Safety and feasibility of deep brain stimulation of the anterior cingulate and thalamus in chronic refractory neuropathic pain: a pilot and randomized study by Denys Fontaine, Aurélie Leplus, Anne Donnet, Nelly Darmon, Anne Balossier, Bruno Giordana, Benoit Simonet, Petru Isan, Jean Regis, Michel Lanteri-Minet

“…Changes on pain intensity (Visual Analogic Scale) and quality of life (EQ-5D scale) were used to evaluate DBS efficacy. …”
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Serum Interleukin-17 and Its Association with Inflammation and Bone Remodeling in Rheumatoid Arthritis and Hand Osteoarthritis: Insights from Musculoskeletal Ultrasound by Amany M. Ebaid, Essam Atwa, Mohamed A. Mortada, Hibah Abdulrahim Bahri, Noura Almadani, Noha M. Hammad

“…<b>Objectives</b>: The objective of this study was to evaluate the relationship between interleukin-17 (IL-17) serum levels, musculoskeletal ultrasound (MSUS) observations, and clinical disease activity in patients with rheumatoid arthritis (RA) and hand osteoarthritis (OA). <b>Methods</b>: This case–control study involved 120 participants, with 40 individuals assigned to each of the three groups: RA, OA, and control. …”
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Clinic and diagnosis of encephalopathy of critical conditions in children with infectious diseases by E. S. Egorova, A. V. Klimkin, A. A. Vilnits, N. V. Skripchenko, V. B. Voitenkov, Yu. P. Vasilyeva, M. A. Bedova

“…Purpose: to assess the functional state of the brain in critically ill encephalopathy in children with infectious diseases.Materials and methods: 75 patients aged from 1 month to 17 years 11 months with infectious diseases, who were in the intensive care unit of the clinic, were examined, divided into two groups: the main group and the comparison group. …”
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Untensed fibronectin fibers: a novel hallmark of microthrombi by Arnaud Miéville, Petra Wolint, Nikola Cesarovic, Nikola Cesarovic, Volkmar Falk, Volkmar Falk, Viola Vogel

“…Fibronectin, one of these omnipresent extracellular matrix (ECM) proteins, exists in distinct physical states in healthy versus diseased tissues, presenting stretched versus untensed fibers, which may serve as potential diagnostic and therapeutic targets.MethodsThe peptide FnBPA5, a highly specific probe that binds selectively to untensed fibronectin fibers, as its multivalent binding motif is destroyed upon fiber stretching, was employed here to assess fibronectin's fiber tension in microthrombi before and after the onset of MINOCA in a pig model of autologous microthrombi-induced MINOCA.ResultsLoss of fibronectin fiber tension was identified here as a novel key feature of microthrombi in a pig model of autologous microthrombi-induced MINOCA, whereas fibronectin fibers in the surrounding healthy myocardium remained highly stretched. …”
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The efficacy of a novel tomato extracts formulation on skin aging and pigmentation: A randomized, double-blind, parallel-controlled trial by Silu Zhang, Shan Lu, Yun Wang, Jiayi Ni, Guoxun Xiao

“…Objective: To evaluate the effects of an orally administered formulation on the skin aging and pigmentation. Material and Methods: In this study, a randomized, double-blind, parallel-controlled trial was conducted, utilizing the WONDERLAB® Tomato Niacinamide beverage. …”
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Endovascular Treatment of Venous Sinus Stenosis in Idiopathic Intracranial Hypertension: Complications, Neurological Outcomes, and Radiographic Results by Robert M. Starke, Tony Wang, Dale Ding, Christopher R. Durst, R. Webster Crowley, Nohra Chalouhi, David M. Hasan, Aaron S. Dumont, Pascal Jabbour, Kenneth C. Liu

“…Intracranial venous stenting has emerged as a potential treatment alternative. Methods. A systematic review was carried out to identify studies employing venous stenting for IIH. …”
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Prevention strategies against academic burnout: the perspective of Romanian health sciences students in the aftermath of the COVID-19 pandemic by Ovidiu Popa-Velea, Ioana Ruxandra Stoian-Bǎlǎşoiu, Ioana Ruxandra Stoian-Bǎlǎşoiu, Alexandra Mihai, Alexandra Ioana Mihǎilescu, Alexandra Ioana Mihǎilescu, Liliana Veronica Diaconescu

“…This study aimed to investigate academic burnout and the perception of its prevention strategies among Romanian health sciences students.MethodsThree hundred and five health sciences students (from General Medicine, Dental Medicine, Pharmacy, and Midwifery and Nursing) (36 men, 269 women, mean age 21.9, standard deviation 1.911) self-rated their burnout using the Burnout Assessment Tool (BAT) and a visual analog scale, and answered a survey with open and closed questions about the most effective coping strategies to prevent burnout.ResultsAbove average scores (mean = 3.05; SD = 0.67) on burnout were met (with the highest scores on exhaustion and psychological distress and the lowest on mental distance and psychosomatic symptoms). …”
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Clinical effect analysis of posterior longitudinal ligament resection during anterior cervical discectomy and fusion in the treatment of cervical spondylotic myelopathy by NIU Hai‐ying, MENG Xiang‐yu, ZUO Shan‐shan, SUN Xiao‐li, LI Yan, LIU Hong‐lei

“…Objective To investigate the effect and safety of microscopic posterior longitudinal ligament resection during anterior cervical discectomy and fusion (ACDF) in the treatment of cervical spondylotic myelopathy (CSM). Methods A total of 38 patients with CSM completed resection of posterior longitudinal ligament during ACDF under microscopy were enrolled in The First Hospital of Hebei Medical University from August 2023 to August 2024. …”
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Cytophysiological manifestations of wheat’s defense reactions against stem rust induced by the biofungicide Novochizol by A. B. Shcherban, L. Ya. Plotnikova, V. V. Knaub, E. S. Skolotneva, V. V. Fomenko

“…The research will be continued using molecular genetics, biochemical and cytophysiological methods.…”
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Combined systemic immune-inflammatory index and prognostic nutritional index predicts the efficacy and prognosis of ES-SCLC patients receiving PD-L1 inhibitors combined with first-... by Yi Ge, Xiaoyu Liu, Yishi Xu, Yanwei Su, Yixin Li, Liping Wang

“…Therefore, the purpose of this study was to explore how the pre-treatment SII-PNI score can predict the tumor response and prognosis of extensive-stage SCLC patients treated with PD-L1 inhibitors and first-line chemotherapy.MethodsThis research conducted a retrospective review of 70 ES- SCLC patients from December 2019 to January 2023. …”
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EVALUATION OF THE IMPACT OF DRUG THERAPY FOR OBESITY ON THE CLINICAL MANIFESTATIONS OF KNEE OSTEOARTHRITIS IN OVERWEIGHT WOMEN by E. A. Strebkova, I. V. Solovyeva, E. P. Sharapova, A. M. Mkrtumyan, L. I. Alekseeva, E. L. Nasonov

“…Objective: to evaluate the impact of orlistat therapy on the clinical manifestations of knee osteoarthritis (OA) in obese patients.Subjects and methods. The investigation enrolled 50 women aged 45–65 years with Kellgren–Lawrence Stages II–III knee OA and obesity [body mass index (BMI) &gt; 30 kg/m2] who were randomized into 2 groups: 1) 25 patients who took Orlistat in a dose of 120 mg (one capsule) thrice daily for 6 months in conjunction with a low-calorie diet and exercise; 2) 25 patients who received only non-drug therapy for obesity (a low-calorie diet and exercise). …”
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Deep Learning in Glaucoma Detection and Progression Prediction: A Systematic Review and Meta-Analysis by Xiao Chun Ling, Henry Shen-Lih Chen, Po-Han Yeh, Yu-Chun Cheng, Chu-Yen Huang, Su-Chin Shen, Yung-Sung Lee

“…<b>Purpose:</b> To evaluate the performance of deep learning (DL) in diagnosing glaucoma and predicting its progression using fundus photography and retinal optical coherence tomography (OCT) images. <b>Materials and Methods:</b> Relevant studies published up to 30 October 2024 were retrieved from PubMed, Medline, EMBASE, Cochrane Library, Web of Science, and ClinicalKey. …”
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Research on rheumatic heart disease from 2013 to early 2024: a bibliometric analysis by Yifan Chen, Liuding Wang, Dan Ma, Zhijie Cui, Yanjiao Liu, Qinghua Pang, Zhonghui Jiang, Zhuye Gao

“…Abstract Objectives The aim of this bibliometric analysis was to highlight potential future areas for the practical application of research on rheumatic heart disease (RHD), considering past and current research efforts. Methods A systematic search was conducted in the WoSCC to find articles and reviews focused on RHD published between 2013 and 2024. …”
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Comparison of Scrotal Hitch Technique and Conventional Scrotal Dressing in Reducing the Postoperative Scrotal Oedema in Inguinoscrotal Surgeries: A Non Randomised Clinical Study by Balaji Rajavarman, Manigandan Raju, Umesh Raj Somasundaram, AS Sangeethapriya

“…In Group-A, the median Visual Analogue Scale (VAS) score at 6, 24, 48 and 72 hours was 6, 3, 1 and 0. …”
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Development and validation of a novel glucolipid metabolism-related nomogram to enhance the predictive performance for osteoporosis complications in prediabetic and diabetic patien... by Junhong Li, Cong Ma, Xinran Wang, Jianwen Li, Ping Liu, Meipeng Zhu

“…The research examined the osteoporosis risk prediction potential of these indices and developed a nomogram to enhance predictive performance. Methods 2,735 prediabetic and diabetic subjects were derived from National Health and Nutrition Examination Survey (NHANES) dataset collected between 2011 and 2020, then randomly assigned to development and validation cohorts in 7:3. …”
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25-gauge vitrectomy with gas tamponade for uncomplicated rhegmatogenous retinal detachment: experienced vs. inexperienced surgeons by Martin Pencak, Zbynek Stranak, Jakub Dite, Jana Vranova, Pavel Studeny, Miroslav Veith

“…Introduction Comparison of the results and complication rates of a 25-gauge (25 g) PPV with gas tamponade for RRD between experienced and inexperienced surgeons. Methods This is a retrospective comparative consecutive case series study of patients with uncomplicated RRD treated with 25 g PPV with gas tamponade. …”
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Effect of Myopic Defocus on the Retina and Choroid and Its Interaction with Defocus Regions, Diurnal Rhythm, and Accommodation by Yingying Huang, MD, Jiali Zhang, MD, Xue Li, PhD, Hao Chen, MD, OD, Jinhua Bao, PhD

“…Participants: Twenty-one adults aged between 18 and 30 years, myopia between −1.00 D and −6.00 D, were included. Methods: Four lenses were used in random order at 4 separate days for each participant. …”
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Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024 by Xinran He, Tingyi Xie, Li Shi, Xuyi Kuang, Lei Li, Xingyu Shang, Bo Fu

“…This study aims to provide a comprehensive picture of the current research status, hotspots, and future trends in this field from a bibliometric perspective.MethodsIn this study, the publications about colorectal cancer and tumor microenvironment from 2014 to 2024 were searched based on the Web of Science Core Collection database. …”
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The impact of malocclusion on the prevalence of pain-related temporomandibular disorders in children and adolescents: a systematic review by Liliana Szyszka-Sommerfeld, Magdalena Sycińska-Dziarnowska, Karolina Gerreth, Gianrico Spagnuolo, Gianrico Spagnuolo, Krzysztof Woźniak, Agata Czajka-Jakubowska

“…This systematic review aims to synthesize the current scientific evidence regarding impact of malocclusion on the prevalence of pain-related TMD in individuals under 18 years.MethodsThe study was based on a searching of the PubMed, Scopus, Embase, and Web of Science databases. …”
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Clinical Study on the Application of Ultrasound-guided Quadratus Lumborum Block Combined with Ilioinguinal/Iliohypogastric Nerve Block in Inguinal Surgery in the Elderly by Jian Zhang, Guohai Sun, Lei Zhang, Lihui Zhang

“…Background: This study aimed to investigate the effects of combining an ilioinguinal/iliohypogastric nerve block with an ultrasound-guided quadratus lumborum block during inguinal surgery in older patients. Methods: Between December 2020 and June 2023, 300 elderly patients who underwent inguinal surgery at our institution were randomly divided into an observation group (n = 150) and a control group (n = 150). …”
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