Antimycobacterial activity of the plectasin derivative NZ2114 by Camilla Davids, Komal Rao-Fransson, Nitya Krishnan, Erik Tenland, Erik Tenland, Matthias Mörgelin, Brian Robertson, Gabriela Godaly

“…In this study, we investigated another plectasin variant, NZ2114, known for its effectiveness against Gram-positive bacteria, as a potential antimycobacterial peptide both in vitro and in vivo.MethodsThe resazurin microtiter assay (REMA) was used to determine MIC; a time-kill assay was performed to evaluate long-term effects; scanning electron microscopy (SEM) was employed to visualize peptide impact; a checkerboard assay assessed drug compatibility; MTT and WST-8 assays were used to estimate peptide toxicity; intracellular killing was evaluated using primary macrophages; peptide stability was assessed in human serum; and a murine tuberculosis (TB) infection model was used to verify the peptide’s efficacy.ResultsNZ2114 effectively killed mycobacteria at a minimal inhibitory concentration (MIC99) of 6.1 µM, was non-toxic to primary human cells, and remained resistant to serum degradation while preserving its antimycobacterial capacity. …”
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Implementation of RT-RAA and CRISPR/Cas13a for an NiV Point-of-Care Test: A Promising Tool for Disease Control by Jingqi Yin, Jin Cui, Hui Zheng, Tingting Guo, Rong Wei, Zhou Sha, Shaopeng Gu, Bo Ni

“…Compared with conventional detection methods, this RT-RAA-CRISPR/Cas13a-based method is rapid and simple and does not require scientific instruments. …”
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HIGH TIBIAL OSTEOTOMY IN THE TREATMENT OF PATIENTS WITH STAGE II–III OF KNEE OSTEOARTHRITIS. IMMEDIATE RESULTS AND FACTORS INFLUENCING THE OUTCOME by V. E. Byalik, S. A. Makarov, L. I. Alekseeva, E. I. Byalik, S. V. Arkhipov, S. I. Glukhova

“…Objective: to investigate the efficiency of HTO for stage II–III knee OA and the impact of age, body mass index (BMI), and correction angle on the immediate result of surgery. Subjects and methods. Thirty-five HTOs were carried out in 32 patients in 2003 to 2016. …”
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A Regression Analysis Study on the Presence of Pain in Specific Body Regions Based on Smartphone Usage Posture, Smartphone Addiction, Smartphone Usage Patterns by YiXin Wang, Ye-Jin Kim, Kyeong-Ah Moon, Hye-Seon Jeon

“…This study aimed to comprehensively elucidate the factors contributing to the pain associated with smartphone use. Methods: A cross-sectional survey was conducted with 316 participants aged 20–59 years. …”

Knowledge level of diagnostic procedures and risk factors for oral cancer among oral healthcare providers in Germany by Rieke Scharbrodt, Sarah Habig, Michael Kalab, Eva Baumann, Lisa Felgendreff, Astrid Dempfle, Katrin Hertrampf

“…The majority of cases are diagnosed at a late stage, even though oral cancer can be detected early by routine visual and tactile examination. Dental healthcare providers thus play a vital role in its early detection. …”
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Preoperative inflammatory markers in pediatric appendicitis: associations with disease severity, postoperative recovery, pain, and surgical outcomes by Xi Li, Shungang Gong, Yuan Ding, Yijia Chen, Zhengbo Yu

“…Postoperative outcomes included time to ambulation, bowel sound recovery, first defecation, hospital stay duration, 12-hour Visual Analog Scale (VAS) pain scores, and complication rates. …”
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Analysis of risk factors and construction of nomogram model for arthroscopic single-row rivet repair by Hao Fan, YuLong Ouyang, ShuiLin Chen, DeFei Zhao, GuiCai Sun

“…The differences of preoperative and postoperative Visual Analogue Score (VAS) scores and University of California, Los Angeles (UCLA) scores were analyzed and compared. …”
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CGF with Bio-Oss collagen as grafting materials for simultaneous implant placement after osteotome sinus floor elevation: a prospective study by Bashar Shahood, Seba Harphoush, Belal O. M. Muhaisen, Jing Qiu

“…The purpose of this study was to radiologically evaluate the efficacy of using Bio-Oss Collagen with Concentrated Growth Factor (CGF) as grafting materials for OSFE with simultaneous implant placement in the atrophic maxilla after one year of functional loading. Methods A total of 126 implants were placed for 123 patients. …”
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The Association of Myopia Progression with Changes in Retinal Thickness among Primary School Students with Myopia by Jing Shang Zhang, Jing Li, Jin Da Wang, Ying Xiong, Kai Cao, Meng Li, Kai Jie Wang, Ying Yan Mao, Jian Ying Liu, Xiu-Hua Wan

“…To observe the relationship between myopia progression and changes in retinal thickness during one year of follow-up among primary school children. Methods. The study included 1161 eyes of 708 myopic children, with 616 (53.06%) right eyes and 545 (46.94%) left eyes. …”
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A randomized controlled interventional study for analgesic effects of intrathecal versus intravenous dexmedetomidine on subarachnoid anesthesia with hyperbaric bupivacaine by Manu Dadhwal, Anupama Gupta, Ajay Kurian

“…The duration of sensory and motor block was prolonged in groups B and C. The Visual analog scale scores were comparatively higher in group A than in groups B and C. …”
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Evaluation of retinal nerve fiber layer and choroidal thickness with spectral domain optical coherence tomography in children with sickle cell anemia by Kamil Yılmaz, Hasan Öncül, Hülya Uzel, Kahraman Öncel, E Deniz Yılmaz, Murat Söker

“…SD-OCT is a useful imaging method in the diagnosis and screening in patients with SCA without retinopathy. …”
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Evaluation of Postoperative Pain in Patients Undergoing Erector Spinae Plane Block in Breast Surgeries by Gizem Kara, Metin Alkan, Ramazan Kozan, Nuray Camgöz Eryılmaz, Mustafa Arslan

“…In this study, we evaluated the analgesic efficacy of erector spinae plane block (ESPB) in patients undergoing breast surgery. Methods: Our study was conducted retrospectively by reviewing the data from medical records of 94 adult female patients with ASA I-II-III who underwent breast surgery. …”
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Autograft vs Allograft With Bone Marrow Aspirate Concentrate as an Osteotomy Gap Filler in Lateral Column Lengthening for Progressive Collapsing Flatfoot Deformity by Ramesh Radhakrishnan MBBS, MRCS(Eng), Don Thong Siang Koh MBBS, BSc(Hon), MRCS, MMED(Ortho), Eric Wei Liang Cher MD, MRCS, MMed(Ortho), FRCSEd(Ortho), Wenxian Png MBBS, MMed(Ortho), MRCSEd, FRCSEd(Ortho), Inderjeet Rikhraj Singh MBBS, FRCS, FAMS, MHPE (Maastricht)

“…This study compares the clinical and radiologic outcomes of autografts vs allografts with BMAC in LCL for PCFD. Methods: This retrospective study reviewed 38 patients who underwent LCL for PCFD at a tertiary institution from 2012 to 2022. …”
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Internet-Based Telerehabilitation Versus in-Person Therapeutic Exercises in Young Adult Females With Chronic Neck Pain and Forward Head Posture: Randomized Controlled Trial by Patcharin Nilmart, Arrada Sichuai, Asree Chedang, Chanikarn Goontharo, Nollapan Janjamsai

“…Outcome measures included pain intensity (assessed using the Visual Analog Scale [VAS]), CVA, neck disability (assessed using the Neck Disability Index [NDI]), and cervical range of motion (CROM). …”
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Medium-term Results of Body Balance Trainings in Primary School-Aged Children with Generalized Joint Hypermobility and Symptomatic Mobile Flat Foot: Cohort Study by Alena Yu. Dimitrieva, Vladimir M. Kenis

“…The foot examination included: clinical assessment of feet shape and position (FPI-6 scale), visual and manual mobility tests, computer scanning with calculation of anthropometric indices (basic anthropometric parameters were calculated from scanned foot images). …”
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Temporal lobe white matter pathways: clinical and anatomical examination related to surgery of drug-resistant structural focal epilepsy by A. A. Sufianov, I. S. Shelyagin, K. Simfukwe, E. S. Markin, S. Zh. Stefanov, Yu. A. Yakimov, P. O. Akimova, R. A. Sufianov

“…Speech disorders (mostly transient) were detected in 35.7% of the subjects, visual field disorders (mainly transient) – in 21.4%, neuropsychiatric disorders – in 43.9%. …”
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Comparison of Laparoscopic Sacrocolpopexy and Vaginal Sacrospinous Ligament Fixation Techniques Applied Concomitantly in Patients Undergoing Vaginal or Laparoscopic Hysterectomy fo... by Ömer Ünal, Ozan Karadeniz

“…Postoperative 6th-hour visual analog scale values were significantly higher in the TLH + SCP group (p = 0.01). …”
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Physicochemical Stability of Nab-Paclitaxel (Pazenir) Infusion Dispersions in Original Glass Vials and EVA Infusion Bags by Helen Linxweiler, Judith Thiesen, Irene Krämer

“…Directly after reconstitution and on days 1, 3, 5, 7, 14, 21, and 28 samples were withdrawn and paclitaxel concentrations assayed by a stability-indicating HPLC method. In parallel, pH and osmolality were measured. …”
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Improved CSW-YOLO Model for Bitter Melon Phenotype Detection by Haobin Xu, Xianhua Zhang, Weilin Shen, Zhiqiang Lin, Shuang Liu, Qi Jia, Honglong Li, Jingyuan Zheng, Fenglin Zhong

“…This research provides an accurate and reliable method for bitter melon phenotype identification and also offers technical support for the visual detection technologies of other agricultural products.…”
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Early Real-World Outcomes of Switching to 8 mg Aflibercept for Neovascular Age-Related Macular Degeneration in the United Kingdom by Muiz Musadiq, Mohammed Musadiq, Fozia Latif, Benjamin Ng, Matthew Azzopardi, Noa Gilead, Andrew Needham, Yu Jeat Chong

“…At baseline, the mean (SD) best corrected visual acuity (BCVA) was 66.0 (14.4) letters, with 33 (55.9%) eyes achieving ≥70 letters. …”
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