kawakami

“…We evaluated the efficacy and safety as well as the optimal dosage of L.E.M. extract for OIPN in patients with colorectal cancer (CRC).MethodsAfter curative resection, we used a 1:1:1 ratio to randomly assign patients with CRC with persistent OIPN (defined by a visual analogue scale [VAS] numbness score ≥40 mm) to the low-dose (L.E.M. 300 mg twice daily [bid]), high-dose (L.E.M. 900 mg bid), and placebo groups. …”
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