Therapeutic outcomes of enzalutamide-docetaxel combination versus docetaxel monotherapy in post-sequential androgen receptor axis-targeted therapy failure metastatic castration-res... by Zhiyu Zhang, Yanhang Yu, Chuanao Zhang, Jianglei Zhang, Xuefeng Zhang, Jun Ouyang

“…ObjectiveThis study aimed to evaluate the therapeutic efficacy and adverse effects of combining enzalutamide with docetaxel versus using docetaxel alone in treating metastatic castration-resistant prostate cancer (mCRPC) that progresses after treatment with abiraterone followed by enzalutamide.MethodsA retrospective analysis involved 67 mCRPC patients at the First Affiliated Hospital of Soochow University’s Urology Department between October 2021 and August 2023. …”
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Post-operative Analgesia with Intraperitoneal Bupivacaine Alone and with Dexmedetomidine Following Laparoscopic Cholecystectomy by Anees Ahmad, Ambreen Khan, Syed Shakeel Ahmed, Saima Noreen, Mohammad Idrees, Shahryar

“…This study aimed to compare the mean duration of analgesia (DOA) of intraperitoneal bupivacaine (BPV) with dexmedetomidine (DEX) to intraperitoneal BPV alone in patients undergoing LC. Methods: This randomized controlled trial was done at the Department of Anesthesiology, Bahawalpur Victoria Hospital, Bahawalpur, Pakistan, from October 2023 to March 2024. …”
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Refractive Errors in Children with Retinoblastoma by S. V. Saakyan, A. Iu. Tsygankov, S. S. Tadevosyan, A. A. Makarova, L. V. Kogoleva, R. A. Tatskov

“…Analysis of refractive errors’ frequency in children with retinoblastoma.Patients and Methods. A retrospective study included 57 children with retinoblastoma (31 male and 26 female) who received treatment in 2013–2017. …”
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Examining the impact of rhythmic breathing and progressive muscle relaxation on acute pain following inguinal hernia repair: a parallel randomized clinical trial by Hosein Bagheri, Mobin Mottahedi, Seyedeh Solmaz Talebi, Sara Mehralizade, Hossein Ebrahimi

“…The purpose of this study was to examine the effects of PMR and RB on postoperative pain following repair of inguinal hernia. Methods This parallel randomized controlled trial was conducted to examine 120 patients in the age range of 18 to 75 years with inclusion criteria: Repair of Inguinal Hernia under general anesthesia and no addiction to drugs and narcotics. …”
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Changes in Macular Pigment Optical Density and Serum Lutein Concentration in Japanese Subjects Taking Two Different Lutein Supplements. by Akira Obana, Masaki Tanito, Yuko Gohto, Shigetoshi Okazaki, Werner Gellermann, Paul S Bernstein

“…<h4>Purpose</h4>To investigate macular pigment optical density (MPOD) and serum concentration changes of lutein in Japanese subjects participating in a clinical trial in which two formulations of lutein and zeaxanthin supplements with different physiochemical properties are used.<h4>Methods</h4>Thirty-six healthy volunteers were recruited into this prospective, randomized, parallel-group, double-masked comparative study at a single institute. …”
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Steroid versus steroid plus ozone during posterior epiduroscopy in the treatment of lumbar herniated disc: results of a 1-year follow-up study by Derya Bayram, Dostali Aliyev, İbrahim Aşık

“…The objective of this study was to evaluate the effects of the steroids alone or steroids plus ozone during epiduroscopy for chronic low back and radicular lower extremity pain. Methods The files of 76 individuals with chronic lumbar and lower extremity pain who had undergone posterior epiduroscopy were analyzed. …”
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Impact of robotic-assisted versus video-assisted thoracoscopic surgery on efficacy and quality of life in patients with pulmonary opacities: a propensity score-matched analysis by Liuchun Huang, Shengjing Liang, Jing He, Junqi Qin, Jiaping Wei, Jianwei Huang, Shucong Peng, Xianglan Chen, Chunhui Pan, Huifang Pen, Yu Wen, Yifan Zhou, Yonglong Zhong

“…While debates persist regarding the comparative efficacy and postoperative quality of life (QOL) between robot-assisted thoracoscopic surgery (RATS) and video-assisted thoracoscopic surgery (VATS), this study aimed to compare the perioperative outcomes and postoperative QOL between RATS and VATS in patients with pulmonary opacities.MethodsA retrospective analysis was performed on patients who underwent pulmonary opacities resection at the Department of Thoracic Surgery, Guangxi Zhuang Autonomous Region People’s Hospital, between January 2021 and November 2024. …”
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Abstract 127: Delayed Thrombectomy In A Patient With Recurrent MCA Strokes by Pradeep Joseph, Ivo Bach, Priyank Khandelwal

“…Introduction Prior research has demonstrated mechanical thrombectomy (MT) to be a safe and effective treatment for stroke patients with a large vessel occlusion (LVO).1 However, MT has generally only been studied in a time window of less than 24 hours.2 To the best of the authors' knowledge, this case report is the first publication of a MT done months after the initial stroke event, in a patient with recurrent strokes and an evolving occlusion visualized in the middle cerebral artery (MCA). Methods The patient is a 55‐year‐old man with a past medical history of a left‐sided MCA stroke 2 months prior to current admission with multiple transient ischemic attacks (TIAs) on dual antiplatelet therapy (DAPT), with no persistent residual deficits. …”
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Social prescribing for children and young people with neurodisability and their families initiated in a hospital setting: a systematic review by Katie Gordon, Anna Purna Basu, Laura Gordon

“…We undertook a review of hospital-initiated SP for CYP with neurodisability.Design Systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance and using Mixed Methods Appraisal Tool.Data sources Medline, PsycINFO, PsycARTICLES, Embase, CINAHL, Scopus, Web of Science and FutureNHS, searched from 1 January 2000 to 19 October 2023, with no language restrictions.Eligibility criteria Studies describing SP interventions for CYP (ages 0–25 years) with neurodisability/neurodivergence. …”
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A fusion analytic framework for investigating functional brain connectivity differences using resting-state fMRI by Yeseul Jeon, Jeong-Jae Kim, SuMin Yu, Junggu Choi, Sanghoon Han, Sanghoon Han

“…Nonetheless, interconnections among ROIs provide essential insights into brain activity and exhibit unique characteristics across groups.MethodsTo address these challenges, we propose an interpretable fusion analytic framework to identify and understand ROI connectivity differences between two groups, revealing their distinctive features. …”
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Modulation of Neurturin Expression by Lumbosacral Spinal Stenosis, Lifestyle Factors, and Glycemic Dysregulation by Małgorzata Sobańska, Dawid Sobański, Rafał Staszkiewicz, Paweł Gogol, Damian Strojny, Tomasz Pawłaszek, Werner Dammerman, Beniamin Oskar Grabarek

“…Neurturin (NRTN), a member of the glial cell line-derived neurotrophic factor family, has emerged as a potential mediator of neural plasticity and nociception, but its role in spinal stenosis is largely unexplored. <b>Methods</b>: We analyzed <i>NRTN</i> mRNA and protein expression in ligamentum flavum samples from 96 patients undergoing surgery for LSS and 85 non-degenerative postmortem controls. …”
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Dynamic neurocognitive adaptation: A follow‐up exposome investigation in aging by Filippo Cieri, Chad Lee Cross, Giulia Di Francesco, Jessica Zoe Kirkland Caldwell

“…Validated tools for measuring environmental factors, with precision equal to that of current biological and genetic assessment tools, are currently lacking. METHODS We used the dynamic Neurocognitive Adaptation (dNA) scale, our validated tool to explore protective factors in AD, in 410 older adult participants (50% women). …”
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Comparison of the efficacy of ultrasound-guided dextrose 25% hypertonic prolotherapy and intra-articular normal saline injection on pain, functional limitation, and range of motion... by Alireza Teymouri, Nafiseh Birang, Maryamsadat Fakheri, Aref Nasiri

“…In this randomized controlled trial (RCT), we aimed to compare DPTx with intra-articular normal saline injection (IA-NS) to treat knee OA in terms of effectiveness and patient-reported outcomes. Methods The study was a double-blind RCT with an allocation ratio of 1:1. …”
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Psychological readiness for return to sport following distal femoral osteotomy in patients with recurrent patellar instability by Maximilian Hinz, Peter Rab, Moritz Brunner, Marco-Christopher Rupp, Armin Runer, Luca Grüning, Lisa Rahn, Sebastian Siebenlist, Andrea Achtnich

“…The purpose of this study was to investigate the influence of psychological factors on the return to the preoperative level of sports and knee function in patients with complex PFI who were treated with distal femoral osteotomy (DFO). Methods Patients who underwent DFO for recurrent PFI associated with increased femoral antetorsion and/or valgus malalignment were included. …”
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Assessing the Dissemination of Federal Risk Communication by News Media Outlets During Enteric Illness Outbreaks: Canadian Content Analysis by Hisba Shereefdeen, Lauren Elizabeth Grant, Vayshali Patel, Melissa MacKay, Andrew Papadopoulos, Leslie Cheng, Melissa Phypers, Jennifer Elizabeth McWhirter

“…Data were tabulated and visualized using RStudio (Posit). ResultsNews media communicated about almost all PHNs (44/46, 96%). …”
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Clinical Deformity Correction Following Minimally Invasive Akin Osteotomy Fixated with Single 2.5mm Screw, A Prospective Study by Austin Alecxih MD, Tyler Goodwin MD, Joseph Duff MD, Dillon Morrow MD, Andrew Wilson BS, Jesse Doty MD

“…Patient demographics, visual analog scales, and patient-reported outcome measures were compiled. …”
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Prevalence and functional impact of flexible flatfoot in school-aged children: a cross-sectional clinical and postural assessment by Saleh M. Kardm, Ziad Ahmed Alanazi, Tariq Abdullah S. Aldugman, Ravi Shankar Reddy, Ajay Prashad Gautam

“…Objectives This study aimed to (1) determine the prevalence of flexible flatfoot among children aged 6–12 years using standardized clinical criteria and the Foot Posture Index-6 (FPI-6); and (2) evaluate its functional implications by analyzing associations with pain intensity, physical activity levels, and body mass index (BMI). Methods A cross-sectional clinical study was conducted among 326 school-aged children. …”
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Strategy of Surgical Treatment of Patients with Pigment Dispersion Syndrome and Myopia by S. N. Sakhnov, O. A. Klokova, P. A. Karagodina, T. I. Arlanova, A. A. Leonova

“…Purpose: to conduct a prospective study of the results of surgical treatment of patients with pigment dispersion syndrome and complex myopic astigmatism. Materials and methods. As a result of a comprehensive examination of 10453 adult primary patients with complex myopic astigmatism, the diagnosis of pigment dispersion syndrome was made in 99 patients (0.94 %). …”
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IMPACT OF AGE ON THE COST-EFFECTIVENESS OF FACET AND SACRAL EPIDURAL BLOCKS by MARíLIA DE JESUS NOGUEIRA, ANDERSON GOMES MARIN, MARIANA DEMéTRIO DE SOUSA PONTES, CHRISTIANO CRUZ DE ANDRADE LIMA, CARLOS FERNANDO PEREIRA DA SILVA HERRERO

“…ABSTRACT Objective: To evaluate the cost-effectiveness of combining sacral epidural block with foraminal block in the treatment of degenerative lumbar spine diseases and compare it with patient age. Materials and Methods: This is a retrospective cohort study. A total of 47 patients with degenerative lumbar spine disease associated with radiating leg pain were included. …”
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Analysing Open-source Images to Assess Face Mask Usage for Epidemiological Studies by Dr Hang Ding, Mrs Ashley Quigley, Professor Raina MacIntyre

“…This study aims to develop and validate an Artificial Intelligence (AI) solution to automatically analyse open-source crowd photos for estimation of mask use. Methods: Our AI solution includes four analysis stages: 1) detecting individual faces on a given image, 2) excluding unusable (blurry or occluded) face images, 3) classifying face images with or without a mask, and 4) identifying the indoor or outdoor environment. …”
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