Assessment of sub-maximal aerobic capacity in North African patients with chronic hepatitis B: a pilot case-control study [version 2; peer review: 2 approved] by Houda Chaouch, Imed Latiri, Jihene Bergaoui, Sawssen MRAD, Helmi Ben Saad, Samia Ernez Hajri, Jihene Ben Abdallah, Salma Amous

“…This study aimed to evaluate sub-maximal aerobic capacity in CHB patients compared to apparently healthy participants (control-group (CG)). Methods A 6-min walk test (6MWT) was performed. The 6-min walk distance (6MWD) was recorded, along with heart-rate (HR), oxy-hemoglobin saturation (SpO2), blood-pressure, and dyspnea ( ie ; visual analogue scale) at rest (Rest) and at the end (End) of the 6MWT. …”
Get full text

Optical Coherence Tomography Angiography Changes in Diabetic Macular Ischemia after Systemic Normobaric Oxygen Therapy by Diba Idani, Seyed Mohammadjavad Mashhadi, Hamze Babaei, Farideh Sharifipour, Ramin Nourinia, Bahareh Kheiri, Arezoo Miraftabi

“… Purpose: To evaluate vascular changes on optical coherence tomography angiography (OCTA) in patients with diabetic macular ischemia (DMI) after systemic normobaric oxygen (NBO) therapy. Methods: This before–after interventional study included 26 eyes of 26 patients with DMI. …”
Get full text

Global burden of breast cancer and application of patient-reported outcomes in clinical trials: a systematic analysis based on the global burden of disease study 2021 and WHO inter... by Jiaxin Hao, Jiaxin Hao, Yijia Gong, Yijia Gong, Xiaowen Zhang, Xiaowen Zhang, Xiaowen Zhang, Minghong Du, Minghong Du, Minghong Du, Huan Wang, Huan Wang, Huan Wang, Guolin Guo, Mengqing Zhou, Tian Tian, Hongguo Rong, Hongguo Rong, Hongguo Rong

“…This study aims to evaluate the global burden and the application of patient-reported outcomes (PROs) in clinical trials of breast cancer.MethodsData of breast cancer burden is extracted from the Global Burden of Disease Study (GBD) 2021 database. …”
Get full text

Integrating Transcriptomic and Proteomic Data: IL‐27B as a Key Protein in the Development of Septic Cardiomyopathy—A Retrospective Study by Yifeng Mao, Qingqing Chen, Yongpo Jiang, Xijiang Zhang, Qin Si, Panpan Xu, Zhongheng Zhang, Cheng Zheng, Ronghai Lin

“…In this study, transcriptomic and proteomic analyzes of serum samples from sepsis patients were conducted to uncover the underlying pathological mechanisms and identify potential therapeutic targets for SCM. Methods This retrospective, dual‐center study investigated the progression of sepsis to SCM in patients admitted to intensive care units. …”
Get full text

Acute Pharmacological Effects of Two Synthetic Cathinones in Humans: An Observational Study of <i>N</i>-Ethylhexedrone and <i>N</i>-Ethyl-nor-pentedrone by Melani Núñez-Montero, Clara Pérez-Mañá, Olga Hladun, Lourdes Poyatos, Dolly Andrea Caicedo, Georgina De la Rosa, Martha Catalina Argote, Soraya Martín, Mireia Ventura, Nunzia La Maida, Annagiulia Di Trana, Silvia Graziano, Simona Pichini, Magì Farré, Esther Papaseit

“…However, still, little is known with regard to their pharmacological effects in humans. <b>Methods</b>: For the first time, we conducted a naturalistic, prospective observational study in 16 participants (7 women and 9 men) with a previous history of psychostimulant recreational use. …”
Get full text

Scope of practice of primary care nurses: a protocol for an umbrella review of international literature by Kris Aubrey-Bassler, Marie-Ève Poitras, Shabnam Asghari, Michelle Swab, Lindsay Hedden, Maria Mathews, Ruth Martin-Misener, Elizabeth J Halcomb, Julia Lukewich, Leslie Meredith, Dana Ryan, Suzanne Braithwaite, Danielle Macdonald, Kathleen Leslie, Anaelle Morin, Monica McGraw, Patrick Chiu, Émilie Dufour, Sophia Myles, Annie Rioux-Dubois, Deanne Curnew, Jen Calver, Jill Bruneau

“…We will synthesise data from included studies in a detailed literature review table and develop visual aids to communicate the shared and unique roles and activities of PCN scope of practice. …”
Get full text

AI-driven MRI analysis reveals brain atrophy patterns in benign relapsing-remitting multiple sclerosis by M. Niiranen, M. Niiranen, P. Bendel, P. Bendel, J. Koikkalainen, J. Lötjönen, T. Selander, E. Solje, E. Solje, P. Hartikainen, S. Simula, R. Vanninen, R. Vanninen, A. M. Portaankorva

“…In this study, we aimed to investigate the brain atrophy patterns related to benign relapsing-remitting MS (BRRMS), particularly regarding location and extent.MethodsWe analyzed global and regional gray matter (GM) and white matter (WM) volumes, WM lesion load, corpus callosum index (CCI) and corpus callosum area (CCA) in well-defined benign relapsing-remitting MS patients (BRRMS, n = 35) compared to healthy controls (HC, n = 35). …”
Get full text

Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial CellsSUMMARY by Siyuan Ma, Nawras W. Habash, Mrunal K. Dehankar, Nidhi Jalan-Sakrikar, Shawna A. Cooper, Abid A. Anwar, Sofia Jerez, Papawee Sutthirat, Jinhang Gao, Tamir Diamond, Jing Jiao, Caixin Qiu, Jingchun Yang, Sumera I. Ilyas, Markcus Lee, Usman Yaqoob, Sheng Cao, Rebecca G. Wells, Vijay H. Shah, Moira B. Hilscher

“…We studied spatial changes in immune cells in the sinusoid that contribute to congestive fibrosis and portal hypertension (PHTN). Methods: To visualize the distribution of immune cells in congestive hepatopathy (CH), we performed imaging mass cytometry (IMC) on liver tissue from patients with CH, Fontan-associated liver disease (FALD), and controls. …”
Get full text

End-to-end deep fusion of hyperspectral imaging and computer vision techniques for rapid detection of wheat seed quality by Tingting Zhang, Jing Li, Jinpeng Tong, Yihu Song, Li Wang, Renye Wu, Xuan Wei, Yuanyuan Song, Rensen Zeng

“…These findings were further supported by external samples and visualizations. The proposed end-to-end decision fusion DCNN model simplifies the training process compared to traditional two-stage fusion methods. …”
Get full text

Impact of IYCF practices, as measured by national nutrition surveys from 2018 to 2022, on stunting and under-5 survival in Burkina Faso: a LiST analysis by Natacha Kere, Ella W. R. Compaore, Ella W. R. Compaore, Youssouf Keita, Daniel S. Ouedraogo, Souleymane Tirogo, Estelle A. Bambara, Z. Thierry Coulibaly, Mamoudou H. Dicko

“…This study aims to assess the impact of these interventions on the nutritional status of children aged 0–5 years between 2018 and 2022.MethodsThis study is a modeling of the impact of changes in the coverage of interventions with known effect sizes, using the LiST (Lives Saved Tool). …”
Get full text

Comparative efficacy and safety of anti-HGF/MET pathway agents plus chemotherapy versus chemotherapy alone as first-line treatment in advanced gastric cancer: a protocol for a syst... by Chunyu Liu, Bo Zhang, Zhiyuan Jiang, Zhaolun Cai, Yuan Yin, Chaoyong Shen, Qin Ma, Xiaonan Yin, Chen Chang, Zhou Zhao, Mingchun Mu

“…Statistical heterogeneity will be assessed by visual inspection of forest plots and measured using the I2 statistics. …”
Get full text

Attention Performance and Altered Amplitude of Low-frequency Fluctuations in the Attention Network of Patients with MCI: A Resting-state Functional MRI Study by Jia Luo, Yi Zeng, Yuwei Ye, Yiping Xiao, Qiurong Xie, Jijing Zhang, Weilin Cai, Huanyun Xu, Shengxiang Liang, Jia Huang

“…Background: This study aimed to explore attention alteration in mild cognitive impairment (MCI) patients and their association with abnormalities of autonomic brain activity within the attention network to reveal the neuroimaging basis behind these changes. Methods: A total of 25 MCI patients and 31 normal controls (NCs) were recruited for the study. …”
Get full text

Treatment effects of human amnion-derived mesenchymal stem cells for skin lesions and metastatic pulmonary calcification in calciphylaxis patients – case series and literature revi... by Shijiu Lu, Ming Zeng, Fan Li, Chun Ouyang, Jingjing Wu, Jiaying Hu, Yanggang Yuan, Hongqing Cui, Yi Xu, Wei Liu, Ling Zhang, Yan Lu, Zhonglan Su, Xiaoxue Ye, Cui Li, Anning Bian, Chunyan Jiang, Yugui Cui, Xiang Ma, Song Ning, Xiaolin Lv, Ling Wang, Jiahui Yang, Xiuqin Wang, Ningxia Liang, Changying Xing, Jiayin Liu, Lianju Qin, Ningning Wang

“…Background Calciphylaxis, also termed calcific uremic arteriolopathy (CUA) in patients with end-stage kidney disease (ESKD), is a rare and fatal condition characterized by cutaneous ischemic necrosis.Methods Three patients with calciphylaxis and metastatic pulmonary calcification (MPC) were treated with human amnion-derived mesenchymal stem cells (hAMSCs). …”
Get full text

Clinical observation of the effectiveness of radiofrequency ablation on improving internal hemorrhoidal bleeding symptom by Zhu Zhihong, Cao Mohan, Wang Zhimin, Li Tao, Wu Guoliang, Wu Xianhai, Yang Tengteng

“…[Objectives] To investigate the clinical effectiveness of radiofrequency ablation (RFA) on improving internal hemorrhoidal bleeding symptom. [Methods] A total of 160 patients with internal hemorrhoidal bleeding symptom treated at Shandong Second Provincial General Hospital and The First Affiliated Hospital of Shandong First Medical University from June 2022 to March 2023 were enrolled. …”
Get full text

Telemedicine for under-resourced patients with systemic lupus erythematosus: a qualitative study exploring the views and experiences of patients and their healthcare team by Savannah Bowman, Sandeep K. Agarwal, Keshia C. Ferguson, Maryjo J. Maliekel, Maria A. Lopez-Olivo, Maria E. Suarez-Almazor, Maria I. Danila, Maria I. Danila, Jinoos Yazdany, Sebastian Bruera

“…Themes and subthemes were identified and visualized.ResultsFourteen interviews were conducted. …”
Get full text

Model of superior semicircular canal dehiscence: asymmetrical vestibular dysfunction induces reversible balance impairment by Sean S. Hong, P. Ashley Wackym, P. Ashley Wackym, Damian J. Murphy, Eran Peci, Matthew Y. Kiel, Aaron Tucker, Nicolas L. Carayannopoulos, Shrivaishnavi C. Chandrasekar, Nikhil Suresh, Umut A. Utku, Justin D. Yao, Justin D. Yao, Todd M. Mowery, Todd M. Mowery

“…In this study, we completed our assessment of this model to include reversible asymmetrical vestibular impairments that interfere with balance.MethodsAdult Mongolian gerbils (N = 6) were trained to complete a balance beam task. …”
Get full text

Quality of Life and Well‐Being in Adults With Fontan Physiology: Findings From the Australian and New Zealand Fontan Registry Quality of Life Study by Kate H. Marshall, Yves d'Udekem, David S. Winlaw, Diana Zannino, David S. Celermajer, Robert Justo, Ajay Iyengar, Rachael Cordina, Gary F. Sholler, Susan R. Woolfenden, Nadine A. Kasparian

“…Background To characterize global and health‐related quality of life (QOL) among adults with Fontan physiology enrolled in the Australian and New Zealand Fontan Registry (ANZFR), and identify sociodemographic, clinical, psychological, and relational factors associated with outcomes. Methods and Results Using a cross‐sectional survey design, 66 adults with Fontan physiology (58% women; mean age, 29.6±7.7 years; range, 18–50 years) completed validated self‐report measures. …”
Get full text

An evidence map on traditional medicine across health outcomes by Lin Ang, Eunhye Song, Miek C Jong, Terje Alræk, Barbara Wider, Tae-Young Choi, Ji Hee Jun, Boram Lee, Yujin Choi, Hye Won Lee, Changsop Yang, Mi Hong Yim, Hitoshi Yamashita, Zhaochen Ji, Haiyin Hu, Junhua Zhang, Jianping Liu, Yaolong Chen, Yishan Qin, Liming Lu, Fan Qu, Odd-Magne Hansen, Chan-Young Kwon, Jungtae Leem, Hyangsook Lee, Tae-Hun Kim, Kun Hyung Kim, Sunju Park, Ye-Seul Lee, Soobin Jang, Jiyoon Won, Jiae Choi, Juah Lee, Song-Yi Kim, Myeong Soo Lee

“…This study aimed to map systematic reviews (SRs) of TM modalities across health conditions and identify gaps in the research literature to facilitate priority setting in future TM research. Methods: We searched 17 databases from January 2018 to December 2022. …”
Get full text

Bioactive natural alkaloid 6−Methoxydihydrosanguinarine exerts anti−tumor effects in hepatocellular carcinoma cells via ferroptosis by Linfen Han, Linfen Han, Chengchang Gao, Xiaorui Jin, Yingping Li, Liangjie Chen, Donglin Li, Qinqin Deng, Xueli Bian, Xueli Bian

“…Natural active compounds have great potential in cancer treatment.MethodsThe impact of 6-ME on the cell viability of HCC cells was assessed using the Cell Counting Kit-8 (CCK‐8) assay and colony formation assay. …”
Get full text

N-Glycoside of Indolo[2,3-<i>a</i>]pyrrolo[3,4-<i>c</i>]carbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell Cycle Arrest and CDK1 Activity Modulation: Molecular Docking S... by Nikolay Kalitin, Natalia Koroleva, Anna Lushnikova, Maria Babaeva, Nadezhda Samoylenkova, Ekaterina Savchenko, Galina Smirnova, Yulia Borisova, Alexander Kostarev, Aida Karamysheva, Galina Pavlova

“…Mitotic figures were visualized by fluorescence microscopy. Quantitative RT-PCR was used to evaluate the gene expression. …”
Get full text