Catheter-associated urinary tract infections in urethral stricture patients indwelling suprapubic catheter: Insights from a retrospective investigation into specific antibiogram an... by Jiahao Lin, Changhao Hou, Yubo Gu, Wei Yuan, Xianjie Xiu, Zhenwei Yu, Ruihang Zhang, Guangyu Mao, Qiang Fu, Lujie Song

“…Objectives: This study aimed to evaluate the incidence and risk factors of suprapubic catheter-associated bacteriuria (SPCAB) and multidrug-resistant bacteria (MDRB) in patients with urethral strictures, and compare antimicrobial resistance patterns between pathogens isolated from urinary samples and suprapubic catheters. Methods: A retrospective analysis was performed on patients with urethral strictures who had urethral reconstructive surgery with suprapubic catheters from January 2010 to June 2023. …”
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Efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis: a protocol for a multicentre, randomised, parallel... by José Antonio Pinto, Alex Fonollosa, Ester Carreño, Maria Isabel Rodriguez, David Diaz-Valle, Diana Peiteado, Luis Rodriguez-Rodriguez, Miguel Cordero-Coma, Marta Tejera Santana, Lidia Cocho, Ana Belen Rivas, Amanda Lopez-Picado, Valentina Calamia, Felix M Francisco Hernandez, Angel Garcia-Aparicio, Javier Garcia-Gonzalez, Jose Juan Mondejar, Leticia Lojo-Oliveira, Llucí Martínez-Costa, Santiago Munoz, Beatriz Rodriguez-Lozano, Esperanza Pato, Elena Molina, Luis Alberto Tebar, Mara Albert Fort, Mayte Ariño Gutierrez, Pedro Arriola Villalobos, Joseba Artaraz Beobide, Antonio Atanes Sandoval, Jose Manuel Sanchez, Francisco Blázquez, Pablo Borges Deniz, Lara Borrego Sanz, Gabriela Bustamante Sanchez-Arnedo, Bruno Casco Silva, Ricardo Cuiña Sardiña, Almudena De Pablo Cabrera, Maria Del Mar Esteban Ortega, Patricia Fernandez Puente, Dalifer Dayanira Nuñez, Javier Garcia Bella, Sara Garcia Carazo, Luis Garcia Onrubia, Jose Maria Morales, Jose Antonio Fernandez, Vanesa Hernandez Hernandez, Inés Hernanz Rodriguez, Jose Maria Cantalapiedra, Ventura Hidalgo Barrero, Maria De Jovani Casano, Sara López Sierra, Virginia Lozano Lopez, Alfredo Madrid Garcia, Rosalia Mendez Fernandez, Pilar Nozal Aranda, Eugenio Perez Blazquez, Chamaida Plasencia Rodriguez, Sheila Recuero Diaz, Ignacio Robles Barrena, Esther Rodriguez Almaraz, Fayna Maria Gonzalez, Guadalupe Rodriguez Martinez, Fredeswinda Isabel Bueno, Ioana Ruiz Arruza, Beatriz Sanchez Marugan, Olga Sanchez Pernaute, Armelle Schlinker Giraud, Alvaro Seijas Lopez, Patricia Simon Alonso, Elia Valls Pascual

“…However, a direct comparison between these two treatment strategies has not been carried out yet.Methods and analysis The Combination THerapy with mEthotrexate and adalImumAb for uveitis (CoTHEIA) study is a phase III, multicentre, prospective, randomised, single-blinded with masked outcome assessment, parallel three arms with 1:1:1 allocation, active-controlled, superiority study design, comparing the efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis. …”
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Fundamental Parameters for Central Stars of 103 Infrared Bow Shock Nebulae by Nikhil Patten, Henry A. Kobulnicky, Matthew S. Povich, Angelica S. Whisnant, Sydney Andrews, Alexandra Boone, Srujan Dandu, Naomi Jones, S. Nick Justice, Dylan Hope, Alexander Larsen, Ryan McCrory, Julia Meredith, Maria Renee Meza, Alexandra C. Rosenthal, William Salazar, Alexander R. Sterling, Noshin Yesmin, Daniel A. Dale

“…Stellar bow shock nebulae provide a promising means to measure wind-driven mass loss, independent of other established methods. In this work, we characterize the stellar sources at the center of bow shock nebulae drawn from all-sky catalogs of 24 μ m–selected nebulae. …”
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Bahir Dar Child Development Cross-Sectional Study, Ethiopia: study protocol by Alemayehu Worku, Yemane Berhane, Lian V Folger, Anne CC Lee, Krysten North, Nebiyou Fasil, Kalkidan Yibeltal, Fred Van Dyk, Firehiwot Workneh, Theresa I Chin, Sarah K G Jensen, Unmesha Roy Paladhi, Betelhem Haimanot Abate, Atsede Teklehaimanot, Tizita Lemma Melka, Moriah E Thomason, Terrie Inder, Patricia Ellen Grant

“…A battery of paper and tablet-based assessments of neurocognitive outcomes including visual and verbal reasoning, executive functions and school readiness will be completed for children aged 48–60 months. …”
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Investigating the Effect of Reducing the Signs and Symptoms of Lid Wiper Epitheliopathy in Patients With Dry Eye Disease With Perfluorohexyloctane by Chris Lievens, OD, MS, PhD, FNAP, FAAO, Andrew D. Pucker, OD, PhD, FAAO, Quentin Franklin, BS, Stephen M. Montaquila, OD, FAAO, Brad Giedd, OD, MS, FAAO, Gina Wesley, OD, MS, FAAO, Morgan Bromley, PhD, Zackarias Coker, MS, John Meyers, MS, Marta Vianya-Estopa, PhD

“…Objective: To examine the potential of using perfluorohexyloctane for reducing the signs and symptoms of lid wiper epitheliopathy (LWE). Methods: Data were collected at 4 visits spanning 2 months. …”
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Displacement-related stressors in a Sudanese war-affected community; identifying the impact of war exposure and ongoing stressors on trauma symptom severity: a national multi-cente... by Lina Hemmeda, Alaa S. Ahmed, Gasm Alseed Abdelmonim Gasm Alseed Fadlalmoula, Doaa Rabeie Hassan, Mohammed Haydar Awad, Gotof Salim, Abeer Osman Mukhtar Elabid, Alaa Azhary mohammed Ali, Asmaa O. Algasim, Ethar Hamad, Fatima Afif, Fatima Mustafa, Maha Rhamttallah, Mai Fathi Awadalla Alsedig, Miada Ali Mohammed Taha, Muram Ahmed Sayed Khaleel, Nazik Abdalla Nourin, Roaa Salah Eltaheir Mohieldin, Sara Ali, Shimaa Suliman, Khabab Abbasher Hussien Mohamed Ahmed

“…A structural equation model was generated to visualize the comprehensive relationship between the study variables. …”
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The Connection between Galaxy Mergers, Star Formation, and Active Galactic Nuclei Activity in the HSC-SSP by Kiyoaki Christopher Omori, Connor Bottrell, Sabine Bellstedt, Aaron S. G. Robotham, Hassen M. Yesuf, Andy D. Goulding, Marcin Sawicki, Tohru Nagao, Tsutomu T. Takeuchi

“…We quantitatively examine the merger–SFR–AGN connection using Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) galaxies using novel methods for both galaxy classification and property measurements. …”
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Retinal biomarkers for the risk of Alzheimer’s disease and frontotemporal dementia by Ruihan Wang, Jiajie Cai, Yuzhu Gao, Yingying Tang, Hui Gao, Linyuan Qin, Hanlin Cai, Feng Yang, Yimeng Ren, Caimei Luo, Shiyu Feng, Hongbo Yin, Ming Zhang, Chunyan Luo, Qiyong Gong, Xiong Xiao, Qin Chen

“…Our aim was to identify retinal biomarkers for the risk of AD and FTD in populations without dementia and explore underlying brain structural mechanisms.MethodsWe included a total of 3,0573 UK Biobank participants without dementia, ocular disorders, and diabetes who underwent baseline retinal optical coherence tomography (OCT) imaging. …”
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Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway by Ning Wang, Chengyang Sun, Yijie Yang, Dandan Zhang, Lulu Huang, Chenrui Xu, Minghan Wang, Mengmeng Xu, Tongtong Yan, Yue Wu, Li Xu, Yahan Ju, Hao Sun, Wenyi Guo

“…This study elucidates the neuroprotective role of gut microbiota derived tryptophan metabolites in glaucoma through gut-eye communication and inhibition of microglia-mediated neuroinflammation. Methods Gut microbiota profiling (16 S rRNA sequencing) and serum indoleacetic acid (IAA) quantification were performed in glaucoma patients versus controls. …”
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Meta-analysis of clinical trials of osteoarthritis treatment effectiveness with Chondroguard by I. Yu. Torshin, A. M. Lila, A. V. Naumov, A. Yu. Kochish, L. I. Alekseeva, E. A. Taskina, I. V. Sarvilina, A. N. Galustyan, A. N. Gromov, A. K. Khadzhidis, L. V. Vasilieva, E. F. Yevstratova, M. I. Udovika, O. A. Gromova

“…., EOD, course 20-30 injections) in the complex therapy of osteoarthritis (OA).Materials and Methods. Tie meta-analysis according to tie fixed-effects model included all published clinical studies on tie efficacy and safety of the CG drug in OA). …”
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Gallium Resistance in <i>Staphylococcus aureus</i>: Polymorphisms and Morphology Impacting Growth in Metals, Antibiotics and Polyfluorinated Compounds by Akamu Ewunkem, Felicia Simpson, David Holland, Tatyana Bowers, Ariyon Bailey, Ja’nyah Gore, Uchenna Iloghalu, Vera Williams, Sarah Adjei-Fremah, Larisa Kiki, Brittany Justice

“…Additionally, scanning electron microscopy (SEM) observation was utilized to visualize distinct morphological changes on the surface of gallium-resistant populations and compare with the control populations. …”
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Anti-Fibrotic Effect of Tacrolimus on Preventing Adhesion after Achilles Tendon Surgery in a Murine Model by Seyedeh Elnaz Nazari, Elnaz Ghorbani, Abdulridha Mohammed Al-Asady, Sayyed-Hadi Sayyed-Hosseinian, Farzad Rahmani, Ehsan Vahedi, Amir Avan, Mohammad-Mostafa Askarnia-Faal, Hamideh Naimi, Majid Khazaei, Seyed Mahdi Hassanian

“…This study aims to evaluate the repurposed potential of the immunosuppressive approved drug, tacrolimus, in decreasing adhesion band formation post-Achilles tendon surgeries in an animal model.Methods: Rats were randomly assigned to four groups: control, sham with surgical intervention but no adhesion, positive control group with surgical transection and adhesion received no treatment, tacrolimus group was the same as the positive control group except that rats were treated with 2 mg/Kg/day tacrolimus orally for 21 days. …”
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Atelectasis predicts poor prognosis in pediatric macrolides-unresponsive Mycoplasma pneumoniae pneumonia with A2063/2064G mutations treated with azithromycin by Jie Cheng, Ya Liu, Guangli Zhang, Yuanyuan Li, Xiaoyin Tian, Liping Tan, Zhengxiu Luo

“…ObjectiveWe aimed to investigate prognostic indicators for pediatric macrolides-unresponsive Mycoplasma pneumoniae pneumonia (MUMPP) cases with A2063/2064G mutations with azithromycin therapy.MethodsThis was a retrospective observational cohort study conducted at the Children’s Hospital of Chongqing Medical University. …”
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Tailoring Chronic Disease Interventions to Meet Specific Needs of Women: A Case Example of a Hypertension Program by Caroline A. Dancu, Julie Schexnayder, Hayden B. Bosworth, Allison Lewinski, Abigail Shapiro, Tiera Lanford, Courtney White Clark, Bevanne Bean-Mayberry, Leah L. Zullig, Jennifer M. Gierisch, Karen M. Goldstein

“…This study describes a process for tailoring existing evidence-based interventions to the biological and sociocultural determinants of health for women. Methods: This study adapted the Team-supported, Electronic Health Record (EHR)-leveraged, Active Management (TEAM) CVD preventative care intervention designed for telehealth-based remote hypertension (HTN) care in rural Veterans. …”
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Midline 1 associated with Fas signaling enhances murine antigen-induced arthritis by Nina Lukač, Nina Lukač, Darja Flegar, Darja Flegar, Sara Priselac, Tomislav Kelava, Tomislav Kelava, Alan Šućur, Alan Šućur, Maša Filipović, Maša Filipović, Dino Šisl, Dino Šisl, Martina Fadljević, Igor Radanović, Vedran Katavić, Vedran Katavić, Nives Zimmermann, Danka Grčević, Danka Grčević, Nataša Kovačić, Nataša Kovačić

“…Arthritis was scored visually, histologically and by micro-computerized tomography. …”
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Performance on the Rey-Osterrieth complex figure test and the correlation with the magnetic resonance imaging brain lesion volume in multi-infract versus small vessel disease demen... by Semnić Marija D., Semnić Robert, Nikolašević Željka, Bugarski-Ignjatović Vojislava V., Vujanić-Stankov Tijana Ž., Kostić Smiljana, Ocić Gordana, Kozić Duško

“…The importance of visuospatial, visuoconstructional deficit and impairment of visual memory is disregarded in VaD subtypes. These impairments are more severe in MID than SSVD and the deficit of ROCF copying in MID patients correlates with posterior and total MRI lesion volume.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi, Dalia Ali, Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Muhammad Atteya, Abdulaziz Siyal, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem, Nehad M. Alajez

“…Alkaline phosphatase (ALP) activity and formation of mineralized matrix visualized by Alizarin red staining were employed as markers for osteoblastic differentiation. …”
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Development and validation of a predictive nomogram for differentiating diabetic nephropathy from non-diabetic nephropathy in patients with T2DM: a multicenter study by Zishan Lin, Zishan Lin, Zishan Lin, Tao Hong, Tao Hong, Tao Hong, Wenfeng Wang, Wenfeng Wang, Wenfeng Wang, Shidong Xie, Shidong Xie, Shidong Xie, Caiming Chen, Caiming Chen, Caiming Chen, Feng Yang, Dewen Jiang, Dewen Jiang, Dewen Jiang, Jianxin Wan, Jianxin Wan, Jianxin Wan, Zugang Xie, Yanfang Xu, Yanfang Xu, Yanfang Xu

“…This multicenter study aims to develop a non-invasive diagnostic model to distinguish DN from NDN in T2DM patients.MethodsFrom January 2014 to December 2023, T2DM patients undergoing percutaneous renal biopsies at three hospitals in Fujian were enrolled. …”
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Identification of genetic mechanisms of non-isolated auditory neuropathy with various phenotypes in Chinese families by Yang Cao, Xiaolong Zhang, Lan Lan, Danyang Li, Jin Li, Linyi Xie, Fen Xiong, Lan Yu, Xiaonan Wu, Hongyang Wang, Qiuju Wang

“…This study focuses on two mitochondrial function-related genes which result in non-isolated AN, FDXR and TWNK, providing a summary and enrichment analysis of genes associated with non-isolated AN to elucidate the genotype-phenotype correlation and underlying mechanisms. Methods Seven independent Chinese Han patients with mutations in FDXR and TWNK underwent comprehensive clinical evaluations, genetic testing, and bioinformatics analyses. …”
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Topical Application of VitB6 Ameliorates PM2.5-Induced Dry Eye via NFκB Pathway in a Murine Model by Jinyu Hu, Yanmei Zeng, Liying Tang, Lei Ye, Cheng Chen, Qian Ling, Xiaoyu Wang, Liangqi He, Xu Chen, Yixin Wang, Qianmin Ge, Yi Shao

“…The aim of this experiment was to investigate the therapeutic effect of VitB6 eye drops on particulate matter 2.5 (PM2.5)-induced dry eye in mice. <b>Methods</b>: Mice induced with the dry eye group were first induced using PM2.5 eye drops in a standard environment for 14 days, and then treated with different concentrations of VitB6 eye drops for 14 consecutive days. …”
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