A nociceptor-specific RNAi screen in Drosophila larvae identifies RNA-binding proteins that regulate thermal nociception by Amber Dyson, Gita Gajjar, Katherine C. Hoffman, Dakota Lewis, Sara Palega, Erik Rangel Silva, James Auwn, Andrew Bellemer

“…In this study, we conducted a nociceptor-specific RNAi screen of 112 candidate RNA-binding protein genes to identify those that are required for normal sensitivity to noxious thermal stimuli. The screen and subsequent validation experiments identified nine candidate genes (eIF2α, eIF4A, eIF4AIII, eIF4G2, mbl, SC35, snf, Larp4B and CG10445) that produce defects in nociceptive response latency when knocked down in larval nociceptors. …”
Get full text

Strategies for Optimizing Acute Burn Wound Therapy: A Comprehensive Review by Andrei Cretu, Andreea Grosu-Bularda, Eliza-Maria Bordeanu-Diaconescu, Florin-Vlad Hodea, Vladut-Alin Ratoiu, Catalina-Stefania Dumitru, Mihaela-Cristina Andrei, Tiberiu-Paul Neagu, Ioan Lascar, Cristian-Sorin Hariga

Subjects: Get full text

Vitamin D Level in Postmenopausal Breast Cancer Patients Before and After Adjuvant Chemotherapy and Endocrine Therapy by Barrak F. Al Obeidy, Alya A. Al Zobair, Mohammed A. Hayawi

Subjects: Get full text

Peer Review of “Safety and Efficacy of Chimeric Antigen Receptor T-Cell Therapy for Recurrent Glioblastoma: An Augmented Meta-Analysis of Phase 1 Clinical Trials (Preprint)” by Vanessa Fairhurst, Randa Salah Gomaa Mahmoud, Toba Olatoye, Sylvester Sakilay

Get full text

Some Fixed Point Theorems for Nonlinear Set-Valued Contractive Mappings by Zeqing Liu, Zhihua Wu, Shin Min Kang, Sunhong Lee

“…Four fixed point theorems for nonlinear set-valued contractive mappings in complete metric spaces are proved. …”
Get full text

Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India by S. Sinha, H. Ahmad, R. C. Shekhar, N. Kumar, L. Dar, J. C. Samantaray, S. K. Sharma, A. Bhargava, R. M. Pandey, R. L. Mitsuyasu, J. L. Fahey

“…The increased use of antiretroviral therapy (ART) has reduced the morbidity and mortality associated with HIV, adversely leading to the emergence of HIV drug resistance (HIVDR). …”
Get full text

Index Funds, Strategic Engagement and Common Ownership Theory (A Rising Tension Between Competition and Governance in the EU) by Luz García Martinez

Get full text

Change in Antimicrobial Therapy Based on Bronchoalveolar Lavage Data Improves Outcomes in ICU Patients with Suspected Pneumonia by Bharti Chogtu, Vrinda Mariya Elenjickal, Dharma U. Shetty, Mahsheeba Asbin, Vasudeva Guddattu, Rahul Magazine

“…A change in antimicrobial therapy based on BAL data was associated with improved outcomes. …”
Get full text

A New Credit and Loan Lending Strategy and Credit in Banking Systems: An Evolutionary Game Theory Approach by Zohreh Lashgari, Alireza Bahiraie, Madjid Eshaghi Gordji

“…In this paper, authors offer one novel mathematical model of credit lending to customers based on evolutionary game theory, and the model presents an efficient and realistic approach. …”
Get full text

Effect of Thermal Treatment on the Extraction and Antioxidant and Antiglycation Activities of (Poly)phenols from <i>Ribes magellanicum</i> by Felipe Ávila, Natalia Martinez, Nicolás Mora, Katherine Márquez, Felipe Jiménez-Aspee

Subjects: Get full text

Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallstone Disease by Sanjana Murali, Nandini Krishnamurthy, R. B. Devi Krishna, Shanthi Vijayaraghavan, S. Rajesh Kumar, Andrea Mary Francis

“…We investigate potential therapeutic targets within the NOD1 signaling pathway and its interactions with other host factors, suggesting methods to restore imbalances in the gut microbiota and improve GD management. …”
Get full text

Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic target by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…Additionally, we employed molecular docking techniques to evaluate the potential of inhibin subunit beta B (INHBB) as therapeutic targets and to assess the binding affinity of candidate drugs. …”
Get full text

CFD Simulation of Thermal-Hydraulic Benchmark V1000CT-2 Using ANSYS CFX by Thomas Höhne

Get full text

First-line chemotherapy with selective internal radiation therapy for intrahepatic cholangiocarcinoma: The French ACABi GERCOR PRONOBIL cohort by Nicolas Adamus, Julien Edeline, Julie Henriques, Nadim Fares, Thierry Lecomte, Anthony Turpin, Dewi Vernerey, Mathilde Vincens, Brice Chanez, David Tougeron, Christophe Tournigand, Eric Assenat, Matthieu Delaye, Sylvain Manfredi, Olivier Bouché, Nicolas Williet, Angelique Vienot, Lorraine Blaise, Léo Mas, Cindy Neuzillet, Alice Boilève, Gaël S. Roth

“…Background &amp; Aims: Selective internal radiation therapy (SIRT) is a promising option for liver-only unresectable intrahepatic cholangiocarcinoma (iCCA). …”
Get full text

Enhancing antibacterial photodynamic therapy with NIR‐activated gold nanoclusters: Atomic‐precision size effect on reducing bacterial biofilm formation and virulence by Chengyu Liu, Tenghui Tian, Yujia Shi, Meiqi Li, Le Hong, Jing Zhou, Jia Liu, Yuan Zhong, Xue Wang, Zhenyu Wang, Xue Bai, Lin Wang, Chunyan Li, Zhennan Wu

Subjects: “…antibacterial photodynamic therapy…”
Get full text

Mosaic Structure of GaN Film Grown on Sapphire Substrate by AP-MOCVD: Impact of Thermal Annealing on the Tilt and Twist Angles by J. Laifi, M. F. Hasaneen, H. Bouazizi, Fatimah Hafiz Alsahli, T. A. Lafford, A. Bchetnia

Subjects: Get full text

Le projet pénitentiaire de Théodore Charpentier by Claire Illi

Subjects: Get full text

A critical review of the thermophysical properties and applications of carbon-based hybrid nanofluids in solar thermal systems by Adeola Borode, Thato Tshephe, Peter Olubambi

“…This review focuses on the potential of carbon-based hybrid nanofluids to enhance the performance of solar thermal energy systems. Solar thermal technology is pivotal in transitioning towards renewable energy sources, offering sustainable alternatives to conventional fossil fuels. …”
Get full text

Prostate Cancer Stereotactic Body Radiation Therapy with Image-guided Radiation Therapy (IGRT) Technique with Three-Dimensional Transperineal Ultrasound for IGRT Tracking of the Prostate by Igor Migowski, Arn Migowski

“… Introduction Ultrahypofractionated radical radiotherapy for prostate cancer, also known as stereotactic body radiation therapy (SBRT), is an unprecedented modality of prostate radiotherapy and is still used very sparsely in Brazil. …”
Get full text

Two ways to one goal: new strategy of antiviral therapy for chronic hepatitis C by S. N. Batskikh

Subjects: Get full text