Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

“…Improved therapeutic protocols shall overcome therapeutic limitations such as the (i) tolerability and safety (i.e., minimal toxic side-effects); (ii) progression free survival (e.g., reduced relapse disease frequency); (iii) duration response (i.e., decreased drug resistance). …”
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Lady Clara Cavendish: Reynolds and Rymer’s Political Hoax by Rebecca L. Nesvet

“…She and her novels are in fact the inventions of Reynolds and his regular employee James Malcolm Rymer (1814–84), who in the 1840s created ‘Sweeney Todd’ and ‘Varney, the Vampire’ for the penny blood publisher Edward Lloyd. …”
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À l’Est de l’Europe, quoi de neuf en matière de réformes territoriales ? Réflexions à partir de la régionalisation en Bulgarie by Emmanuelle Boulineau

“…It shows that two types of regionalization both exist; one oriented towards administrative functions, the other based on territorial competitiveness. …”
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EDITORIAL by Universidad Autónoma de Chiapas

“…Por lo que celebramos el inicio de un fructífero 2025, deseando que nuestra comunidad universitaria, lectora y colaboradores tengan plenitud en todos los aspectos de su vida personal, académica y profesional. …”
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Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses by Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk

“…Extrachromosomal DNA (ecDNA), in contrast, represents a rapid, reversible, and predictable DNA alteration critical for cancer’s adaptive response.MethodsIn this study, we developed a novel post-processing pipeline for automated detection and quantification of ecDNA in metaphase Fluorescence in situ Hybridization (FISH) images, leveraging the Microscopy Image Analyzer (MIA) tool. This pipeline is tailored to monitor ecDNA dynamics during drug treatment.ResultsOur approach effectively quantified ecDNA changes, providing a robust framework for analyzing the adaptive responses of cancer cells under therapeutic pressure.DiscussionThe pipeline not only serves as a valuable resource for automating ecDNA detection in metaphase FISH images but also highlights the role of ecDNA in facilitating swift and reversible adaptation to epigenetic remodeling agents such as JQ1.…”
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Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice by Yanhua Zhao, Lili Huang, Huan Xu, Guangxi Wu, Mengyi Zhu, Jie Tian, Hao Wang, Xiangrui Wang, Weifeng Yu, Liqun Yang, Diansan Su

“…While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data about the very young adult individuals are lacking. …”
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« A Flight », de Charles Dickens (1851), récit de voyage ? by Isabelle Hervouet-Farrar

“…Dickens’s article is published today by Penguin both as a piece of journalism (in Selected Journalism) and as a piece of fiction (in Selected Short Fiction), which raises the question of the genre(s) to which it belongs. …”
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The effect of service quality and customer satisfaction on the flip app customer loyalty in Indonesia by Galang Pramudika Sukandar, Mochamad Yudha Febrianta

“…The research population is all Flip.id users in Indonesia, totaling 12,000,000 people. A sample of 400 respondents was selected by simple randomization. …”
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Statistical and Experimental Investigation of Hardened AISI H11 Steel in CNC Turning with Alternative Measurement Methods by Emrah Şahin, İsmail Esen

“…In this experimental study, AISI H11 hot work tool steel that has been hardened up to 50 HRC was subjected to hard turning tests with coated carbide tooling. …”
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ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

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Size-controlled assembly of phase separated protein condensates with interfacial protein cages by Hyeok Jin Oh, Yongsuk Lee, Haerang Hwang, Kibeom Hong, Hyeongjoo Choi, Jin Young Kang, Yongwon Jung

“…In addition, the 3D structures of intact protein condensates with interfacial cages are visualized with cryo-electron tomography (ET). This work offers a versatile platform for designing size-controlled, surface-engineered protein condensate materials.…”
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INVESTIGATING REASONS FOR RESISTANCE AMONG PROJECT AND GENERAL MANAGERS IN ENTERPRISE RESOURCE PLANNING IMPLEMENTATIONS by Amer Celjo, Azra Hanić, Marietta Kazalac

“… Enterprise Resource Planning (ERP) primary goal is to connect all organizational units together under the single data base. It is intended to speed up all the processes and track all the actions easily. …”
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A User-Centered Design Approach for a Screening App for People With Cognitive Impairment (digiDEM-SCREEN): Development and Usability Study by Michael Zeiler, Nikolas Dietzel, Fabian Haug, Julian Haug, Klaus Kammerer, Rüdiger Pryss, Peter Heuschmann, Elmar Graessel, Peter L Kolominsky-Rabas, Hans-Ulrich Prokosch

“…This is also a crucial step toward promoting broader adoption of such digital tools. …”
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Optimizing the Supply Chain for Recycling Electric Vehicle NMC Batteries by Fransisca Indraningsih Kasy, Muhammad Hisjam, Wakhid Ahmad Jauhari, Syed Ahmad Helmi Syed Hassan

“…Lithium-ion battery waste harms the environment as it contains toxic and flammable chemicals. New raw materials need to be procured economically due to the need for more infrastructure and a circular economy. …”
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Post-angiography spontaneous closure of cavernous sinus dural arteriovenous fistula: case report in Indonesia by Affan Permana, Stevanus Samudra, Fabianto Santoso, Adiguno Wicaksono

“…At the therapeutic DSA a month later, the fistula between left and right meningohypophyseal trunk toward the cavernous sinus was no longer identified. …”
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Eco-friendly synthesis of chitosan NPs from Fioria vitifolia (L.) L: Potential to antibacterial, antioxidant, cytotoxicity properties of HepG2 cells and their evaluation of safety... by Mohamed Imath, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Ramalingam Karthik Raja, Gholamreza abdi

“…Using the MTT Assay, the dose-dependent response of FV-CNPs against HepG2 cells was determined, and an IC50 value of 59.41 µg/mL was obtained. Finally, the toxicity test conducted on zebrafish eggs revealed that bending bodies only became visible at levels exceeding 100 μg/mL. …”
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Community Dynamics of Fish Larvae in Coastal Zhejiang: Seasonal Variations in Spatiotemporal Distribution and Environmental Driving Factors by Peng Zhao, Rijin Jiang, Qiqun Li, Rui Yin, Yuelian He, Qingxi Han, Guangjie Fang

“…Fish larvae are typically found to be aggregated along estuaries and bays in spring, autumn, and summer, while in winter, they tend to shift towards areas near the boundaries of motor trawler fisheries areas. …”
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Mathematical modelling and phylodynamics for the study of dog rabies dynamics and control: A scoping review. by Maylis Layan, Simon Dellicour, Guy Baele, Simon Cauchemez, Hervé Bourhy

“…Through a detailed search of the PubMed, Web of Science, and Scopus databases, we identified a total of n = 59 relevant studies using mathematical models (n = 30), phylodynamic inference (n = 22) and interdisciplinary approaches (n = 7). …”
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Factors Controlling Carbon Metabolism and Humification in Different Soil Agroecosystems by S. Doni, C. Macci, E. Peruzzi, B. Ceccanti, G. Masciandaro

“…The soils under organic (Alberese, soil cultivated with Triticum durum Desf.) and nonintensive management practices (Puch, soil cultivated with Triticum aestivum L. and Avena sativa L.) showed higher enzymatically active humic carbon, total organic carbon, humification index (B/E3s), and metabolic potential (dehydrogenase activity/water soluble carbon) if compared with conventional agriculture and plough-based tillage, respectively. …”
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Financial Incentives for Green Energy Usage within the Scope of Sustainable Energy Policies: Survey Study with Production Companies in İzmir and Manisa by Atakan Gerger, Güneş Çetin Gerger, Devrim Şavlı

“…This situation has increased the orientation towards renewable energy sources and brought the circular economy to the forefront. …”
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