A phase I study of the CDK4/6 inhibitor ribociclib combined with gemcitabine in patients with advanced solid tumors by Aurora Norman, Mahesh Seetharam, Jacob Allred, Jianping Kong, Mateusz Opyrchal, Wen Wee Ma, Yanyan Lou, Grace K. Dy, Amit Mahipal, S. John Weroha, Andrea E. Wahner Hendrickson, Joel M. Reid, Alex A. Adjei

“…Abstract Background Based on preclinical data showing addition of CDK4/6 inhibitors to gemcitabine was synergistic, ribociclib was evaluated in combination with gemcitabine to determine the maximum tolerated dose (MTD) and dose limiting toxicities (DLT). …”
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Criteria base of the Hartmann–Sprenger pipe workflow by V. V. Makarov, V. I. Kuznetsov, I. O. Kuznetsova

“…On the basis of a closed mathematical model, the main parameters affecting the increase in the total temperature of the gas at the end of the dead-end cavity above the deceleration temperature of the incoming flow are recorded. …”
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The proportion of clinically relevant alarms decreases as patient clinical severity decreases in intensive care units: a pilot study by Ryota Inokuchi, Kent Doi, Kazuaki Shinohara, Kensuke Nakamura, Takehiro Matsubara, Susumu Nakajima, Hajime Sato, Masataka Gunshin, Takahiro Hiruma, Takeshi Ishii, Yoichi Kitsuta, Naoki Yahagi, Yuko Nanjo, Masahiro Echigo, Aoi Tanaka, Mitsuo Umezu

“…Objectives To determine (1) the proportion and number of clinically relevant alarms based on the type of monitoring device; (2) whether patient clinical severity, based on the sequential organ failure assessment (SOFA) score, affects the proportion of clinically relevant alarms and to suggest; (3) methods for reducing clinically irrelevant alarms in an intensive care unit (ICU).Design A prospective, observational clinical study.Setting A medical ICU at the University of Tokyo Hospital in Tokyo, Japan.Participants All patients who were admitted directly to the ICU, aged ≥18 years, and not refused active treatment were registered between January and February 2012.Methods The alarms, alarm settings, alarm messages, waveforms and video recordings were acquired in real time and saved continuously. …”
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Medication Belief and Adherence among Patients with Epilepsy by Yirga Legesse Niriayo, Abraham Mamo, Kidu Gidey, Gebre Teklemariam Demoz

“…Result. We included a total of 292 patients. Almost two-thirds (65.4%) of the patients were nonadherent to their medications. …”
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Instrumental balance assessment in Parkinson's disease and parkinsonism. A systematic review with critical appraisal of clinical applications and quality of reporting by Andrea Merlo, Lorenzo Cavazzuti, Maria Chiara Bò, Francesco Cavallieri, Maria Chiara Bassi, Benedetta Damiano, Sara Scaltriti, Valentina Fioravanti, Giulia Di Rauso, Giulia Di Rauso, Giacomo Portaro, Franco Valzania, Mirco Lusuardi, Isabella Campanini

“…Study methodology, clinical aspects, assessment protocol, technical aspects, and transferability to clinical practice were critically appraised by a set of quality questions, scored on three levels (0, 0.5, 1). Total scores were used to assess overall studies' quality.Results132 studies were included. …”
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Promotion of microfracture-mediated cartilage repair by the intra-articular injection of Mg2+ by Zhian Chen, Tianhua Zhou, Zhengbo Yin, Peiya Duan, Ying Zhang, Yujiao Feng, Rongmao Shi, Yongqing Xu, Rongqing Pang, Hongbo Tan

“…This study aimed to investigate the beneficial effects of the combination of MFX and Mg2+ in cartilage repair. Methods: A total of 60 rabbits were classified into five groups (n = 12 each): sham, MFX, and three different doses of Mg2+ treatment groups (0.05, 0.5, and 5 mol/L). …”
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Gastrointestinal Disturbances Associated with the Consumption of Sugar Alcohols with Special Consideration of Xylitol: Scientific Review and Instructions for Dentists and Other Hea... by Kauko K. Mäkinen

“…This review will also touch upon the FODMAPs diet concept.…”
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Cohousing and new dwelling cultures in post-seismic urban planning by Mauro Francini, Rosario Chimirri, Annunziata Palermo, Maria Francesca Viapiana

“…The present contribution, also on the basis of historical-anthropological studies, concerning past community life and current reality, between fragility of the landscape and incongruity of human actions, indicates a return to cohousing as one of the most interesting criteria for the redefinition of urban interventions, opening towards scientific scenarios based on interdisciplinarity, as well as creating an experimental laboratory for planning.…”
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How the tulip breaking virus creates striped tulips by Aidan A. Wong, Gustavo Carrero, Thomas Hillen

“…The model, which describes the viral inhibition of pigment expression (anthocyanins) and their interaction with viral reproduction, incorporates a pattern formation mechanism identified as an activator-substrate mechanism, similar to the well-known Turing instability, working together with Wolpert’s positional information mechanism. …”
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Pancreatic Perivascular Epithelial Cell Tumor (PEComa) with Liver Metastasis: a Case Report and Literature Review by Yu. A. Stepanova, Kh. A. Ayvazyan, D. V. Kalinin, O. I. Zhavoronkova, V. S. Shirokov, A. V. Zhao

“…Synchronously, metastases were detected in both liver lobes, for which she took Everolimus for 6 years under the control of radiology methods with dose adjustment and frequency of administration. …”
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Zasada zrównoważonego rozwoju w turystyce by Dominika Dzwonkowska

“…Tourism has become one of the most popular leisure activities and the number of tourists has increased remarkably in recent years. …”
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An Assessment of Human versus Climatic Impacts on Jing River Basin, Loess Plateau, China by Yi He, Fei Wang, Xingmin Mu, Huiting Yan, Guangju Zhao

“…The impacts of climate change and human activities on runoff and sediment load are too integrated to distinguish their own contributions. …”
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Multicriteria assessment of recently implemented conservation agriculture cropping systems across farmers’ plots in northwestern Cambodia by Sambo Pheap, Alexis Thoumazeau, Jun Murase, Vang Seng, Jean-Pierre Sarthou, Veng Sar, Linda Kimbo, Soklin Kheam, Pheakdey Chan, Pao Srean, Samrith Leang, Lyda Hok, Florent Tivet

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A profit maximization model for sustainable inventory under preservation technology and linear time-dependent holding cost by - Aashish, Pavan Kumar

“…A numerical experimentation is carried to compute the total profit and the order quantity. To validate the proposed model, the sensitivity analysis is conducted for the total profit function as well as the order quantity. …”
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Non-Archimedean valued quasi-invariant descending at infinity measures by S. V. Lüdkovsky

“…Measures with values in non-Archimedean fields, which are quasi-invariant and descending at infinity on topological vector spaces over non-Archimedean fields, are studied in this paper. …”
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Novo normal na modernidade líquida: uma visão do amanhã presente by Roberta Krewer Molina

“…O presente artigo disserta sobre o novo normal da história recente devido à pandemia de COVID-19 que se espalhou pelo mundo todo, mas que, ao mesmo tempo, não deixa de ser parecida com outras pandemias que ocorreram anteriormente, estabelecendo, assim, um novo padrão de convívio social. …”
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Gamonalismo y dominación en los Andes by Henán Ibarra

“… El presente artículo académico trabaja sobre la identificación del gamonalismo como una forma de dominación y extorsión a la población rural que sería parte tópica de los discursos agraristas y de izquierda que se hallaban incorporado al lenguaje político de época de estudio. …”
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An analysis of the role of non-governmental organizations in improving the urban management system from the perspective of the citizens of the metropolis of Tehran by sirous rahimzadeh sisibig, alireza shichaslami, Kianoosh zakerhaghighi

“…The research method was descriptive-analytical and the data collection method was documentary and survey. The research tool was a questionnaire. The statistical population of the study was the citizens of Tehran and the sample size was 383 people. …”
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Modified Modal Pushover Design for Asymmetric-Plan RC Shear-Wall Structures by Mohammad Sadegh Birzhandi, Daniyal Mirzakhani

“…Higher mode contributions in responses of all structures are calculated by the elastic jagged response spectrum; mean-matched smoothed displacement response spectrum ± standard deviation curve is also used to compare stories’ shear and torsional demands estimated by these two response spectra. …”
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Dead Reckoning Using Play Patterns in a Simple 2D Multiplayer Online Game by Wei Shi, Jean-Pierre Corriveau, Jacob Agar

“…In today’s gaming world, a player expects the same play experience whether playing on a local network or online with many geographically distant players on congested networks. …”
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