Complete histopathological regression in rectal cancer after neoadjuvant chemoradiotherapy and sphincter preserving surgical treatment by Petrović Tomislav, Knežević-Ušaj Slavica, Radovanović Dragana, Lukić Dejan, Petrović Nemanja, Petroivić Tanja

“…The aim of this study was to evaluate overall survival in rectal cancer patients treated with preoperative chemoradiotherapy and sphincter preserving surgery. …”
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Challenges and opportunities to minimize the dose in the neurovascular bundles during prostate radiotherapy by Victor J. Brand, Linda Rossi, Maaike T.W. Milder, Femke E. Froklage, Alison C. Tree, Mischa S. Hoogeman, Luca Incrocci

“…Material and methods: 20 previously treated patients with localized PCa. Based on a MRI-CT match, the NVB were retrospectively delineated. …”
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Efficacy of alpelisib with rational use of metformin in HR+/HER2- advanced breast cancer patients with <i>PIK3CA</i> mutations (m): retrospective analysis in routine practice of se... by D. A. Filonenko, R. V. Orlova, M. I. Gluzman, A. A. Vakhitova, A. Yu. Goryainova, K. S. Grechukhina, I. I. Bykonya, L. G. Zhukova

“…Pts were stratified to risk groups of HG based on the algorithm before starting ALP and received MET for prevention of HG. …”
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Proposing a New Classification for Managing Prostaglandin-Induced Enophthalmos in Glaucoma Patients by Ferraro V, Gaeta A, Barone G, Confalonieri F, Tredici C, Vinciguerra P, Di Maria A

“…The proposed therapeutic algorithm stratifies treatment: mild cases benefit from conservative management or fillers, moderate cases from calcium hydroxyapatite (CAHY) injections, and severe cases from combined CAHY and autologous fat grafting.Conclusion: A lack of a standardized grading system hinders consensus on management of PAPS. …”
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Multi-objective optimization of sustainable cement-zeolite improved sand based on life cycle assessment and artificial intelligence [version 1; peer review: 1 approved, 2 approved... by Hossein MolaAbasi, Satinder Kaur Brar, Amin Tanhadoust, Sepideh Nasrollahpour, Omolbanin Ataee, Moncef L. Nehdi

“…This study proposes a multi-objective optimization approach using back-propagation neural network (BPNN) to predict the mechanical strength, along with an adaptive geometry estimation-based multi-objective evolutionary algorithm (AGE-MOEA) to identify the best parameters for cement-zeolite-improved sand, filling a long-lasting research gap. …”
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Estimating the prediction ability of reverse degree-based entropy indices for the physicochemical properties of lymes disease drugs by Guoping Zhang, Guoping Zhang, Yali Li, Yali Li, Abdul Rauf, Muhammad Aamir Afzal, Parvez Ali, Adnan Aslam

“…We focus specifically on antibiotic drugs such as doxycycline, ceftriaxone, Doxy 100, cefotaxime, Ceftin, Cefuroxime, Erythromycin, EryPed, Erythrocin Lactobionate, Ofloxacin, Moxifloxacin, amoxicillin, and penicillin G potassium—commonly used to treat Lyme disease—and leverage a novel Maple-based algorithm for calculating reverse degree-based entropy indices. …”
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Comparison of the effectiveness of various conservative treatment options for trophic ulcers and varicose eczema by E. V. Ivanov, E. P. Burleva

“…Based on the obtained data, therapeutic algorithms were proposed for the management of patients with venous TU and VE in outpatient settings.Conclusions. …”
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Loneliness and the risk of type 2 diabetes by Sara Fokdal Lehn, Lau Caspar Thygesen, Trine Allerslev Horsbøl, Allan Kofoed-Enevoldsen, Siri Rosenkilde, Sofie Have Hoffmann, Anne Bonde Thorsted, Katrine Rich Madsen, Peter Bindslev Iversen, Marie Stjerne Grønkjær

“…Loneliness was based on self-report, while type 2 diabetes was measured using an algorithm combining several health registers including type 2 diabetes patients treated both within the hospital sector and general practice. …”
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Visual outcomes and treatment adherence of patients with macular pathology using a mobile hyperacuity home-monitoring app: a matched-pair analysis by Livia Faes, Lucas M Bachmann, Martin K Schmid, Dawn A Sim, Michael A Thiel, Meriam Islam, Nico Gross, Andrew Schimel

“…Objective We compared patients with neovascular age-related macular degeneration (nvAMD), diabetic macular oedema (DMO) and other macular pathologies testing their vision with the hyperacuity home-monitoring app Alleye to patients not performing home-monitoring regarding clinical outcomes and clinical management.Design Matched-pair analysis.Setting Retina Referral Centre, Switzerland.Participants For each eye using Alleye, we matched 2–4 controls not using home-monitoring based on age, gender, number of previous intravitreal injections (IVI), best corrected visual acuity (BCVA) (Early Treatment Diabetic Retinopathy Study letters), central macular thickness (CRT) and time point of enrolment, using the Mahalanobis distance matching algorithm. We included 514 eyes (288 patients); 107 eyes with nvAMD using home monitoring and 218 controls not using home monitoring, 25 eyes with DMO (n=52 controls) and 40 eyes with miscellaneous conditions (n=72 controls). 173 eyes (33.7%) received no IVI during follow-up.Main outcome measures Improvement of ≥5 letters, number of injection visits and treatment retention after correcting for differences in baseline characteristics with multivariate analyses.Results The mean follow-up duration was 809 days (range 147–1353) and the mean number of IVI/year among treated eyes was 6.7 (SD 3.1). …”
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Collaborative governance model for spoil disposal and gully infill land creation near open-pit coal mines by Shaogang LEI, Jianying ZHANG, Chang LIU, Liang WANG, Zhenwang JIA

“…The main technical steps include: extracting the location of the gully to be treated based on the algorithm of constructing concentric rectangular windows inside and outside, optimizing the earthwork allocation path of the waste dump based on the “source sink” theory, backfilling the gully area based on the reshaping of the near natural landform, screening the waste materials and reconstructing the soil layer profile of the gully backfilling, greening and land reuse of the covering soil, and evaluating the ecological effects of collaborative mining and treatment. …”
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RATIONAL USE OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS. CLINICAL GUIDELINES by A. E. Karateev, E. L. Nasonov, V. T. Ivashkin, A. I. Martynov, N. N. Yakhno, G. P. Arutyunov, L. I. Alekseeva, G. R. Abuzarova, M. A. Evseev, M. L. Kukushkin, S. S. Kopenkin, A. M. Lila, T. L. Lapina, D. S. Novikova, T. V. Popkova, A. P. Rebrov, K. V. Skorobogatykh, N. V. Chichasova

“…To do this, the authors proposed a NSAID choice algorithm based on the assessment of risk factors for AE, the individual characteristics of various representatives of this drug group, and the possibility of prevention of AE.Since then, new data on the efficacy and safety of NSAIDs have been obtained. …”
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Host and bacterial urine proteomics might predict treatment outcomes for immunotherapy in advanced non-small cell lung cancer patients by David Dora, Peter Revisnyei, Peter Revisnyei, Alija Pasic, Gabriella Galffy, Edit Dulka, Anna Mihucz, Brigitta Roskó, Sara Szincsak, Anton Iliuk, Glen J. Weiss, Zoltan Lohinai, Zoltan Lohinai

“…Internal validation was performed using the Random Forest (RF) machine learning (ML) algorithm. RF was validated with a non-linear Bayesian ML model. …”
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Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy by T.   I. Dеshkina, L.  V. Bolotina, A.  R. Gevorkov, A.  V. Boyko, A.  L. Kornietskaya, A. P. Polyakov, P.   V. Golubev, R.  S. Sydykova, A. A. Fedenko

“…To date, there are no randomized trials to determine the optimal treatment algorithm for this group of patients. Data on the use of induction chemotherapy in squamous cell carcinoma of sino-nasal tract are limited to a small series of clinical observations and, often, are retrospective in nature.Aim. …”
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Delta-radiomics analysis based on magnetic resonance imaging to identify radiation proctitis in patients with cervical cancer after radiotherapy by Jing Xue, Menghan Wu, Jing Zhang, Jiayang Yang, Guannan Lv, Baojun Qu, Yanping Zhang, Xia Yan, Xia Yan, Jianbo Song, Jianbo Song

“…ObjectivesTo develop a magnetic resonance imaging (MRI)-based radiomics model for predicting the severity of radiation proctitis (RP) in cervical cancer patients’ post-radiotherapy.MethodsWe retrospectively analyzed clinical data and MRI images from 126 cervical squamous cell carcinoma patients treated with concurrent chemoradiotherapy. Logistic regression (LR), Pearson correlation coefficient, and least absolute shrinkage and selection operator (LASSO) methods were utilized to select optimal imaging features, leading to a combined prediction model developed using a random forest (RF) algorithm. …”
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Initial experience of parenchyma-sparing liver resection with systematic selective hepatic vein reconstruction for colorectal metastases by Yevhenii Trehub, Åsmund Avdem Fretland, Artem Zelinskyi, Dzmitrii Kharkov, Oleksii Babashev, Dmytro Chieverdiuk, Artem Shchebetun, Kyrylo Khyzhniak, Maksym Pavlovskii, Andrii Strokan, Sergii Zemskov

“…HV reconstructions allowed the preservation of additional parenchyma (mean 495.4 mL, 95% CI 350.2 to 640.7). A decision-making algorithm to be used within the described approach is proposed.Conclusions Selective HV reconstruction is a feasible approach for PSH for CRLM. …”
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Machine learning modeling for the risk of acute kidney injury in inpatients receiving amikacin and etimicin by Pei Zhang, Qiong Chen, Jiahui Lao, Juan Shi, Jia Cao, Xiao Li, Xin Huang

“…Univariate analyses and the least absolute shrinkage and selection operator algorithm were used to screen risk factors and construct the model. …”
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Quality of life of patients with primary open-angle glaucoma, primary angle closure glaucoma, and pseudoexfoliation glaucoma in Central Serbia by Marčeta Elizabeta, Šarenac-Vulović Tatjana, Petrović Nenad, Vulović Dejan, Trenki Marija, Ranđelović Danijela, Todorović Dušan

“…Using the appropriate algorithm, the total NEI VFQ-25 scores were calculated for each group. …”
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Adverse Drug Reactions during COVID-19 Treatment: A Comprehensive Analysis Focused on Hospitalized Patients, with the Use of a Survey in Cuba in 2020 by Lizette Gil-del-Valle, Rosario Gravier-Hernández, Waldemar Baldoquin-Rodríguez, Beatriz Sierra-Vázquez, Ana Beatriz Perez-Díaz, Pablo Sariol-Resik, Tatiana Prieto-Dominguez, Mario Manuel Delgado-Guerra, Joniel Arnoldo Sánchez- Márquez, Olga Elena López-Fernández, Faustina Fonseca-Betancourt, Liana Valdés-Lanza, Odalys Orraca-Castillo, Xaveer Van Ostade, Wim Vanden Berghe, Veerle Vanlerberghe, M. Guadalupe Guzmán-Tirado

“…Each potential ADR case was assessed for causality based on the WHO-UMC algorithm, concomitant drug influences, and the presence of any drug-drug interactions (DDI). …”
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Intrahepatic cholangiocarcinoma trends and treatment lines: real-world evidence from the French National Hospital Discharge database by M. Delaye, B. Grenier, A. Lièvre, C. Neuzillet

“…Background: Little is known about the therapeutic trajectory of patients treated in hospitals for intrahepatic cholangiocarcinoma (iCCA) and patterns of care in daily clinical practice. …”
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Immunohistochemical Subtype and Parameters of International Prognostic Index in the New Prognostic Model of Diffuse Large B-Cell Lymphoma by SV Samarina, AS Luchinin, NV Minaeva, IV Paramonov, DA D’yakonov, EV Vaneeva, VA Rosin, VA Rosin

“…Median age was 58 years (range 23–83). All patients were treated with R-СНОР. The creation of overall survival (OS) prognostic model for DLBCL patients was based on machine learning with classification and regression trees. …”
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