AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity by Giulia Cerrato, Peng Liu, Liwei Zhao, Adriana Petrazzuolo, Juliette Humeau, Sophie Theresa Schmid, Mahmoud Abdellatif, Allan Sauvat, Guido Kroemer

“…CON was characterized using SYTO 14 fluorescent staining and holotomographic microscopy, and visualized by AI-deconvoluted transmitted light microscopy. …”
Get full text

Sensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation by Hanyu Xia, Hanyu Xia, Travis J. Jerde, Travis J. Jerde, Jill C. Fehrenbacher, Jill C. Fehrenbacher, Jill C. Fehrenbacher, Jill C. Fehrenbacher

“…Recent studies have highlighted a role for sensory nerves beyond perception of noxious stimuli, as anterograde release of neuropeptides from sensory nerves can affect vascular tone and local immune responses.MethodsTo identify the degree of sensory innervation in the prostate, we utilized state-of-the-art tissue clearing and microscopy to visualize sensory innervation in the different lobes of the mouse prostate. …”
Get full text

Cell graph analysis in hepatocellular carcinoma: predicting local recurrence and identifying spatial relationship biomarkers by Yizhe Yuan, Ziyin Zhao, Xin Fang, Qing Zhang, Wenqing Zhong, Midie Xu, Gongqi Li, Rushi Jiao, Heng Yu, Ruoxi Wang, Shuyu Liu, Weitao Zu, Bingsen Xue, Yuze Chen, Chengxiang Wang, Ya Zhang, Minghui Liang, Bing Han, Cheng Jin

“…Conventional pixel-based visual processing techniques are insufficient to accurately capture the complexities inherent with cell-entity deployment and formation strategy. …”
Get full text

Real-Life Clinical Use and Outcomes of Fusion Imaging-Guided Percutaneous Microwave Ablation of Hepatocellular Carcinoma: Experience from Two Italian Centers by Pierpaolo Biondetti, Francesco Cicchetti, Gaetano Valerio Davide Amato, Velio Ascenti, Niccolò Finardi, Jacopo Tintori, Francesco Ugo Iovino, Carolina Lanza, Salvatore Alessio Angileri, Pierluca Torcia, Anna Maria Ierardi, Giacomo Vignati, Lorenzo Giovanni Monfardini, Gianpaolo Carrafiello

“…<b>Conclusions:</b> USFI-guided MWA is a safe and effective option for treating HCC nodules not adequately visualized with conventional US, expanding eligibility to complex cases.…”
Get full text

Evaluation of pulse therapy with intravenous methylprednisolone on leprosy neuritis in a Brazilian referral center by Diogo Fernandes dos Santos, Diogo Fernandes dos Santos, Pedro Henrique Sirotheau Corrêa Alves, Fernanda de Oliveira Cirino, Leonardo Peixoto Garcia, João Paulo Moreira Fernandes, Douglas Eulálio Antunes, Isabela Maria Bernardes Goulart, Isabela Maria Bernardes Goulart

“…This observational study aimed to evaluate the use of intravenous methylprednisolone in refractory LN cases in a national reference center of leprosy in Brazil.MethodsEpidemiological and clinical data were collected, and the following instruments were used on evaluation: visual analog pain scale (VAS), Douler Neuropathic 4 questionnaire (DN4), Screening of Activity Limitation and Safety Awareness (SALSA), and the simplified neurological assessment protocol by the Brazilian Ministry of Health. …”
Get full text

Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model by Mingfeng Li, Xinghan Wu, Lin Jiang, Min Liu, Gong Yanju, Xiaomeng Li, Fan Tian, Fan Ye, Jinlong Wang, Siyuan Wang, Chuan Qin, Ling Zhang

“…However, the precise mechanism by which AD antagonizes lung cancer progression warrants further elucidation. Methods To this end, we established a co‐morbidity model using 5xFAD transgenic mice induced with the carcinogen urethane. …”
Get full text

Indoor endotoxin and house dust mite concentrations in the canine homologue of human atopic dermatitis by Yunji Song, Yeji Kim, Jihyun Kim, Ha-Jung Kim

“…The aim of this study is to analyze the effects of HDM and endotoxin concentrations on AD in dogs and compare their immunological profiles with humans. Methods: We graded the canine AD Extent and Severity Index-4 (CADESI-4), Pruritus Visual Analogue Scale (PVAS), and transepidermal water loss (TEWL) in dogs with (n = 42) and without AD (controls; n = 18). …”
Get full text

O-arm navigation-based transforaminal unilateral biportal endoscopic discectomy for upper lumbar disc herniation: an innovative preliminary study by Dong Hyun Lee, Choon Keun Park, Jin-Sung Kim, Jin Sub Hwang, Jin Young Lee, Dong-Geun Lee, Jae-Won Jang, Jun Yong Kim, Yong-Eun Cho, Dong Chan Lee

“…Methods The UBE approach targeted the ventral part of the superior articular process in the transforaminal UBE setup, specifically for upper lumbar disc herniation, with an approach angle of approximately 30º on the axial plane. …”
Get full text

Determinants of academic performance of healthcare professional students in a medical university, Ajman, United Arab Emirates by Shahnaz Mohamed Wazil, Sathyapriya Nandagopal, Afreen Abdul Rahim Sanaullah, Liju Susan Mathew, Nermine Nosseir, Jayadevan Sreedharan, Jayadevan Sreedharan, Anusha Sreejith, Anusha Sreejith, Latifa Nabeel Alsaad, Latifa Nabeel Alsaad, Jayakumary Muttappallymyalil, Jayakumary Muttappallymyalil

“…Most students reported a preference for visual learning styles, the use of active recall as a study technique, and studying primarily at home. …”
Get full text

X-Linked CGD Chorioretinitis in Two Young Girls by Johnathan Abraham Bailey, Maximilian Daechul Kong, Chanakarn Piamjitchol, Baichun Hou, Abdhel Exinor, Antara Nayak, Noah Heaps, Aykut Demirkol, Stephen H. Tsang

“…Despite these structural changes, visual function remained stable with minimal progression over time. …”
Get full text

Comparison of analgesic effects between betamethasone and dexamethasone in total knee arthroplasty: a prospective randomized controlled trial by Kai Qin, Kai Qin, Xiangxiang Sun, Qunli Dou, Bowei Li, Guoyang Bai, Guoyang Bai, Xiaobo Sun, Xiaobo Sun, Jianbing Ma, Chao Xu, Yuanchi Huang

“…Therefore, this study aims to compare the analgesic efficacy and safety of betamethasone and dexamethasone in TKA through a prospective randomized controlled trial (RCT).MethodsA total of 120 patients were randomly assigned to three groups: Control (Con) group, Dexamethasone (Dex) group and Betamethasone (Beta) group. …”
Get full text

Acute pharmacological effects of α-PVP in humans: a naturalistic observational study by Georgina De la Rosa, Georgina De la Rosa, Esther Papaseit, Esther Papaseit, Olga Hladun, Olga Hladun, Lourdes Poyatos, Dolly Andrea Caicedo, Dolly Andrea Caicedo, Martha Catalina Argote, Martha Catalina Argote, Soraya Martín, Mireia Ventura, Nunzia La Maida, Annagiulia Di Trana, Silvia Graziano, Simona Pichini, Magí Farré, Magí Farré, Clara Pérez-Mañá, Clara Pérez-Mañá

“…Since the pharmacology of α-PVP remains scarcely studied, we aimed to evaluate the acute pharmacological effects and its abuse potential in humans after intranasal administration.MethodsWe carried out a non-controlled observational study in a naturalistic environment in nine participants (3 women and six men) with a previous history of psychostimulant use. …”
Get full text

The network and interactive pattern of social adjustment and psychological symptoms in patients with spinal cord injury: a network analysis by Hui Liu, Yi Ni, Haixia Xie, Yijun Xie, Chenhui Fan, Yao Li, Weinan Shen, Hua Zhai, Chenghua Jiang, Jing Wu, Hengjing Wu

“…Graphical lasso networks and directed acyclic graphs (DAGs) were used to visualize and analyze the associations between symptom levels corresponding to the four scales. …”
Get full text

Efficacy and safety of interferon-alpha 1b injection into the intervertebral foramen with ultrasonic guidance in patients with postherpetic neuralgia: study protocol for a randomiz... by Hui-Min Hu, Hui-Min Hu, Wen-Hui Liu, Wen-Hui Liu, Chen Li, Chen Li, Qing Shi, Qing Shi, Chun-Hua Liu, Chun-Hua Liu, An-Xiang Liu, An-Xiang Liu, Yi-Fan Li, Yi Zhang, Peng Mao, Bi-Fa Fan

“…The primary outcomes will include the visual analog scale score and duration of pain relief. …”
Get full text

Comparison of effect and mechanism between nalfurafine hydrochloride and narrow-band ultraviolet B phototherapy in the treatment of pruritus in hemodialysis patients by Sooyeon Choi, Dong Hui Shin, Jae-Seok Kim, Jun Young Lee, Seung Ok Choi, Byoung-Geun Han, Eun Jung Kim, Eung-Ho Choi, Jae Won Yang

“…We aim to compare newly developed Nalfuranfine HCL, kappa-opioid receptor agonist, with NB-UVB in HDP.Methods Twenty HDP were enrolled from Wonju severance Christian hospital. …”
Get full text

Daily digital biomarkers in the follow-up and clustering of patients with asthma by Bernardo Sousa-Pinto, Florence Schleich, Gilles Louis, Bilun Gemicioglu, Violeta Kvedarienė, Frederico S. Regateiro, Claudia Chaves Loureiro, Luis Taborda-Barata, Rita Amaral, Josep M. Antó, Anna Bedbrook, Wienczyslawa Czarlewski, Ignacio J. Ansotegui, Karl-C Bergmann, Matteo Bonini, Apostolos Bossios, Louis-Philippe Boulet, Fulvio Braido, Christopher Brightling, Guy Brusselle, Luisa Brussino, G. Walter Canonica, Alvaro A. Cruz, Tari Haahtela, Liam G. Heaney, Michael Hyland, Juan Carlos Ivancevich, Ludger Klimek, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Desiree E. Larenas-Linnemann, Michael Makris, Manuel Marques-Cruz, Sara Gil-Mata, Mário Morais-Almeida, Marek Niedoszytko, Markus Ollert, Nikolaos G. Papadopoulos, Vincenzo Patella, Oliver Pfaar, Celeste Porsbjerg, Francesca Puggioni, Santiago Quirce, Carlos Robalo Cordeiro, Nicolas Roche, Boleslaw Samolinski, Joaquin Sastre, Nicola Scichilone, Sabina Skrgat, Sanna Toppila-Salmi, Omar S. Usmani, Arunas Valiulis, Brigita Gradauskiene, Ilgim Vardaloğlu Koyuncu, Maria Teresa Ventura, Rafael José Vieira, Arzu Yorgancioglu, João A. Fonseca, Torsten Zuberbier, Benoit Pétré, Renaud Louis, Jean Bousquet

“…Clusters were compared using digital biomarkers (visual analogue scale [VAS] on asthma symptoms and electronic daily asthma control score [e-DASTHMA]). …”
Get full text

Structural Retinal and Optic Nerve Changes in Prostate Cancer Patients Receiving Androgen Receptor Pathway Inhibitors: An OCT-Based In Vivo Analysis by Yasemin Bakkal Temi, Büşra Yılmaz Tuğan, İlkay Çıtakkul, Ece Baydar, Gözde Karaca, Sibel Balcı, Devrim Çabuk, Umut Kefeli, Nurşen Yüksel, Kazım Uygun

“…No significant differences were observed between groups in terms of age, visual acuity, intraocular pressure, central corneal thickness, or lens status. …”
Get full text

The Effect of the Ripening Period on the Quality Attributes of Pear Fruit by Smaranda-Oana Boghean, Mădălina Militaru, Eugenia Gherghina (Mareși), Radu E. Sestras, Orsolya Borsai, Andreea F. Andrecan, Catalina Dan, Adriana F. Sestras, Anca Livia Butiuc-Keul

“….), internationally renowned cultivars and new cultivars developed through Romanian breeding programs, with distinct ripening periods, using an integrative approach based on morphological, biochemical, and sensory traits. Standardized methods were applied to assess attributes including fruit size, firmness, soluble solids, organic acid composition, skin color, and hedonic sensory responses for taste, aroma, texture, and visual appeal. …”
Get full text

Individual metabolic brain network abnormalities associated with drug-resistant mTLE vary in surgical outcomes by Xinyi Wang, Xinyi Wang, Pan Zhang, Pan Zhang, Dandan Lin, Chunlei Zhao, Chunlei Zhao, Zhifeng Huang, Zhifeng Huang, Ziqian Chen, Ziqian Chen, Hui Li, Hui Li, Shangwen Xu, Shangwen Xu

“…ObjectiveThis investigation aimed to elucidate alterations in metabolic brain network connectivity in drug-resistant mesial temporal lobe epilepsy (DR-MTLE) patients, relating these changes to varying surgical outcomes.MethodsA retrospective cohort of 87 DR-MTLE patients who underwent selective amygdalohippocampectomy was analyzed. …”
Get full text

Use and meaning teachers assign to the integration of the MICA 3.0 kit for teaching climate change by Sonia Pino, César Cofre, Humberto Vergara, Luis Vergara, Jaime Solís-Pinilla, Andoni Arenas-Martija, Andoni Arenas-Martija, Andoni Arenas-Martija, Paulina Ampuero, Paulina Ampuero, Cristian Merino, Cristian Merino

“…IntroductionTeaching climate change requires teachers to have the educational resources that will facilitate teaching this content and visualize how a global problem has various local implications. …”
Get full text