Explainable clinical diagnosis through unexploited yet optimized fine-tuned ConvNeXt Models for accurate monkeypox disease classification by Muhammad Waqar, Zeshan Aslam Khan, Shanzey Tariq Khawaja, Naveed Ishtiaq Chaudhary, Saadia Khan, Khalid Mehmood Cheema, Muhammad Farhan Khan, Syed Sohail Ahmed, Muhammad Asif Zahoor Raja

“…A number of pre-processing and data augmentation methods have also been assessed and adjusted with regard to computing time and performance. …”
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Critical role of Oas1g and STAT1 pathways in neuroinflammation: insights for Alzheimer’s disease therapeutics by Zhixin Xie, Linxi Li, Weizhong Hou, Zhongxi Fan, Lifan Zeng, Limin He, Yunxiang Ji, Jingbai Zhang, Fangran Wang, Zhou Xing, Yezhong Wang, Yongyi Ye

“…Machine learning algorithms were applied to DEGs, and genes selected by both methods were identified as hub genes, with ROC curves used to evaluate their diagnostic accuracy. …”
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A comparative study on the clinical efficacy of laser hemorrhoidoplasty and rubber band ligation for grade Ⅱ to Ⅲ internal hemorrhoids by Jin Lei, Wu Jiong, Wang Zhenyi, Qin Kaijian, Wu Renjie

“…[Conclusion] In conclusion, both LHP and RBL are viable surgical methods for effectively treating gradeⅡ to Ⅲ internal hemorrhoids. …”
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Preemptive Analgesia with Nonsteroidal Anti-Inflammatory Drugs in the Perioperative Period by M. S. Danilov, I. S. Simutis, D. S. Salygina, E. G. Polovtsev, A. A. Syrovatsky, V. A. Ratnikov, A. A. Bogatikov, A. E. Karelov

“…Efficacy and safety were assessed using a visual analog scale (VAS), patient’s need in opioid analgesics, laboratory parameters (serum levels of cortisol, cystatin C, CBC, coagulogram, TEG) and instrumental methods (algesimetry — qNOX).Results. …”
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Gender-specific association of STON2 rs2371597 polymorphism in keratoconus patients of Saudi origin by Altaf A. Kondkar, Altaf A. Kondkar, Altaf A. Kondkar, Tahira Sultan, Taif A. Azad, Tanvir Khatlani, Glenn P. Lobo, Hatem Kalantan, Saleh A. Al-Obeidan, Saleh A. Al-Obeidan, Abdulrahman M. Al-Muammar

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Preoperative detection of extraprostatic tumor extension in patients with primary prostate cancer utilizing [68Ga]Ga-PSMA-11 PET/MRI by Clemens P. Spielvogel, Jing Ning, Kilian Kluge, David Haberl, Gabriel Wasinger, Josef Yu, Holger Einspieler, Laszlo Papp, Bernhard Grubmüller, Shahrokh F. Shariat, Pascal A. T. Baltzer, Paola Clauser, Markus Hartenbach, Lukas Kenner, Marcus Hacker, Alexander R. Haug, Sazan Rasul

“…The ML approach integrating invasive features demonstrated better predictive capabilities for EPE compared to visual clinical read-outs (Cross-validation AUC 0.88 versus 0.71, p = 0.02). …”
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Immune responses in rodent whole eye transplantation: elucidation and preliminary investigations into rejection diagnosis and monitoring by Bing Li, Yong Wang, Charles R. Owens, Touka Banaee, Charleen T. Chu, Kayvon Jabbari, Anna D. Lee, Neil J. Khatter, Alan G. Palestine, An-Jey A. Su, Christene A. Huang, Kia M. Washington

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Identification of hypoxia-related diagnostic biomarkers and immune signatures in diminished ovarian reserve by Minxue Song, Lili Ni, Zebing Ma, Xin Zhong, Yibing Liu, Jilin Kuang, Ping Li

“…This study investigated the genetic links between hypoxia and DOR.MethodsThe GSE87201 dataset for DOR was sourced from Gene Expression Omnibus database, normalized for common differentially expressed genes (Co-DEGs), and identified Hypoxia-related differentially expressed genes (HRDEGs) via GeneCards; Receiver Operating Characteristic (ROC) curves evaluated HRDEGs’ diagnostic value, and protein-protein interaction networks were visualized with STRING and Cytoscape. …”
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Feasibility of home initiation of an airway clearance device (SIMEOX) by telecare in people with non-cystic fibrosis bronchiectasis: a pilot study by Jean-Christian Borel, Nathalie Arnol, Sylvie Leroy, Marlène Murris-Espin, Rebecca Hamidfar, Marie Mahot, Raphael Abouly, Hughes Gauchez, Sophie Jacques, Eloise Joffray, Laurent Morin

“…We hypothesised that telecare would be an effective means to train people with NCFB in the handling of device and to monitor and promote device adherence.Objectives (1) To evaluate frequency of use of the SIMEOX for 10 weeks after telecare training. (2) To assess user satisfaction and clinical efficacy of the SIMEOX+telecare.Methods Multicentre, prospective, pilot study in adults with NCFB. …”
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Ocular manifestations in pediatric tumor suppressor gene mutations: a case series and literature review of RB1, NF1, NF2, VHL, and TSC by Aoxiang Wang, Chanyuan Wang, Wen Li, Jing Qiao, Yulin Luo, Yu Tian

“…We have summarized the ocular presentations of these common tumor suppressor gene mutations in pediatric patients. Methods We reviewed 11 representative case reports, documenting in detail the ocular manifestations and progression of each case. …”
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Risk prediction of stroke-associated pneumonia in acute ischemic stroke with atrial fibrillation using machine learning models by Tai Su, Peng Zhang, Peng Zhang, Bingyin Zhang, Zihao Liu, Zexing Xie, Xiaomei Li, Jixiang Ma, Tao Xin

“…The optimal prediction model was visualized using a nomogram. In this study, SAP was identified in 10.16% of cases. …”
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18F-FDG PET/CT-based deep learning models and a clinical-metabolic nomogram for predicting high-grade patterns in lung adenocarcinoma by Yue Guo, Xibin Jia, Chuanxu Yang, Chao Fan, Hui Zhu, Xu Chen, Fugeng Liu

“…Abstract Background To develop and validate deep learning (DL) and traditional clinical-metabolic (CM) models based on 18 F-FDG PET/CT images for noninvasively predicting high-grade patterns (HGPs) of invasive lung adenocarcinoma (LUAD). Methods A total of 303 patients with invasive LUAD were enrolled in this retrospective study; these patients were randomly divided into training, validation and test sets at a ratio of 7:1:2. …”
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Symptom variability in outpatients with COPD and validation of the Colombian COPD Symptom Variability Instrument (EPOC-CoVaSy) by Eidelman Antonio González-Mejía, Olga Constanza Uñate-Suárez, Carlos José Bula- Gutiérrez, Yojana Patricia Patiño-Jiménez

“…According to the analysis of the diaries, the mean scores (visual analog scale) for all symptoms and the performance of activities of daily living ranged between 0.5 and 2.5, being higher in the morning (mean scores between 1.5 and 2.5) than in the afternoon and night (mean scores between 0.5 and 1.5); however, symptom variability was minimal. …”
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Exploring the influences of myopia in primary and secondary school students in Xinjiang using propensity score matching by Xiaopeng Hu, Xianyan Yuan, Hua Li, Haoxuan Gong, Zhicong Fu, Yuting Xie, Lin Zhu, Haina Chen, Yingli Yang, Dongsheng Rui

“…ObjectiveDue to the high prevalence of myopia among primary and secondary school students in Shihezi City in recent years, this study was conducted to understand the prevalence and the factors influencing it and to provide a scientific basis for future interventions to improve, protect, and promote the visual health of these students.MethodsThe study population consisted of primary and secondary school students in Shihezi City. …”
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Treatment of Hallux Rigidus: Comparison of Hemiarthroplasty with Cartiva Implant, Allograft Interpositional Arthroplasty, and Arthrodesis by Ryan Sanii MD, MPH, Kevin Phan MD, Drew Krumm MD, Daniel J. Patton MD, Tyler Madden MD, John G. Anderson MD, John D. Maskill MD, Donald R. Bohay MD, FACS, Michelle A. Padley PhD, Cameron G. Patthanacharoenphon MD

“…Methods: A retrospective cohort study of 99 patients was performed. …”
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Safety and efficacy of mycophenolate mofetil in treating neuromyelitis optica spectrum disorders: a protocol for systematic review and meta-analysis by Yang Chen, Ming Jin, Mengyu Han, Luqi Nong, Ziqiang Liu, You Chen, Huan Meng, Yali Qin, Zhijun Wang

“…The secondary outcomes will consist of the frequency and severity of adverse events, best-corrected visual acuity, relapse-free rate and time to the next attack. …”
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Comparison of percutaneous endoscopic lumbar discectomy (PELD) and unilateral biportal endoscopic (UBE) discectomy in the treatment of far lateral lumbar disc herniation (FLLDH): a... by Liang Li, Jilong An, Lei Guo, Xiuqi Shan, Yapeng Sun, Jiaqi Li, Fei Zhang, Wei Zhang

“…Abstract Purpose This study aimed to compare the clinical efficacy of percutaneous endoscopic lumbar discectomy (PELD) and unilateral biportal endoscopic (UBE) discectomy in treating patients with far lateral lumbar disc herniation (FLLDH). Methods From January 2020 to January 2022, 65 patients with FLLDH underwent either PELD or UBE discectomy. …”
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Gut Microbial Signatures in Long COVID: Potential Biomarkers and Therapeutic Targets by Soyoung Oh, Sujin An, Kihyun Park, Soohyung Lee, Yoo Min Han, Seong-Joon Koh, Joowon Lee, Hyerin Gim, Donghyun Kim, Haesook Seo

“…Here, we aimed to investigate connections between the gut microbiota and long COVID severity. Methods Fecal samples were collected from 31 patients with long COVID, 14 with COVID-19 but not long COVID, and 23 healthy controls. …”
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Deep learning-based cough classification using application-recorded sounds: a transfer learning approach with VGGish by Sanghoon Han, Yu-rim Lee, Ji-ho Lee, JinHee Jeon, Choongki Min, Kyungnam Kim, Donghoon Kim, Myung Pyo Kim, Young Mi Park, Uiri An, Kyoung Min Moon

“…To enhance interpretability, we applied Grad-CAM to visualize the features that influenced the model’s decision-making. …”
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UK Medical Cannabis Registry: An Analysis of Outcomes of Medical Cannabis Therapy for Hypermobility‐Associated Chronic Pain by Mary Dickinson, Simon Erridge, John Warner‐Levy, Evonne Clarke, Katy McLachlan, Ross Coomber, Wendy Holden, James J. Rucker, Michael W. Platt, Mikael H. Sodergren

“…Objective The study aims to evaluate the clinical outcomes in patients with hypermobility spectrum disorder (HSD) and hypermobile Ehlers–Danlos syndrome (hEDS) with chronic pain following treatment with cannabis‐based medicinal products (CBMPs). Methods This was a case series conducted with the UK Medical Cannabis Registry. …”
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