Alterations in ganglion cell and nerve fiber layer in Leber hereditary optic neuropathy across clinical stages by Michael Oeverhaus, Mareile Knetsch, Ying Chen, Leyla Jabbarli, Carmen Nolden, Anja Eckstein, Nikolaos E. Bechrakis, Philipp Rating

“…As the condition progresses, there is a decline in visual function, accompanied by noticeable structural alterations. …”
Get full text

Selenium and Coenzyme Q₁₀ Supplementation and Sex Differences in Cardiovascular Mortality Results from a Prospective Randomized Double-Blind Placebo-Controlled Trial in... by Urban Alehagen, Jan Olav Aaseth, Lutz Schomburg, Trine B. Opstad, Anders Larsson, Jan Alexander

“…The higher prevalence of structural CVD and smoking in males may have contributed to the observed greater supplementation benefits in females. …”
Get full text

Dehydrotanshinone II A alleviates osteoarthritis via activating PPARγ to inhibit ferroptosis in chondrocytes by Wenli Guan, Fahu Yuan, Xin Wang

“…The study confirmed that DHT IIA could improve the articular cartilage structure of OA rats by elevating PPARγ and inhibiting ferroptosis. …”
Get full text

Physical Activity after Cardiac EventS (PACES): a group education programme with subsequent text message support designed to increase physical activity in individuals with diagnose... by Melanie J Davies, Kamlesh Khunti, Laura J Gray, Thomas Yates, Helen Dallosso, Samuel Seidu, Alex V Rowlands, Patrick J Highton, Louisa Y Herring, Sally Schreder, Emily J Smith, Ghazala Waheed, Ian Hudson

“…Aim To assess the effectiveness of a low-cost pragmatic intervention (structured education and ongoing text message support) to increase daily physical activity in participants 12–48 months after a coronary heart disease cardiac event (myocardial infarction, angina or acute coronary syndrome) diagnosis.Methods A single-centre randomised controlled trial of 291 adults randomised to a structured education programme (n=145) or usual care (n=146). …”
Get full text

Assessment of psychosocial aspects in adults in post-COVID-19 condition: the EURONET-SOMA recommendations on core outcome domains for clinical and research use by Stefan Salzmann, Lars de Vroege, Petra Engelmann, Per Fink, Susanne Fischer, Stephan Frisch, Lise Kirstine Gormsen, Katharina Hüfner, Willem J. Kop, Ferenc Köteles, Nadine Lehnen, Bernd Löwe, Christoph Pieh, Victor Pitron, Charlotte Ulrikka Rask, Markku Sainio, Rainer Schaefert, Meike Shedden-Mora, Anne Toussaint, Roland von Känel, Ursula Werneke, Winfried Rief, on behalf of the EURONET-SOMA Group

Get full text

Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…Additionally, MO-HPA1.0 hydrogel demonstrated effective oxygen-producing and cell migration-promoting functions in both in vitro and cellular experiments. …”
Get full text

Integrating an exercise program into opioid agonist therapy: a pilot study on feasibility, fitness improvements, and participation challenges by Einar Furulund, Siv-Elin Leirvåg Carlsen, Silvia Eiken Alpers, Jørn Henrik Vold, Karl Trygve Druckrey-Fiskaaen, Tesfaye Madebo, Sindre M. Dyrstad, Torgeir Gilje Lid, Lars Thore Fadnes

“…Changes in aerobic fitness (4-minut step test), psychological distress (10-item Hopkins Symptom Checklist, SCL-10), fatigue (3-items Fatigue Severity Scale, FSS-3), lung function (spirometry), and respiratory symptoms (modified Medical Research Council Dyspnea Scale, mMRC) were assessed, while qualitative interviews provided insights into intervention feasibility. …”
Get full text

A rare case of ectopic pituitary adenoma originating from the third ventricle floor: Surgical approach and outcomes by Guive Sharifi, Elham Paraandavaji, Shahin Naghizadeh, Yalda Nilipour, Mohammad Ali Kazemi, Mahbube Ebrahimpur, Ali Jafari, Farzad Taghizadeh-Hesary

“…Surgical intervention resulted in complete tumor resection without complications, leading to improved visual and endocrine function postoperatively. …”
Get full text

中學生成長型思維與學習投入之關係： 以後設認知與羞愧感為中介變項 A Study on the Impact of Growth Mindset on Learning Engagement Among Junior and Senior High School Students: Exploring the Mediating Roles of Metac... by 王佳琪 Chia-Chi Wang, 孫國瑋 Guo-Wei Sun

“…本研究探討中學生成長型思維與學習投入的關係，並檢驗後設認知與羞愧感的中介效果，以1,167位國、高中生為研究對象，完成「思維量表」、「後設認知量表」、「羞愧感量表」與「學習投入量表」等研究工具的填答，採結構方程模式（Structural Equation Modeling, SEM）進行分析。研究結果顯示，一、學生的成長型思維能正向預測後設認知、後設認知能直接正向預測學習投入、成長型思維會間接正向預測學生的學習投入；二、學生的成長型思維能直接負向預測羞愧感、羞愧感會直接負向預測學生的學習投入；三、學生的後設認知與羞愧感，在成長型思維與學習投入間具有中介效果。…”
Get full text

Implementing an online-delivered exercise program for childhood cancer survivors: A hybrid effectiveness-implementation protocol for the MERRIER studyKey points by David Mizrahi, Alexandra Martiniuk, Laurence Hibbert, Dinisha Govender, Tora Sibbald, Richard Mitchell, Natalia Millard, Lauren Ha, Damian Ragusa, Kylie Brown, Ben Smith

“…The RE-AIM framework will assess reach (e.g. recruitment rate), effectiveness (e.g. physical activity levels), adoption (e.g. qualitative interviews), implementation (e.g. exercise adherence), and maintenance (e.g. self-efficacy at follow-up). Physical function and patient-reported outcomes will be assessed at baseline (T0), post-intervention (T1; week 12) and follow-up (T2, week 24). …”
Get full text

Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation by Pazhanichamy Kalailingam, Khalilatul‐Hanisah Mohd‐Kahliab, SoFong Cam Ngan, Ranjith Iyappan, Evelin Melekh, Tian Lu, Gan Wei Zien, Bhargy Sharma, Tiannan Guo, Adam J MacNeil, Rebecca EK MacPherson, Evangelia Litsa Tsiani, Deborah D O'Leary, Kah Leong Lim, I Hsin Su, Yong‐Gui Gao, A Mark Richards, Raj N Kalaria, Christopher P Chen, Neil E McCarthy, Siu Kwan Sze

Get full text

Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

“…While habitat composition and planting strategies offer substantial localized benefits, their variability necessitates tailored interventions informed by specific ecological and social contexts. …”
Get full text

Membrane Associated RNA‐Containing Vesicles Regulate Cortical Astrocytic Microdomain Calcium Transients in Awake Ischemic Stroke Mice by Zhongqiu Zhou, Ying Bai, Xiaochun Gu, Hui Ren, Wen Xi, Yu Wang, Liang Bian, Xue Liu, Ling Shen, Xianyuan Xiang, Wenhui Huang, Zhuojuan Luo, Bing Han, Honghong Yao

“…Abstract Astrocytic processes minutely regulate neuronal activity via tripartite synaptic structures. The precision‐tuning of the function of astrocytic processes is garnering increasing attention because of its significance in promoting brain repair following ischemic stroke. …”
Get full text

Measurement of purpose in life among Arabic-speaking adolescents: psychometric properties of an Arabic-language version of the Claremont purpose scale (CPS) by Amir Noureddine, Souheil Hallit, Souheil Hallit, Souheil Hallit, Diana Malaeb, Fouad Sakr, Mariam Dabbous, Tylor Cosgrove, Sahar Obeid, Feten Fekih-Romdhane, Feten Fekih-Romdhane, Ahmed A. Moustafa, Ahmed A. Moustafa

Get full text

Conservative or surgical treatment? Optimizing management strategies in medial hypertensive intracerebral hemorrhages by M.Ye. Polishchuk, A.A. Kaminskyi, A.A. Oblyvach, D.V. Shchehlov, O.M. Honcharuk, A.V. Muravskyi

“…From a prognostic perspective, surgical treatment of medial hematomas increases the likelihood of fatal outcomes and does not enhance functional neurological recovery. Therefore, even in cases of large hemorrhages involving medial (subcortical) brain structures, surgical intervention appears to be unwarranted.…”
Get full text

463 Identification of molecular and cellular events during recurrence of focal segmental glomerulosclerosis in human allografts by Haseeb Zubair, Thomas V Rousselle, Amol C Shetty, Azim Shafquat, Akalin Enver, Manish Talwar, Daniel G Maluf, Gallon Lorenzo, Valeria R Mas

“…Objectives/Goals: The identification of the cascade of molecular and cellular events occurring during the progression of focal segmental glomerulosclerosis in human kidney biopsies from kidney transplant (KTx) recipients (KTR) with normal function or recurrent FSGS to determine potential targets of intervention and therapy. …”
Get full text

Development and Characterization of CD44-Targeted X-Aptamers with Enhanced Binding Affinity for Cancer Therapeutics by Hongyu Wang, Weiguo He, Miguel-Angel Elizondo-Riojas, Xiaobo Zhou, Tae Jin Lee, David G. Gorenstein

Get full text

Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways by Ge Gong, Xiangxuan Chen, Xinghu Zhang, Jian Yin, Wenhui Wan

“…In a mouse model, cardiac function deteriorated and ventricular structural changes were observed 14 days post-myocardial infarction relative to controls. …”
Get full text

Effects of a multicomponent exercise regimen on subchondral bone and cartilage in postmenopausal women with knee osteoarthritis: protocol for a randomized controlled trial by Ville-Markus Konola, Jari Parkkari, Juhani Multanen, Riku Nikander, Timo Rantalainen, Johanna Vesanto, Satu Pekkala, Merja Kalaja, Johanna K. Ihalainen, Benjamin Waller, Matti Munukka, Harri Sievänen, Mika Nevalainen, Hannu Kautiainen, Victor Casula, Juha Paloneva, Tommi Vasankari, Arttu Peuna, Simo Saarakkala, Miika T. Nieminen, Ari Heinonen

“…Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance. …”
Get full text

Exploring Early Mobilization Practices in Adult Intensive Care Units in Jordan: A Cross-Sectional Survey by Wshah A, Obaidat S, Shallan AI, Muhsen A, Bin Sheeha B, Alkasassbeh A, Wshah S, Al Hadidi ARB, Altaim TA, Sawafta B, Alqallab S

“…Adnan Wshah,1 Sakher Obaidat,1 Amjad I Shallan,1 Ahmad Muhsen,1 Bodor Bin Sheeha,2 Asmaa Alkasassbeh,3 Shadi Wshah,4 Abdel Razzaq Bassam Al Hadidi,5 Thamer A Altaim,1 Batul Sawafta,1 Salsabeel Alqallab6 1Department of Physical Therapy, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan; 2Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; 3Physiotherapy Department, Faculty of Allied Medical Sciences, Isra University, Amman, Jordan; 4Physical Therapy Department, Jordanian Royal Medical Services, Amman, Jordan; 5Department of Physical Therapy, School of Rehabilitation Sciences, The University of Jordan, Amman, Jordan; 6Al Patrawi Physiotherapy Center, Zarqa, JordanCorrespondence: Adnan Wshah, Department of Physical Therapy, Faculty of Applied Medical Sciences, The Hashemite University, P.O box 330127, Zarqa, 13133, Jordan, Email adnan.wshah@hu.edu.joBackground: Prolonged immobilization in critically ill patients in the intensive care unit (ICU) is associated with adverse health outcomes, such as ICU-acquired weakness (ICU-AW), pressure ulcers, and decreased cardiopulmonary function. Early mobilization has been shown to be an important intervention to mitigate these effects; however, there is limited information regarding its implementation in ICUs in Jordan. …”
Get full text