Robust circulating microRNA signature for the diagnosis and early detection of pancreatobiliary cancer by Shuichi Mitsunaga, Masafumi Ikeda, Makoto Ueno, Satoshi Kobayashi, Masahiro Tsuda, Ikuya Miki, Takamichi Kuwahara, Kazuo Hara, Yukiko Takayama, Yutaro Matsunaga, Keiji Hanada, Akinori Shimizu, Hitoshi Yoshida, Tomohiro Nomoto, Kenji Takahashi, Hidetaka Iwamoto, Hideaki Iwama, Etsuro Hatano, Kohei Nakata, Masafumi Nakamura, Hiroko Sudo, Satoko Takizawa, Atsushi Ochiai

“…The aim of this study was to identify serum microRNA (miRNA) signatures comprising reproducible and disease-related miRNAs. Methods This multicenter study involved patients with treatment-naïve PBca and healthy participants. …”
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Analysis of the effects of acetyl tributyl citrate on bone cancer based on network toxicology and molecular docking by Lujun Jiang, Lujun Jiang, Lujun Jiang, Juncheng Shen, Juncheng Shen, Jinghong Yang, Jinghong Yang, Jinghong Yang, Zi Wang, Zi Wang, Zi Wang, Lian Tang, Lian Tang, Yuqi Li, Jialin Liu, Jialin Liu, Zhong Li, Zhong Li, Zhong Li, Yanshi Liu, Yanshi Liu

“…The aim of this study is to elucidate the complex effects of Acetyl tributyl citrate (ATBC) on bone cancer and to unravel the potential molecular mechanisms by which environmental pollutants influence the disease process.MethodsThis study utilized multiple online databases to identify target genes associated with ATBC and bone cancer. …”
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A single-institution experience with intraoperative in vivo confocal laser endomicroscopy for brain tumors in 50 patients by Yuan Xu, Thomas J. On, Irakliy Abramov, Oscar Alcantar-Garibay, Joelle N. Hartke, Jennifer M. Eschbacher, Kivanc Yangi, Michael T. Lawton, Kris A. Smith, Randall W. Porter, Mark C. Preul

“…We evaluated the feasibility and diagnostic capability of the first clinically approved CLE system for intraoperative in vivo imaging of brain tumors.MethodsA total of 50 patients who were to undergo brain tumor surgery were prospectively enrolled. …”
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Mediation Analyses Link Cardiometabolic Factors and Liver Fat With White Matter Hyperintensities and Cognitive Performance: A UK Biobank Study by Daniel E. Askeland-Gjerde, Lars T. Westlye, Patrik Andersson, Max Korbmacher, Ann-Marie de Lange, Dennis van der Meer, Olav B. Smeland, Sigrun Halvorsen, Ole A. Andreassen, Tiril P. Gurholt

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Antitumor effect of a new human epidermal growth factor receptor inhibitor by O. I. Kit, I. P. Kodonidi, E. M. Frantsiyants, I. V. Kaplieva, A. A. Glushko, L. K. Trepitaki, E. I. Surikova, V. A. Bandovkina, Yu. A. Pogorelova, I. V. Neskubina, O. V. Bykadorova, E. V. Serdyukova

“…Preclinical study in experiment of antitumor efficacy of a new substance synthesized on the basis of pyrimidin-4-one derivative.Materials and methods. The sodium salt of 4-{2-[2-[2-(4-hydroxy-3-methoxyphenyl)-vinyl]-6-ethyl-4-oxo-5-phenyl-4H-pyrimidin-1-yl}-benzsulfamide, a new inhibitor of the internal domain of the epidermal growth factor receptor (EGFR), was used in this study. …”
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Unraveling the mitochondrial genome of the medicinal Chinese motherwort (Leonurus japonicus, Lamiaceae): structural dynamics, organelle-to-nuclear gene transfer, and evolutionary i... by Xinyu Bai, Xinyu Bai, Tingting Zhu, Huiru Chen, Xiaoqun Wang, Jing Liu, Yuqing Feng, Yuqing Feng, Yanbo Huang, Joongku Lee, Goro Kokubugata, Zhechen Qi, Xiaoling Yan

“…Elucidating mitogenomic structure and evolution can inform plant genetics, phylogenetics, and molecular breeding.MethodsWe assembled the complete mitochondrial genome of L. japonicus using a combination of Oxford Nanopore long reads and Illumina short reads. …”
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Feasibility of magnetic resonance imaging-guided cardiac catheterization, angioplasty, and stenting in a commercial wide-bore 0.55T scanner by Aimee K. Armstrong, Yixuan Liu, John M. Kelly, Ramkumar Krishnamurthy, Jason Swinning, Yingmin Liu, Matthew Joseph, Ning Jin, Jianing Pang, Florian Maier, Axel J. Krafft, Orville Bramwell, Nathan Ooms, Jesse Roll, Joshua Krieger, David C. Gross, Lucien de Mos, Paul Borm, Orlando P. Simonetti

“…A secondary aim was to evaluate three different sizes of magnetic resonance (MR)-visible markers. Methods: Sheaths were placed in the femoral vein and artery of juvenile Yorkshire pigs under general anesthesia. …”
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Interactive Prompt‐Guided Robotic Grasping for Arbitrary Objects Based on Promptable Segment Anything Model and Force‐Closure Analysis by Yan Liu, Yaxin Liu, Ruiqing Han, Kai Zheng, Yufeng Yao, Ming Zhong

“…Grasp generation methods based on force‐closure analysis can calculate the optimal grasps for objects through their appearances. …”
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Network Pharmacology Approach to Unveiling the Mechanism of Wolfberry Mulberry Raspberry Decoction in the Treatment of Sepsis-Induced Myocardial Dysfunction by Zhang Q, Wen L, Li J, Liu P, Sun X, Liu Q, Chen X, Zhang Y

“…This data was integrated into the STRING platform to visualize protein interactions. Cytoscape software was then used to construct a network diagram illustrating relationships between drug components and their corresponding targets. …”
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Ultraviolet laser induced periodic surface structures positively influence osteogenic activity on titanium alloys by Luiz Schweitzer, Luiz Schweitzer, Janosch Schoon, Niklas Bläß, Katrin Huesker, Janine V. Neufend, Nikolai Siemens, Sander Bekeschus, Sander Bekeschus, Rabea Schlüter, Peter Schneider, Eckart Uhlmann, Eckart Uhlmann, Georgi Wassilew, Frank Schulze

“…Scanning electron microscopy was used for visualization of surface topography and adherent cells. …”
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Co-Designing a Web-Based and Tablet App to Evaluate Clinical Outcomes of Early Psychosis Service Users in a Learning Health Care Network: User-Centered Design Workshop and Pilot St... by Kathleen E Burch, Valerie L Tryon, Katherine M Pierce, Laura M Tully, Sabrina Ereshefsky, Mark Savill, Leigh Smith, Adam B Wilcox, Christopher Komei Hakusui, Viviana E Padilla, Amanda P McNamara, Merissa Kado-Walton, Andrew J Padovani, Chelyah Miller, Madison J Miles, Nitasha Sharma, Khanh Linh H Nguyen, Yi Zhang, Tara A Niendam

“…MethodsOur UCD approach included incorporation of user feedback, prototyping, iterative design, and continuous evaluation. …”
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Cell death pathway regulation by fatty acid metabolism-related genes in neuroblastoma: a multi-omics analysis identifying CHD5 as a novel biomarker by Yankun Chen, Junzhi Liu, Yubin Jia, Jiaxing Yang, Yan Jin, Yun Liu, Benfu Zhong, Qiang Zhao

“…While dysregulated cell death mechanisms and metabolic reprogramming are hallmarks of cancer progression, the interplay between fatty acid metabolism and cell death pathway regulation in neuroblastoma remains incompletely understood. Methods Identifying molecular subtypes influenced by fatty acid metabolism were built by consensus clustering analysis. …”
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Comparison of endoscopic and microscopic microvascular decompression for treating primary trigeminal neuralgia by Lei Li, Lei Li, Dongqi Shao, Xialin Zheng, Yuanbo Pan, Tao Sun, Huadong Tang, Hongjie Zhai, Xiaohui Dong, Jing Sun, Mengtian Fang, Feiyun Lou, Zhiquan Jiang, Zhiquan Jiang

“…ObjectiveTo compare the intraoperative outcome and postoperative efficacy of endoscopic and microscopic microvascular decompression (MVD) under neuroelectrophysiological monitoring in the treatment of primary trigeminal neuralgia (PTN).MethodsThis retrospective study included 131 patients with PTN who were admitted to our hospital between January 2019 and October 2022. …”
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The Role of the Educational Programs in the Improving of Confidence in Vaccination against Pneumococcal Infection among Population by N I Briko, V A Korshunov, A Ya Mindlina, R V Polibin, A V Shamis, A G Saltykova

“…In this regard, we conducted a study to assess the effectiveness of the educational programs in the improving of confidence in vaccination against pneumococcal infection among various target groups of population. Materials and methods. The results of the developed and conducted educational campaigns, consisting of two stages, were used as material: a series of face-to-face events for young people (students of non-medical universities in Moscow) and a series of webinars for medical professionals of various specialties. …”
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Percutaneous Lapidus Procedure for the Management of Primary Hallux Valgus Deformity – A Retrospective Cohort Analysis by Alasdair John Henry Barrie MBChB MSc FRCS, James Ryeburn BSc, Alastair S.E. Younger MB ChB, ChM, FRCSC, Andrea Veljkovic MD, MPH, BComm, FRCSC, Kevin Wing MD, FRCSC, Murray J. Penner MD, FRCSC, Oliver Gagne MD, FRCSC

“…We aim to assess postoperative complications and radiographic correction achieved following primary hallux valgus surgeries using our percutaneous Lapidus procedure as the default surgical technique of the lead author. Methods: Patients aged 16 and above who underwent the percutaneous Lapidus procedure for primary hallux valgus deformity between January 1st, 2018, and April 1st, 2023, were retrospectively identified in our database. …”
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Distribution Patterns and Driving Factors of Highly Educated Talent in China from a Heterogeneity Perspective: An Examination Based on Prefectural Administrative Regions by Wu Rongwei, Wang Yuanxin, Zhang Qin, Zhou Liang

“…We employed the Gini coefficient and visualization methods to depict the spatiotemporal patterns of talent distribution at college, undergraduate, and graduate education levels in Chinese prefecture-level administrative regions. …”
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Application of augmented reality technology in the surgery of skull base tumor and cerebrovascular disease by GUO Yi⁃ding, ZHAO Ben⁃qi, ZHANG Pei⁃hai, LIU Yong, CHEN Gang, YANG Xue⁃jun, GUO Yi

“…The feasibility and applicability of AR assisted technology is currently the most important topic in clinical research. Methods Four cases engaged from January to December 2024 in Department of Neurosurgery of Beijing Tsinghua Changgung Hospital with vestibular schwannoma (one case), intracranial aneurysm (2 cases) and subclavian artery (SA) occlusion caused vertebral artery steal syndrome (one case) have been conducted tumor resection, internal carotid artery (ICA)⁃posterior communicating artery (PCoA) aneurysm clipping and common carotid artery (CCA)⁃SA bypass, respectively. …”
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Extended Trochanteric Osteotomy Increases the Risk of Tapered Splined Stem Subsidence in Revision Total Hip Arthroplasty by Josef E. Jolissaint, MD, Samuel Rodriguez, MD, Leonardo Albertini Sanchez, BA, Travis R. Weiner, BS, Elizabeth B. Gausden, MD, MPH, Jason L. Blevins, MD, Peter Sculco, MD, Jose Rodriguez, MD, FAOA

“…We sought to investigate whether an extended trochanteric osteotomy (ETO) at the time of TSTS insertion increased mean subsidence and whether the amount of cortical contact was associated with subsidence, failure, and revision. Methods:. This is a single-center retrospective cohort study of a prospectively collected database including all patients who received a TSTS from 2016 to 2020. …”
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Algorithm for the provision of comprehensive psychotherapeutic support to women experiencing neuropsychiatric symptoms during rehabilitation following the treatment of malignant ne... by D. V. Blinov, A. G. Solopova, E. E. Achkasov, E. S. Akarachkova, O. V. Kotova, S. A. Akavova, V. N. Galkin, G. K. Bykovshchenko, L. N. Sandzhieva, D. I. Korabelnikov, T. A. Blbulyan, D. A. Petrenko, A. Yu. Vlasina

“…Chronic pain syndrome, distress, anxiety and depression, decreased self-esteem, sexual dysfunction and social maladjustment reduce quality of life (QoL) and require psychotherapeutic support.Objective: to create an algorithm for the provision of comprehensive psychotherapeutic support during rehabilitation following the treatment of reproductive system MNs and to evaluate its effect on QoL indicators in women with neuropsychiatric disorders.Material and methods. The algorithm for the provision of comprehensive psychotherapeutic support included clinical interview, cognitive behavioral therapy, visualization, audio therapy, art therapy, group and individual psychotherapy, family psychotherapy, image therapy. …”
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Efficacy and Safety of Biologics Targeting Type 2 Inflammation in COPD: A Systematic Review and Network Meta-Analysis by Li S, Yi B, Wang H, Xu X, Yu L

“…Shujie Li,1,* Baiyi Yi,1,* Huan Wang,2 Xianghuai Xu,1 Li Yu1 1Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 2Clinical Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianghuai Xu, Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, People’s Republic of China, Email 05849@tongji.edu.cn Li Yu, Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, People’s Republic of China, Email 96778@tongji.edu.cnPurpose: This study aims to comparatively evaluate the efficacy and safety profiles of biologic agents targeting type 2 inflammation in COPD.Methods: As of September 1, 2024, we identified and screened eight clinical studies evaluating biologic agents targeting type 2 inflammation for COPD treatment from multiple databases. …”
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