Annexin A5 knockdown inhibits cardiomyocyte apoptosis and alleviates cardiac hypertrophy via activating the PI3K/AKT/Bcl-2 signaling pathway by Lina Zhao, Hongjuan Cao, Yao Yuan, Chunyan Liao, Dan Huang, Xiaoyi Li, Yueyao Zhao, Quanfeng Huang, Sha Li, Bei Zhang

“…It should be noted that LY290004 (PI3K/Akt signaling pathway inhibitor) can weaken the inhibitory effect of knockdown ANXA5 on cardiomyocyte apoptosis and myocardial protection. Therefore, ANXA5 knockdown improves hypertensive myocardial hypertrophy and cardiac function by inhibiting apoptosis and inflammatory response and activating PI3K/AKT/Bcl-2 pathway, ANXA5 may be a potential therapeutic direction for the treatment of hypertensive myocardial hypertrophy.…”
Get full text

Minimal CR-submanifolds of a six-dimentional sphere by M. Hasan Shahid, S. I. Husain

“…We establish several formulas for a 3-dimensional CR-submanifold of a six-dimensional sphere and state some results obtained by making use of them.…”
Get full text

Management of the Striga epidemics in pearl millet production: a review by Armel Rouamba, Hussein Shimelis, Inoussa Drabo, Kwame Wilson Shamuyarira, Emmanuel Mrema

“…Breeding for host plant resistance presents a cost-effective, environmentally friendly and affordable method for smallholder farmers to control and reduce Striga infestations and improve pearl millet yields. Therefore, the objectives of this study were to present the impact of S. hermonthica damage on pearl millet production and productivity and assess the effectiveness of different management methods of S. hermonthica with an emphasis on host plant resistance. …”
Get full text

Smarandache Ruled Surfaces according to Frenet-Serret Frame of a Regular Curve in E3 by Soukaina Ouarab

“…It concerns TN-Smarandache ruled surface, TB-Smarandache ruled surface, and NB-Smarandache ruled surface. We investigate theorems that give necessary and sufficient conditions for those special ruled surfaces to be developable and minimal. …”
Get full text

Retina Modeling by Artificial Neural Networks by Amelia Stewart

“…The objective of this article is to provide a theoretical framework for the structure and function of the retina. …”
Get full text

Uncovering the Impact of Financial Anxiety on Emotional Exhaustion and Financial Performance of MSMEs and the Role of Islamic Financial Literacy: Implementation of the Third Sustai... by Lestari Sri, Laksmi Indyastuti Devani, Pradipta Setyanto Refius

“…Interventions focusing on Islamic financial literacy and psychological wellbeing can improve the performance and sustainability of SMEs in Indonesia, helping them overcome financial and emotional challenges for long-term success.…”
Get full text

Association Between Diabetic Control And Anti-Diabetic Medication Adherence Using 8-Point Morisky Medication Adherence Scale In Local Population Of Khyber Pakhtunkhwa by Fuad Ahmad Siddiqi, Bilal Saeed, Mehmood Hussain, Wasif Anwar, Sidra Riaz, Naveed Abbas

“…In treatment options, 53 (48.18%) individuals were only managed with oral therapy, 16 (14.55%) on insulin only while 41 (37.27%) were prescribed with both oral hypoglycemic drugs and insulin. …”
Get full text

Hopf Bifurcation and Turing Instability Analysis for the Gierer–Meinhardt Model of the Depletion Type by Lianchao Gu, Peiliang Gong, Hongqing Wang

“…It is of great guiding importance for people to understand the real world by studying the Turing patterns of the reaction diffusion system changing with the system parameters. Therefore, in this paper, we study Gierer–Meinhardt model of the Depletion type which is a representative model in the reaction diffusion system. …”
Get full text

Synthesis, Characterizations and Antimicrobial Activity of Metal Complexes of 2-(2-Furanylmethylaminocarbonyl)benzoic Acid by R. H. Patel, B. L. Hiran

“…The ligand, 2-(2-furanylmethylaminocarbonyl)benzoic acid (FMBA) and it’s transition metal complexes have been synthesized and characterized by elemental analysis, spectral studies, magnetic moments and thermal studies. The antifungal activity of all the samples was monitored against common fungi.…”
Get full text

Une discussion des fondements philosophiques habermassiens de la discussion à visée philosophique à l’école et du rôle du maître en son cours by Pierre Usclat

“…In this article, our objective is to reflect and answer the critics concerning our study dealing with the " Emergence of Discussion with a Philosophical goal in primary schools".( EDP) Our thesis is based on the work of J. Habermas, explaining the role of the school teacher during EDP, that is to say a full and active participant.Therefore, in this article, after recalling the links between what the German philosopher thinks and EDP, we will study the criticisms we have received. …”
Get full text

The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

“…Beyond its hepatoprotective effects, an expanding body of research has underscored the immunoregulatory properties of SCO, indicating its potential therapeutic benefits for autoimmune and other inflammatory diseases. …”
Get full text

Balancing E-Commerce Platform and Manufacturer Goals in Sustainable Supply Chains: The Impact of Eco-Friendly Private Labels by Zhiheng Liu, Xiangcheng Cui, Yuanyuan Ji

“…We construct a game-theoretic model that encompasses both an e-commerce platform and a manufacturer. …”
Get full text

High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana by Naomi Hauser, Tanmay Sahai, Rocco Richards, Todd Roberts

“…Tacrolimus has a narrow therapeutic index with variable oral bioavailability and metabolism via cytochrome P-450 3A enzyme. …”
Get full text

Association among financial toxicity, depression and fear of cancer recurrence in young breast cancer patient-family caregiver dyads: an actor-partner interdependence mediation mod... by Tianye Yang, Zhu Zhu, Jianjun Shi, Lingling Tong, Jia Yang, Songli Mei, Hui Ren

“…Conclusions Depression in young BC patients was affected not only by themselves but also by their family caregivers. Emphasis should be placed on the interplay between financial toxicity and FCR of patients and family caregivers, with the aim of improving depression for young BC patients. …”
Get full text

Modelling random antibody adsorption and immunoassay activity by D. Mackey, E. Kelly, R. Nooney

“…However, crowding of antibodies can alsohave the opposite effect by favouring upright orientations.A specific aim of our model is topredict which of thesecompeting effects prevails under different experimental conditionsand study the existence of an optimalcoverage, which yields the maximum expectedconcentration of activeparticles (and hence the highest signal).…”
Get full text

Effect of Multimodal App-Based Interventions on Glycemic Control in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis by Emma Bodner, Lena Roth, Kathleen Wiencke, Christian Bischoff, Peter EH Schwarz

“…ObjectiveThis systematic review aims to analyze the efficacy of multimodal digital therapies that mainly meet the DiGA criteria for patients with T2DM and to elicit the potential of such therapies. …”
Get full text

Association Between Artificial Liver Support System and Prognosis in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Cui K, Liu CH, Teng X, Chen F, Xu Y, Zhou S, Yang Q, Du L, Ma Y, Bai L

“…Patients were divided into standard medical therapy (SMT) and ALSS groups. Kaplan-Meier survival analysis curves show the 28-day, 60-day and 90-day transplant-free mortality. …”
Get full text

An Inventory Model under Trapezoidal Type Demand, Weibull-Distributed Deterioration, and Partial Backlogging by Lianxia Zhao

“…Finally, numerical examples are provided to illustrate the theoretical results, and a sensitivity analysis of the major parameters with respect to the optimal solution is also carried out.…”
Get full text

Feasibility of material and media aspects of guidebook for group guidance implementation with the socratic method to increase anti-bullying awareness of middle school students by Dila Rahmawati, Suwarjo Suwarjo

Get full text

The helper strategy in vector-transmission of plant viruses by Di Mattia, Jérémy, Zeddam, Jean-Louis, Uzest, Marilyne, Blanc, Stéphane

“…This hypothesis appeared fully satisfactory as HCs were reported solely in viruses transmitted non-circulatively -- i.e. the virus particle binds externally to the mouthpart of its vector, and can later be released therefrom and inoculated. Recently, however, HCs have also been reported in viruses transmitted circulatively, where the virus particles are internalized in gut cells and cycle within the body to reach the salivary glands. …”
Get full text