Features of Crohn's Disease Depending on the Age of Disease Onset by E. G. Ganich, O. B. Shchukina

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Prior Appendectomy and the Onset and Course of Crohn’s Disease in Chinese Patients by Dafan Chen, Jing Ma, Qiwen Ben, Lungen Lu, Xinjian Wan

“…The relationship between prior appendectomy and Crohn’s disease (CD) has previously revealed conflicting findings. …”
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Serum Cytokine Profiles in Children with Crohn’s Disease by Ekaterina Vasilyeva, Sayar Abdulkhakov, Georgi Cherepnev, Ekaterina Martynova, Irina Mayanskaya, Alina Valeeva, Rustam Abdulkhakov, Dilyara Safina, Svetlana Khaiboullina, Albert Rizvanov

“…Crohn’s disease (CD) is a chronic inflammatory bowel disease that can be diagnosed at any age. …”
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Characteristics of Pediatric Crohn’s Disease in Saudi Children: A Multicenter National Study by Omar I. Saadah, Mohammad El Mouzan, Mohammad Al Mofarreh, Ali Al Mehaidib, Mohammad Al Edreesi, Mohammed Hasosah, Abdulrahman Al-Hussaini, Khalid AlSaleem

“…Background and Aims. Crohn’s disease (CD) is an evolving disease in KSA. …”
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Arthralgia and Extraintestinal Manifestations in Crohn’s Disease Elevate the Risk of IBD-Related Arthritis over Sacroiliitis by Ivan Giovannini, Nicola Cabas, Marco Marino, Annarita Tullio, Ilaria Tinazzi, Angela Variola, Carmelo Cicciò, Fabro Cinzia, Berretti Debora, Chiara Zuiani, Rossano Girometti, Luca Quartuccio, Alen Zabotti, Lorenzo Cereser

“…Magnetic resonance enterography (MRE) is used to assess small bowel disease involvement in Crohn’s disease (CD) and can detect signs of sacroiliitis in up to 23.5% of patients. …”
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Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients by Francesco Giudici, Tiziana Cavalli, Cristina Luceri, Edda Russo, Daniela Zambonin, Stefano Scaringi, Ferdinando Ficari, Marilena Fazi, Amedeo Amedei, Francesco Tonelli, Cecilia Malentacchi

“…CARD15/NOD2 is the most significant genetic susceptibility in Crohn’s disease (CD) even though a relationship between the different polymorphisms and clinical phenotype has not been described yet. …”
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Differentiation of Isolated Small Bowel Crohn’s Disease from Other Small Bowel Ulcerative Diseases: Clinical Features and Double-Balloon Enteroscopy Characteristics by Meng Niu, Zheng-Hao Chen, Meng Li, Xing Zhang, Chun-Xiao Chen

“…The diagnosis of isolated small bowel Crohn’s disease (ISBCD) has always been challenging. …”
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Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study by Juan Zhou, BinRong Chen, ZhiCheng Wang, Li Liu, HongJuan OuYang, YanHong Luo, WenTing Zhang, ChenXi Liu, MeiZheng Zhan, JiaQi Duan, CanLin Li, Na Jiang, JieYu You, HongMei Zhao

“…For the effect on growth indicators, the length of follow-up was at least 3 months from diagnosis.ResultsThis study included 222 children with IBD, predominantly with Crohn's disease (86.0%). Approximately one-quarter of children require more than 366 days to be diagnosed with IBD, primarily due to the extended interval between the onset of initial symptoms and hospital admission. …”
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Using Dose-Effect Relationship for Optimising Systemic Corticosteroid Dosage in Treatment of Inflammatory Bowel Diseases by O. P. Alekseeva, S. V. Krishtopenko, A. A. Alekseeva

“…The study included 86 patients with moderate to severe active disease (61 with UC and 25 with CD) aged 18 to 65 years. …”
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Clinical features, treatment, and prognosis of secukinumab-induced inflammatory bowel disease by Ronghui Li, Haibo Lei, Chunjiang Wang, Xiang Liu

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Dual Biologic or Small Molecule Therapy in Pediatric Inflammatory Bowel Disease: A Single Center Experience by Cheng Guo, Jin Zhou, Guoli Wang, Jie Wu

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Very Early-Onset Inflammatory Bowel Disease (VEO-IBD) Presenting with Recurrent Leukocytoclastic Vasculitis Preceded by Streptococcal Pharyngitis by Ashley Fonseca, Julee Sunny, Lina M. Felipez

“…Inflammatory bowel disease (IBD) that presents in children <6 years of age is known as very early-onset IBD (VEO-IBD). …”
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Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…BackgroundUpadacitinib, a Janus kinase inhibitor, has been increasingly used over the past few years to treat moderate to severe ulcerative colitis and Crohn’s disease in patients who are insufficiently responsive or intolerant to tumor necrosis factor (TNF) antibodies, demonstrating notable clinical efficacy. …”
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Genetic Counselling and Family in IBD: 30 years' Experience at the Cleveland Clinic by WM Michener, M Caulfield, RG Farmer, R Wyllie, K Cotman, J Hertzer

“…The Cleveland Clinic has followed 1288 patients with inflammatory bowel disease (IBD) (437 with mucosa! ulcerative colitis and 851 with Crohn's disease) from 1955 through 1984. …”
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Fecal Lactoferrin: Reliable Biomarker for Intestinal Inflammation in Pediatric IBD by Stephan Buderus, James H. Boone, Michael J. Lentze

“…Three patient groups were determined: n=21 (mean age 13.2) with Crohn’s disease (CD), n=15 (mean age 10.9) with ulcerative colitis (UC), and n=20 (mean age 11.9) in whom IBD was ruled out. …”
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Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents by R. Alan Harris, Rajesh Shah, Emily B. Hollister, Rune Rose Tronstad, Nils Hovdenak, Reka Szigeti, James Versalovic, Richard Kellermayer

“…Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn’s disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). …”
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