Efficient Acquisition of Fully Human Antibody Genes against Self-Proteins by Sorting Single B Cells Stimulated with Vaccines Based on Nitrated T Helper Cell Epitopes by Liangliang Jiang, Tao Jiang, Jianhua Luo, Yanliang Kang, Yue Tong, Xiaoda Song, Xiangdong Gao, Wenbing Yao, Hong Tian

“…We randomly selected eight genes for cloning, six of which expressed antibodies that can bind to HER2. …”
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Advance in the Role of Epigenetic Reprogramming in Somatic Cell Nuclear Transfer-Mediated Embryonic Development by Xiaolei Zhang, Shaorong Gao, Xiaoyu Liu

“…Many species are successfully cloned up to date, including nonhuman primate. With this technology, not only the protection of endangered animals but also human therapeutics is going to be a reality. …”
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Designing a multi-epitope vaccine candidate against human rhinovirus C utilizing immunoinformatics approach by Tajul Islam Mamun, Tajul Islam Mamun, Md. Ahad Ali, Md. Nazmul Hosen, Jillur Rahman, Md. Anwarul Islam, Md. Golam Akib, Kamruz Zaman, Md. Masudur Rahman, Md. Masudur Rahman, Ferdaus Mohd Altaf Hossain, Ferdaus Mohd Altaf Hossain, Samir Ibenmoussa, Mohammed Bourhia, Turki M. Dawoud

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USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer by Fang Yuan, Juan Xu, Lingmei Xuan, Chan Deng, Wei Wang, Rong Yang

“…Additionally, we used CCK8, cloning, and migration tests to examine the proliferation and migration of ESCA cells. …”
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Mechanistic insights into 125I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2 by Jun Luo, Zheng Yao, Weiren Liang, Danjun Song, Hui Zeng, Yi Jiang, Zhehan Bao, Jiaping Zheng, Yinan Ding

“…Conclusion 125I seed implantation therapy exerts therapeutic effects on CCA by inducing ROS-mediated apoptosis. …”
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Use of Rituximab in Autoimmune Hemolytic Anemia Associated with Non-Hodgkin Lymphomas by Claudio Fozza, Maurizio Longinotti

“…However, considering that the main pathogenetic mechanism of AHA in course of lymphoproliferative disorders seems to be an antibody production directly or indirectly mediated by the neoplastic clone, this monoclonal antibody represents an ideal therapeutic approach. …”
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Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm by Angela G. Fleischman

“…An inflammatory response to the neoplastic clone may be responsible for some pathologic aspects of MPN. …”
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Melanocortin Peptide Therapy for the Treatment of Arthritic Pathologies by S. J. Getting, M. Kaneva, Y. Bhadresa, D. Renshaw, Giovanna Leoni, H. B. Patel, M. J. P. Kerrigan, I. C. Locke

“…This review highlights the therapeutic potential of naturally occurring hormones and their peptides, in both arthritic models of disease and patients. …”
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Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report by Zewei Chen, Shangxi Fu, Jun Wu, Xiaoling Luo, Zhiguo Mao, Dechao Xu, Xiang Gao

“…The standard management of PGNMID has been unclear, currently based on data from small cohorts, which requires a need for additional therapeutic regimens in this disease. A human IgG monoclonal antibody that targets CD38 (daratumumab) was recently identified as a potential therapeutic option for treating PGNMID. …”
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Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer by Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia, Huanxin Lin

“…Conclusions DMRDEGs hold promise as diagnostic markers and therapeutic targets for breast cancer. Among the associated mutated genes, ATP7B, FUS, AIFM1, and PPARG could serve as early diagnostic indicators, and notably, AIFM1 may present itself as a promising therapeutic target.…”
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Two Cases of γ-Heavy Chain Disease and a Review of the Literature by I. Ramasamy, Z. Rudzki

“…In the second patient, histopathology identified a separate clone responsible for the secretion of the gamma heavy chain. …”
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Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature by José C. De La Flor, Marina Alonso, Edna Sandoval, Alexander Marschall, Miguel Rodeles

“…Future research is needed to better understand the disease course and establish the efficacy and safety of the therapeutic approach for the relapse of MGRS.…”
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Investigation of <i>ITGB3</i> Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer by Asiye Busra Boz Er

“…<i>ITGB3</i> expression varied significantly among resistant clones, correlating with increased expression of TGF-β-responsive genes and enhanced migration markers. …”
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Discovery and in vitro characterization of a human anti-CD36 scFv by Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sandra L. Guerrero-Rodríguez, Keyla Gómez-Castellano, Gregorio Carballo-Uicab, Juan Carlos Almagro, Juan Carlos Almagro, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, Marco A. Velasco-Velázquez

“…Since D11 reduces the acquisition of pathogenic features induced by CD36 ligands, it could support the generation of therapeutic proteins targeting CD36.…”
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Role of gp91phox Homolog Nox1 in Induction of Premalignant Spindle Phenotypes of HPV 16 E6/E7—Immortalized Human Keratinocytes by Walee Chamulitrat

“…Nox1 was the first of the Nox catalytic subunits to be cloned and shown to induce tumorigenic conversion of mouse fibroblasts. …”
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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

“…First, guided by the sequence of a related clone and the crystal structure of h1340.CC in complex with PD-1, we generated variant h1340.SA.LV with a potency and cross-reactivity similar to h1340.CC, but only partially recovered affinity. …”
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Characterization of Somatostatin Receptor Subtype 2 Expression in Stably Transfected A-427 Human Cancer Cells by Jesse J. Parry, Martin Eiblmaier, Rebecca Andrews, Laura A. Meyer, Ryuji Higashikubo, Carolyn J. Anderson, Buck E. Rogers

“…It would be highly beneficial, particularly for therapeutic purposes, to have several clones of one human sst2-positive cell line that express a range of sst2 concentrations for evaluating the dose response and intracellular processing of radiolabeled somatostatin analogs. …”
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Immune‐dysregulation harnessing in myeloid neoplasms by Mohammad Jafar Sharifi, Ling Xu, Nahid Nasiri, Mehnoosh Ashja‐Arvan, Hadis Soleimanzadeh, Mazdak Ganjalikhani‐Hakemi

“…Immune suppression is one of the most important stages in myeloid leukemia progression. Leukemic clone expansion and immune dysregulation occur simultaneously in bone marrow microenvironments. …”
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Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53. by Kenneth Y Wertheim, Robert Chisholm, Paul Richmond, Dawn Walker

“…Our results are in agreement with those reported in the literature and add new insights into how the MYCN-amplified clone's reproductive advantage in a tumour, its gene expression profile, the tumour's other clones (with different mutations), and the tumour's microenvironment are inter-related. …”
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Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation by Wen Zeng, Hanjun Dai, Ming Yan, Xiaojun Cai, Hong Luo, Min Ke, Zeming Liu

“…Collectively, these results suggest that FOXO3A reactivation may contribute to the therapeutic effects of DAC in MDS.…”
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