255 The impact of a personal cancer diagnosis on adolescent and young adult cancer survivors’ social connectedness: A qualitative analysis by Pooja Rao, Joel E Segel, Kristin Bingen, Katie A Devine, Allison M Scott, Laura M Koehly, Ashton M Verdery, Courtney L Rumbaugh, Emily Wasserman, Heather J Costigan, Smita Dandekar, Kevin Rakszawski, Natthapol Songdej, George F Blackall, Monali Vasekar, Seema Naik, Eugene J. Lengerich, Lauren J Van Scoy

“…Objectives/Goals: This study’s objective was to explore how a personal cancer diagnosis impacts the social connectedness (i.e., quality, structure, and functions of social relationships) of adolescent/young adult cancer survivors (AYACS, patients diagnosed with cancer between 15 and 39 years old), to inform intervention development fostering social health. …”
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Advantages of long-term combination pharmacotherapy with a beta-blocker and eplerenone in patients with ST-segment elevation acute coronary syndrome by O. A. Osipova, V. P. Mikhin, A. I. Golovin, O. N. Belousova, D. N. Perutsky, P. K. Alferov, S. L. Konstantinov

“…The advantages of long-term combination pharmacotherapy of nebivolol and eplerenone in HFmrEF patients after STE-ACS on both structural and functional cardiac parameters were established.…”
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Research on knowledge, attitude and practice (KAP) regarding dengue infection: a community-based study in rural Cox's Bazar by Saima Bibi

“…Face-to-face interviews were performed using a pretested and semi-structured questionnaire. Problem: DI poses a serious threat to public health, especially in tropical and subtropical areas where the dengue virus vector, the Aedes aegypti mosquito, is abundant.1,2 Bangladesh experienced its major dengue outbreak in 2019, with 100,000 cases and 120 deaths, followed by the second-largest outbreak in 2022, with 60,078 cases and 266 deaths.3,4 Assessment of problem and analysis of its causes: Bangladesh is severely affected by DI, largely due to factors including tropical climate, a dense population, unplanned urbanisation, inadequate vector control and low-literacy rates.5,6DI can cause mild fever to severe conditions, such as haemorrhagic fever, dengue shock syndrome, respiratory symptoms, gastrointestinal disturbance, low platelet count and deranged liver function tests. …”
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Health perceptions of older individuals on the cognitive benefits of a multicomponent green physical activity program: A qualitative exploration in the Southwest Region of Bahia, B... by Carolina Rego Chaves Dias, Saulo Vasconcelos Rocha, Milena Fernandez Dias, Bruno Morbeck de Queiroz, Natália Nascimento Silva, Ariani França Conceição, Bruna Maria Palotino-Ferreira, Sonia Brito-Costa, Sofia de Lurdes Rosas da Silva, Clarice Alves dos Santos, Lélia Renata Carneiro Vasconcelos, Guilherme Eustáquio Furtado

“…Background and aims: A multicomponent exercise program (MEP) is a tailored, physical activity-based intervention that incorporates several exercise modalities to improve physical function and reduce negative health consequences, such as cognitive decline. …”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Multimodal magnetic resonance imaging (MRI) was acquired for each participant at baseline (before TMS treatment) with T1-weighted (structural MRI) and resting state (task-free) functional MRI (rsfMRI). …”
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Development of the Psychosocial Rehabilitation Web Application (Psychosocial Rehab App) by Fagner Alfredo Ardisson Cirino Campos, José Carlos Sánches García, Gabriel Lamarca Galdino da Silva, João Antônio Lemos Araújo, Ines Farfán Ulloa, Edilson Carlos Caritá, Fabio Biasotto Feitosa, Marciana Fernandes Moll, Tomás Daniel Menendez Rodriguez, Carla Aparecida Arena Ventura

“…<b>Results:</b> The web app “Psychosocial Rehabilitation Application” displays a home screen for registration and other screens structured into the stages of the psychosocial rehabilitation project (assessment, diagnosis, goals, intervention, agreements, and re-assessment). …”
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Individualized frequency and montage tACS to engage theta-gamma coupling and enhance working memory in mild cognitive impairment by Mina Mirjalili, Mina Mirjalili, Iryna S. Palamarchuk, Iryna S. Palamarchuk, Heather Brooks, Heather Brooks, Reza Zomorrodi, Reza Zomorrodi, Ashley Melichercik, Wei Wang, Wei Wang, Sean M. Nestor, Sean M. Nestor, Daniel M. Blumberger, Daniel M. Blumberger, Daniel M. Blumberger, Abhishek Datta, Christopher Bowie, Christopher Bowie, Bernadette Mdawar, Bernadette Mdawar, Kullervo Hynynen, Kullervo Hynynen, Sanjeev Kumar, Sanjeev Kumar, Sanjeev Kumar, Sanjeev Kumar, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji

“…Participants will be randomized to receive either individualized tACS or sham tACS for 10 days. tACS individualization will involve adjusting the theta frequency, tACS electrode locations, and current intensity for each participant. Cognitive and functional assessments will occur at baseline and post-intervention. …”
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Revisión de Programas de Antiviolencia o Valores en el Fútbol (Review of Anti-Violence or Values in Football Programmes) by Antonio Aguilar Gómez

“…Today, organizations such as football clubs and associations function as football micro ecosystems where different forms of violence can manifest. …”
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A network analysis study of anxiety, depression and loneliness among middle-aged and elderly people in Xining area by Bixuan Dong, Bin Li, Xiaowei Fan, Hongru Chen, Zhancui Dang, Ze Li

“…Additionally, the study conducted a comparative analysis of the network structures to explore gender differences.The objective of this study was to provide theoretical intervention strategies and practical guidelines for the mental health of middle-aged and older individuals in high-altitude regions. …”
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Impact of HIV-1 capsid polymorphisms on viral infectivity and susceptibility to lenacapavir by Derek Hansen, Matthew R. Hendricks, Silvia Chang, Arthur Cai, Jason K. Perry, Thomas Aeschbacher, Ross Martin, Tomas Cihlar, Stephen R. Yant

“…Collectively, these results indicate that existing CA natural HIV-1 sequence diversity within the LEN-binding site is rare and should minimally impact LEN efficacy in treatment-naïve individuals.IMPORTANCEHIV-1 capsid protein mediates multiple essential functions throughout the viral replication cycle, making it an attractive target for therapeutic intervention. …”
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Lower RXRA and TFRC expression despite higher mineral and vitamin intake in diabetic pregnant women with pregnancy-specific urinary incontinence by Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, Matheus Naia Fioretto, João Paulo de Castro Marcondes, Igor de Carvalho Deprá, Camila Renata Corrêa, Danielle Cristina Honorio França, David Rafael Abreu Reyes, Sérgio Luis Felisbino, Angélica Mércia Pascon Barbosa, Marilza Cunha Vieira Rudge, M.V.C. Rudge, A.M.P. Barbosa, I.M.P. Calderon, F.P. Souza, T. Lehana, C.F.O. Graeff, C.G. Magalhães, R.A.A. Costa, S.A.M. Lima, M.R.K. Rodrigues, S.L. Felisbino, W.F. Barbosa, F.J. Campos, G. Bossolan, J.E. Corrente, H.R.C. Nunes, J.F. Abbade, P.S. Rossignoli, C.R. Pedroni, Á.N. Atallah, Z.I. Jármy-Di Bella, S.M.M. Uchôa, M.A.H. Duarte, E.A. Mareco, M.E. Sakalem, N.M. Martinho, D.G. Bussaneli, M.I.G. Orlandi, C. Pascon, T.D. Dangió, C.V.C. Rudge, F. Piculo, G.M. Prata, R.E. Avramidis, C.N.F. Carvalho, A.B.M. Magyori, G.T.A. Nava, T.C.D. Caldeirão, R.H.L. Shetty, D.R.A. Reyes, F.C.B. Alves, J.P.C. Marcondes, M.L.S. Takemoto, C.B. Prudencio, F.A. Pinheiro, C.I. Sartorao Filho, S.B.C.V. Quiroz, T. Pascon, S.K. Nunes, B.B. Catinelli, F.V.D.S. Reis, R.G. Oliveira, S.M.B. Costa, M.O. Menezes, N.J. Santos, E.M.A. Enriquez, L. Takano, A.M. Carr, G.A. Garcia, L.F. Iamundo, H.C.M. Bassin, V.P. Barbosa, M. Jacomin, A.J.B. Silva, I.O. Lourenço, J. Marostica de Sá, I.P. Caruso, L.T. Rasmussen, V.K.C. Nogueira, J.T. Ribeiro-Paes, D.C.H. França, H.V.M. Bastos, M.L.A. Heliodoro, M.N. Kuroda, H.L. Carvalho

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Confirming the Presence of Neurapraxia and Its Potential for Immediate Reversal by Novel Diagnostic and Therapeutic Ultrasound-Guided Hydrodissection Using 5% Dextrose in Water Wit... by Ho Won Lee, Jihyo Hwang, Chanwool Park, Minjae Lee, Yonghyun Yoon, Yeui-Seok Seo, Hyemi Yu, Rowook Park, Jaehyun Shim, Junhyuk Ann, Daniel Chiung-Jui Su, Teinny Suryadi, Keneath Dean Reeves, King Hei Stanley Lam

“…At one- and three-month follow-ups, the patient maintained complete resolution of symptoms and normal function. <b>Conclusions:</b> This case highlights two key findings: (1) HD with D5W can serve as both a diagnostic tool (confirming reversible neurapraxia through immediate response) and therapeutic intervention, and (2) early HD may circumvent prolonged disability associated with conservative management. …”
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Case report: Endolymphatic sac tumor with blurred vision by Ke Yuan, Weijian Luo, Weijian Luo, Weijian Luo, Weijian Luo, Jia Chen, Jia Chen, Jia Chen, Jia Chen, Quanzhou Peng, Quanzhou Peng, Quanzhou Peng, Xiaoguang Tong, Xiaoguang Tong, Xiaoguang Tong, Xiaoguang Tong, Xiaoguang Tong, Jiliang Hu, Jiliang Hu, Jiliang Hu, Jiliang Hu

“…It is currently believed that prompt surgical intervention is recommended for endolymphatic sac tumors upon diagnosis. …”
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Social participation and cognitive activities as explanation factor for the association between income and self-rated health for older adults by A. M. Buß, F. G. Wittmann, A. Pabst, M. Luppa, A. Oey, I. Blotenberg, M. I. Cardona, S. Weise, A. Bauer, R. P. Kosilek, F. Bader, C. Brettschneider, B. Wiese, W. Hoffmann, W. Hoffmann, T. Frese, J. S. Gensichen, H.-H. König, J. R. Thyrian, J. R. Thyrian, J. R. Thyrian, S. G. Riedel-Heller

“…The aim of this study was therefore to explore whether and to what extent various health-promoting behaviors can explain the association between household income and self-rated health among older people at risk of dementia.MethodsThe sample consisted of 845 participants (average age 68.9 years; 52.6% female) from the AgeWell.de study, an intervention trial aiming to preserve cognitive function. …”
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Correlates of duration between initial drug use and first drug injection among people who inject drugs in Iran, 2020 by Zahra Abdolahinia, Zahra Jaafari, Ali Karamoozian, Soheil Mehmandoost, Nima Ghalekhani, Mehrdad Khezri, Ghazal Mousavian, Mostafa Shokoohi, Ali Mirzazadeh, Ali Akbar Haghdoost, Mohammad Karamouzian, Mohammad Mehdi Gooya, Samaneh Akbarpour, Hamid Sharifi, Fatemeh Tavakoli

“…A generalized linear mixed model with a gamma-distributed dependent variable and log link function was used to investigate the correlates of transition time from non-injection to injection drug use. …”
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Focal Segmental Glomerulosclerosis Patient Baseline Characteristics in the Sparsentan Phase 3 DUPLEX Study by Howard Trachtman, Jai Radhakrishnan, Michelle N. Rheault, Charles E. Alpers, Jonathan Barratt, Hiddo J.L. Heerspink, Irene L. Noronha, Vlado Perkovic, Brad Rovin, Hernán Trimarchi, Muh Geot Wong, Alex Mercer, Jula Inrig, William Rote, Ed Murphy, Patricia W. Bedard, Sandra Roth, Stewart Bieler, Radko Komers

“…Thirty-three patients (9.4% of 352 evaluable samples) had pathogenic or likely pathogenic (P/LP) variants of genes essential to podocyte structural integrity and function, 27 (7.7%) had P/LP collagen gene (COL4A3/4/5) variants, and 14 (4.0%) had high-risk APOL1 genotypes. …”
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Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis by Tingting Zhu, Qixia Shen, Lingling Shen, Yucheng Wang, Bochen Zhu, Lifeng Ma, Shi Feng, Cuili Wang, Sijing Yan, Jingyi Li, Zhimin Chen, Jingyi Zhou, Hongfeng Huang, Bingjue Li, Zhouji Shen, Qian Wang, Jianwei Wang, Wilfried Gwinner, Irina Scheffner, Song Rong, Bing Yang, Junwen Wang, Hermann Haller, Xiaoping Han, Guoji Guo, Zhinan Yin, Jin Jin, Hui-Yao Lan, Jianghua Chen, Hong Jiang

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Regulatory culture and architectural project by Mario Losasso

“…One notable aspect is the adoption of the regulating principle of ‘do no significant harm’ (DNHS), along with the choice to link together the numerous intervention proposals aimed at implementing structural and lasting changes in the built environment, both in terms of implementation and methodology. …”
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Pantethine ameliorates dilated cardiomyopathy features in PPCS deficiency disorder in patients and cell line models by Fangfang Zhang, Tatjana Dorn, Barbara Gnutti, Yair Anikster, Sarah Kuebler, Rebecca Ahrens-Nicklas, Rachel Gosselin, Shamima Rahman, Ronen Durst, Enrica Zanuttigh, Miriam A. Güra, Christine M. Poch, Anna B. Meier, Karl-Ludwig Laugwitz, Hans-Joachim Schüller, Ana C. Messias, Ody C. Sibon, Dario Finazzi, Alyssa Rippert, Dong Li, Kristen Truxal, Deipanjan Nandi, Brent C. Lampert, Mildrid Yeo, Alice Gardham, Batel Nissan, Smadar Horowitz Cederboim, Alessandra Moretti, Arcangela Iuso

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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Guiding Distributive Justice: Capability Theory Capability theory is an account of justice opportunity that places a fundamental moral significance on individuals' ability to reach proper functioning and well-being.[52] Whether or not an individual can make use of a particular set of resources and convert them into a state of functioning depends on personal, sociopolitical, and environmental conditions ("conversion factors").[53] In this sense, liberty is not the absence of restraint from others or institutions but the freedom achieved through capability-enhancing relationships.[54] Within the context of bioethics, capability theory shifts focus toward creating circumstances by which individuals can direct their lives as they choose.[55] Acting in accordance with the principle of beneficence, peer-support specialists could enhance the capability of patients to be self-determined and autonomous, which would promote patient well-being and empowerment.[56] Those living with SMI, such as schizophrenia and bipolar disorder, are among the most disadvantaged in society, experiencing social and economic hardship related to their illness.[57] These individuals are often feared and rejected by others, which increases depression, lowers self-esteem, and engenders feelings of social isolation.[58] Compounding their challenges, especially for those facing structural inequalities, is insufficient access to appropriate mental health services supporting recovery.[59] Capability theory provides a sound justification for the resource distribution necessary to create and sustain a thriving network of peer-support specialists, to which those with SMI currently do not have access. …”
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