Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkins... by Dang Wei, Anna Freydenzon, Octave Guinebretiere, Karim Zaidi, Fen Yang, Weimin Ye, Niklas Hammar, Karin Modig, Naomi R. Wray, Maria Feychting, Nadine Hamieh, Bruno Ventelou, Beranger Lekens, Laurene Gantzer, Stanley Durrleman, Allan McRae, Baptiste Couvy-Duchesne, Fang Fang, Thomas Nedelec, Stanley Durrleman, Bruno Ventelou, Thomas Nedelec, Octave Guinebretiere, Karim Zaidi, Fang Fang, Dang Wei, Fen Yang, Allan McRae, Naomi Wray, Baptiste Couvy-Duchesne, Anna Freydenzon, Lydie Tran, Evans Cheruiyot

“…Constipation and use of related medications were associated with an increased risk of AD and PD, while diabetes and use of antidiabetics were associated with a reduced risk of ALS. …”
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Unveiling the prognostic value of ARID3A in breast cancer through bioinformatic analysis by Wen-Run Cai, Xu-Gang Sun, Yue Yu, Xin Wang, Xu-Chen Cao, Xiao-Feng Liu

“…Clinical prognostic parameters and survival data were examined through bioinformatics tools, including GEPIA, Bc-GenExMiner, and BEST. …”
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Effect of the gut core microbiota Cetobacterium on the growth, physiology, and nutritional metabolism of Nile tilapia (Oreochromis niloticus) by Miao Wang, Chenglin Tang, Ziyue Zhang, Zijian Fan, Lijin Jiang, Zhigang Liu, Jianmeng Cao, Zhang Wang, Maixin Lu, Mengmeng Yi, Xiaoli Ke

“…We performed a feeding experiment to identify its function in the growth, physiology, and nutritional metabolism in Nile tilapia (Oreochromis niloticus). Tilapia were fed either a control diet (CK) or a Cetobacterium NK01-supplemented diet (1 × 107 CFU/g diet) (NK) for a period of 42 days. …”
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Relaciones entre el recuento de células somáticas, test de mastitis California, conductividad eléctrica y el diagnóstico de mastitis subclínicas en cabras lecheras by V.H. SUAREZ, G.M. MARTINEZ, V. GIANRE, L. CALVINHO, A. RACHOSKI, M. CHAVEZ, A. SALATIN, S. OROZCO, V. SANCHEZ, E. BERTONI

“…El CCS se realizó por Fossomatic, y a modo de control por microscopía directa mediante técnicas de Breed clásica y método de Verde metil Y pironina (VMYP). La pruebas de conductividad eléctrica (CE) se realizaron por dispositivo manual y el CMT fue el clásico. …”
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The clinical value of computed tomography Hounsfield unit for diagnosing palpable inguinal lymph node metastasis in patients with penile cancer by Yu Li, Yu Chen, Gansheng Xie, Gang Li, Huming Yin

“…BackgroundComputed tomography (CT) Hounsfield units (HUs) of pathologically confirmed metastatic inguinal lymph nodes (ILNs) were proved to be higher than negative ones. We designed this study to explore the clinical value of CT HU for diagnosing palpable ILN metastasis in patients with penile cancer.MethodsA total of 32 patients with penile cancer, including 84 palpable ILNs, were recruited in this study. …”
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Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model by Shao Duan, Chao Li, Feng Yan, Yifei Xia, Shuaiming Shao, Weiyu Chen, Zunyu Xiao, Gongping Xu

“…Methods The humanized arthritis model, Human peripheral blood mononuclear cells- adjuvant induced arthritis (HuPBMC-AIA) was established, and flow cytometry and immunofluorescence were employed to determine ICOS expression in huPBMC-AIA model. …”
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Diagnostic accuracy of drooling, reluctance, oropharynx, others, and leukocytosis score as a predictor of mortality and complications following acute corrosive ingestion by Fawaz Poonthottathil, Soorya Suresh, Jamshed Nayer, Praveen Aggarwal

“…Nausea, vomiting, and pain abdomen were the common symptoms. The median DROOL score was 4. …”
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Typical and atypical metabolic characteristics of three iridaceae isoflavone components: in vitro and in silico studies by Jifeng Gu, Jifeng Gu, Huishan Zhang, Mei Wang, Yuyang Zhou, Yuyang Zhou, Zhipeng Deng, Rong Shi

“…However, the metabolic characteristics of isoflavone aglycones remain unclear.MethodsIn this study, human liver microsomes (HLMs) and Cytochrome P450 (CYP) recombinant enzymes were used to study the metabolic stability, identify the metabolic pathways and enzyme kinetics of these three components, and elucidate their possible binding sites through molecular docking.ResultsWhen tectorigenin, irigenin, and irisflorentin were co-incubated with HLMs and CYP recombinant enzymes, hydroxylation metabolite for tectorigenin, demethylated metabolite for irigenin, and 6,7-dihydroxy-5,3′,4′,5′-tetramethoxy isoflavone originating from irisflorentin were identified. …”
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A EFICÁCIA DE PLANTAS MEDICINAIS NO TRATAMENTO DE DOENÇAS CRÔNICAS NÃO TRANSMISSÍVEIS by Luis Roberto Gomes Mohana, Rodolfo Francisco, Hálmisson D’Árley Santos Siqueira, Caroline Jordana Azevedo dos Santos, Josemeire da Costa Ximenes, Nair Portela Silva Coutinho, Jéssica Maria Silva Ribeiro, Jacqueline Martins Cantanhede, Renata Pinheiro Pedra Fernandes, Rodolfo Ritchelle Lima dos Santos

“…Considerações Finais: ressalta-se que o uso de plantas medicinais deve ser feito sobre orientação profissional da saúde e que ainda são necessários mais estudos que enfatizem sobre dosagem, segurança e reais efeitos das plantas medicinais no tratamento de doenças crônicas não transmissíveis.  …”
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MAEMC-NET: a hybrid self-supervised learning method for predicting the malignancy of solitary pulmonary nodules from CT images by Tianhu Zhao, Tianhu Zhao, Yong Yue, Hang Sun, Jingxu Li, Yanhua Wen, Yudong Yao, Wei Qian, Yubao Guan, Shouliang Qi, Shouliang Qi

“…A total of 494 patients from two centers were included.ResultsMAEMC-NET achieved an area under curve (95% Confidence Interval) of 0.962 (0.934–0.973). …”
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Genetic differentiation and historical dynamics of the endemic species Rheum pumilum on the Qinghai-Tibetan Plateau inferred from phylogeography implications by Shuliang Liu, Jianxin Gao, Bo Xiao, Wenjie Guo, Qiushi Yu, Ailan Wang, Weiwei Li

“…Abstract Background Rheum pumilum, an endemic species on the Qinghai-Tibetan Plateau (QTP), serves as an ideal material for investigating the phylogeography of alpine plants. …”
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Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax by Caroline A. Coughlin, Dhanvantri Chahar, Marianna Lekakis, Abdessamad A. Youssfi, Lingxiao Li, Evan Roberts, Natalia Campos Gallego, Claude-Henry Volmar, Ola Landgren, Shaun Brothers, Anthony J. Griswold, Catalina Amador, Daniel Bilbao, Francesco Maura, Jonathan H. Schatz

“…Though potentially curable with frontline combination chemoimmunotherapy, DLBCL carries persistently poor prognosis for those with relapsed or refractory (rel/ref) disease, despite recent advances in immunotherapy. Here, we build on recent findings implicating gain-of-function mutations in the BCL10 signaling protein as drivers of resistance to Bruton’s tyrosine kinase (BTK) inhibitors. …”
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Analysis of risk factors for radiation-induced oral mucositis for nasopharyngeal carcinoma and prognostic value of EGF and STREM-1 by Puyu Jiang, Po Xue, Jiani Wu

“…The risk factors of RIOM were evaluated by multivariate logistic regression. …”
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A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound by An Wei, Yan Zou, Zhen-Hua Tang, Feng Guo, Yan Zhou

“…The sensitivity, specificity, and AUC of the model were 0.884 (0.807–0.962), 0.837 (0.762–0.911), and 0.927 (0.890–0.963), respectively. …”
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La conservation hermétique des céréales : comment les avancées de la recherche ont été ignorées au XXe siècle en France by Fleurat-Lessard Francis

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Epidemiological features and risk factors of human psittacosis in Hangzhou City, eastern China by Zhou Sun, Ke Xu, Liangliang Huo, Xingliang Zhang, Yi Wang, Yonghui Gong, Bingbing Chen

“…Among the cases, 48.91% were female, and the median age was 63 years. There were more female cases among those aged <60 years, while there were more male cases among those aged ≥60 years. …”
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Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysis by Duc Long Tran, Phu Nguyen Trong Tran, Paweena Susantitaphong, Phichayut Phinyo, Palittiya Sintusek

“…Comprehensive Meta-Analysis ver. 3, R, and Review Manager ver. 5.4.1 software were used to assess the optimal cutoff, sensitivity, specificity, and area under the curve (AUC). …”
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Operation time as a prognostic indicator on postoperative complications following percutaneous nephrolithotomy by Alireza Pakdel, Abdolreza Mohammadi, Amirreza Shamshirgaran, Ehsan Zemanati Yar, Leila Zareian Baghdadabad, Farshid Alaeddini, Roghayeh Koohi Ortakand, Leonardo Oliveira Reis, Seyed Reza Hosseini, Seyed Mohammad Kazem Aghamir

“…Additionally, 47.8% of patients were systemic inflammatory response syndrome positive postprocedure, and operation times were not shown to be predictive of systemic inflammatory response syndrome. …”
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Advancing GIS-based suitability analysis of BtX, PtX, PBtX, and eBtX facilities using the fuzzy analytic hierarchy process by Marcel Dossow, Mengxi Chen, Hartmut Spliethoff, Sebastian Fendt

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