Carrier-Free, Hyaluronic Acid-Modified Self-Assembled Doxorubicin, and Chlorin e6 Nanoparticles Enhance Combined Chemo- and Photodynamic Therapy in vivo by Lin B, Lin P, Zhang X, Liao Y, Yu Y, Xu X, Wang X

“…Hyaluronic acid (HA) can bind to overexpressed HA receptors on the tumor cell surface, increasing cell internalization and resulting in good tumor-targeting properties.Methods: Herein, we propose an easy and environmentally friendly approach for fabricating a novel formulation of carrier-free pure nanodrugs through self-assembly of the antitumor drug doxorubicin (DOX) and the photosensitizer chlorin e6 (Ce6), followed by sequential modification with HA to achieve simultaneous and targeted photodynamic therapy and chemotherapy.Results: The fabricated HA-DOX-Ce6 nanoparticles (NPs) exhibited enhanced drug loading and stability while possessing the properties of near-infrared fluorescence imaging, self-targeting drug delivery, and combined photodynamic therapy and chemotherapy.Conclusions: HA-DOX-Ce6 NPs, along with laser irradiation, effectively suppressed tumor development both in vitro and in vivo with minimal side effects. …”
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Cost-Effectiveness of Automated Digital Microscopy for Diagnosis of Active Tuberculosis. by Swati Jha, Nazir Ismail, David Clark, James J Lewis, Shaheed Omar, Andries Dreyer, Violet Chihota, Gavin Churchyard, David W Dowdy

“…The cost-effectiveness of TB diagnostic algorithms using automated digital microscopy remains uncertain.<h4>Methods</h4>Using data from a demonstration study of an automated digital microscopy system (TBDx, Applied Visual Systems, Inc.), we performed an economic evaluation of TB diagnosis in South Africa from the health system perspective. …”
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Spectral-Domain Optical Coherence Tomography-Based Morphofunctional Characterization of Dome-Shaped Maculopathy in Indian Population by Naresh Babu Kannan, Sagnik Sen, Prithviraj Udaya, Obuli Ramachandran, Kim Ramasamy

“…To study the clinicodemographic profile of dome-shaped maculopathy (DSM) eyes in the Indian population and characterization using spectral-domain optical coherence tomography (SD-OCT). Methods. This observational cross-sectional study included 25 eyes of 14 patients diagnosed with DSM. …”
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The Impact of Integrating Shallow and Deep Information on Knowledge Distillation by Yilin Miao, Yuhong Tang, Huangliang Ren, Jianjun Li

“…Compared to state-of-the-art knowledge distillation methods (e.g., RKD and VID), the performance of our student model improves by 1.03% and 1.56%, respectively.…”
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Scleral buckling in retinal detachment due to retinal dialysis – A vitreoretina fellow’s perspective by Akshaya Balaji, Saurabh Verma, Nawazish Shaikh, Shorya V Azad, Parmanand Kumar, Rohan Chawla, Vinod Kumar

“…Purpose: To analyze the efficacy of scleral buckling in the hands of vitreo-retina (VR) fellows under training in eyes with retinal detachment associated with retinal dialysis and analyze the patient and retinal characteristics in these eyes. Methods: We carried out a retrospective consecutive case review at a tertiary eye care center in North India. …”
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Hospital at home (virtual wards): developing a logic model and dark logic model by Faiza Yahya, Matthew Cooper, Hamde Nazar

“…Conclusion These logic models provide a clear visual representation of intended (logic) and unintended outcomes (dark logic) of HaH (virtual wards) in England, and factors contributing to them. …”
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Role of eperisone as an oral analgesic adjunct after arthroscopic rotator cuff repair by Cheryl Gatot, Wen Qiang Lee, Brjan Kaiji Betzler, Yao Kang Shuy, Denny Lie Tijauw Tjoen

“…The goal of our study is to evaluate the effect of Eperisone in patients undergoing arthroscopic rotator cuff repair, with regards to post-operative pain and functional outcomes. Methods: All patients who underwent arthroscopic rotator cuff repair between January to September 2022 were assessed. …”
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Nalbuphine as a Potential Alternative to Morphine in Sickle Cell Disease Patients with Vaso-occlusive Crisis: A Retrospective Cohort Study by Mohannad Alghamdi, Mohamed Almulhim, Qasem Almulihi, Yousef A. Alhamaid, Mohammad Assiri, Abdullah Alzahid, Basmah Al Ghanim, Lama Albaish, Lama Alkhunaizi, Shahad Alali, Layan Alshehri

“…Objective: To compare the efficacy and safety of nalbuphine and morphine in pain management among adult SCD patients presenting with VOC. Methods: This retrospective study included adult patients with SCD treated at King Fahad Hospital, Hofuf, Saudi Arabia, between 2019 and 2023. …”
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Influence of different anesthetic depth on postoperative delirium in elderly pre-frail patients undergoing abdominal surgery by Rongman Chen, Pengfei Hou, Wanxin Liu, Haiqi Mi, Shuaiying Jia, Jingyan Lin

“…This study investigated the impact of varying readings of Cerebral State Index (CSI) on postoperative delirium in elderly pre-frail patients undergoing abdominal surgery. Methods A total of 150 elderly pre-frail patients aged over 65 years scheduled for selective abdominal surgery under general anesthesia were enrolled. …”
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Cognitive Priming During Warmup Enhances Sport and Exercise Performance: A Goldilocks Effect by Jesús Díaz-García, Ana Rubio-Morales, David Manzano-Rodríguez, Tomás García-Calvo, Christopher Ring

“…The research objectives were to evaluate the effects of physical and combined physical plus cognitive warmup activities on subsequent sport, exercise, and cognitive performance when rested and fatigued by sleep restriction in athletes (Study 1) and older adults (Study 2). <b>Methods:</b> In Study 1, 31 padel players completed a padel performance test and Stroop task after physical and combined warmups when rested and fatigued by sleep deprivation. …”
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Applications of Natural Language Processing and Large Language Models for Social Determinants of Health: Protocol for a Systematic Review by Swati Rajwal, Ziyuan Zhang, Yankai Chen, Hannah Rogers, Abeed Sarker, Yunyu Xiao

“…ObjectiveThis research protocol describes a systematic review to identify and highlight NLP techniques, including large language models, used for SDOH-related studies. MethodsA search strategy will be executed across PubMed, Web of Science, IEEE Xplore, Scopus, PsycINFO, HealthSource: Academic Nursing, and ACL Anthology to find studies published in English between 2014 and 2024. …”
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A tailored distractor-assisted percutaneous minimally invasive treatment for Sanders II and III calcaneus fractures: a consecutive cohort study with medium-term results by Xiong Liao, Jianliang Deng, Wei Liu, Di You

“…This study aimed to introduce a tailored distractor-assisted percutaneous minimally invasive surgery (MIS) and reported its medium-term outcomes in patients with Sanders II and III calcaneus fractures.Methods63 cases (63 feet) of DIACFs, subjected to a tailored distractor-assisted MIS in our orthopedic department were retrospectively analyzed. …”
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Validity and reliability of the Critical-Care Pain Observation Tool (CPOT) for critically ill pediatric patients. by Haruhiko Hoshino, Mitsuki Ikeda, Yujiro Matsuishi, Yuki Enomoto, Nobutake Shimojo, Misaki Kotani, Shunsuke Kobayashi, Takahiro Kido, Satomi Hayashi, Yoko Furuya, Yoshiaki Inoue

“…The purpose of this study was to evaluate CPOT for critically ill pediatric patients.<h4>Methods</h4>We conducted a prospective observational study in an eight-bed open PICU from January 2022 to March 2023. …”
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Retrospective study of incidence/prevalence of pigmentary maculopathy and retinopathy in patients receiving pentosan polysulfate sodium. by Zhong Yuan, Subusola Vaughan, Carolyn Jeffcoat, Peter Hu, Ritchie Yuson, Daniel Fife, Durga Borkar

“…<h4>Methods</h4>This is a retrospective cohort study (January 2015-March 2021) which included adult de-identified patients from the American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) and Komodo Health database. …”
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Short-Term Effects of Overnight Orthokeratology on Corneal Sensitivity in Chinese Children and Adolescents by Wanqing Jin, Jiangping Ye, Jiafan Zhang, Yu Zhu, Frank Thorn, Ningning Liu, Ruzhi Deng

“…To assess the effects of the 3-month period of orthokeratology (OK) treatment on corneal sensitivity in Chinese children and adolescents. Methods. Thirty subjects wore overnight OK lenses in both eyes for 3 months and were assessed at baseline, 1 day, 1 week, 1 month, and 3 months after the treatment. …”
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Comparison of OnBaseU Tests with Biomechanical Motion Analysis in Youth Baseball Pitchers by Tessa Hulburt, Taylor Catalano, Kristen F. Nicholson

“…The secondary purpose was to compare OnBaseU and 3D motion capture seated trunk rotation test results to determine the validity of the OnBaseU test. # Methods OnBaseU screening and 3D motion capture pitching evaluations were completed for 103 adolescent pitchers (age = 15.2 ± 1.29 years; height = 1.80 ± 0.0866 m; weight = 76.2 ± 13.8 kg). …”
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Sutureless Intrascleral Posterior Chamber Intraocular Lens Fixation: Analysis of Clinical Outcomes and Postoperative Complications by Jiannan Liu, Wenxue Fan, Xinyu Lu, Shaomin Peng

“…Study Design. 68 eyes of 66 patients who received the technique were studied retrospectively. Methods. The best-corrected visual acuity (BCVA), intraocular pressure (IOP), anterior chamber depth (ACD), IOL tilt and decentration, corneal topography (K1 and K2), and postoperative complications were determined at 3 months. …”
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Surgical Reduction and Direct Repair Using Pedicle Screw-Rod-Hook Fixation in Adult Patients with Low-Grade Isthmic Spondylolisthesis by Yongjian Gao, Chen Zhao, Lei Luo, Liehua Liu, Lichuan Liang, Dianming Jiang, Pei Li, Qiang Zhou

“…To assess the surgical effect of reduction and direct repair surgery with a pedicle screw-rod-hook system combined with autogenous bone grafts in adult patients with low-grade isthmic spondylolisthesis. Methods. Sixty-four adult patients with low-grade isthmic spondylolisthesis underwent reduction and direct repair using a pedicle screw-rod-hook system in our department from September 2009 to April 2018. …”
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Impact of Total Ischemic Time on the Recovery of Regional Wall Motion Abnormality after STEMI in the Modern Reperfusion Era by Jeong Hun Seo, Kang Hee Kim, Kwang-Jin Chun, Bong-Ki Lee, Byung-Ryul Cho, Dong Ryeol Ryu

“…Therefore, we investigated changes in the wall motion score index (WMSI) value based on TIT in STEMI patients who underwent primary percutaneous coronary intervention (PCI) and subsequent transthoracic echocardiography. Methods. STEMI patients who underwent primary PCI and follow-up coronary angiography were analyzed after the exclusion of cases of in-stent restenosis (ISR). …”
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CHANGE IN THE QUALITY OF LIFE OF CHILDREN AFTER SURGICAL TREATMENT OF RETINAL DETACHMENT by A. N. Sergienko, V. V. Dashina, A. V. Malyshev, O. I. Lysenko, S. V. Yanchenko

“…The study was designed for the evaluation of the quality of life of children with retinal detachment during vitrectomy.Materials and methods. 23 children with retinal detachment aged from 10 to 17 years were treated. …”
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