Fingolimod and risk of skin cancer among individuals with multiple sclerosis: a population-based cohort study protocol by Lisa Kuramoto, Larry D Lynd, Amir Khakban, Jacquelyn J Cragg, Anthony Traboulsee, Jiwon Oh, Analisa Jia, Weng Sut Sio, M A De Vera, Jonathan Loree, Roger Tam

“…Individuals with MS aged ≥18 years will be identified using a validated algorithm. Incident users of fingolimod and active comparators (natalizumab, alemtuzumab, dimethyl fumarate, teriflunomide) will then be identified. …”
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Rehabilitation for Chronic Constipation: Integrative Approaches to Diagnosis and Treatment by Luana Alexandrescu, Ionut Eduard Iordache, Alina Mihaela Stanigut, Laura Maria Condur, Doina Ecaterina Tofolean, Razvan Catalin Popescu, Andreea Nelson Twakor, Eugen Dumitru, Andrei Dumitru, Cristina Tocia, Alexandra Herlo, Ionut Tiberiu Tofolean

“…Additionally, this particular management is to be used in conjunction with an algorithm designed to enhance and support clinical practice.…”
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A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types by Zhen Zeng, Tianbei Zhang, Jiajia Zhang, Shuai Li, Sydney Connor, Boyang Zhang, Yimin Zhao, Jordan Wilson, Dipika Singh, Rima Kulikauskas, Candice D. Church, Thomas H. Pulliam, Saumya Jani, Paul Nghiem, Suzanne L. Topalian, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith

“…Our three-gene “MANAscore” algorithm outperforms other RNAseq-based algorithms in identifying validated neoantigen-specific CD8+ clones, and accurately identifies TILs that recognize other classes of tumor antigens, including cancer testis antigens, endogenous retroviruses and viral oncogenes. …”
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Predicting pathologic ≥N2 disease in women with breast cancer by Kerollos Nashat Wanis, Wenli Dong, Yu Shen, Funda Meric-Bernstam, Taiwo Adesoye, Henry M. Kuerer, Abigail S. Caudle, Nina Tamirisa, Sarah M. DeSnyder, Susie X. Sun, Isabelle Bedrosian, Puneet Singh, Solange E. Cox, Kelly K. Hunt, Rosa F. Hwang

“…Of these, 415 (70.7%) underwent completion ALND, with 64 (15.4%) having ≥pN2 disease. The trained algorithm had an AUC of 0.87 (95% CI: 0.74, 0.97) in the held-out test data, and 0.78 (95% CI: 0.76, 0.79) in recent NCDB data where completion ALND was much less commonly performed. …”
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Machine learning‐based risk prediction model for neuropathic foot ulcers in patients with diabetic peripheral neuropathy by Ge Shi, Zhenxuan Gao, Ze Zhang, Quanyu Jin, Sitong Li, Jiaxin Liu, Lei Kou, Abudurezhake Aerman, Wenqiang Yang, Qi Wang, Furong Cai, Li Zhang

“…Methods Clinical data from 400 DPN patients treated at the China–Japan Friendship Hospital (September 2022–2024) were retrospectively analyzed. …”
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Light attenuation as a substitute for nutrient supply for maximizing protein content in Gracilaria cornea (Rhodophyta): Modeling nitrogen and phosphorus supplementation using a pha... by Niva Tadmor-Shalev, Dan Tchernov, Andrea Ghermandi, Eli Shemesh, Álvaro Israel, Anna Brook

“…In-situ spectral measurements and Artificial Neural Network (ANN) algorithm were used to determine protein content accumulation. …”
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Endovascular Therapy in Patients With Acute Ischemic Stroke With Large Infarct: A Guideline From the Society of Vascular and Interventional Neurology by Maxim Mokin, Tudor G. Jovin, Sunil A. Sheth, Thanh N. Nguyen, Kaiz S. Asif, Ameer E. Hassan, Ashutosh P. Jadhav, Cynthia Kenmuir, David S. Liebeskind, Ossama Mansour, Raul G. Nogueira, Robin Novakovic, Santiago Ortega‐Gutierrez, Albert J. Yoo, Waldo R. Guerrero, Amer M. Malik

“…Recommendations were assigned using the Guidelines and Practice Standards Class of Recommendation/Level of Evidence algorithm and guideline format. The recommendations were developed through a consensus process involving an expert panel of vascular neurologists, neurointensivists, and neurointerventionalists. …”
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Clinical Validation of a Machine Learning-Based Biomarker Signature to Predict Response to Cytotoxic Chemotherapy Alone or Combined with Targeted Therapy in Metastatic Colorectal C... by Duilio Pagano, Vincenza Barresi, Alessandro Tropea, Antonio Galvano, Viviana Bazan, Adele Caldarella, Cristina Sani, Gianpaolo Pompeo, Valentina Russo, Rosa Liotta, Chiara Scuderi, Simona Mercorillo, Floriana Barbera, Noemi Di Lorenzo, Agita Jukna, Valentina Carradori, Monica Rizzo, Salvatore Gruttadauria, Marco Peluso

“…Various machine learning algorithms, like random survival forest and neural networks, will be integrated to develop a highly accurate and stable predictive model. …”
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Comparative efficacy of Bruton tyrosine kinase inhibitors in high-risk relapsed/refractory CLL: a network meta-analysis by Mazyar Shadman, Jennifer R. Brown, Leyla Mohseninejad, Keri Yang, Heather Burnett, Binod Neupane, Rhys Williams, Nicole Lamanna, Susan M. O'Brien, Alessandra Tedeschi, Constantine S. Tam

“…Abstract: Bruton tyrosine kinase inhibitors (BTKis) have led to changes in the treatment algorithm for patients with high-risk relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), defined based on the presence of genetic mutations. …”
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Study on water quality analysis and early-warning technology based on rough set and evidence theory by ZHU Qiong-yao, ZHANG Guang-xin, FENG Tian-heng, HUANG Ping-jie, HOU Di-bo

“…The accuracy of water quality analysis and early-warning is hard to guarantee. Aiming to treat these problems, a new method for a water monitoring system is needed to study on.In this study, the rough set and Dempster-Shafer (D-S) evidence theories were researched, and the water quality analysis and early-warning algorithm based on rough set and D-S evidence theories were presented. …”
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The relationship between the expression of serum asprosin and miR-21 in patients with osteoporosis and delayed healing after OVCF surgery by Gaoming Song, Silong Lin, Xianqi Zhang, Hong Pan

“…Methods: A prospective study inducted 300 OVCF patients treated with percutaneous vertebroplasty (PVP) from June 2022 to June 2024. …”
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OSTEOPOROSIS TREATMENT ADHERENCE: RESULTS FROM A RETROSPECTIVE COHORT STUDY by O. A. Nikitinskaya, N. V. Toroptsova, E. L. Nasonov

“…Patients who were more adherent to OP treatment were those who underwent determination of serum vitamin D levels (p=0.009), calculation of a 10-year absolute osteoporotic fracture risk according to the FRAX® algorithm (p=0.022), an annual bone densitometry examination (p=0.0158) and, more often than annually, biochemical blood tests (p=0.0043), as well as those who had visited their physician 3 times or more during the estimated period (p=0.003). …”
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Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer by Tianyue Sun, Yan Chen, Ying-Xuan Chen

“…Despite increasing insights into the complex tumor microenvironment (TME), the metabolic heterogeneity of CRC cells and their interactions with tumor-infiltrating immune cells remain poorly understood.MethodsWe analyzed 46,374 epithelial cells from 17 CRC patients treated with PD-1 blockade to develop an amino acid (AA) metabolism score using the AUCell algorithm. …”
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Prognostic correlation analysis of colorectal cancer patients based on monocyte to lymphocyte ratio and folate receptor-positive circulating tumor cells and construction of a machi... by Siying Pan, Chi Lu, Chi Lu, Hongda Lu, Hongda Lu, Hongfeng Zhang

“…PurposeTo evaluate the prognostic value of the monocyte to lymphocyte ratio (MLR) and folate receptor-positive circulating tumor cells (FR+CTCs) in patients with colorectal cancer (CRC) and to develop predictive model for post-treatment survival using machine learning (ML) algorithms.MethodsWe retrospectively analyzed 67 CRC patients treated with radical surgery or chemoradiotherapy at The Central Hospital of Wuhan from January 2020 to December 2022. …”
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Nordic inflammatory bowel disease treatment strategy trial: protocol for the NORDTREAT randomised controlled biomarker-strategy trial by Jonas Halfvarson, Robin Christensen, Vibeke Andersen, Jens Kjeldsen, Johan D Söderholm, Anja Fejrskov, Johannes David Füchtbauer, Lóa G Davíðsdóttir, Martin Rejler, Dirk Repsilber, Marte Høivik

“…In the access to protein signature group, patients displaying a protein signature suggestive of an increased risk of an aggressive disease course will be treated in line with a top-down treatment algorithm (anti-tumour necrosis factor agent with/without an immunomodulator). …”
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Measurement-Based Assessment of Energy Performance and Thermal Comfort in Households Under Non-Controllable Conditions by George M. Stavrakakis, Dimitris Bakirtzis, Dimitrios Tziritas, Panagiotis L. Zervas, Emmanuel Fotakis, Sofia Yfanti, Nikolaos Savvakis, Dimitris A. Katsaprakakis

“…The recorded indoor environmental conditions are initially compiled to the Predicted Mean Vote (PMV) index, followed by the formulation of databases of hourly electricity consumption, PMV and local outdoor climate conditions retrieved by an official source of meteorological conditions. A special algorithm for database processing was developed which takes into account the eligibility of data series, i.e., only the ones corresponding to non-zero electricity consumption are treated as eligible. …”
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Learning Transversus Abdominis Activation in Older Adults with Chronic Low Back Pain Using an Ultrasound-Based Wearable: A Randomized Controlled Pilot Study by Luis Perotti, Oskar Stamm, Hannah Strohm, Jürgen Jenne, Marc Fournelle, Nils Lahmann, Ursula Müller-Werdan

“…Segmental stabilization exercises (SSEs) are commonly used to treat CLBP, but the selective activation of deep abdominal muscles during these exercises can be challenging for patients. …”
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Burden of Glucocorticoid Use and Risk of Toxicities Among Patients with Immunoglobulin-G4-Related Disease: A Retrospective US-Based Claims Study by Zachary S. Wallace, Jenny Y. Park, Elizabeth Serra, Patrick Gagnon-Sanschagrin, Annie Guérin, Kristina Patterson, Haridarshan Patel, Vikesh K. Singh

“…Abstract Introduction Glucocorticoids are commonly used to treat immunoglobulin G4-related disease (IgG4-RD), but there is limited real-world evidence describing glucocorticoid-related toxicities in this population. …”
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Evaluating natalizumab first-line and later-line use in multiple sclerosis: a US claims database analysis by Robin L. Avila, Nicole S. Croteau, Fei Tang, Jason C. Simeone, Khalil Jomaa, Boyang Bian, Mattia Gianinazzi

“…Relapses were identified using a validated claims-based algorithm, and time to first relapse was analyzed using Kaplan–Meier methods. …”
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Use of the GLYCEMIZER® tool by general practitioners to meet individual glycated hemoglobin goals in patients with type 2 diabetes mellitus by Nicolas Byron Hatziisaak, Telemachos Hatziisaak, Urs Keller

“…Objective — We assessed the usefulness of an easy-to-use algorithm (GLYCEMIZER®) to calculate individual HbA1c-goals and compared them with targeted (‘gut feeling’ of the GP’s) and achieved levels. …”
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