New Fixed Point Theorems for θ‐ϕ-Contraction on Rectangular b-Metric Spaces by Abdelkarim Kari, Mohamed Rossafi, El Miloudi Marhrani, Mohamed Aamri

“…The Banach contraction principle is the most celebrated fixed point theorem and has been generalized in various directions. …”
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Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies by Wanli Zhang, Luqi Ge, Yiwen Zhang, Zhentao Zhang, Wen Zhang, Feifeng Song, Ping Huang, Tong Xu

“…Furthermore, the tumor microenvironment, which is intricately linked to cancer development, acts as a mediator in the proliferation of numerous cancers and presents a viable target for oncological therapies. This paper primarily explores how HDAC inhibitors can regulate cancer progression via the tumor microenvironment and suppress tumor growth through multiple pathways, in addition to examining the synergistic effects of combined drug therapies involving HDAC inhibitors.…”
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Editorial: Advancements in proteomics and PTMomics: unveiling mechanistic insights and targeted therapies for metabolic diseases by Xiulan Chen, Yanchang Li, Daniela Braconi

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Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis by Beatriz Cicuéndez, Alfonso Mora, Juan Antonio López, Andrea Curtabbi, Javier Pérez-García, Begoña Porteiro, Daniel Jimenez-Blasco, Pedro Latorre-Muro, Paula Vo, Madison Jerome, Beatriz Gómez-Santos, Rafael Romero-Becerra, Magdalena Leiva, Elena Rodríguez, Marta León, Luis Leiva-Vega, Noemi Gómez-Lado, Jorge L. Torres, Lourdes Hernández-Cosido, Pablo Aguiar, Miguel Marcos, Martin Jastroch, Andreas Daiber, Patricia Aspichueta, Juan Pedro Bolaños, Jessica B. Spinelli, Pere Puigserver, José Antonio Enriquez, Jesús Vázquez, Cintia Folgueira, Guadalupe Sabio

“…MCJKO mice, even without UCP1, a fundamental thermogenic protein, exhibit elevated BAT thermogenesis. …”
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Exosome-Like Vesicles as New Mediators and Therapeutic Targets for Treating Insulin Resistance and β-Cell Mass Failure in Type 2 Diabetes Mellitus by Qian Ge, Xin Xin Xie, Xiaoqiu Xiao, Xi Li

“…This review focuses on the roles of ELVs in insulin resistance and β-cell failure and also highlights the potential use of ELVs and exosome-based delivery systems in therapeutic interventions aimed at treating type 2 diabetes mellitus as well as the challenges associated with exosome-targeting therapeutics.…”
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Anomalous Microwave Emission: Theory, Modeling, and Observations by Clive Dickinson, Roberta Paladini, Laurent Verstraete

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The Potential of Single-Chain Variable Fragment Antibody: Role in Future Therapeutic and Diagnostic Biologics by Getachew Gezehagn Kussia, Tesfaye Sisay Tessema

“…Besides, this review comprises construction protocols, therapeutics, and diagnostic applications of scFv, as well as related challenges. …”
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THE DEVELOPMENT OF MATHEMATICAL MODEL AND THEORETICAL ANALYSIS OF THE ROLLING PROCESS IN HIGH-SPEED REDUCING-CALIBRATION BLOCK OF MODERN WIRE MILL by S. M. Zhuchkov, A. A. Gorbanev, V. A. Matochkin

“…Тhе mathematical model of the process of continuous rolling in reducing-calibrating block, with the help of which the theoretical analysis of this process is carried out, is developed.…”
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Comparison of Therapeutic Effects of Different Rehabilitation Methods on Patients Undergoing Total Knee Arthroplasty: A Network Meta‐Analysis of Randomized Controlled Trials by Zhaokai Jin, Yi Tang, Hua Huang, Lei Chen, Zhongyi Zhang, Tianyou Ma, Zhengming Wang, Hai Su, Haojing Zhou, Shuaijie Lv, Peijian Tong

“…Among them, NT may be the best postoperative rehabilitation therapy.…”
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Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen by Yu-Chan Chih, Amelie C. Dietsch, Philipp Koopmann, Xiujian Ma, Dennis A. Agardy, Binghao Zhao, Alice De Roia, Alexandros Kourtesakis, Michael Kilian, Christopher Krämer, Abigail K. Suwala, Miriam Stenzinger, Halvard Boenig, Agnieszka Blum, Victor Murcia Pienkowski, Kuralay Aman, Jonas P. Becker, Henrike Feldmann, Theresa Bunse, Richard Harbottle, Angelika B. Riemer, Hai-Kun Liu, Nima Etminan, Felix Sahm, Miriam Ratliff, Wolfgang Wick, Michael Platten, Edward W. Green, Lukas Bunse

“…Here, we identify a therapeutic HLA-A*02-restricted PTPRZ1-reactive TCR retrieved from a vaccinated glioblastoma patient. …”
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Addressing Psychological Factors in Sports Injury Rehabilitation – What is a Physical Therapist to do? by Niklas Cederström, Simon Granér, Eva Ageberg

“…International Journal of Sports Physical Therapy…”
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Free Vibration of Embedded Porous Plate Using Third-Order Shear Deformation and Poroelasticity Theories by Ali Ghorbanpour Arani, Zahra Khoddami Maraghi, Mehdi Khani, Iman Alinaghian

“…In order to increase the accuracy of results in comparison with classical plate and first-order shear deformation theories, Reddy’s theory was utilized in this research. …”
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The Effectiveness of Fluorescent Light Energy as Adjunct Therapy in Canine Deep Pyoderma: A Randomized Clinical Trial by Andrea Marchegiani, Alessandro Fruganti, Andrea Spaterna, Matteo Cerquetella, Adolfo M. Tambella, Susan Paterson

“…Assessments were undertaken weekly for 8 weeks and every 2 weeks thereafter until 12 weeks after enrolment. At each visit, lesions were scored and cytology was conducted to determine a neutrophil engulfing bacteria score. …”
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The Fixed Point Theory for Some Generalized Nonexpansive Mappings by Enrique Llorens Fuster, Elena Moreno Gálvez

“…We study some aspects of the fixed point theory for a class of generalized nonexpansive mappings, which among others contain the class of generalized nonexpansive mappings recently defined by Suzuki in 2008.…”
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The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells by Sabrina Bimonte, Maddalena Leongito, Antonio Barbieri, Vitale del Vecchio, Michela Falco, Aldo Giudice, Raffaele Palaia, Vittorio Albino, Raimondo Di Giacomo, Antonella Petrillo, Vincenza Granata, Francesco Izzo

“…In this review, we synthesize the latest findings on therapeutic regulation of HCSCs by miRNAs, in order to highlight the perspective of novel miRNA-based anticancer therapies for HCC treatment.…”
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Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study by Zohreh Tehranchinia, Bita Saghi, Hoda Rahimi

“…Addition of tranexamic acid injections to conventional hydroquinone therapy can increase the efficacy of topical treatment. …”
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Thermosensitive In Situ Ophthalmic Gel for Effective Local Delivery and Antifungal Activity of Ketoconazole Nanoparticles by Chutima Chaiwut, Sarin Tadtong, Puriputt Akachaipaibul, Jutamas Jiaranaikulwanitch, Sudarshan Singh, Siriporn Okonogi, Dwi Marlina Syukri, Chuda Chittasupho

“…Current antifungal treatments face limitations such as low solubility, poor corneal penetration, and limited therapeutic options. This study aimed to develop a thermosensitive in situ gel incorporating ketoconazole nanoparticles (NPs) to enhance drug solubility, stability, and antifungal activity. …”
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Brownian Dynamics Simulation of Microscale Thermophoresis in Liquid by Koki Ide, Tetsuro Tsuji, Takayuki Suzuki, Kenji Setoura

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The examination of the Tofā Māmāo cultural concept and repositioning it as a theoretical approach to guide Pacific research by Aliitasi Su’a-Tavila, James Mbinta

“…The Samoan cultural concept named Tofā Māmāo (in-depth knowledge) is a potential theoretical approach to guide Pacific research. This study explored Tofā Māmāo from the perspective of paramount chiefs and its theoretical position within academia. …”
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Application of syntrophic co-culture Chlorella sorokiniana and Streptomyces thermocarboxydus in semi-continuous system for cassava wastewater treatment and biomass production by Mohamad Padri, Nittaya Boontian, Maisarah Munirah Latief, Misdar Amdah, Mohamed Sahrul Tamzil

“…This study aimed to examine and compare the application of single and co-culture of alga Chlorella sorokiniana P21 with Streptomyces thermocarboxydus BMI in semi-continuous system to treat biogas effluent wastewater and generate algal biomass. …”
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