Gal-3 blocks the binding between PD-1 and pembrolizumab by Henrik Schmidt, Torben Steiniche, Bent Deleuran, Malene Hvid, Morten Aagaard Nielsen, Stinne Ravn Greisen, Mia Bendix, Kathrine Pedersen, Nina Haunstrup Jensen, Jakob Hauge Mikkelsen, Taner Drace, Thomas Boesen

“…We have previously demonstrated the binding between programmed cell death 1 (PD-1) and Gal-3, and here, we investigated the interaction between PD-1, pembrolizumab, and Gal-3 in metastatic MM patients.Methods The binding between PD-1, pembrolizumab and Gal-3 was investigated by surface plasmon resonance (SPR) and cryogenic electron microscopy (cryo-EM). …”
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Anomalous drainage of the ductus venosus into the coronary sinus: prenatal ultrasound diagnosis utilizing two-dimensional and three-dimensional imaging techniques and differential... by Weng-dong Zhang, Bin Ma, Ping-an Qi, Gang Wang, Xiao Rong Su, Xiao Yun Ma, Tian-gang Li

“…STIC imaging successfully visualized the abnormal course of the DV, enhancing diagnostic confidence. …”
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A new technique of inverted internal limiting membrane flap formation in a surgical treatment for large idiopathic macular holes by I. A. Belyi, A. V. Tereshchenko, D. O. Shkvorchenko, E. V. Erokhina, N. M. Shilov

“…To develop a surgical treatment for large idiopathic macular holes using a new technique of internal limiting membrane fragment formation to close the macular hole.Material and methods. We observed 19 patients, from 56 to 71 years old (average age was 63,8±5,3 years old) with idiopathic macular holes (IMH) stage III according to J. …”
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ASSESSMENT OF THE QUALITY OF LIFE OF PATIENTS WITH THE JUVENILE IDIOPATHIC ARTHRITIS TREATED BY THE ETANERCEPT by A. N. Fetisova, E. I. Alexeeva, T. M. Bzarova, S. I. Valieva, V. V. Chernikov, I. V. Vinyarskaya, R. V. Denisova, K. B. Isaeva, E. G. Chistyakova, Т. V. Sleptsova, N. I. Taibulatov

“…Aim: To assess the influence of the genetically engineered biologic drug etanercept on the quality of life of patients with juvenile idiopathic arthritis (JIA). Patients and methods: The research included 85 children with poly-and oligoarticular variant of the JIA at the age of 5 (2; 17) years. …”
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Role of hypoxia-related genes and immune infiltration in intervertebral disc degeneration: molecular mechanisms and diagnostic potential by Kai Zhou, Jiaxiang Zhou, XianJin Luo, Yan Chen, Jian Ao, Wei Wu, Bo Yang, Zhongyuan He

“…ObjectiveTo investigate the role of hypoxia-related genes and immune infiltration in intervertebral disc degeneration (IDD) to identify molecular mechanisms and potential therapeutic targets.MethodsUsing GEO data, IDD-related gene expression datasets were analyzed for hypoxia-related differentially expressed genes (HRDEGs). …”
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Detection of pulmonary nodules: a clinical study protocol to compare ultra-low dose chest CT and standard low-dose CT using ASIR-V by Marie Ludwig, Emilie Chipon, Julien Cohen, Emilie Reymond, Maud Medici, Anthony Cole, Alexandre Moreau Gaudry, Gilbert Ferretti

“…The aim of this study is to demonstrate that an ultra-low dose (ULD) chest CT protocol, using recently introduced hybrid iterative reconstruction (ASiR-V, GE medical Healthcare, Milwaukee, Wisconsin, USA), is as performant as a standard ‘low dose’ (LD) CT to detect non-calcified lung nodules ≥4 mm.Methods and analysis The total number of patients to include is 150. …”
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The interplay of factors influencing the carbon footprint of hospital care—A causal mapping analysis of scientific reports by L.H.J.A. Kouwenberg, D.S. Kringos, W.J.K. Hehenkamp, E.S. Cohen, N.H. Sperna Weiland

“…Recent research has highlighted the carbon footprint of hospital care by identifying hotspots and mitigation areas, but key factors influencing these outcomes remain underexplored. Methods: This study used causal mapping of textual data to systematically evaluate scientific reports on the carbon footprint of hospital services and care pathways. …”
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Efficacy of photodynamic therapy combined with cross-punch technique for the treatment of keloid by Xiaomei Cui, Jie Ji, Lipan Fan, Xingbao Luan, Litian Zhao, Zhangjun Ding, Xiaodong Chen, Dan Luo

“…Our study explored the use of the punch technique in conjunction with photodynamic therapy, a novel approach that may swiftly reduce keloid volume, promote collagen remodeling, mitigate inflammation and enhance the wound healing process. Methods: In our study, we conducted a retrospective analysis of 47 keloid patients who were treated with cross-punch technique combined with photodynamic therapy (punch+PDT group), compared them with a control group of 42 patients who received cross-punch therapy alone (punch group). …”
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Multicentre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients: the ASPIRED stu... by Steve Goodacre, Praveen Thokala, Neil Grubb, Chris Lang, Rachel O’Brien, Christopher J Weir, Trudie Lobban, Matthew J Reed, Nicola Freeman, Julia Boyd, Lynn Dinsmore, Caroline Blackstock, Imad Adamestam, Pam Macrae, Robert Hannigan

“…Results will be disseminated via scientific publication, lay summary and visual abstract.Trial registration number ISRCTN 10278811.…”
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The Influence of Mixing Orders on the Microstructure of Artificially Prepared Sand-Clay Mixtures by Kexin Yin, Anne-Laure Fauchille, Eugenia Di Filippo, Khaoula Othmani, Samuel Branchu, Giulio Sciarra, Panagiotis Kotronis

“…Most homogeneous microstructures can be achieved by applying the mixing order “sand-water-clay.” The following methods were used to validate this statement: (1) optical observation, (2) X-ray tomography, (3) scanning electron microscopy, and (4) Mercury intrusion porosimetry. …”
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Aging2Cancer: an integrated resource for linking aging to tumor multi-omics data by Dahua Xu, Yutong Shen, Nihui Zhang, Guoqing Deng, Dehua Zheng, Peihu Li, Jiale Cai, Guanghui Tian, Qingchen Wei, Hongyan Jiang, Jiankai Xu, Bo Wang, Kongning Li

“…Discovering the link between aging and cancer in terms of multiomics characteristics remains a challenge for biomedical researchers. Methods We collected high-throughput datasets for 57 human tumors and 20 normal tissues, including 23,125 samples with age information. …”
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Clinical characteristics of atrophic macular hole in pathologic myopia: A multicenter study by Hai-Long He, Guang-Qi An, Yue Qi, Xiao-Bing Yu, Ming-Wei Zhao, Zong-Ming Song, Xue Min Jin, Li-Ping Du, Zi-Bing Jin

“…Purpose: This study aims to describe and analyze the clinical characteristics of atrophic macular hole (AMH), a severe complication in patients with pathologic myopia (PM). Methods: A multicenter, retrospective analysis was conducted involving 17 patients (17 eyes) diagnosed with AMH and 52 patients (52 eyes) diagnosed with simple macular hole (SMH) in PM from January 2023 to December 2023. …”
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Enhanced Broad-Spectrum Efficacy of an L2-Based mRNA Vaccine Targeting HPV Types 6, 11, 16, 18, with Cross-Protection Against Multiple Additional High-Risk Types by Kosuke Tsukamoto, Akio Yamashita, Masatoshi Maeki, Manabu Tokeshi, Hirotatsu Imai, Akira Fukao, Toshinobu Fujiwara, Koji Okudera, Nobuhisa Mizuki, Kenji Okuda, Masaru Shimada

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Agreement between Gonioscopic Examination and Swept Source Fourier Domain Anterior Segment Optical Coherence Tomography Imaging by Mohammed Rigi, Nicholas P. Bell, David A. Lee, Laura A. Baker, Alice Z. Chuang, Donna Nguyen, Vandana R. Minnal, Robert M. Feldman, Lauren S. Blieden

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Clinical and laboratory manifestations of systemic lupus erythematosus in patients with neuropsychiatric disorders (eurasian renaissance register) by G. M. Koilubaeva, E. A. Aseeva, S. K. Solovyev, N. Yu. Nikishina, E. L. Nasonov, N. P. Tkachenko, E. R. Karimova, A. Zh. Zhumakadyrova, A. A. Moldobaeva, E. Zh. Dzhishambaev

“…Objective: to investigate the clinical and laboratory manifestations of systemic lupus erythematosus (SLE) with nervous system lesions in a Kyrgyz cohort.Subjects and methods. The prospective study enrolled 460 patients with SLE who fulfilled American College of Rheumatology (ACR) 1987 and SLICC 2012 criteria, and had been followed up at Academician M. …”
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Forecasting the diabetic retinopathy progression using generative adversarial networks by Huiyu Qiao, Feilong Tang, Huanfen Zhou, Yun Cai, Kairou Guo, Jin Wang, Tong Ma, Lie Ju, Wei Feng, Zhiqiang Ma, Juan Chen, Yuan Luo, Bin Wang, Zongyuan Ge, Qiansu Yang

“…Methods DRForecastGAN model, consisting of a generator, discriminator, and registration network, was trained, validated, and tested in training (12,852 images), internal validation (2734 images), and external test (8523 images) datasets. …”
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The effects of color and neutral density filters on dynamic accommodation in individuals with mild traumatic brain injury by Nawaf M. Almutairi, John Hayes, Yu-Chi Tai, Khawlah Alfaifi, Mohammed M. Alnawmasi, Muteb K. Alanazi, Bandar M. Alenezi, Sulaiman Aldakhil, Chunming Liu

“…This study objectively measured dynamic accommodation in individuals with mTBI and healthy controls under various filter conditions to determine if visual performance could be improved.MethodsThirty participants with a medically diagnosed history of mTBI (age range 18–33 years) and 54 healthy controls (age range 21–30 years) completed monocular dynamic accommodation testing under three randomized viewing conditions: baseline with no filter (NF), a subjectively selected color filter (CF), and a luminance-matched neutral density filter (ND). …”
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Stepwise Total Hip Arthroplasty with Lateral and Posterolateral Approaches: Intraoperative Imaging, Fixation Strategy, and Early Functional Outcomes by Roland Fazakas, Laura Ioana Bondar, Csongor Toth, Brigitte Osser, Iosif Ilia, Gabriel Roberto Marconi, Victor Niculescu, Ramona Nicoleta Suciu, Liviu Gavrila-Ardelean, Alexandru Pop

“…Methods: A prospective observational study was conducted at Arad Clinical Emergency County Hospital between March 2023 and March 2024, involving 23 patients undergoing primary THA. …”
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Meta-analysis: long/short-term efficacy of anti-VEGF vs. panretinal photocoagulation in preventing severe complications in proliferative diabetic retinopathy by Tiago N. O. Rassi, Lucas M. Barbosa, Dillan Cunha Amaral, Ricardo N. Louzada, Helvécio N. F. Filho, Guilherme N. Marques, Breno C. Vieira, Sobha Sivaprasad, Mauricio Maia

“…We aim to assess this dispute through a meta-analysis. Methods We searched PubMed, Embase, and Cochrane databases until August 2024 for studies comparing anti-VEGF with PRP in PDR. …”
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Understanding basic and social emotions in Alzheimer's disease and frontotemporal dementia by Carlotta Sola, Vanessa Zanelli, Maria Angela Molinari, Claudia Casadio, Francesco Ricci, Omar Carpentiero, Manuela Tondelli, Fausta Lui, Paolo Frigio Nichelli, Francesca Benuzzi

“…The present study aims to investigate emotion understanding (both basic and social emotions), using different tasks with visual and auditory stimuli, to identify supramodal deficits in AD and FTD to provide a reliable tool to better outline their behavioral and emotional profile and useful instruments for their management.MethodsEighteen patients with AD and 15 patients with FTD were included in the study. …”
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