Rationale and design of a multicentre randomised controlled trial on circulating tumour DNA-guided neoadjuvant treatment strategy for locally advanced rectal cancer (CINTS-R) by Bin Wu, Yi Xiao, Xiao Zhang, Tao Xu, Qian Liu, Wei Fu, Yang An, Yongheng Li, Guole Lin, Huadan Xue, Guoju Wu, Jiaolin Zhou, Hongwei Yao, Zhenjun Wang, Weijie Chen, Junyang Lu, Guannan Zhang, Xiaoyuan Qiu

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FTACMT study protocol: a multicentre, double-blind, randomised, placebo-controlled trial of faecal microbiota transplantation for autism spectrum disorder by Li Ling, Wei Wei, Li Lin, Li Ke, Ye Chen, Li Ning, Wang Yu, Zhang Xin, Yang Rong, Zhang Xueying, Cui Jiaqu, Chen Qiyi, Qin Huanlong, Du Yasong, Zhao Xiaoxin, Lu Jubao, Lv Xiaoqiong, Ma Chunlian, Chen Shidong, Kuang Guifang, Zhao Dongmei, Fang Shuanfeng, Zhang Xujing, Yang Binrang, Wang Yanxia, Yuan Song, Zhou Xiang, Zhang Beihua, Jiang Lin, Ji Hong, Yan Yinmei, Yan Peihua, Huang Linsheng, Zhang Shaoyi, Ma Chenhuan, Miao Yun, Ling Wenqi, Geng Bojing, Feng Xueying, Li Huilin, Liu Liyan, Wu Weijia, Li Dexin, Jiang Qianru

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Clinicogenetic characterization and response to disease-modifying therapies in spinal muscular atrophy: real-world experience from a reference center in Southern Brazil by Ana Letícia Amorim de Albuquerque, Júlia Kersting Chadanowicz, Isabela Possebon Bevilacqua, Ana Lucia Portella Staub, Pablo Brea Winckler, Patricia Zambone da Silva, Simone Chaves Fagondes, Renata Salatti Ferrari, Claudia Denise de Oliveira Trojahn, Viviane Zechlinski Sacharuk, Thayne Woycinck Kowalski, Karina Carvalho Donis, Michele Michelin Becker, Jonas Alex Morales Saute

“…Most patients with SMA type 1 were on disease-modifying treatment, whereas only slightly over a third of patients with type 2 and about 10 % of type 3 were receiving such treatments. …”
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Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007... by Leo Anthony Celi, Jonathan Shaffer, Marie-Laure Charpignon, Liam G McCoy, Luis Filipe Nakayama, Jack Gallifant, Urvish Jain, Joao Matos, Pia Gabrielle I Alfonso, Marisa Cobanaj, Amelia Morel Fiske, Alexander J Gates, Frances Dominique V Ho, Mohammad Kashkooli, Naira Link

“…On average, approximately one-third (33.1%) of the authors of a given paper were inferred to be women; this result was consistent across the journals we studied. …”
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Perbandingan Insidensi Hipotensi Saat Induksi Intravena Propofol 2 Mg/Kg Bb Pada Posisi Supine dengan Perlakuan dan Tanpa Perlakuan Elevasi Tungkai by Beni Indra, Untung Widodo, Yunita Widyastuti

“…Demografic characteristics (age, sex, body weight and height) and  baseline haemodynamic parameters of the patients were similar in two groups (p > 0.05) except for BMI (p < 0.05) . …”
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AKRASIJA IR SUBJEKTAS EGONOMIKOJE by Zenonas Norkus

“…In traditional (Davidsonian) perspective, akrasia is free intentional action against the better (conditional) judgement. (2) In the traditional view, the baseline is nonacratic behaviour. Such behaviour is background against which the "anomaly" of akrasia must be explained. …”
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AKRASIJA IR SUBJEKTAS EGONOMIKOJE by Zenonas Norkus

“…In traditional (Davidsonian) perspective, akrasia is free intentional action against the better (conditional) judgement. (2) In the traditional view, the baseline is nonacratic behaviour. Such behaviour is background against which the "anomaly" of akrasia must be explained. …”
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BRAF inhibitor monotherapy in BRAFV600E-mutated pediatric low-grade glioma: a single center’s experience by S. S. McThenia, S. S. McThenia, S. S. McThenia, K. M. Reddy, K. M. Reddy, E. Damaraju, E. Castellino, Z. He, R. Beer, F. Chien, F. Chien, F. Chien, R. C. Castellino, R. C. Castellino, R. C. Castellino, A. E. Goldman-Yassen, A. E. Goldman-Yassen, J. R. Fangusaro, J. R. Fangusaro, J. R. Fangusaro, T. MacDonald, T. MacDonald, T. MacDonald

“…Tumor locations included: hypothalamus/optic chiasm (N=6); brainstem (N=4); third ventricle/thalamus (N=2); parietal/temporal lobe (N=2); and spinal cord (N=1). …”
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Evaluating the effectiveness of integrated traditional Chinese and Western treatment based on symptom grading: a study protocol for a multi-center, randomized controlled trial of p... by Jiaxi Mai, Tingwei Zhou, Tingwei Zhou, Tingwei Zhou, Chen Wang, Chen Wang, Junrong Ye, Junrong Ye, Jiao Chen, Jiao Chen, Jiao Chen, Wen Wang, Wen Wang, Wen Wang, Yuanxin Pan, Yuanxin Pan, Yuanxin Pan, Yanheng Wei, Yanheng Wei, Lexin Yuan, Lexin Yuan, Hang Yang, Hang Yang, Shengwei Wu, Shengwei Wu, Jianxiong Guo, Jianxiong Guo, Jianxiong Guo, Aixiang Xiao, Aixiang Xiao, Aixiang Xiao

“…BackgroundApproximately one-third of depressed individuals receive treatment globally. …”
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Risk Factors for Urgency Incontinence in Women Undergoing Stress Urinary Incontinence Surgery by Leslie M. Rickey, Liyuan Huang, David D. Rahn, Yvonne Hsu, Heather J. Litman, Elizabeth R. Mueller

“…Multivariate models were constructed with UUI and symptom severity as outcomes. Results. Over two-thirds of subjects reported bothersome UUI at baseline. …”
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Ciprofloxacin and Clozapine: A Potentially Fatal but Underappreciated Interaction by Jonathan M. Meyer, George Proctor, Michael A. Cummings, Laura J. Dardashti, Stephen M. Stahl

“…Given the potentially fatal pharmacokinetic interaction between clozapine and ciprofloxacin, clinicians are advised to monitor baseline clozapine levels prior to adding strong CYP450 1A2 inhibitors, reduce the clozapine dose by at least two-thirds if adding a 1A2 inhibitor such as ciprofloxacin, check subsequent steady state clozapine levels, and adjust the clozapine dose to maintain levels close to those obtained at baseline.…”
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Assessment of Spontaneous Retinal Arterial Pulsations in Acute Central Retinal Vein Occlusions by Nicolas Arej, Vivien Vasseur, Elyse Jabbour, Anthony Manassero, Céline Giraud, Sébastien Bruneau, Yannick Le Mer, Martine Mauget-Faÿsse

“…A 10-second infrared film centered on the optic disc was recorded within a month of the onset of symptoms, and SRAPs were detected in two-thirds of the cases. Patients with SRAP were significantly younger than those without SRAP. …”
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Program Adherence and Effectiveness of a Commercial Nutrition Program: The Metabolic Balance Study by Cornelia Meffert, Nikolaus Gerdes

“…After 12 months, nearly two thirds of the samples had achieved >5% reduction of their initial weights. …”
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p-Norm Broad Learning for Negative Emotion Classification in Social Networks by Guanghao Chen, Sancheng Peng, Rong Zeng, Zhongwang Hu, Lihong Cao, Yongmei Zhou, Zhouhao Ouyang, Xiangyu Nie

“…Moreover, it can suppress the adverse effects of more outliers and noise in data by flexibly changing the value of p. Thirdly, we conduct extensive experiments on the public datasets, and the experimental results show that our proposed method outperforms the baseline methods on the tested datasets.…”
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A Retrospective Claims-Based Study Evaluating Clinical and Economic Burden Among Patients With Moderate to Severe Osteoarthritis Pain in the United States by Patricia B. Schepman, Sheena Thakkar, Rebecca L. Robinson, Craig G. Beck, Deepa Malhotra, Birol Emir, Ryan N. Hansen

“…Eligible patients were aged ≥45 years with ≥12 months pre-index (baseline) and ≥24 months (follow-up) of continuous enrollment; index date was defined as a physician diagnosis of hip or knee OA. …”
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Effects of proton pump inhibitors and histamine-2 receptor antagonists on response to fidaxomicin or vancomycin in patients with Clostridium difficile-associated diarrhoea by Thomas Louie, Karl Weiss, Mark A Miller, Kathleen Mullane, Derrick W Crook, Sherwood L Gorbach

“…Treatment group was the single significant predictor of recurrence; the probability of recurrence after fidaxomicin therapy was half that following vancomycin therapy.Conclusions Acid-suppressing drugs, used by nearly two-thirds of inpatients with CDAD, did not worsen clinical response or recurrence when used concurrently with fidaxomicin or vancomycin. …”
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Effects of high-intensity interval and moderate-intensity continuous training on ambulatory blood pressure and cardiovascular outcomes in older adults with hypertension (HEXA Study... by Francisco Dalton-Alves, Maria Beatriz F Araújo, Bruno Erick B Lucena, Gabriel C Souto, Daniele Samara D Lopes, Maria Isabel S Lucena, Raíssa de Melo Silva, Ludmila L P Cabral, Yuri A Freire, Fabíola L Golveia, Telma Maria Araújo Lemos, Rodrigo A V Browne, Eduardo Caldas Costa

“…Introduction Approximately two-thirds of Brazilian older adults have hypertension. …”
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Do current maternal health staffing and bed occupancy benchmarks work in practice? Results from a simulation model by Giorgia Gon, Carolin Vegvari, Rebecca F Baggaley, Said Mohammed Ali, Salma Abdi Mahmoud, Farhat Jowhar

“…Introduction The WHO has issued the global target of reducing maternal mortality rates by two-thirds of 2010 baseline levels by 2030. In low-income settings, high birth rates and a relative lack of medical resources mean that an efficient use of resources and skilled staff is important in ensuring quality of intrapartum and postpartum care.Methods We use a stochastic, individual-based model to explore whether WHO resourcing benchmarks are sufficient to ensure consistent quality of care. …”
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Creatinine- and Cystatin C-Based Incidence of Chronic Kidney Disease and Acute Kidney Disease in AKI Survivors by Claire Rimes-Stigare, Bo Ravn, Akil Awad, Klara Torlén, Claes-Roland Martling, Matteo Bottai, Johan Mårtensson, Max Bell

“…Acute kidney disease (AKD) describes renal dysfunction 7 to 90 days after AKI and is determined by percentage change in creatinine from baseline. Chronic kidney disease (CKD) is defined as the estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 m2 persisting for more than 90 days. …”
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Cognitive Behavioural Therapy to Optimize Post-Operative Recovery (COPE): a randomized controlled feasibility trial in extremity fracture patients by Kyle Gouveia, Sheila Sprague, Jodi L. Gallant, Sarah MacRae, Gina Del Fabbro, Sofia Bzovsky, Paula McKay, Herman Johal, Jason W. Busse, on behalf of the COPE Investigators

“…Abstract Background Outcomes following surgery to operatively manage extremity fractures are variable, and up to two-thirds of patients report chronic post-surgical pain. …”
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