Icarisid Ⅱ modulates mitochondrial dynamics for anti-HBV activity by Zhengyun Liu, Haiyan Yang, Juan Wen, Dongyan Xiao, Dongyan Xiao, Wan Yu, Guo Luo, Qihai Gong, Huan Wang

“…IntroductionTo investigate the potential anti-hepatitis B virus (HBV) activity of Icariside Ⅱ (ICS Ⅱ), and elucidate its underlying mitochondrial dynamics mechanisms.MethodsThe study employed in vivo and in vitro assays to evaluate anti-HBV effects of ICS Ⅱ. …”
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From digitized whole‐slide histology images to biomarker discovery: A protocol for handcrafted feature analysis in brain cancer pathology by Xuanjun Lu, Yawen Ying, Jing Chen, Zhiyang Chen, Yuxin Wu, Prateek Prasanna, Xin Chen, Mingli Jing, Zaiyi Liu, Cheng Lu

“…Among the 72 models combining nine feature selection methods and eight machine learning classifiers, the optimal model combination achieved discriminative performance with an average area under the curve (AUC) of 0.615 over 100 iterations under five‐fold cross‐validation. …”
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Impact of the Timing of Rocuronium Injection after Propofol Administration on Temporal Summation of Pain in Gynecologic Laparoscopic Surgery: A Prospective and Controlled Study by Jaehak Jung, Byoungryun Kim, Seong Nam Park, Jiheui Lee, Insung Choi, Myeong Jong Lee, Hyeonbin Yim, Cheol Lee, JuHwan Lee

“…This study aimed at determining the impact of the timing of rocuronium after induction with propofol on the temporal summation of pain. Methods. One hundred patients aged 19–60 years underwent gynecologic laparoscopic surgery. …”
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Efficacy of a new treatment algorithm for capsulitis of the fingers in rock climbers by Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Christoph Lutter, Christoph Lutter, Hans-Christoph Lang, Mario Perl, Othmar Moser, Michael Simon

“…BackgroundAlthough finger joint capsulitis has been described among the most frequent injuries in climbers, no clinical studies on treatment strategies and outcomes are available.Study designProspective case series study.MethodsBetween 2015 and 2018 we prospectively treated 50 patients (38 male, 12 female) with a total number of 69 independent finger joint capsulitis according to a clinic specific treatment regimen and evaluated the outcome retrospectively. …”
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Comparative study of the vascular structures of the retina and choroid in Chinese Han and Uygur populations with proliferative diabetic retinopathy: An OCTA study by Yunxian Gao, Zhumahan Tuokedaerhan, Jie Zhang, Lei Yang, Yani Zhang, Wanying Cheng, Yong Zhao, Jiawei Wang

“…Background: To compare the vascular structures of the retina and choroid in Chinese Han and Uygur populations with proliferative diabetic retinopathy (PDR) using swept-source OCTA (SS-OCTA). Methods: Fifty-three eyes of 53 healthy volunteers (25 from Hans and 28 from Uygurs) and 40 eyes of 40 PDR patients (20 from Hans and 20 from Uygurs) were included. …”
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Identification of maize leaf diseases using red, green, blue-based images with convolutional neural network (CNN) and residual network (ResNet50) models by Basani Lammy Nkuna, Khaled Abutaleb, Johannes George Chirima, Solomon W. Newete, Adriaan Johannes van der Walt, Adolph Nyamugama

“…However, it is susceptible to diseases that drastically reduce yields if not controlled. Traditional methods of disease detection of visual inspections are often inaccurate and uncertain. …”
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Quantitative tremor monitoring before, during and after MR-guided focused ultrasound thalamotomy for essential tremor with MR compatible accelerometers by Thomas Bancel, Mohammed Bashaiweth, Thomas J. Manuel, Benoît Béranger, Cécile Galléa, Mathieu Santin, Mélanie Didier, Eric Bardinet, Pierre Pouget, Mickael Tanter, Stéphane Lehéricy, Marie Vidailhet, David Grabli, Nadya Pyatigorskaya, Carine Karachi, Elodie Hainque, Jean-François Aubry

“…Currently, clinical examination is used to identify therapeutic efficacy during treatment, but MRgFUS surgery could benefit from real-time, rater-independent quantitative monitoring of tremor, such as accelerometry data.Methods Fourteen patients with medically refractory essential tremor underwent MRgFUS thalamotomy. …”
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Combining radiomics and deep learning to predict liver metastasis of gastric cancer on CT image by Yimin Guo, Yimin Guo, Haixiang Yin, Haixiang Yin, Hanyue Zhang, Hanyue Zhang, Pan Liang, Pan Liang, Jianbo Gao, Jianbo Gao, Ming Cheng, Ming Cheng

“…ObjectiveOur study aimed to explore the potential of deep learning (DL) radiomics features from CT images of primary gastric cancer (GC) in predicting gastric cancer liver metastasis (GCLM) by establishing and verifying a prediction model based on clinical factors, classical radiomics and DL features.MethodsWe retrospectively analyzed 1001 pathologically confirmed GC patients from June 2014 to May 2024, divided into non-LM (n=689) and LM groups (n=312). …”
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Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance by Santiago Rodríguez de Córdoba, Andrea Reparaz, Daniel Sanchez, Sheila Pinto, Lucia Juana Lopez, Héctor Martin Merinero, Iria Calvete, Julian Perez-Perez, Sydney S. Jellison, Yuzhou Zhang, Richard J. H. Smith, Inmaculada Moreno, Mercedes Dominguez

“…The visually-based immunochromatographic test (ICT) described herein allows for quick detection and quantification of IgG and IgM FH-FHAA complexes in human EDTA-plasma or serum. …”
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Influence of L-tryptophan use on the dynamics of cognitive functions in the complex therapy of delayed psycho-speech development in children by V. M. Polyakov, L. V. Rychkova, T. A. Belogorova, V. I. Mikhnovich, O. V. Bugun, O. N. Berdina, Zh. V. Prokhorova, T. A. Teterina, L. N. Lebedeva, L. I. Lebedeva

“…The purpose of this study is to evaluate the ability of L-tryptophan used in complex therapy of delayed psycho-speech development in children to influence the dynamics of cognitive performance.Materials and methods. The study included 80 children aged 3–7 years with delayed psycho-speech development (DPSD). …”
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Resting-State Functional MRI in Dyslexia: A Systematic Review by Bruce Martins, Isabel A. B. Verrone, Mariana M. I. Sakamoto, Mariana Y. Baba, Melissa E. Yvata, Katerina Lukasova, Mariana P. Nucci

“…By synthesizing extant evidence, this work aims to clarify dyslexic connectivity profiles and provide a foundation for future research and clinical translation. <b>Methods:</b> This systematic review analyzed publications from the last 10 years in two scientific databases, focusing on individuals with dyslexia, without previous injuries, who underwent resting-state functional magnetic resonance imaging (rs-fMRI) assessments, comparing them with typical readers. …”
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Prevalence of eating disorders in South Asian countries: a systematic analysis of Global Burden of Disease (1990–2021) by Prakasini Satapathy, Vijay Kumar, Mahalaqua Nazli Khatib, Lalji Baldaniya, Suhas Ballal, V. Kavitha, Laxmidhar Maharana, Renu Arya, Ganesh Bushi, Muhammed Shabil, Rukshar Syed, Manika Gupta, Sunil Kumar, Sabah Ansar, Sanjit Sah, Diptismita Jena, Edward Mawejje

“…Geospatial patterns and temporal changes were visualized using QGIS software. The correlation between the Sociodemographic Index (SDI) and the DALY rate was assessed using R software. …”
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Greater pain and functional impairment in chronic erosive hand osteoarthritis compared to treated rheumatoid arthritis: A comparative study by S. Berkani, S. Tuffet, A. Rousseau, N. Rincheval, E. Maheu, B. Combes, A. Saraux, B. Fautrel, L. Gossec, F. Berenbaum, J. Sellam, A. Courties

“…Objectives: To compare the burden of established chronic rheumatoid arthritis (RA) and erosive hand osteoarthritis (EHOA), in terms of pain, functional impairment, comorbidities, and cardiometabolic diseases (CMD). Methods: This study included EHOA patients from the inclusion visit of the DIGICOD cohort and RA patients from the 10th year visit of the ESPOIR cohort. …”
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Iso-lating optimal automated external defibrillator signage: An international survey by Brandon Stretton, Gregory Page, Joshua Kovoor, Ammar Zaka, Aashray Gupta, Stephen Bacchi, Anjalee Amarasekera, Anoja Gunaratne, Aravinda Thiagalingam, Gopal Sivagangabalan, Pramesh Kovoor

“…Introduction: This study investigated the public’s preference to a recognisable and meaningful signage for Automated External Defibrillators (AEDs) in alignment with ISO 7010 standards, aiming to identify improvements for better public awareness and response during out-of-hospital cardiac arrests (OHCA). Methods: A survey was administered via SurveyMonkey® and Heart of the Nation’s social media. …”
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Dual Attention-Based Global-Local Feature Extraction Network for Unsupervised Change Detection in PolSAR Images by Dazhi Xu, Ming Li, Yan Wu, Peng Zhang, Xinyue Xin

“…Numerical experiments on five real spaceborne PolSAR datasets demonstrate that our DA-GLN is more competitive than other state-of-the-art methods.…”
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Comparison of Transforaminal Percutaneous Endoscopic Lumbar Discectomy with and without Foraminoplasty for Lumbar Disc Herniation: A 2-Year Follow-Up by Binbin Wu, Gonghao Zhan, Xinyi Tian, Linyu Fan, Chenchen Jiang, Beekoo Deepti, Hong Cao, Jun Li, Qingquan Lian, Xixi Huang, Feng Xu

“…However, the safety and effectiveness between the TF PELF and TF PELD have not been investigated. Methods. Of the included 140 LDH patients, 62 patients received TF PELF (PELF group) and 78 patients received TF PELD (PELD group). …”
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Anoikis classification of lung squamous cell carcinoma reveals correlation with clinical prognosis and immune characteristics by Yixin Zhai, Cheng Li, Xiang He, Wenqi Wu, Donghui Xing, Kaiping Luo, Zhigang Zhao

“…However, the clinical prognostic significance of anoikis in lung squamous cell carcinoma (LUSC) remains poorly studied.Methods The differentially expressed ARGs and candidate genes were selected by the differential analysis to construct a predictive model. …”
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Hydrodissection technique for pain relief during peri-microwave ablation in patients with subpleural non-small cell lung cancers by Nan Wang, Tianyu Xue, Peng Liu, Pikun Cao, Jingwen Xu, Zhigang Wei, Xin Ye

“…Purpose This study aimed to assess the application value of the hydrodissection technique (HT) for pain relief during peri-microwave ablation (MWA) in patients with subpleural non-small cell lung cancers (NSCLCs).Methods This retrospective study comprised 218 patients with subpleural NSCLCs who underwent computed tomography (CT)-guided percutaneous MWA. …”
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Extracellular vesicle GABA responds to cadmium stress, and GAD overexpression alleviates cadmium damage in duckweed by Zhanpeng Sun, Zhanpeng Sun, Ziyang Qu, Yuman He, Yujie Han, Yun Xing, Sizheng Liu, Yi Hu, Yumeng Jiang, Yiqi Yu, Yuanyuan Liu, Weibo Sun, Lin Yang

“…While γ-aminobutyric acid (GABA) is known to accumulate rapidly under environmental stress, the real-time dynamics of GABA signaling and its mechanistic link to stress adaptation remain poorly understood.MethodsIn this study, a sensitive GABA biosensor, iGABASnFR, was introduced into plants for the first time to monitor GABA signaling. …”
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Assessing the cataract surgical rate and gender equity in cataract services in south-east Nigeria by Clare Gilbert, Onyinye Onyia, Ada Ejealor Aghaji, Christiana Ubaka, Eberechukwu Ogbeanu Achigbu, Ifeoma Lilian Ejiakor, Adaku I Mbatuegwu, Chiamaka J P Okeke, Barbara C Okoli, Emmanuel U Ogborogu, Kenneth C Dike, Florence U Nkwogu

“…Background In 2020, almost 100 million people were blind or visually impaired from cataract. Cataract surgery is a cost-effective treatment for cataracts. …”
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