Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach by Shabir Ahmad Ganai, Suma Mohan, Shahid Ahmad Padder

“…Among the 32 molecules demonstrating a stronger binding affinity than reference, only the two most potent molecules were chosen and their binding free energy was compared to AZD1080 using the Desmond trajectory clustering and eventual MM-GBSA. …”
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Społeczna odpowiedzialność biznesu jako czynnik ograniczający rozwój przedsiębiorstwa by Kazimierz Cyran, Sławomir Dybka

“…Wyniki przeprowadzonych badań uzasadniają tezę głoszącą, że jeżeli celem funkcjonowania przedsiębiorstwa jest chęć osiągnięcia zysku, a metody gospodarowania mają prowadzić do maksymalizacji tego efektu, to reguły społecznej odpowiedzialności biznesu mogą ograniczać maksymalizację wyników finansowych.…”
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Multigene Panel Testing in Turkish Hereditary Cancer Syndrome Patients by Esra ARSLAN ATES, Ayberk TURKYILMAZ, Ceren ALAVANDA, Ozlem YILDIRIM, Ahmet Ilter GUNEY

“…In this study, the most affected gene was the ATM gene, in which pathogenic variations were detected in 8 of 218 cases, followed by CHEK2 (3.2%), MUTYH (3.2%), BRIP1 (1.8%), BARD1 (0.9%), TP53 (0.9%), PALB2 (0.4%), MLH1 (0.4%), MSH2 (0.4%), PMS2 (0.4%), RAD50 (0.4%), and RAD51C (0.4%). …”
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Evaluation of a compressed air foam system to clean quail rearing facilities by Jill Wright Skrobarczyk, David James Caldwell, Kenneth Scott McKenzie, Ashley Charles Blankenburg, James Allen Byrd, Morgan Brian Farnell

“…A firefighting foam concentrate (Phos-Chek WD881) and foaming cleaner (Chlor-A-Foam XL) were diluted in water and applied to floor pen and caged rearing facilities using a compressed air foam system. …”
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The sequential approach to the product of distribution by C. K. Li

“…It is well known that the sequential approach is one of the main tools of dealing with product, power, and convolution of distribution (cf. Chen (1981), Colombeau (1985), Jones (1973), and Rosinger (1987)). …”
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Kajian Farmakoinformatika Senyawa Alkaloid Anggur Laut (Caulerpa racemose) Sebagai Inhibitor Collagenase Dalam Mekanisme Antiaging by Dewi Ratih Tirto Sari, M.Eko Pranoto, Siti Zamilatul Azkiyah

“…This study investigated the potential antiaging activity of alkaloids compounds from sea grapes through inhibiting collagenase protein by farmacoinformatic study. six alkaloid structure of sea grapes including Caulerpin, Caulersin, Caulerchlorin, Racemosin A, Racemosin B, and Racemosin C, were retrieved from PubChem database and collagenase protein also was downloaded from Protein Data Bank with ID 2TCL. …”
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Investigation of the physicochemical properties and pharmacokinetics of the active compounds in Quercus infectoria gall extract by Roohallah Yousefi

“…The molecular weight, hydrophobicity, polarity, and solubility of these compounds play a key role in their biological activity and pharmacokinetics, which can be evaluated using SwissADME and PubChem. …”
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Diagnostic Limitations of Applying a Human Portable Blood Glucose Meter in the Detection of Hypoglycemia in Pregnant Ewes by José Lucas Xavier Lopes, Raquel Fraga e Silva Raimondo, Luiza Rodegheri Jacondino, Beatriz Riet Correa, Clara Satsuki Mori, Álan Gomes Pöppl

“…The PBGM tested was considered analytically inaccurate according to ISO 15197:2013, which states that when glucose levels are below 100 mg/dL, 95% of the measurements should deviate by no more than 15 mg/dL from the RM value, and 1/3 of the PBGM results were above this limit. …”
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Male involvement in prevention of mother-to-child transmission of HIV, and its association with knowledge and residence in Ethiopia: a systematic review and meta-analysis by Mastewal Arefaynie, Yitayish Damtie, Bereket Kefale, Melaku Yalew, Bezawit Adane, Habtamu Shiferaw, Yesuf Ahemed, Abel Shiferaw, Tenaw Yimer, Hasab Tibebu

“…Different studies were conducted on male involvement in prevention of mother-to-child transmission (PMTCT) of HIV, but there is inconsistency among the findings. Thus, the aim of this systematic review and meta-analysis was to determine the pooled prevalence of male involvement in PMTCT of HIV, and its association with knowledge and residence in Ethiopia. …”
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Technical note: A fast and reproducible autosampler for direct vapor equilibration isotope measurements by J. Pyschik, S. Seeger, S. Seeger, B. Herbstritt, M. Weiler

“…<span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M9" display="inline" overflow="scroll" dspmath="mathml"><mrow><msup><mi mathvariant="italic">δ</mi><mn mathvariant="normal">2</mn></msup><mrow class="chem"><mi mathvariant="normal">H</mi></mrow><mo>=</mo><mo>±</mo><mn mathvariant="normal">5.7</mn></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="58pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="8e74806c04be2ae4cec85869f56a2ae7"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="hess-29-525-2025-ie00004.svg" width="58pt" height="14pt" src="hess-29-525-2025-ie00004.png"/></svg:svg></span></span> ‰ and <span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M10" display="inline" overflow="scroll" dspmath="mathml"><mrow><msup><mi mathvariant="italic">δ</mi><mn mathvariant="normal">18</mn></msup><mrow class="chem"><mi mathvariant="normal">O</mi></mrow><mo>=</mo><mo>±</mo><mn mathvariant="normal">0.37</mn></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="69pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="cb200124dbcb53e5f74aa1a6cdda1c53"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="hess-29-525-2025-ie00005.svg" width="69pt" height="14pt" src="hess-29-525-2025-ie00005.png"/></svg:svg></span></span> ‰ for manual analysis). …”
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Le voisinage entre hommes, forêt et les chimpanzés : point de vue depuis le territoire des villageois, à l’extérieur du Parc National de Kibale by Sarah Bortolamiol, Marianne Cohen, Andrew Seguya, Richard Dumez, Sabrina Krief

“…Nous avons combiné des entretiens semi-directifs et des observations participantes (N = 42 villageois et agriculteurs, gestionnaires, employés des usines de thé) avec des relevés floristiques en lisière de forêt (N = 8 transects soit 32 relevés situés entre 0 et 150 mètres de part et d’autre de la lisière de la forêt – janvier à avril 2013) dans un Système d’Information Géographique (SIG) pour spatialiser les rapports entre les hommes que nous avons interrogés et les chimpanzés que nous étudions. …”
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Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoids by Yuxin Luo, Chenrui An, Ke Zhong, Ping Zhou, Dan Li, Hui Liu, Qing Guo, Wei Wei, Hen Pan, Zheying Min, Rong Li, Yang Yu, Yong Fan

“…Methods: We used a novel three-dimensional system with totipotent blastomere-like cells (TBLCs) to construct TBL-blastoids and established senescence-related embryo models derived from oxidative stress-induced TBLCs. …”
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Świadomość ubezpieczeniowa pracowników biur rachunkowych w Polsce by Anna Jańska, Paulina Dziewit

“…Z perspektywy zakładów ubezpieczeniowych interesująca może być informacja potwierdzająca chęć rozszerzania ochrony ubezpieczeniowej o dodatkowe klauzule oraz deklaracje zakupu dodatkowych ubezpieczeń dobrowolnych w omówionym zakresie. …”
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Evaluation of survival rate of implants with immediate loading compared to implants with conventional load in implants with fixed prosthesis, update of a systematic review and meta... by Meysam Heidari, Masomeh Rostamzadeh, Ideh Talimkhani

“…The aim of this study is to review the rate of bone resorption, success rate and gingivitis in implants with immediate loading (IL) compared to conventional Lading (CL), which was performed as an update of the meta-analysis study by Chen J, et al (2019). Materials and Methods: The study is a systematic review and meta-analysis, using a descriptive-analytical method and in four stages. …”
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Fusion of the 2nd with the 3rd Cervical Vertebrae (C2-C3): A Case Series with Possible Clinical Significance by Eirini Demeneopoulou, Dorina Papa, Ilias Giotas, Angelos Nikolaou, George Tsakotos, Vasilios Karampelias, Theodore Mariolis-Sapsakos, Dimitrios Filippou, Maria Piagkou

“…The osseous complexes were derived from disarticulated skeletons of body donors and were collected from the osseous collection of the Anatomy Department of the Medical School of the National and Kapodistrian University of Athens. Results. Three blocked vertebral complexes (2 partial and 1 complete C2-C3 osseous masses) were identified. …”
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The origin and development of procedural rules in Ancient Greece by D. V. Slynko, L. I. Kalenichenko

“…The article examines the origin and development of procedural rules in Ancient Greece and the administration of justice in Athens, analyses its forms, and considers procedural aspects of the activities of representative institutions of that time in Greece. …”
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Genome sequencing enhances the diagnostic yield and expands the genetic landscape of male breast cancer by Wen Wen, Sen Zhao, Yiwen Jiang, Chengzhu Ou, Changyuan Guo, Ziqi Jia, Jiayi Li, Yansong Huang, Hengyi Xu, Pengming Pu, Tongxuan Shang, Lin Cong, Xiang Wang, Nan Wu, Jiaqi Liu

“…Elevated average polygenic risk score was noted compared with controls, with a significant correlation to early-onset MBC when combined with high-penetrance germline pathogenic variants (P = 1.10 × 10−4). …”
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Hydrogeochemical Assessment and Identification of Controlling Factors of Chemical Composition of Spring Waters in Alashtar Plain, Lorestan Province by Vahab Amiri

“…Based on the Chadha diagram and output of AquaChem program, the amount of alkali earth elements (Ca and Mg) is more than alkali ones (Na and K) and the value of weak acidic anions (CO3 and HCO3) is more than strong acidic anions (Cl and SO4). …”
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Transcultural Adaptation of Environmental Health Questionnaire with Attitude, Knowledge, and Skills Scales for Portuguese Nursing Students by Cristina Álvarez-García, Beatriz Edra, Goreti Marques, Catarina Simões, Mª Dolores López-Franco

“…<b>Methods</b>: A cross-sectional observational study was developed to translate, adapt, and validate the questionnaire consisting of the following three scales: Attitude Scale (SANS_2), knowledge scale (ChEHK-Q), and skills scale (ChEHS-Q). …”
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AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription by Lingshan Zhou, Yuan Yang, Qian Qiao, Yingying Mi, Yuling Gan, Ya Zheng, Yuping Wang, Min Liu, Yongning Zhou

“…Methods The study utilized databases such as PhosphositePlus, TRANSFAC, CHEA, GPS 5.0, and TCGA, along with experimental techniques including Western Blot, co-IP, in vitro kinase assay, construction of lentiviral overexpression and silencing vectors, immunoprecipitation, modified proteomics, immunofluorescence, ChIP-PCR, EdU assay, Transwell assay, and scratch assay to investigate the effects of AKT1-induced Notch1 phosphorylation on cell proliferation, invasion and migration in vitro, as well as growth and epithelial-mesenchymal transition (EMT) in vivo. …”
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