Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy by Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui

“…Background: A key factor underlying the failure of Chimeric Antigen Receptor-T Cell (CAR-T) therapy in ovarian cancer (OC) is the presence of an immunosuppressive tumor microenvironment, which is intricately linked to M2 polarization among tumor-infiltrating macrophages. …”
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Testing an Electronic Patient-Reported Outcome Platform in the Context of Traumatic Brain Injury: PRiORiTy Usability Study by Christel McMullan, Grace Turner, Ameeta Retzer, Antonio Belli, Elin Haf Davies, Laura Nice, Luke Flavell, Jackie Flavell, Melanie Calvert

“…Each participant took part in cognitive interviews using with the “Think Aloud” method, encouraging them to verbalize their thoughts and experiences while using the platform. …”
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Development and Implementation of a Registry of Patients Attending Multidisciplinary Pain Treatment Clinics: The Quebec Pain Registry by M. Choinière, M. A. Ware, M. G. Pagé, A. Lacasse, H. Lanctôt, N. Beaudet, A. Boulanger, P. Bourgault, C. Cloutier, L. Coupal, Y. De Koninck, D. Dion, P. Dolbec, L. Germain, V. Martin, P. Sarret, Y. Shir, M.-C. Taillefer, B. Tousignant, A. Trépanier, R. Truchon

“…Between 2008 and 2013, 6902 patients were enrolled in the QPR, and data were collected prior to their first visit at the pain clinic and six months later. More than 90% of them (mean age ± SD: 52.76 ± 4.60, females: 59.1%) consented that their QPR data be used for research purposes. …”
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Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies by Yumeng Ji, Baixue Li, Rongjin Lin, Jing Yuan, Yang Han, Yuping Du, Yang Zhao

“…Abstract Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function than classical enhancers, thereby regulating cellular activities. …”
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Memory B cells and their transcriptomic profiles associated with belimumab resistance in systemic lupus erythematosus in the maintenance phase by Takeshi Iwasaki, Takeshi Iwasaki, Hajime Yoshifuji, Koji Kitagori, Shuji Sumitomo, Shuji Akizuki, Ran Nakashima, Hideaki Tsuji, Ryosuke Hiwa, Mirei Shirakashi, Kosaku Murakami, Akira Onishi, Hideo Onizawa, Masao Tanaka, Fumihiko Matsuda, Akio Morinobu, Koichiro Ohmura, Koichiro Ohmura

“…Here, we collected blood samples from patients with SLE (n=44) treated with belimumab before and three and six months after treatment. RNA-Seq of whole blood was performed, and gene expression was quantified. …”
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Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence by Xiaoyin Wu, Xiaoyin Wu, Buyu Guo, Buyu Guo, Xingyu Chang, Xingyu Chang, Yuxuan Yang, Yuxuan Yang, Qianqian Liu, Qianqian Liu, Jiahui Liu, Jiahui Liu, Yichen Yang, Yichen Yang, Kang Zhang, Yumei Ma, Songbo Fu, Songbo Fu, Songbo Fu

“…The expression levels of diagnostic signatures were verified in vitro.ResultsThrough the 108 combinations of machine learning algorithms, we selected 12 diagnostic signatures, including CD163, CYBB, ELF3, FCN1, PROM1, GPR65, LCN2, LTF, S100A4, SOX4, TGFB1 and TNFAIP8. Based on them, an integrative model named GScore was established for predicting DN onset and stratifying clinical risk. …”
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Classification of risk for transmission of vaccine-preventable diseases in Brazilian municipalities: comparative analysis before and after the national movement for vaccination and... by Ana Catarina de Melo Araújo, Thales Philipe Rodrigues da Silva, Janaina Fonseca Almeida Souza, Krishna Mara Rodrigues Freire, Fernanda Penido Matozinhos, Eder Gatti Fernandes

“…In 2023, 34.90% of municipalities were classified as adequate (≥ 70%), and among them, 582 (10.46%) achieved 100% HCV for all vaccines. …”
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Digital technologies for water use and management in agriculture: Recent applications and future outlook by Carlos Parra-López, Saker Ben Abdallah, Guillermo Garcia-Garcia, Abdo Hassoun, Hana Trollman, Sandeep Jagtap, Sumit Gupta, Abderrahmane Aït-Kaddour, Sureerat Makmuang, Carmen Carmona-Torres

“…This article provides a comprehensive overview of digital technologies for water use and management in agriculture, examining recent applications and future prospects. It examines key water-related challenges - scarcity, pollution, inefficient use and climate change - and shows how various digital technologies such as Remote Sensing, Artificial Intelligence, the Internet of Things, Big Data, Robotics, Smart Sensors and Blockchain can help address them. …”
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The effect of nursing care provided to coronary intensive care patients according to their circadian rhythms on sleep quality, pain, anxiety, and delirium: a randomised controlled... by Meryem Pelin, Havva Sert

“…Melatonin increased and cortisol decreased in both groups without statistically significant differences between them (melatonin and cortisol levels: p > 0.05). Considering the sound levels in the environment, the first-night decibel mean was significantly higher in the intervention group than in the control group (first-night decibel mean: intervention group 56.58 ± 2.43 dB vs. control group 54.51 ± 2.41 dB, p < 0.05). …”
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Studying and enhancing the methods for distance teaching of computer science in Kazakh secondary school students during the pandemic by M. M. Zhamankarin, A. M. Sivinskiy, M. K. Aitkenova, M. B. Zhanibekov

“…The authors conducted three control evaluations of the quality of knowledge in each of the 320 participants. …”
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Successful Achievement of Demanding Outcomes in Upadacitinib-Treated Atopic Dermatitis Patients: A Real-World, 96-Week Single-Centre Study by Stamatios Gregoriou, Ioannis-Alexios Koumprentziotis, Ileana Afroditi Kleidona, Michail Bakakis, Eleni Hatzidimitriou, Theodora Douvali, Aikaterini Tsiogka, Styliani Mastraftsi, Aristeidis Vaiopoulos, Alexander Stratigos

“…Six (16.7%) patients experienced AEs with four of them discontinuing medication; no patient discontinued because of upadacitinib inefficacy. …”
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Adherence to stand-by emergency treatment and mosquito protection measures in short-term travellers to moderate malaria risk areas by Daniel Julien Franken, Vita Willemijn Jongen, Anna Rooyakkers, Martin Peter Grobusch, Jelte Elsinga, Margarita Boering, Maria Prins, Brigitte Antonia Geertruida Lucía van Cleef

“…Of these travellers 44 % received a pre-travel SBET prescription, although presumably only a small fraction of them actually travelled remotely. None of the 25 travellers who reported fever used the prescribed SBET and five sought medical care. …”
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Exploring the Diversity of Some Microorganisms from Lake Al-Asfar, KSA: The Good, the Bad, and the Pathogenic by Fatimah Al Tammar, Nermin El Semary, Munirah F. Aldayel, Duaa Althumairy, Gowhara Alfayad

“…Some pose serious health risks, but some of them also contribute to reducing some of the pollution levels. …”
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Recombinant Anti-PF4 Antibodies Derived from Patients with Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT) Facilitate Research and Laboratory Diagnosis of VITT by Luisa Müller, Venkata A. S. Dabbiru, Lucy Rutten, Rinke Bos, Roland Zahn, Stefan Handtke, Thomas Thiele, Marta Palicio, Olga Esteban, Marta Broto, Tom Paul Gordon, Andreas Greinacher, Jing Jing Wang, Linda Schönborn

“…Chemiluminescence assays and both anti-PF4 IgG and anti-PF4 IgG/heparin ELISA showed concentration-dependent PF4 binding of all six rAbs, however, with different reactivities among them. PIPA showed a similar, concentration-dependent platelet activation pattern. rAbs varied in their reactivity and the majority of the tested rAbs were able to induce procoagulant platelets. …”
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HPLC and GC-MS analyses of phytochemicals from Ficus carica leaf extract and essential oil along with their antimicrobial properties by Maximilian Lackner, Abdelfattah Z.M. Salem, Mohamed Z.M. Salem, Abeer A. Mohamed, José Luis Ponce-Covarrubias, Shady Selim

“…This work highlights the potential of side stream valorization from fig production to obtain safe and sustainable antimicrobial agents for crop protection, amongst them potatoes, tomatoes, and cucumber.…”
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Prokaryotic diversity of the rhizosphere from Argentinean wine-producing regions by Andres Martin Toscani, Monica Oyuela Aguilar, Constanza Rey, Ramiro Eugenio Rocco Welsh, Alex Gobbi, Maria Florencia del Papa, Liliana Carmen Semorile, Lars Hestbjerg Hansen, Mariano Pistorio

“…In this work, we conducted a comprehensive examination of the diversity of prokaryotic microorganisms in the rhizosphere of vineyards located in three wine regions of Argentina. We used next-generation sequencing methods, concentrating the analysis on two relevant cultivars, Malbec and Cabernet Sauvignon. …”
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The behavior of the Bacillus probiotic species under conditions of co-cultivation by O. V. Knysh, A. V. Martynov, S. I. Pokhyl, N. I. Skliar

“…The studied probiotic species of the bacilli did not show a strong ability to inhibit each other’s growth. The B. clausii culture had no inhibitory effect, and the B. coagulans culture demonstrated a moderate inhibitory influence on the growth of the other two species of bacilli when using both diffusion methods. …”
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Cigarette Smoking Patterns Among Racial and Ethnic Groups With Chronic Lung Diseases During the COVID-19 Pandemic by Vijaya L. Seegulam, MPH, Caretia J. Washington, BS, Parvathy P. Surendran, BPT, Alyssa M. Falise, PhD, MSPH, Diana Gomez-Manjarres, MD, Catalina Lopez-Quintero, MD, MPH, PhD

“…Results: Current cigarette smoking was reported by about one fifth (20%) of U.S. adults diagnosed with chronic obstructive pulmonary disease and asthma. Among them, the mean number of days of cigarette smoking in the past 30 days was 27 days, and the mean number of cigarettes smoked in the past 30 days was 14. …”
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Ten practical guidelines for microclimate research in terrestrial ecosystems by Pieter De Frenne, Rémy Beugnon, David Klinges, Jonathan Lenoir, Pekka Niittynen, Sylvain Pincebourde, Rebecca A. Senior, Juha Aalto, Kryštof Chytrý, Phillipa K. Gillingham, Caroline Greiser, Eva Gril, Stef Haesen, Michael Kearney, Martin Kopecký, Peter C. le Roux, Miska Luoto, Ilya Maclean, Matěj Man, Rachel Penczykowski, Liesbeth van denBrink, Stijn Van de Vondel, Karen De Pauw, Jonas J. Lembrechts, Julia Kemppinen, Koenraad Van Meerbeek

“…Our guidelines encompass the significance of microclimates; the specifics of what, where, when and how to measure them; the design of microclimate studies; and the optimal approaches for analysing and sharing data for future use and collaborations. …”
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Assessment of Types, Factors Contributing to Violence Against Women and its Effects on the Health Seeking Behaviour of Women in Rubanda Town Council Rubanda District. by Byumvuhore, Stephen

“…Factors that predisposed women to higher VAW were being married (AOR =3.3, 95%CI: 1.2-9.2p = 0.020) but worse when separated (AOR = 46.3, 95%CI: 4.0-533.4, p = 0.002). …”
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