The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction by Junjie Hang, Junjie Huang, Siyuan Zhou, Lixia Wu, Yingwei Zhu, Lina Zhu, Hanyu Zhou, Kequn Xu, Hua Jiang, Xuguang Yang

“…Flow cytometry was performed to evaluate the level of baseline peripheral naïve and memory T cells from 137 APC patients before receiving first‐line chemotherapy. …”
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Comparative efficacy of neuroprotective agents for improving neurological function and prognosis in acute ischemic stroke: a network meta-analysis by Yuchen Wang, Yuchen Wang, Mengqi Li, Mengqi Li, Yuye Jiang, Yuye Jiang, Qiuhong Ji

“…BackgroundIschemic stroke is the second leading cause of death and the third leading cause of combined disability and mortality globally. …”
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Multiple time points for detecting circulating tumor DNA to monitor the response to neoadjuvant therapy in breast cancer: a meta-analysis by Shuyi Niu, Tie Sun, Mozhi Wang, Litong Yao, Tianyi He, Yusong Wang, Hengjun Zhang, Xiang Li, Yingying Xu

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Pragmatic performance, its relationship with symptom severity, and early clinical predictors of pragmatics in 5 ~ 6-year-old children with autism spectrum disorder by Lu Qian, Ning Ding, Hui Fang, Ting Xiao, Bei Sun, HuiYun Gao, XiaoYan Ke

“…Social-communication, language, and parent‒child interaction measures were collected for the ASD group at baseline. Three years later, all subjects were assessed for pragmatic ability via the Chinese version of the Language Use Inventory (LUI-Mandarin). …”
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Changes in hemodynamic parameters with different anaesthesia induction agents in elderly patients with coronary heart disease by A.R. Vitovskyi, O.A. Loskutov

“…After the administration of induction drugs, a significant difference was observed only in mean arterial pressure (MAP): group 1 — 72.71 ± 4.76 %, group 2 — 81.29 ± 5.4 % of the baseline, p = 0.0001. At the third stage, a statistically significant difference between the groups was determined in three indicators: MAP (86.74 ± 8.82 %, 92.34 ± 7.26 %; p < 0.05), stroke volume index (SVI) (99.91 ± 2.94 %, 109.63 ± 8.16 %, p < 0.05), cardiac index (CI) (96.63 ± 11.77 %, 110.38 ± 12.37 %, p < 0.05). …”
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FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis by David Hunt, Siddharthan Chandran, Peter Connick, Peter Foley, Patrick K A Kearns, Sergio E Baranzini, Adam D Waldman, Sarah J Martin, Elizabeth Freyer, F J Carod-Artal, Lee Murphy, Amy Stenson, Jessie Chang, Rozanna Meijboom, Elizabeth N York, Yingdi Chen, Christine Weaver, Katarzyna Hafezi, Stacey Thomson, Adil Harroud, Margaret McLeod, Jonathon O'Riordan, Niall J J MacDougall

“…Here, we describe the cohort design and present a profile of the participants at baseline and 1 year of follow-up.Future plans A third follow-up wave for the cohort has recently begun at 5 years after first visit and a further wave of follow-up is funded for year 10. …”
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Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres by Felipe Nasser, Joaquim Maurício Motta Leal Filho, Breno Boueri Affonso, Francisco Leonardo Galastri, Rafael Noronha Cavalcante, Diego Lima Nava Martins, Vanderlei Segatelli, Lilian Yuri Itaya Yamaga, Rene Claudio Gansl, Bernardino Tranchesi Junior, Antônio Luiz de Vasconcellos Macedo

“…Lipase concentration was 8407 U/L at baseline, rose to 12,705 U/L after pancreatectomy, and declined to 344 U/L after SIRT. …”
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Development and validation of an integrated model for the diagnosis of liver cirrhosis with portal vein thrombosis combined with endoscopic characters and blood biochemistry data:... by Jie Yang, Xu Zhang, Jia Chen, Xianghong Hou, Minghong Shi, Longlong Yin, Longchun Hua, Cheng Wang, Xiaolong Han, Shuyan Zhao, Guolan Kang, Ping Mai, Rui Jiang, Hongwei Tian

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Sofosbuvir-Based Therapies for Patients with Hepatitis C Virus Infection: Real-World Experience in China by Chengguang Hu, Guosheng Yuan, Junwei Liu, Huaping Huang, Yanyu Ren, Yinping Li, Xuefu Chen, Wei Li, Tao Wu, Hong Deng, Yanzhong Peng, Yong-Yuan Zhang, Yuanping Zhou

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Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial by Anlong Li, Runze Huang, Han Ge, Dajie Liu, Shaochun Liu, Yingxue Jia, Jiaying Chai, Xinyi Zheng, Lijun Liu, Chen Gan, Jian Xu, Ling Cheng, Mingjun Zhang, Huaidong Cheng

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Climate change risks illustrated by the Intergovernmental Panel on Climate Change (IPCC) “burning embers” by P. Marbaix, P. Marbaix, P. Marbaix, A. K. Magnan, A. K. Magnan, A. K. Magnan, V. Muccione, V. Muccione, P. W. Thorne, Z. Zommers

“…<p>The completion of the Sixth Assessment Cycle of the Intergovernmental Panel on Climate Change (IPCC) provides a unique opportunity to understand where the world stands on climate-change-related risks to natural and human systems at the global level, as well as for specific regions and sectors. Since its Third Assessment Report (AR3), released 2 decades ago, the IPCC has developed a synthetic representation of how risks increase with global warming, with risk levels reflected by the colours used, including shades of yellow and red, which led to the nickname “burning embers”. …”
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Energy management education for persons living with long COVID-related fatigue (EMERGE): protocol of a two-parallel arms target trial emulation study in a multicentre outpatient in... by Emilia Riggi, Marco Barbero, Gian Luca Di Tanna, Ruth Hersche, Andrea Weise

“…Four self-reported questionnaires (fatigue impact, self-efficacy in performing energy management strategies, competency in performing daily activities, health-related quality of life) will be administered at baseline (T0; week 0), after lesson 7 (T1; week 6), post-intervention (T2; week 14) and follow-up (T3, week 24). …”
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Efficacy of TIPS plus extrahepatic collateral embolisation in real-world data: a validation study by Chao Chen, Feng Zhang, Hao Wu, Wei Wu, Hui Xue, Yuzheng Zhuge, Chunqing Zhang, Guangchuan Wang, Zhengjie Li, Qiong Wu, Bo Wei, Jun Tie, Xiubin Sun, Lianhui Zhao, Yifu Xia, Jiao Xu, Peijie Li

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Are female athlete specific health considerations being assessed and addressed in preparticipation examinations? A scoping review and proposed framework by Jenna M. Schulz, Lois Pohlod, Samantha Myers, Jason Chung, Jane S. Thornton

“…Background: Preparticipation examinations (PPEs) are unstandardized screening tools routinely used to collect an athlete's baseline health information prior to the start of a new competitive season. …”
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Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study by Yan Huang, Qiuxia Zhong, Junzhi Chen, Xianhui Qin, Yaya Yang, Yanhuan He, Zizhen Lin, Yumin Li, Shenglin Yang, Yongxin Lu, Yanhong Zhao, Yaozhong Kong, Qijun Wan, Qi Wang, Sheng Huang, Yan Liu, Aiqun Liu, Fanna Liu, Fanfan Hou, Min Liang

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A Long-Term Study of Aerobic Performance in Elite Cross-Country Skiers: How Age and Sex Influence Career Development by Elias Bucher, Jon P. Wehrlin, Grégoire P. Millet, Thomas Steiner

“…At age 18, males had a 23.2% higher baseline LT2 (3.34 vs. 2.71 W/kg). In the 24-min DP test, both sexes initially improved significantly (p<0.001). …”
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Correlates of and changes in aerobic physical activity and strength training before and after the onset of COVID-19 pandemic in the UK: findings from the HEBECO study by Lion Shahab, Abigail Fisher, Phillippa Lally, Aleksandra Herbeć, Dimitra Kale, Verena Schneider

“…Objectives Understanding changes in moderate to vigorous aerobic physical activity (MVPA) and muscle-strengthening activity (MSA) at the start of the COVID-19 pandemic and their correlates (socio-demographics, health characteristics, living and exercise conditions and pre-pandemic MVPA/MSA) can inform interventions.Design A cross-sectional analysis of retrospective and concurrent data on MVPA/MSA.Setting An online survey in the UK.Participants 2657 adults (weighted n=2442, 53.6% women) participating in the baseline survey (29 April 2020–14 June 2020) of the HEalth BEhaviours during the COVID-19 pandemic (HEBECO) study.Primary and secondary outcome measures Meeting WHO-recommended levels for MVPA/MSA/both (vs meeting neither) during the first lockdown and changes in MVPA/MSA from before to since the COVID-19 pandemic following stratification for pre-pandemic MVPA/MSA.Results A third of adults maintained (30.4%), decreased (36.2%) or increased (33.4%) MVPA. …”
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Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naï... by David J Diemert, Maria Zumer, Mark Bova, Christina Gibbs-Tewary, Elissa M Malkin, Doreen Campbell, Lara Hoeweler, Guangzhao Li, Maria Elena Bottazzi, Peter J Hotez, Jeffrey M Bethony

“…Peak anti-Na-GST-1 IgG levels were observed between 2 and 4 weeks following the third dose, regardless of Na-GST-1 formulation. IgG levels decreased but remained significantly above baseline in all groups by day 290, at which point all participants (20 of 20 evaluable participants) still had detectable IgG. …”
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Can smoking duration alone replace pack-years to predict the risk of smoking-related oncogenic mutations in non-small cell lung cancer? A cross-sectional study in Japan by Masahiko Ando, Yoshihiko Taniguchi, Akihiro Tamiya, Akihide Matsumura, Koichi Ogawa, Yasuhiro Koh, Hiroyasu Kaneda, Motohiro Izumi, Yoshiya Matsumoto, Kenji Sawa, Mitsuru Fukui, Naoki Yoshimoto, Akihito Kubo, Shun-ichi Isa, Hideo Saka, Tomoya Kawaguchi

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SHoes for Adolescent PatEllofemoral pain: study protocol for the SHAPE Australian community-based, randomised clinical trial by Kim L Bennell, Kade L Paterson, Rana S Hinman, Jo-Anne Manski-Nankervis, Adam Bryant, Karen Elaine Lamb, Peixuan Li, Sam Shearer, Anurika P De Silva

“…Introduction Patellofemoral pain affects one-third of adolescents, with most experiencing symptoms into adulthood. …”
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