Expanding Genetic and Clinical Spectra of Inherited Retinal Dystrophies: Identification of Three Novel <i>PRPH2</i> Variants by Raffaella Cascella, Jacopo Sebastiani, Claudia Strafella, Giulia Calvino, Sarah Andreucci, Michele D’ambrosio, Stefania Zampatti, Jung Hee Levialdi Ghiron, Benedetto Falsini, Andrea Cusumano, Emiliano Giardina

“…<b>Methods</b>: A total of 830 Italian subjects diagnosed with IRDs by the multimodal clinical approach underwent WES on the Illumina^® Next-Seq 550 system. …”
Get full text

Effectiveness and safety of lysozyme chloride-based cream on healing of grade-two pressure ulcers: A pilot study by Glogovac-Kosanović Milkica, Bućma Tatjana, Prtina Draško, Gajić Aleksandar, Šukalo Aziz, Mehić Meliha, Tanović-Avdić Amna, Glamočlija Una

“…This study aimed to evaluate the efficacy and safety estimates of lysozyme-based cream in the treatment of pressure ulcers of grade two according to Yarkony-Kirk scale. Methods: Adult patients with neurological diseases and severe functional deficits with grade-two pressure ulcers according to Yarkony-Kirk scale were included. …”
Get full text

Postoperative pain and influencing factors after prophylactic extraction of impacted mandibular third molars: a multicenter prospective cohort study by Zhiwei Cao, Chengzhi Zhao, Renyi Wang, Qianxing Du, Kun Zhang, Jihong Zhao, Yang Xue, Bing Han, Jiuyan Jiang, Liwei Hu, Xuejuan Liao, Jian Pan

“…Abstract Objective This study aims to investigate factors influencing postoperative pain after prophylactic third molar extraction to provide evidence-based recommendations for clinical practice. Methods This study enrolled 804 patients undergoing prophylactic third molar extraction. …”
Get full text

Shared and distinct brain activation patterns of acupoints HT7, ST36, and KI4: a task-based fMRI study by Liyu Hu, Liyu Hu, Jinhuan Zhang, Xiaoxiong Wu, Xingxian Huang, Xinbei Li, Xingchen Liu, Hanqing Lyu, Nan Yang, Jinping Xu, Haibo Yu

“…ObjectiveWe aimed to investigate the shared and distinct of brain responses to manual acupuncture at HT7, ST36, and KI4.MethodsSixteen healthy participants receiving acupuncture at HT7, 19 at ST36, and 16 at KI4. …”
Get full text

Feasibility of vagus nerve modulation (VNMM/taVNS) in cognitive-swallowing dual-task paradigms: a fNIRS pilot study by Zhiyong Wang, Zhiyong Wang, Keling Cheng, Junhui Bai, Cuicui Zhang, Jun Ni, Jun Ni

“…BackgroundNon-invasive vagus nerve stimulation techniques show promise for modulating cortical networks, but their comparative effects during combined cognitive-swallowing tasks remain underexplored.AimsThis feasibility study aimed to: (1) establish a protocol for assessing transauricular vagus nerve stimulation (taVNS) and VNMM effects using fNIRS during dual-task paradigms, and (2) compare their impacts on cortical activation and functional connectivity.MethodsThis protocol (ChiCTR2200065698) consisted of two separate blocks, a cognitive task (n = 25) and a swallowing task (n = 25), and healthy subjects in either block were randomly assigned to the taVNS and VNMM groups. …”
Get full text

The relationship between the CYP2C19*17 genetic polymorphism and the efficacy and safety of diazepam in patients with alcohol withdrawal syndrome by V. Yu. Skryabin, M. S. Zastrozhin, E. A. Grishina, K. A. Ryzhikova, V. V. Shipitsyn, I. V. Barna, T. E. Galaktionova, A. S. Sorokin, E. A. Bryun, D. A. Sychev

“…The aim of our study was to study the relationship between the CYP2C19 genetic polymorphism and the efficacy and safety of diazepam in patients with alcohol withdrawal syndrome in order to develop algorithms for optimizing the therapy of diazepam to reduce the risk of dose-dependent adverse drug reactions and pharmacoresistance.Materials and methods. The study was conducted on 30 Russian male patients suffering from alcohol withdrawal syndrome. …”
Get full text

Does pharmacist–patient gender discordance influence medication guidance for gender-specific diseases? by Manato Nomi, Ryota Kumaki, Rieko Takehira, Etsuko Arita, Keiko Kishimoto

“…Background: This study aimed to determine whether community pharmacists perceive barriers to providing medication guidance for gender-specific diseases and to clarify whether these perceived barriers are influenced by pharmacist and patient gender concordance or discordance. Methods: A web-based survey was conducted with pharmacists from five pharmacy groups in Japan. …”
Get full text

A comparative study of ultrasound-guided caudal block versus anatomical landmark-based caudal block in pediatric patients undergoing infra-umbilical surgeries by Suman Halder, Amrita Roy, Payel Mitra, Maitreyee Mukherjee, Arpita Laha

“…Aims and Objectives: This study was done to compare the success rate and complications between ultrasound (USG) and landmark-guided caudal epidural analgesia in infra-umbilical surgeries in children aged more than 1 month–<12 years. Materials and Methods: A total of 150 subjects were randomly allocated into two equal groups (each of 75 patients). …”
Get full text

Anti-skin aging effects and bioavailability of collagen tripeptide and elastin peptide formulations in young and middle-aged women by Shan Lu, Silu Zhang, Yun Wang, Jiayi Ni, Tiantian Zhao, Guoxun Xiao

“…Overall pore volume decreased by 60%, and visual assessments indicated a decrease in skin luminosity by 15.20% and smoothness index by 22.55%. …”
Get full text

Real-World Evaluation of Dupilumab in the Long-Term Management of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps: A Focus on IL-4 and IL-13 Receptor Blockade by Nicola Lombardo, Aurelio D’Ecclesia, Emanuela Chiarella, Corrado Pelaia, Debbie Riccelli, Annamaria Ruzza, Nadia Lobello, Giovanna Lucia Piazzetta

“…The outcomes included Nasal Polyp Score (NPS); Sino-Nasal Outcome Test (SNOT-22), Numeric Rating Scale (NRS), and Visual Analog Scale (VAS) scores; total IgE; and olfactory function. …”
Get full text

Development of a Recombinase Polymerase Amplification-Coupled CRISPR/Cas12a Platform for Rapid Detection of Antimicrobial-Resistant Genes in Carbapenem-Resistant <i>Enterobacterale... by Ji Woo Yang, Heesu Kim, Lee-Sang Hyeon, Jung Sik Yoo, Sangrim Kang

“…Traditional diagnostic methods are often too slow and complex for rapid point-of-care testing. …”
Get full text

Thematic Analysis of Produce Packinghouse Sanitation: Challenges and Recommendations Based on Operator and Educator Insights by Allyson N. Hamilton, Sahaana Chandran, Kristen E. Gibson, Juan Moreira

“…Verification of cleaning effectiveness often relies on visual inspection rather than standardized methods such as environmental monitoring or Adenosine Triphosphate (ATP) testing. …”
Get full text

MLK-TR: a Multi-branch Large Kernel TRansformer for UAV-based images by Xun Li, Yuzhen Zhao, Yang Zhao, Zhun Guo, Jianjing Gao, Baoxi Yuan

“…Abstract Object detection from the perspective of unmanned aerial vehicles (UAV) is a technology that utilizes visual sensors mounted on UAV to automatically identify and locate ground targets. …”
Get full text

HMGB1 released from pyroptotic vascular endothelial cells promotes immune disorders in exertional heatstroke by Chaoping Yu, Yang Huang, Jiangang Xie, Chujun Duan, Shanshou Liu, Wei Zhao, Yutong Wang, Ran Zhuang, Junjie Li, Wen Yin

“…HMGB1 localization and release were visualized using immunofluorescence staining. Human umbilical vein endothelial cells (HUVECs) and THP-1 cells were co-cultured to study the effects of HMGB1 on macrophages. …”
Get full text

Thoracic duct drainage patterns in heterotaxy by Daniel A. Castellanos, Emily M. Bucholz, Katherine Bai, Jesse J. Esch, David Hoganson, Stephen P. Sanders, Raja Shaikh, Sunil J. Ghelani, David N. Schidlow

“…Results: Of 115 eligible patients, the terminal TD was visualized in 56 (49 %). The terminal TD was left-sided in 25 patients, right-sided in 29, and bilateral in two. …”
Get full text

Comparative assessment of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> and <i>Saccharomyces boulardii</i> efficacy at d... by V. T. Ivashkin, O. M. Drapkina, A. A. Sheptulin, O. S. Shifrin, Ye. A. Poluektova, S. Yu. Kuchumova

“…Intensity of abdominal pain and meteorism was estimated by visual analog scale (VAS), consistency of stool – by Bristol stool form scale, defecation rate — by calculation of number of bowel movements during every week of treatment. …”
Get full text

Geospatial impact evaluation of a low-cost agricultural intervention for enhancing environmental resilience by Pratap Khattri, Rachel Sayers, Kunwar K. Singh, Ryan Slapikas, Chet Bahadur Tamang, Dinee Tamang, Brad Sagara, Ariel BenYishay

“…We assessed the causal impact of a program promoting sugarcane farming on its adoption and environmental outcomes, measured using multi-temporal satellite imagery, crop phenology, and clustering algorithms, along with machine learning and visual interpretation methods. Our results show that sugarcane adoption increased significantly in both treated and spillover communities, highlighting its potential as a sustainable agricultural practice. …”
Get full text

Efficacy and Safety of a Dexamethasone Implant in Patients with Diabetic Macular Edema at Tertiary Centers in Korea by Byung Gil Moon, Joo Yong Lee, Hyeong Gon Yu, Ji Hun Song, Young-Hoon Park, Hyun Woong Kim, Yong-Sok Ji, Woohyok Chang, Joo Eun Lee, Jaeryung Oh, Inyoung Chung

“…To evaluate the real-world efficacy and safety of the dexamethasone implant (DEX implant) in patients with diabetic macular edema (DME). Methods. Retrospective, multicenter, and noncomparative study of DME patients who were treated with at least one DEX implant. …”
Get full text

Capsule Endoscopy: Current Trends, Technological Advancements, and Future Perspectives in Gastrointestinal Diagnostics by Chang-Chao Su, Chu-Kuang Chou, Arvind Mukundan, Riya Karmakar, Binusha Fathima Sanbatcha, Chien-Wei Huang, Wei-Chun Weng, Hsiang-Chen Wang

“…This study addresses a significant gap by methodically evaluating CE platforms, outlining their clinical preparedness, and examining the underexploited potential of artificial intelligence in improving diagnostic precision. …”
Get full text

Association between psychosocial factors at work and health outcomes after retirement: a protocol for a systematic review and meta-analysis by Hisashi Eguchi, Akizumi Tsutsumi, Akiomi Inoue, Yuka Kobayashi, Norito Kawakami, Kotaro Imamura, Asuka Sakuraya, Natsu Sasaki, Yumi Asai, Hideaki Arima, Emiko Ando, Reiko Inoue, Mai Iwanaga, Yasumasa Otsuka, Kanami Tsuno, Ayako Hino, Kazuhiro Watanabe, Akihito Shimazu

“…The objective of this systematic review and meta-analysis is to examine the association between psychosocial factors at work and health outcomes after retirement, based on a synthesis of well-designed prospective studies.Methods and analysis The participants, exposures, comparisons and outcomes of the studies in this systematic review and meta-analysis are defined as follows: (P) people who have retired from their job, (E) presence of adverse psychosocial factors at work before retirement, (C) absence of adverse psychosocial factors at work before retirement and (O) any physical and mental health outcomes after retirement. …”
Get full text