Adaptive evolution of SARS-CoV-2 during a persistent infection for 521 days in an immunocompromised patient by Hanno Schmidt, Lea Schick, Jürgen Podlech, Angélique Renzaho, Bettina Lieb, Stefan Diederich, Thomas Hankeln, Bodo Plachter, Oliver Kriege

“…With 11 amino acid substitutions in the receptor binding domain of the virus’ spike protein, substitutions were 15 times more abundant than expected for a random distribution in this highly functional region. Amongst them were the substitutions S:K417T, S:N440S, S:K444R, S:V445A, S:G446N, S:L452Q, S:N460K, and S:E484V at positions that are notorious for their resistance-mediating effects. …”
Get full text

绚丽多姿的甘肃自然保护区 by 赵平友

Get full text

差分法应用于连通水库调洪演算的探讨 by 李莉

Get full text

Multiobjective Salp Swarm Algorithm Approach for Transmission Congestion Management by Anjali Agrawal, Seema N. Pandey, Laxmi Srivastava, Pratima Walde, R. K. Saket, Baseem Khan

“…The proposed incentive-based demand response and distributed generation approach of CM, has been framed with various strategies employing different thermal limits over transmission lines and has resulted into significant reduction in congestion and in-turn improvement of transmission reliability margin. …”
Get full text

Delving into the Design and Implementation of Specifications Grading Systems in Higher Education by William J. Howitz, Kate J. McKnelly, Renée D. Link

“…This review provides a resource for those interested in exploring this alternative grading system, and the emergent themes indicate that there are ripe opportunities for future study.…”
Get full text

Divalent Metal- and High Mobility Group N Protein-Dependent Nucleosome Stability and Conformation by Michelle S. Ong, Dileep Vasudevan, Curt A. Davey

“…Residues outside of the nucleosome binding domain are required for the activity, which is also displayed by an HMGN1 truncation product lacking part of the regulatory domain. In addition, thermal denaturation assays show that the presence of 1 mM Mg2+> or Ca2+ gives a reduction in nucleosome core terminus stability, which is further substantially diminished by the binding of HMGN2 or truncated HMGN1. …”
Get full text

中美合作在上海举办野生动物保护与管理训练班 by 徐宏发

Get full text

Analysis of the influence of Doppler effect on Starlink downlink signals by Zhe LI, Weihong LIN, Wei DENG, Jianfeng YANG, Zhanyu ZHU

“…Understanding the influence of Doppler effect on the transmission performance of the Starlink system was an important prerequisite to decipher its unique physical layer structure.To this end, firstly a Doppler effect model considering relative motion between the satellites and the earth was established, and the maximum Doppler effect parameters of the Starlink was provided.Subsequently, a signal model under Doppler effect was constructed based on the Starlink downlink time-frequency structure and parameters.Finally, time-frequency domain theoretical characteristics under Doppler effect for the three main components of the downlink signal were established.The validity of the theoretical findings is corroborated through simulations, serving as a valuable reference for research on transmission reliability in existing and future low earth orbit satellite communication systems.…”
Get full text

Citoyenneté féminine sous la Seconde République : entre le réformisme social et la démocratisation by Ana Aguado

“…The new republican regime therefore created the necessary conditions -although still insufficient- for women to redefine egalitarian concepts found in certain political cultures, such as republicanism or socialism, with a gender approach. …”
Get full text

Analysis and Structural Optimization of Gearbox for New Type Lightweight Bridge Crane by Zhu Shuaihua, Wang Zhengbing, Zhang Zhihong, Yan Shidang, Liu Zhongming

Get full text

Mezi filosofií a medicínou. Ke Kantovu překonání karteziánského dualismu mysli a těla by Pech, Robin

“…Its starting point is therefore Kant’s reflections in the Metaphysics of Morals (1797) and the Conflict of the Faculties (1798), where Kant presented his concept of so-called “universal medicine,” which focuses on the problem of a healthy regimen. …”

Hybrid Prairie Dog and Dwarf Mongoose optimization algorithm-based application placement and resource scheduling technique for fog computing environment by R. Baskar, E. Mohanraj, M. Saradha, R. Monika

“…As the fog devices are resource constrained, the deployment of diversified IoT applications requires effective ways for determining available resources. Therefore, implementing an efficient resource management strategy is the optimal choice for satisfying application Quality of Service (QoS) requirements to preserve the system performance. …”
Get full text

Development of the cultural tailoring score (CTS): a scoring instrument to assess cultural tailoring of health messaging by Claudia Parvanta, Kayleigh Murray, Samantha Boddupalli, Natalie Erasme, Rheese McNab, Vijay Prajapati, Arabel Severe, Aura Reyes, Richard Harner, Rhonda Holliday

“…Open-ended comments from pretesting respondents support this finding and suggest that cultural components facilitated what the Elaboration Likelihood Model describes as central processing of the main health messages, thereby enhancing health literacy.Discussion The paper discusses recommendations for further development and testing of the CTS to produce a simple tool to guide future multicultural health communication materials production or pretesting.…”
Get full text

Segon lo vers del novel chan (Guillaume de Poitiers, P.-C. 183, 1, vers 4) : essai de mise au point by Jean-Pierre Chambon

“…The author of this article applies himself to establish the meaning of verse 4 of d’Ab la douzor del temps novel, the famous poem of William of Poitiers. Therefore. He analyses therefore previous interpretations about this verse (in particular the most recent ones: Pasero, Vallín, Gambino). …”
Get full text

Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-exp... by Michael A. Deaney, Katherine C. Shihadeh, Alexandra Craig, Margaret M. Cooper, Paul D. Paratore, Timothy C. Jenkins

“…Interrupted time series analysis showed a reduction in the median duration of therapy (–2.3 days, P = .0016), with a sustained decline (slope change –0.2103, P = .005) post-intervention. …”
Get full text

Historiography of life and creative work of Ya.N. Baiburtly, a notable Crimean Tatar man of letters and educator by Tair Kirimov

“…The theoretical basis of the research is the works of A. …”
Get full text

Analysis of the 2016 – 2025 fiscal budget of U.S. Centers for Disease Control and Prevention by Nana LIU, Lieyu HUANG, Yuan DANG, Zekai YU, Qianqiu LIU, Yan GUO

“…From 2016 to 2025, the allocation of basic funds/project budgets mainly focused on areas such as "HIV/AIDS, Viral Hepatitis, STD, and TB Prevention," "Chronic Disease Prevention and Health Promotion," and "Immunization and Respiratory Diseases," all accounting for more than 10% of the total budget. Among them, the budget for "HIV/AIDS, Viral Hepatitis, STD, and TB Prevention" showed significant fluctuations (US$ 0.934 billion to US$ 1.553 billion), while the budget for "Immunization and Respiratory Diseases" remained at a relatively high level with minor fluctuations (US$ 0.701 billion to US$ 1.256 billion). …”
Get full text

Optimal Control of a Delay-Varying Computer Virus Propagation Model by Jianguo Ren, Yonghong Xu, Chunming Zhang

“…By incorporating the objective of keeping a low number of infected nodes and a high number of recovered nodes at a lower cost into a known computer virus model (the delay-varying SIRC model) extended by introducing quarantine, a novel model is described by means of the optimal control strategy and theoretically analyzed. Through the comparison of simulation results, it is shown that the propagation of computer virus with varying latency period can be suppressed effectively by the optimal control strategy.…”
Get full text

Study on Water and Silt Variation and Reacting Countermeasures in Pearl River Estuary by LIAO Xiao-long, WANG Xian-ping, LI Kai-zhi

Get full text

Incorporating edge convolution and correlative self-attention into graph neural network for material properties prediction by Zexi Yang, Qi Yu, Yapeng Zhan, Jiying Liu

“…Traditional methods based on either trial-and-error experiments or large-scale density functional theory calculations are known to possess various limitations. …”
Get full text