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  1. 97781
  2. 97782

    Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression by Yuanyuan Chen, Zongying Zhang, Yuan Yao, Xiaorong Zhou, Yong Ling, Liming Mao, Zhifeng Gu

    Published 2025-01-01
    “…Previous studies have indicated that the aberrant activation of the NLRP3 inflammasome in synovial macrophages plays a significant role in the pathogenesis of RA and has been regarded as a therapeutic target for the disease. In this study, we synthesized a novel canthin-6-one alkaloid, namely methyl canthin-6-one-2-carboxylate (Cant), and assessed its effects on NLRP3 inflammasome activation in macrophages. …”
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  3. 97783

    Characterization of LY3324954 a long-acting glucagon-receptor agonist by William Roell, Tamer Coskun, Teayoun Kim, Libbey O’Farrell, Jennifer A. Martin, Shelly Nason, Jasmin Hernandez-Alamillo, Saidharshana Dhantu, Daniel J. Drucker, Kyle W. Sloop, James P. Steele, Jorge Alsina-Fernandez, Kirk M. Habegger

    Published 2025-01-01
    “…Thus, modulation of glucagon receptor (GCGR) activity in the context of single-molecule multi-receptor co-agonists has become an emerging therapeutic target against obesity and obesity-associated metabolic dysfunction. …”
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  4. 97784

    Increased thyroxine levels of patients with allergic rhinitis by Violeta Lokaj-Berisha, Besa Gacaferri Lumezi

    Published 2025-01-01
    “…Elevated serum IgE levels and alterations in thyroid function, particularly among males, suggest potential pathways for targeted therapeutic interventions. Further research is needed to elucidate these relationships and their underlying mechanisms.…”
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  5. 97785

    Knowledge as cause and tool for resistance against large scale mining: heuristic cases in Ecuador by Cristina Espinosa

    Published 2021-01-01
    “…These questions are illuminated using the theoretical contributions provided by approaches such as the sociology of knowledge, Latin American de-colonial thought, and feminist contributions to the study of science, technology and society. …”
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    Article
  6. 97786

    Investigation of the effects of Afyonkarahisar Region hot springs water on blood calcium and some hormon levels in experimentally-created osteoporosis in rats by Bülent Elitok, Tolgahan Saygin, Yavuz Ulusoy, Bahadir Kilinç

    Published 2021-07-01
    “…The results of the work performed showed that Süreyya I hot spring water contributed to a significant improvement in the clinical, hematological and biochemical blood parameters in rats with osteoporosis, therefore, it can be used for prevention and treatment of this disease in combination with other types of treatment.…”
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  7. 97787

    Elastic Dynamics Modeling and Characteristic Analysis of a 3T Isotropy Parallel Mechanism by Hong Zhang, Panpan Li, Tongde Wang

    Published 2019-05-01
    “…Through the comparison of the theoretical value and the simulation value of the mechanism model, it is found that the three branched chains have an important influence on the kinematic characteristics of the 3T parallel mechanism under the flexible deformation conditions, and further prove the reliability of the elastic dynamics model of the parallel mechanism, which provides an important theoretical basis for the future research and application.…”
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  8. 97788
  9. 97789

    Dust deposition characteristics on photovoltaic arrays investigated through wind tunnel experiments by Juan Wang, Weiwei Hu, Yunyun Wen, Fei Zhang, Xingcai Li

    Published 2025-01-01
    “…Abstract Optimizing the installation parameters of photovoltaic panels in a photovoltaic array to reduce dust accumulation, thereby enhancing their power generation, is a crucial research topic in the construction of solar power stations in desert regions. …”
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  10. 97790

    Impact of eggshell membrane on metabolism and cell adhesion in oxidatively stressed canine chondrocytes by Juraj Vozar, Nikola Hudakova, Natalia Nosalova, Mykhailo Huniadi, Dana Marcincakova, Slavomir Hornak, Lubica Hornakova, Petra Majerova, Dasa Cizkova, Dasa Cizkova

    Published 2025-01-01
    “…Thus, the study offers a valuable contribution to understanding how ESM bioactive compounds can be used therapeutically, bridging the gap between in vitro findings and practical applications in veterinary medicine.…”
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  11. 97791

    Warming Permafrost in the Western Alps: A Further Evidence of Elevation Dependent Warming? by Paolo Pogliotti, Edoardo Cremonese, Umberto Morra di Cella

    Published 2023-10-01
    “…The present study aims at characterising the recent thermal evolution of permafrost in the Aosta Valley region (Italy, Western European Alps) using active layer thickness anomalies and warming trends of both surface and deep temperatures as indicators. …”
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  12. 97792
  13. 97793

    Integrating Ambulatory Care Pharmacists Into Value-Based Primary Care: A Scalable Solution to Chronic Disease by Alexander J. Blood, Harry Saag, Adam Chesler, Dalia Ameripour, Max Gutierrez, Van Nguyen, Cassandra Richardson, Clive Fields, Jen Clair, Aaron Yao, Sashi Moodley

    Published 2025-01-01
    “…Methods: In this cohort study, a pharmacist, enabled by a collaborative drug therapy management agreement, prescribed and titrated therapies for HTN and T2DM. …”
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  14. 97794

    Modified Green-Ampt model for infiltration analysis in loess area and its parameter determination and verification by Yunxin Zheng, Zhiping Hu, Rui Wang, Songli Chen, Xiang Ren, Yonghui Zhang

    Published 2025-01-01
    “…The established MLGA model provides theoretical support for further study of the loess water infiltration mechanism.…”
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  15. 97795

    A Problem of Perspective: Religions in Africa or African Traditional Religion by Osman Şahin

    Published 2024-12-01
    “…Besides, these studies were mostly biased, they often looked at religious phenomena from the perspective of Christianity and tried to Christianise them, and even more importantly, they made generalisations and presented all religions as a single religion. …”
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  16. 97796

    Acupuncture Anxiolytic Effects on Physiological and Psychological Assessments for a Clinical Trial by Monir Shayestehfar, Tohid Seif-Barghi, Sahar Zarei, Amir Mehran

    Published 2016-01-01
    “…A total of 45 athletes were equally allocated to either acupuncture group, sham group, or wait-list control group. Thereafter, all participants were asked to complete an anxiety questionnaire before and after the intervention. …”
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  17. 97797
  18. 97798
  19. 97799
  20. 97800

    Augmentative Asenapine in a Recurrent Manic Catatonic Patient with Partial Response to Clozapine by Massimiliano Buoli, Cristina Dobrea, Alice Caldiroli, Laura Cremaschi, A. Carlo Altamura

    Published 2013-01-01
    “…First-line treatment consists of benzodiazepines, while in case of resistance electroconvulsive therapy (ECT) and clozapine have shown positive results. …”
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