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95921
O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation
Published 2025-01-01“…In conclusion, our study highlights the crucial role of FTO O-GlcNAcylation in RNA m6A methylation and the progression of MDS/AML, thereby providing a potential therapeutic avenue for these formidable diseases.…”
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95922
In Search of Inner Wisdom: Guided Mindfulness Meditation in the Context of Suicide
Published 2004-01-01“…Many participants reported a significant positive experience including connection to knowledge that was highly relevant to them in their current state of life. Whether such insights were experienced as coming from within (a deeper part of the self) or from an external source (a guiding figure or presence), indications are that guided meditation can be a powerful resource for therapists and their clients, suicidal and otherwise. …”
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95923
Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells
Published 2025-01-01“…We conclude that LFA-1-expressing EVMyd88 may be a candidate suitable for delivering therapeutic peptides in inflammatory diseases associated with TLR-activation. …”
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95924
Monitoring and evaluation of public policies in Brazil: conceptual approach and trajectory of legal and institutional development
Published 2021-09-01“…This paper investigates the area of monitoring and evaluation of public policies from a conceptual approach and an interpretation of its institutional development in Brazil. Therefore, we build critical analyzes from the legal and sociopolitical perspectives. …”
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95925
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95926
Bringing Order to Chaos Ethically: “Cataloging Code of Ethics” and critical cataloging
Published 2024-12-01“…Through the methods of comparison, analysis, and synthesis, an inductive approach is used to establish a theoretical framework for the subject of the research. …”
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95927
Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men
Published 2021-01-01“…In cardiomyocytes, testosterone activates AMPK and PPARs. Therefore, the description of local expression of cardiac SHBG and its circulating levels may shed new light to explain physiological and adverse cardiometabolic roles of androgens in different tissues. …”
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95928
Evaluation of Predictors of Response to Ovulation Induction Using Letrozole in Women with Polycystic Ovary Syndrome: A Prospective Cohort Study
Published 2024-12-01“…The predictive ability of candidate biomarkers, particularly with letrozole-based therapy in infertile PCOS women, remains inconclusive as it is yet to be evaluated in a prospective study. …”
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95929
Thyroid Storm Triggered by Rotavirus Infection in a 10-Year-Old Girl
Published 2025-01-01“…In cases of hyperthyroidism, these symptoms confirm the criteria for TS. Therefore, it is possible that some cases of TS are triggered and caused by gastrointestinal conditions such as rotavirus infection. …”
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95930
Mental health challenges faced by professional athletes
Published 2025-02-01“…Professional athletes may experience a variety of mental health problems that influence their everyday life and sport performance. Therefore, the potential risk factors for developing mental disease should be known to coaches and physicians to provide adequate help for athletes. …”
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95931
Existence of the Mild Solutions for Impulsive Fractional Equations with Infinite Delay
Published 2011-01-01“…The existence and uniqueness of a mild solution is established using a solution operator and the classical fixed-point theorems.…”
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95932
Hydrological Models and Artificial Neural Networks (ANNs) to Simulate Streamflow in a Tropical Catchment of Sri Lanka
Published 2021-01-01“…In addition, usage of ANNs is minimum to simulate streamflow in the context of Sri Lanka. Therefore, this study presents an intercomparison between streamflow estimations from conventional hydrological modelling and ANN analysis for Seethawaka River Basin located in the upstream part of the Kelani River Basin, Sri Lanka. …”
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95933
Evaluating the Relationship between Factors Enhancing the Competitiveness of Customer Foreign Currency Services in the Banking Industry
Published 2024-06-01“…They result in high incomes for banks, therefore, banks need to undertake requisite measures to establish a competitive edge in attracting, retaining, and servicing customers, while also evaluating the prevailing conditions in the banking sector. …”
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95934
Development of Automated Image Processing for High-Throughput Screening of Potential Anti-Chikungunya Virus Compounds
Published 2025-01-01“…Chikungunya virus, a member of the Alphavirus genus, continues to present a global health challenge due to its widespread occurrence and the absence of specific antiviral therapies. Accurate detection of viral infections, such as chikungunya, is critical for antiviral research, yet traditional methods are time-consuming and prone to error. …”
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95935
Cerebral Venous Sinus Thrombosis and Hydrocephalus in a Vegan Secondary to Acquired Hyperhomocystinaemia
Published 2019-01-01“…Replacement of vitamin B12, folic acid, pyridoxine along with anticoagulation and control of intracranial pressure with external ventricular drain lead to dramatic improvement of his neurology. Therefore, high index of suspicion is crucial for a better outcome in otherwise irreversible neurological damage in acquired hyperhomocystinaemia.…”
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95936
A Study on the Spatiotemporal Heterogeneity and Driving Forces of Ecological Resilience in the Economic Belt on the Northern Slope of the Tianshan Mountains
Published 2025-01-01“…And among different factors, the dual-factor enhancement effect is greater than the nonlinear enhancement of a single factor. (3) Human activities are important influencing factor, and the impact of urban expansion and economic growth on ecological resilience is becoming increasingly significant. Therefore, in the process of economic development, full consideration should be given to the self-repairing and adaptive capabilities of the ecosystem.…”
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95937
Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration
Published 2018-01-01“…Regenerative therapeutic techniques now appear to be a potential approach to solve this conundrum posed by these poorly self-regenerating tissues. …”
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95938
Enriched microbial consortia from natural environments reveal core groups of microbial taxa able to degrade terephthalate and terphthalamide.
Published 2024-01-01“…In this study, microbial communities were enriched from sediments collected from five unique environments to degrade either terephthalate or terephthalamide by performing biweekly transfers to fresh media and substrate. 16S rRNA sequencing was used to identify the dominant taxa in the enrichment cultures which may have terephthalate or terephthalamide-degrading metabolisms and compare them to the control enrichments. The goals of this study are to evaluate (1) how widespread terephthalate and terephthalamide degrading metabolisms are in natural environments, and (2) determine whether terephthalamide is biodegradable and identify microorganisms able to degrade it. …”
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95939
Innovative determination of phytohormones in Aloe vera
Published 2025-01-01“…IntroductionAloe vera is widely known for its therapeutic properties, but concerns regarding the levels of phytohormones and their potential impact on human health highlight the need for advanced analytical techniques. …”
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95940