Human Pharmacokinetics and Adverse Effects of Pulmonary and Intravenous THC-CBD Formulations by Pascale Meyer, Manuela Langos, Rudolf Brenneisen

“… Background: Due to variable absorption and extensive first-pass metabolism, the bioavailability of oral delta-9-tetra­hydrocannabinol (THC) and cannabidiol (CBD) is low, and, therefore, alternative application forms are necessary. Methods: In an open-label, 2-period phase-1 study on 11 healthy volunteers, a combination of THC and CBD was compared by pulmonary (inh) and intravenous (iv) application. …”
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Correlation Analysis of Macular Function and Peripapillary Retinal Nerve Fiber Layer Thickness Following Successful Rhegmatogenous Retinal Detachment Surgery by María D. Díaz-Barreda, Ana Boned-Murillo, Isabel Bartolomé-Sesé, María Sopeña-Pinilla, Elvira Orduna-Hospital, Guisela Fernández-Espinosa, Isabel Pinilla

“…<b data-eusoft-scrollable-element="1">Objectives:</b> In this study, the objective was to assess the correlation between macular function and peripapillary retinal nerve fiber layer (pRNFL) thickness following successful rhegmatogenous retinal detachment (RRD) surgery, as well as the subsequent recovery of visual acuity. <b data-eusoft-scrollable-element="1">Methods</b>: This was a cross-sectional study including 64 eyes from patients with RRD who underwent successful treatment with 23G pars plana vitrectomy (PPV), endophotocoagulation and sulfur-hexafluoride (SF6) were included and compared to a control group consisting of 136 healthy eyes. …”
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All-inside arthroscopic repair of ATFL and CFL separately for chronic lateral ankle instability in conjunction with subtalar instability by Weiwei Mao, Zhigao Jin, Wei Li, Ying Zhu, Weiqi Kong, Ying Wang, Jianzhong Qin

“…This study aimed to evaluate the clinical importance of CFL repair by comparing the outcomes of isolated ATFL repair versus combined ATFL and CFL repair. Methods A retrospective cohort study was conducted involving patients diagnosed with CLAI in conjunction with STI from January 2018 to January 2022. …”
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The influence of baseline platelet on mortality risk in stroke and cancer patients: a cross-sectional analysis of the NHANES database by Yuqi Pei, Wei Ouyang, Peiyun Qi, Zhongjie Yan, Yaoru Li, Xiangjian Zhang, Cong Zhang, Lili Cui

“…This study aimed to examine the association between baseline platelet level and all-cause mortality in this population using a cross-sectional analysis. Methods Participants with a history of stroke and cancer were selected from the database of the National Health and Nutrition Examination Survey from 2007 to 2018. …”
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Structural–functional coupling abnormalities in temporal lobe epilepsy by Xiaoting Huang, Yangsa Du, Danni Guo, Fangfang Xie, Chunyao Zhou

“…The objective of this study was to evaluate the coupling of structural connectivity (SC) and functional connectivity (FC) in the entire brain of healthy controls (HCs), and to investigate modifications in SC–FC coupling in individuals suffering from temporal lobe epilepsy (TLE).MethodsWe evaluated 65 patients with TLE matched for age and gender with 48 healthy controls. …”
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Russian nonverbal communication in teaching representatives of different cultures by Radif R. Zamaletdinov, Galina S. Kalinina, Gulshat Kh. Zinnatullina

“…The second block contains a series of visual tasks with pictures of Russian gestures typical for different communication intensions and variants of their semantic interpretation. …”
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Long-term multicenter observational study of the drug Alflutop in Russia: use in patients with knee osteoarthritis (report 4) by E. A. Taskina, L. I. Alekseeva, N. G. Kashevarova, A. M. Lila

“…Objective: to investigate the efficacy of Alflutop therapy in patients with knee osteoarthritis (OA) with or without concomitant diseases. Material and methods. The large-scale, multicenter prospective, open-label, observational, non-interventional ISKRA study (Study: Prescribing the drug Alflutop, solution for injection, for OA in real world clinical practice) included 22,525 patients, 10,616 of whom had knee OA. …”
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Efficacy and safety of carbon dioxide versus room-air insufflation in pediatric colonoscopy: a randomized controlled trial by Ajay Aravind, Ujjal Poddar, Anshu Srivastava, Moinak Sen Sarma

“…Purpose This study investigated the efficacy and safety of CO2 insufflation in children undergoing colonoscopy. Methods This prospective randomized clinical trial was conducted at a tertiary care hospital between March 2023 and July 2024. …”
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Effectiveness of cold vibratory stimuli on pain perception governing infiltration anesthesia in the maxillary arch in children: a randomized controlled clinical trial by Hoda Mohamed Hambouta, Dina Aly Sharaf, Nadia Aziz Wahba

“…In addition, it aimed to evaluate its effectiveness in intrapapillary anaesthesia in comparison to the conventional palatal injection following buccal infiltration anaesthesia. Methods Randomized controlled clinical trial with parallel arms. …”
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Minimal clinically important difference for chest discomfort in patients undergoing pleural interventions by Fabien Maldonado, Greta Jean Dahlberg, Heidi Chen, Otis Rickman, Lance Roller, Charla Walston, James Katsis, Robert Lentz

“…The MCID for chest discomfort in patients undergoing pleural interventions has not been determined.Methods Prospectively collected data from two recent randomised trials of therapeutic thoracentesis were used for this investigation. …”
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Total Arthroscopic Resection of the Talocalcaneal Coalition in Adults: Key Points of Surgical Technique by Yiyuan Sun, Wufeng Cai, Xihao Huang, Jian Li, Qi Li

“…The purpose of this study was to retrospectively evaluate the effectiveness and safety of endoscopic resection of the TCC. Methods A retrospective study from June 2019 to February 2023was conducted on 16 consecutively admitted patients who were diagnosed by imaging to have TCC for whom conservative treatment had failed and who undergone arthroscopic resection. …”
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Intraarticular injection of the stromal vascular fraction for the treatment of knee osteoarthritis a prospective randomized controlled clinical trial by Junyue Lu, Tianshan Wen, Haoyuan Huang, Chen Xie, Jiliang Kang, Jiahao Huang, Jiaxuan Hu, Tianyu Wu, Youliang Wen

“…The results of this study indicate that SVF intra-articular injection alone or in combination with conventional rehabilitation methods can significantly improve pain, knee function, and stiffness in KOA patients, with the therapeutic effects continuing to increase over a 12-month period. …”
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A Machine Learning Approach Using Topic Modeling to Identify and Assess Experiences of Patients With Colorectal Cancer: Explorative Study by Kelly Voigt, Yingtao Sun, Ayush Patandin, Johanna Hendriks, Richard Hendrik Goossens, Cornelis Verhoef, Olga Husson, Dirk Grünhagen, Jiwon Jung

“…ObjectiveThis study aims to identify and assess patient experiences on a large scale using a novel machine learning–supported approach, leveraging data from patient forums. MethodsForum posts of patients with colorectal cancer (CRC) from the Cancer Survivors Network USA were used as the data source. …”
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Subtalar arthroereisis for simultaneous treatment of flexible pes planus during surgical correction of hallux valgus by Fan Yang, Chenglin Wu, Jiazheng Wang, Guohua Mei, Jian Zou, Jianfeng Xue, Yan Su, Xin Ma, Jieyuan Zhang, Zhongmin Shi

“…This study aimed to evaluate the effectiveness of simultaneous correction of hallux valgus and flexible pes planus. Methods A total of 85 feet with hallux valgus associated with adult flexible pes planus were retrospectively reviewed. …”
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Factors Associated With Delay in Seeking Abortion Care Until the Second Trimester at Jimma University Medical Centre: A Prospective Cross‐Sectional Study Jimma, Southwest Ethiopia... by Taju Abdi, Fanta Assefa, Dejene T. Debela

“…This study identified factors associated with delays in seeking an abortion until the second trimester at Jimma Medical Centre, Jimma, southwest Ethiopia. Methods From February to August 2023, we conducted a cross‐sectional study on pregnant women seeking safe abortion care. …”
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Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 1; peer review: 1 approved, 2 appro... by Mohammad Nayel Aqil Khan, Zaina Zahur Ahmed, Kalyana Chakravarthy Bairapareddy

“…This study aimed to determine the effectiveness of telerehabilitation exercise intervention in females with chronic non-specific neck pain by measuring the pain score, disability index, cervical range of motion (CROM), cervical muscle endurance, and patient adherence. Methods In this pilot randomized controlled trial, 31 females (mean age 22.7 ± 2.1 years) were given a 6-week home-based exercise programme based on their assigned group: telerehabilitation (TR) – online software or conventional (CG) – exercise manual. …”
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Arthroscopic Anterior Cuciate Ligament Reconstruction Using Neither a Tourniquet nor Drainage: A Perioperative Case Series Report by Dimitrios A. Flevas, Michail Sarantis, Georgios Tsakotos, Grigorios G. Sasalos, Anastasios V. Tokis

“…No cases experienced visual impairment or required ischemia to enhance visibility. …”
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Preservation of the infrapatellar fat pad during total knee arthroplasty reduces subacute postoperative anterior knee pain: a randomized controlled trial by Pruk Chaiyakit, Bunpreedee Petcharat, Ittiwat Onklin

“…The objective of this randomized controlled trial (RCT) was to compare the incidence of AKP between IPFP preservation and partial excision of the IPFP. Methods This prospective RCT included patients with primary varus gonarthrosis < 20° who underwent unilateral computer-assisted TKA between March 2019 and November 2020. …”
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THE PREVALENCE AND CLINICAL FEATURES OF GOUT AND CALCIUM PYROPHOSPHATE DEPOSITION DISEASE IN PATIENTS WITH ACUTE ARTHRITIS by M. S. Eliseev, S. A. Vladimirov

“…Objective: to study the rate of gout and calcium pyrophosphate deposition disease (CPDD) and to provide their clinical characteristics in patients with acute arthritis.Subjects and methods. The investigation enrolled 150 patients (97 men and 53 women) with acute mono- or oligoarthritis of no more than 2 weeks’ duration who had visited the Outpatient Department of V.A. …”
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Clinical manifestations of Rift Valley fever in humans: Systematic review and meta-analysis. by Zacchaeus Anywaine, Swaib Abubaker Lule, Christian Hansen, George Warimwe, Alison Elliott

“…We reviewed and analysed the clinical manifestations of RVF in humans.<h4>Methods</h4>In this systematic review and meta-analysis we searched on different dates, the Embase (from 1947 to 13th October 2019), Medline (1946 to 14th October 2019), Global Health (1910 to 15th October 2019), and Web of Science (1970 to 15th October 2019) databases. …”
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